SEM1 | ENSG00000127922 | NCBI 7979

Details for: SEM1

Gene ID: 7979

Symbol: SEM1

Ensembl ID: ENSG00000127922

Description: SEM1 26S proteasome subunit

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of dna double-strand break repair
(R-HSA-9675136)
Diseases of dna repair
(R-HSA-9675135)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Homology directed repair
(R-HSA-5693538)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 296.0085
Cell Significance Index: -121.9400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 264.2322
Cell Significance Index: -124.7500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 230.4693
Cell Significance Index: -118.5500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 186.3277
Cell Significance Index: -125.0300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 35.1456
Cell Significance Index: -94.1500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 29.6342
Cell Significance Index: -91.0200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 17.5273
Cell Significance Index: -38.3600
Cell Name: granulosa cell (CL0000501)
Fold Change: 4.3917
Cell Significance Index: 115.4800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.7848
Cell Significance Index: 519.7600
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.6379
Cell Significance Index: 1986.7300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.4284
Cell Significance Index: 421.5500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.1395
Cell Significance Index: 565.9600
Cell Name: odontoblast (CL0000060)
Fold Change: 2.8767
Cell Significance Index: 368.7800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.7639
Cell Significance Index: 75.2300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.5148
Cell Significance Index: 296.5700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.4372
Cell Significance Index: 51.0200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.3735
Cell Significance Index: 1049.3700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.3478
Cell Significance Index: 109.4700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.1236
Cell Significance Index: 150.1900
Cell Name: peg cell (CL4033014)
Fold Change: 1.9633
Cell Significance Index: 45.3600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.9207
Cell Significance Index: 21.8200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.8681
Cell Significance Index: 53.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.8518
Cell Significance Index: 138.0100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.6077
Cell Significance Index: 576.6700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.5916
Cell Significance Index: 74.8100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.5497
Cell Significance Index: 80.5000
Cell Name: lactocyte (CL0002325)
Fold Change: 1.5432
Cell Significance Index: 199.3700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.3705
Cell Significance Index: 40.2500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3247
Cell Significance Index: 262.9000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.0561
Cell Significance Index: 13.5300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.0469
Cell Significance Index: 64.3500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9384
Cell Significance Index: 178.5800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.8356
Cell Significance Index: 7.6900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.7662
Cell Significance Index: 8.3300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6630
Cell Significance Index: 42.7800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.3767
Cell Significance Index: 19.0400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3021
Cell Significance Index: 51.5900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.3001
Cell Significance Index: 227.1500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2754
Cell Significance Index: 9.5700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2737
Cell Significance Index: 44.5200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2710
Cell Significance Index: 14.2300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2587
Cell Significance Index: 15.5300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1191
Cell Significance Index: 2.1100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0745
Cell Significance Index: 1.9900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0685
Cell Significance Index: 5.2600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0560
Cell Significance Index: 5.5400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0245
Cell Significance Index: 0.4100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0233
Cell Significance Index: 43.8300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0091
Cell Significance Index: 6.6800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0128
Cell Significance Index: -0.7200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0144
Cell Significance Index: -2.8800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0264
Cell Significance Index: -48.7200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0311
Cell Significance Index: -47.8200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0455
Cell Significance Index: -20.6300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0482
Cell Significance Index: -13.8600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0586
Cell Significance Index: -79.7300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0611
Cell Significance Index: -38.7900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0702
Cell Significance Index: -52.0200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0809
Cell Significance Index: -8.2600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1856
Cell Significance Index: -104.6600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1965
Cell Significance Index: -28.5700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2270
Cell Significance Index: -4.2000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3743
Cell Significance Index: -43.6300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3750
Cell Significance Index: -10.4800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4915
Cell Significance Index: -56.3100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5987
Cell Significance Index: -126.1000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6012
Cell Significance Index: -37.8900
Cell Name: kidney cell (CL1000497)
Fold Change: -0.6325
Cell Significance Index: -5.0500
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.6389
Cell Significance Index: -5.4900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.7177
Cell Significance Index: -32.5300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7281
Cell Significance Index: -23.3200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7342
Cell Significance Index: -49.3700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.8107
Cell Significance Index: -56.0700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8983
Cell Significance Index: -23.0900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.9240
Cell Significance Index: -23.6100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0567
Cell Significance Index: -83.6900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.0914
Cell Significance Index: -48.2800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0973
Cell Significance Index: -114.2600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.1599
Cell Significance Index: -25.1300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.3545
Cell Significance Index: -51.2900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.4711
Cell Significance Index: -35.2800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.5668
Cell Significance Index: -46.1500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.6155
Cell Significance Index: -23.8500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.6463
Cell Significance Index: -67.4600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.6998
Cell Significance Index: -29.1300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.7407
Cell Significance Index: -23.7500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.8942
Cell Significance Index: -22.5800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.9138
Cell Significance Index: -55.1400
Cell Name: preadipocyte (CL0002334)
Fold Change: -1.9173
Cell Significance Index: -37.4200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.9943
Cell Significance Index: -122.2700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.0731
Cell Significance Index: -55.4600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.1550
Cell Significance Index: -32.2900
Cell Name: germ cell (CL0000586)
Fold Change: -2.2183
Cell Significance Index: -16.7500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.3179
Cell Significance Index: -19.4700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.3187
Cell Significance Index: -57.9600
Cell Name: Purkinje cell (CL0000121)
Fold Change: -2.3675
Cell Significance Index: -51.8400
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -2.3723
Cell Significance Index: -14.7400
Cell Name: type I muscle cell (CL0002211)
Fold Change: -2.6763
Cell Significance Index: -65.3000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.6849
Cell Significance Index: -98.5600
Cell Name: lens fiber cell (CL0011004)
Fold Change: -2.9120
Cell Significance Index: -92.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Proteasome Subunit:** SEM1 is a subunit of the 26S proteasome complex, a multi-protein complex responsible for degrading proteins. 2. **Cellular Expression:** SEM1 is expressed in various cell types, including pancreatic A cells, skeletal muscle satellite cells, and myeloid dendritic cells. 3. **Signaling Pathways:** SEM1 is implicated in multiple signaling pathways, including those regulating cell cycle, apoptosis, and antigen processing. 4. **Antigen Processing:** SEM1 plays a crucial role in the processing and presentation of antigens, which is essential for immune recognition and response. **Pathways and Functions:** 1. **Antigen Processing-Cross Presentation:** SEM1 is involved in the processing and presentation of antigens, which is essential for immune recognition and response. 2. **Apoptosis:** SEM1 regulates apoptosis, a process of programmed cell death, which is crucial for maintaining immune homeostasis. 3. **Cell Cycle Regulation:** SEM1 is involved in regulating the cell cycle, particularly in the G1/S transition, which is essential for cell proliferation and differentiation. 4. **Immune System Regulation:** SEM1 plays a critical role in regulating the immune system, including the activation of immune cells and the production of cytokines. **Clinical Significance:** 1. **Immune Disorders:** SEM1 dysregulation has been implicated in various immune disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** SEM1 overexpression has been observed in certain types of cancer, including lymphoma and leukemia, suggesting its potential as a therapeutic target. 3. **Infectious Diseases:** SEM1 plays a crucial role in regulating the immune response to infections, and its dysregulation may contribute to the development of infectious diseases, such as HIV and tuberculosis. 4. **Neurological Disorders:** SEM1 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential as a therapeutic target. In conclusion, SEM1 is a multifaceted gene that plays a critical role in immune regulation and disease. Further research is needed to fully elucidate its mechanisms of action and potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome complex subunit SEM1

Genular Protein ID: 1477336154

Symbol: SEM1_HUMAN

Name: 26S proteasome complex subunit SEM1

UniProtKB Accession Codes:

P60896 Q13437 Q61067

Database IDs:

Citations:

PubMed ID: 8733122

Title: Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development.

PubMed ID: 8733122

DOI: 10.1093/hmg/5.5.571

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 10373512

Title: Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.

PubMed ID: 10373512

DOI: 10.1128/mcb.19.7.4633

PubMed ID: 15117943

Title: Sem1p is a novel subunit of the 26S proteasome from Saccharomyces cerevisiae.

PubMed ID: 15117943

DOI: 10.1074/jbc.m403165200

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 21719596

Title: A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.

PubMed ID: 21719596

DOI: 10.1182/blood-2010-12-324541

PubMed ID: 22307388

Title: Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export.

PubMed ID: 22307388

DOI: 10.1093/nar/gks059

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24896180

Title: BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

PubMed ID: 24896180

DOI: 10.1038/nature13374

PubMed ID: 26833090

Title: Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.

PubMed ID: 26833090

DOI: 10.1016/j.molcel.2015.12.026

PubMed ID: 12228710

Title: BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

PubMed ID: 12228710

DOI: 10.1126/science.297.5588.1837

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 70
Mass: 8278
Checksum: 0E0F58D2F3D9F723
Sequence:

MSEKKQPVDL GLLEEDDEFE EFPAEDWAGL DEDEDAHVWE DNWDDDNVED DFSNQLRAEL 
EKHGYKMETS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SEM1

Associated with

Cells (max top 100)

Other Information

Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. PubMed ID: 8733122

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals. PubMed ID: 10373512

Sem1p is a novel subunit of the 26S proteasome from Saccharomyces cerevisiae. PubMed ID: 15117943

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay. PubMed ID: 21719596

Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. PubMed ID: 22307388

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. PubMed ID: 24896180

Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. PubMed ID: 26833090

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. PubMed ID: 12228710

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858