Details for: DYNC1I1

Gene ID: 1780

Symbol: DYNC1I1

Ensembl ID: ENSG00000158560

Description: dynein cytoplasmic 1 intermediate chain 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.43
    Marker Score: 5,953
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 4.24
    Marker Score: 5,130
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.76
    Marker Score: 12,611
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.45
    Marker Score: 14,457
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.27
    Marker Score: 2,621
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3
    Marker Score: 6,577
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.86
    Marker Score: 63,913
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.8
    Marker Score: 1,636
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.73
    Marker Score: 40,883
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.71
    Marker Score: 856
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.69
    Marker Score: 4,512
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.68
    Marker Score: 9,542
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.67
    Marker Score: 20,469
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.67
    Marker Score: 53,012
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.62
    Marker Score: 99,414
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.57
    Marker Score: 7,337
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.4
    Marker Score: 1,007
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.38
    Marker Score: 9,858
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.37
    Marker Score: 1,383
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.32
    Marker Score: 85,532
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.25
    Marker Score: 8,699
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.17
    Marker Score: 20,412
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.09
    Marker Score: 21,572
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127,392
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.99
    Marker Score: 8,107
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,309
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16,101
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.84
    Marker Score: 503
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.8
    Marker Score: 867
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,550
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.6
    Marker Score: 7,403
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,160
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.58
    Marker Score: 1,822
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.55
    Marker Score: 3,713
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.52
    Marker Score: 444
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,401
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.45
    Marker Score: 2,956
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 20,090
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.27
    Marker Score: 1,208
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 847
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.21
    Marker Score: 2,449
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.17
    Marker Score: 1,453
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 481
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,794
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.12
    Marker Score: 583
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.11
    Marker Score: 4,625
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.09
    Marker Score: 593
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 497
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.06
    Marker Score: 2,031
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.05
    Marker Score: 1,120
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.04
    Marker Score: 385
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.03
    Marker Score: 267
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.02
    Marker Score: 610
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1
    Marker Score: 1,246
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,021
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1
    Marker Score: 402
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.98
    Marker Score: 324
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,319
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.92
    Marker Score: 313
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5,296
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.87
    Marker Score: 575
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.82
    Marker Score: 406
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.82
    Marker Score: 209
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.81
    Marker Score: 17,348
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.81
    Marker Score: 386
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.78
    Marker Score: 348
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.74
    Marker Score: 737
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 238
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.73
    Marker Score: 229
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.72
    Marker Score: 419
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.72
    Marker Score: 1,771
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1,690
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.67
    Marker Score: 1,681
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.66
    Marker Score: 370
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.64
    Marker Score: 167
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 417
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 546
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.63
    Marker Score: 6,380
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.62
    Marker Score: 332
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.61
    Marker Score: 236
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6
    Marker Score: 2,222
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.59
    Marker Score: 168
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.59
    Marker Score: 259
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DYNC1I1 is a member of the dynein family of motor proteins, which are characterized by their ability to transport cargo along microtubules. The intermediate chain 1 subunit is specifically involved in the cytoplasmic dynein complex, which plays a crucial role in maintaining cellular homeostasis. DYNC1I1 is also known for its involvement in the regulation of the mitotic spindle, cell cycle checkpoints, and the cellular response to stress. **Pathways and Functions:** DYNC1I1 is implicated in multiple cellular pathways, including: 1. **Adaptive Immune System:** DYNC1I1 is involved in the regulation of immune responses, particularly in the context of viral infections. Studies have shown that DYNC1I1 is essential for the proper functioning of immune cells, such as T cells and macrophages. 2. **Autophagy:** DYNC1I1 is involved in the regulation of autophagy, a process by which cells recycle damaged organelles and proteins. Dysregulation of autophagy has been linked to various diseases, including neurodegenerative disorders. 3. **Cell Cycle Regulation:** DYNC1I1 plays a critical role in the regulation of the cell cycle, particularly during mitosis. It is involved in the formation of the mitotic spindle and the separation of sister chromatids. 4. **Cytoskeletal Dynamics:** DYNC1I1 is a key player in the regulation of cytoskeletal dynamics, including the transport of organelles and the maintenance of cellular shape. **Clinical Significance:** DYNC1I1 dysregulation has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Mutations in DYNC1I1 have been linked to neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Autoimmune Diseases:** Dysregulation of DYNC1I1 has been implicated in autoimmune diseases, such as multiple sclerosis (MS) and rheumatoid arthritis (RA). 3. **Cancer:** DYNC1I1 is often overexpressed in cancer cells, suggesting its potential role in tumorigenesis. In conclusion, DYNC1I1 is a multifunctional gene that plays a critical role in various cellular processes, including the adaptive immune system, autophagy, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functional significance of this gene.

Genular Protein ID: 3966672870

Symbol: DC1I1_HUMAN

Name: Cytoplasmic dynein 1 intermediate chain 1

UniProtKB Accession Codes:

O14576 B4DME3 F5H050 G5E9K1 Q8TBF7 Q9Y2X1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 12 RefSeq 9 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10049579

Title: Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human.

PubMed ID: 10049579

DOI: 10.1006/geno.1998.5665

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19229290

Title: Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.

PubMed ID: 19229290

DOI: 10.1038/emboj.2009.38

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 27502274

Title: Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB.

PubMed ID: 27502274

DOI: 10.1074/jbc.m116.736884

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 645
  • Mass: 72955
  • Checksum: 55A6FF971E632DA0
  • Sequence:
    • MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 
ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS KSVSTPSEAG SQDSGDLGPL 
TRTLQWDTDP SVLQLQSDSE LGRRLHKLGV SKVTQVDFLP REVVSYSKET QTPLATHQSE 
EDEEDEEMVE SKVGQDSELE NQDKKQEVKE APPRELTEEE KQQILHSEEF LIFFDRTIRV 
IERALAEDSD IFFDYSGREL EEKDGDVQAG ANLSFNRQFY DEHWSKHRVV TCMDWSLQYP 
ELMVASYNNN EDAPHEPDGV ALVWNMKFKK TTPEYVFHCQ SSVMSVCFAR FHPNLVVGGT 
YSGQIVLWDN RSHRRTPVQR TPLSAAAHTH PVYCVNVVGT QNAHNLITVS TDGKMCSWSL 
DMLSTPQESM ELVYNKSKPV AVTGMAFPTG DVNNFVVGSE EGTVYTACRH GSKAGIGEVF 
EGHQGPVTGI NCHMAVGPID FSHLFVTSSF DWTVKLWTTK HNKPLYSFED NADYVYDVMW 
SPVHPALFAC VDGMGRLDLW NLNNDTEVPT ASVAIEGASA LNRVRWAQAG KEVAVGDSEG 
RIWVYDVGEL AVPHNDEWTR FARTLVEIRA NRADSEEEGT VELSA

Genular Protein ID: 3788713155

Symbol: Q8N542_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N542

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 4 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 628
  • Mass: 70707
  • Checksum: 479FBF78061C8E09
  • Sequence:
    • MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 
ALLQSIGISP EPPLVPTPMS PSSKSVSTPS EAGSQDSGDL GPLTRTLQWD TDPSVLQLQS 
DSELGRRLHK LGVSKVTQVD FLPREVVSYS KETQTPLATH QSEEDEEDEE MVESKVGQDS 
ELENQDKKQE VKEAPPRELT EEEKQQIIHS EEFLIFFDRT IRVIERALAE DSDIFFDYSG 
RELEEKDGDV QAGANLSFNR QFYDEHCSKH RVVTCMDWSL QYPELMVASY NNNEDAPHEP 
DGVALVWNMK FKKTTPEYVF HCQSSVMSVC FARFHPNLVV GGTYSGQIVL WDNRSHRRTP 
VQRTPLSAAA HTHPVYCVNV VGTQNAHNLI TVSTDGKMCS WSLDMLSTPQ ESMELVYNKS 
KPVAVTGMAF PTGDVNNFVV GSEEGTVYTA CRHGSKAGIG EVFEGHQGPV TGINCHMAVG 
PIDFSHLFVT SSFDWTVKLW TTKHNKPLYS FEDNADYVYD VMWSPVHPAL FACVDGMGRL 
DLWNLNNDTE VPTASVAIEG ASALNRVRWA QAGKEVAVGD SEGRIWVYDV GELAVPHNDE 
WTRFARTLVE IRANRADSEE EGTVELSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.