Details for: DGKB

Gene ID: 1607

Symbol: DGKB

Ensembl ID: ENSG00000136267

Description: diacylglycerol kinase beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 15.2945
    Cell Significance Index: 217.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 9.6320
    Cell Significance Index: 426.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 8.6824
    Cell Significance Index: 328.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 7.2781
    Cell Significance Index: 489.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.7342
    Cell Significance Index: 2056.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.1007
    Cell Significance Index: 117.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.4326
    Cell Significance Index: 688.5700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 3.2510
    Cell Significance Index: 42.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.1706
    Cell Significance Index: 2192.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.5748
    Cell Significance Index: 61.7500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.2770
    Cell Significance Index: 30.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.2352
    Cell Significance Index: 232.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6152
    Cell Significance Index: 99.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6109
    Cell Significance Index: 98.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.5217
    Cell Significance Index: 33.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1652
    Cell Significance Index: 37.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5815
    Cell Significance Index: 1094.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5066
    Cell Significance Index: 96.4000
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.4731
    Cell Significance Index: 3.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4398
    Cell Significance Index: 19.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3845
    Cell Significance Index: 8.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2225
    Cell Significance Index: 200.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1792
    Cell Significance Index: 35.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0275
    Cell Significance Index: 2.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0138
    Cell Significance Index: 21.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0200
    Cell Significance Index: -36.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0245
    Cell Significance Index: -3.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0265
    Cell Significance Index: -36.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0267
    Cell Significance Index: -16.9800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0347
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0455
    Cell Significance Index: -33.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0681
    Cell Significance Index: -49.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0716
    Cell Significance Index: -1.7900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0734
    Cell Significance Index: -0.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0766
    Cell Significance Index: -43.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0798
    Cell Significance Index: -60.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0928
    Cell Significance Index: -57.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0939
    Cell Significance Index: -51.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0953
    Cell Significance Index: -3.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0963
    Cell Significance Index: -43.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1043
    Cell Significance Index: -46.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1216
    Cell Significance Index: -13.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1582
    Cell Significance Index: -45.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2107
    Cell Significance Index: -6.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2349
    Cell Significance Index: -42.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2442
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2474
    Cell Significance Index: -52.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2777
    Cell Significance Index: -15.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2795
    Cell Significance Index: -38.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2889
    Cell Significance Index: -5.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2942
    Cell Significance Index: -42.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3092
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3122
    Cell Significance Index: -53.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3231
    Cell Significance Index: -3.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3596
    Cell Significance Index: -5.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3618
    Cell Significance Index: -21.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3913
    Cell Significance Index: -48.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3964
    Cell Significance Index: -50.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4216
    Cell Significance Index: -8.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4238
    Cell Significance Index: -29.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4305
    Cell Significance Index: -55.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4530
    Cell Significance Index: -34.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4862
    Cell Significance Index: -49.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4930
    Cell Significance Index: -56.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4977
    Cell Significance Index: -58.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6321
    Cell Significance Index: -50.0600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.7104
    Cell Significance Index: -8.8300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7205
    Cell Significance Index: -8.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7337
    Cell Significance Index: -24.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7470
    Cell Significance Index: -55.6700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7806
    Cell Significance Index: -9.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7843
    Cell Significance Index: -19.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8287
    Cell Significance Index: -23.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8491
    Cell Significance Index: -16.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8877
    Cell Significance Index: -18.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8880
    Cell Significance Index: -31.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.9056
    Cell Significance Index: -10.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9088
    Cell Significance Index: -57.2800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.9380
    Cell Significance Index: -11.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9541
    Cell Significance Index: -50.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9606
    Cell Significance Index: -49.9000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9683
    Cell Significance Index: -20.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9820
    Cell Significance Index: -51.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9935
    Cell Significance Index: -19.5600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.0470
    Cell Significance Index: -14.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0699
    Cell Significance Index: -22.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.0708
    Cell Significance Index: -10.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1164
    Cell Significance Index: -52.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.1192
    Cell Significance Index: -19.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.1598
    Cell Significance Index: -54.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.1650
    Cell Significance Index: -19.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.2602
    Cell Significance Index: -21.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3676
    Cell Significance Index: -50.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.4119
    Cell Significance Index: -28.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.4394
    Cell Significance Index: -62.5900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.4583
    Cell Significance Index: -16.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4628
    Cell Significance Index: -50.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5203
    Cell Significance Index: -39.0800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.6692
    Cell Significance Index: -22.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.7168
    Cell Significance Index: -41.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DGKB is a member of the diacylglycerol kinase family, which consists of enzymes that catalyze the phosphorylation of DAG to produce phosphatidic acid. DGKB is specifically expressed in various cell types, including chromaffin cells, sympathetic neurons, neuronal brush cells, CNS interneurons, cerebral cortex neurons, and smooth muscle cells of the sphincter of the pupil. Its expression pattern suggests a role in modulating immune responses, particularly in the context of neural and cardiovascular systems. **Pathways and Functions:** DGKB is intricately involved in multiple signaling pathways, including: 1. **G protein-coupled receptor (GPCR) signaling**: DGKB phosphorylates DAG, a product of GPCR activation, to produce phosphatidic acid, which in turn modulates downstream signaling events. 2. **Intracellular signal transduction**: DGKB's activity is linked to various signaling pathways, including the protein kinase C (PKC)-activating GPCR signaling pathway and the effects of pip2 hydrolysis. 3. **Lipid binding and phosphorylation**: DGKB's enzymatic activity is crucial for the phosphorylation of DAG, which is then involved in lipid binding and signaling processes. 4. **Diacylglycerol metabolic process**: DGKB is a key player in the DAG metabolic pathway, regulating the production of phosphatidic acid, which is essential for cellular signaling and lipid metabolism. **Clinical Significance:** DGKB's involvement in immune regulation and cellular signaling pathways makes it an attractive target for therapeutic intervention in various diseases, including: 1. **Neurological disorders**: DGKB's expression in CNS interneurons and cerebral cortex neurons suggests a role in modulating neural signaling and immune responses, which may be implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's. 2. **Cardiovascular diseases**: DGKB's expression in smooth muscle cells of the sphincter of the pupil and its involvement in platelet activation and aggregation pathways suggest a potential role in cardiovascular disease. 3. **Immunological disorders**: DGKB's expression in chromaffin cells and sympathetic neurons implies a role in modulating immune responses, particularly in the context of autoimmune and inflammatory diseases. In conclusion, DGKB is a multifaceted enzyme that plays a crucial role in regulating immune responses, cellular signaling, and lipid metabolism. Further research is necessary to fully elucidate its mechanisms and potential therapeutic applications, but its involvement in various human diseases highlights the importance of this enzyme in maintaining cellular homeostasis.

Genular Protein ID: 3212632048

Symbol: DGKB_HUMAN

Name: Diacylglycerol kinase beta

UniProtKB Accession Codes:

Q9Y6T7 A4D116 A4D117 A8MXU2 O75241 Q2M377 Q75MF9 Q75MU7 Q86UI5 Q86UM9 Q9UQ29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 39 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 13 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 14 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 12 SABIO-RK 1 SMART 4 STRING 1 SUPFAM 3 SwissLipids 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11719522

Title: Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties.

PubMed ID: 11719522

DOI: 10.1074/jbc.m110249200

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

Sequence Information:

  • Length: 804
  • Mass: 90595
  • Checksum: CBCABD2339BFE176
  • Sequence:
    • MTNQEKWAHL SPSEFSQLQK YAEYSTKKLK DVLEEFHGNG VLAKYNPEGK QDILNQTIDF 
EGFKLFMKTF LEAELPDDFT AHLFMSFSNK FPHSSPMVKS KPALLSGGLR MNKGAITPPR 
TTSPANTCSP EVIHLKDIVC YLSLLERGRP EDKLEFMFRL YDTDGNGFLD SSELENIISQ 
MMHVAEYLEW DVTELNPILH EMMEEIDYDH DGTVSLEEWI QGGMTTIPLL VLLGLENNVK 
DDGQHVWRLK HFNKPAYCNL CLNMLIGVGK QGLCCSFCKY TVHERCVARA PPSCIKTYVK 
SKRNTDVMHH YWVEGNCPTK CDKCHKTVKC YQGLTGLHCV WCQITLHNKC ASHLKPECDC 
GPLKDHILPP TTICPVVLQT LPTSGVSVPE ERQSTVKKEK SGSQQPNKVI DKNKMQRANS 
VTVDGQGLQV TPVPGTHPLL VFVNPKSGGK QGERIYRKFQ YLLNPRQVYS LSGNGPMPGL 
NFFRDVPDFR VLACGGDGTV GWVLDCIEKA NVGKHPPVAI LPLGTGNDLA RCLRWGGGYE 
GENLMKILKD IENSTEIMLD RWKFEVIPND KDEKGDPVPY SIINNYFSIG VDASIAHRFH 
IMREKHPEKF NSRMKNKFWY FEFGTSETFS ATCKKLHESV EIECDGVQID LINISLEGIA 
ILNIPSMHGG SNLWGESKKR RSHRRIEKKG SDKRTTVTDA KELKFASQDL SDQLLEVVGL 
EGAMEMGQIY TGLKSAGRRL AQCSCVVIRT SKSLPMQIDG EPWMQTPCTI KITHKNQAPM 
LMGPPPKTGL FCSLVKRTRN RSKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.