Details for: DYNC1I1

Gene ID: 1780

Symbol: DYNC1I1

Ensembl ID: ENSG00000158560

Description: dynein cytoplasmic 1 intermediate chain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 238.7998
    Cell Significance Index: -60.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.8014
    Cell Significance Index: -60.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.3445
    Cell Significance Index: -60.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8374
    Cell Significance Index: -21.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 5.0759
    Cell Significance Index: 144.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.4365
    Cell Significance Index: 168.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.3699
    Cell Significance Index: 193.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.1646
    Cell Significance Index: 280.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.8359
    Cell Significance Index: 235.1800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.5184
    Cell Significance Index: 43.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.3560
    Cell Significance Index: 1203.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2181
    Cell Significance Index: 645.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.2156
    Cell Significance Index: 4950.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.1613
    Cell Significance Index: 242.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.9928
    Cell Significance Index: 2069.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.2059
    Cell Significance Index: 4068.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.1678
    Cell Significance Index: 2947.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.7446
    Cell Significance Index: 44.8500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.6725
    Cell Significance Index: 21.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.3148
    Cell Significance Index: 2475.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2251
    Cell Significance Index: 55.5300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.0600
    Cell Significance Index: 14.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0390
    Cell Significance Index: 197.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0286
    Cell Significance Index: 63.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.9309
    Cell Significance Index: 96.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.8975
    Cell Significance Index: 15.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8616
    Cell Significance Index: 27.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8493
    Cell Significance Index: 18.4000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.6783
    Cell Significance Index: 10.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6510
    Cell Significance Index: 295.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5878
    Cell Significance Index: 530.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5617
    Cell Significance Index: 13.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4533
    Cell Significance Index: 44.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4176
    Cell Significance Index: 53.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3859
    Cell Significance Index: 245.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2759
    Cell Significance Index: 49.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2588
    Cell Significance Index: 51.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2133
    Cell Significance Index: 2.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1761
    Cell Significance Index: 28.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0113
    Cell Significance Index: 1.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0013
    Cell Significance Index: -0.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0167
    Cell Significance Index: -10.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0175
    Cell Significance Index: -12.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0498
    Cell Significance Index: -28.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0597
    Cell Significance Index: -0.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0743
    Cell Significance Index: -54.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0755
    Cell Significance Index: -2.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0900
    Cell Significance Index: -68.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0973
    Cell Significance Index: -10.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1058
    Cell Significance Index: -46.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1566
    Cell Significance Index: -32.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1677
    Cell Significance Index: -48.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2004
    Cell Significance Index: -34.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2480
    Cell Significance Index: -30.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2567
    Cell Significance Index: -3.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3123
    Cell Significance Index: -9.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3401
    Cell Significance Index: -46.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3690
    Cell Significance Index: -43.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3718
    Cell Significance Index: -25.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3736
    Cell Significance Index: -7.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3857
    Cell Significance Index: -24.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3950
    Cell Significance Index: -7.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4038
    Cell Significance Index: -13.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4405
    Cell Significance Index: -56.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4630
    Cell Significance Index: -24.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4847
    Cell Significance Index: -9.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5573
    Cell Significance Index: -13.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5632
    Cell Significance Index: -64.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5665
    Cell Significance Index: -64.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5776
    Cell Significance Index: -59.0100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6085
    Cell Significance Index: -5.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6299
    Cell Significance Index: -9.3000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.6336
    Cell Significance Index: -4.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6413
    Cell Significance Index: -38.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6712
    Cell Significance Index: -29.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7253
    Cell Significance Index: -15.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7559
    Cell Significance Index: -10.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7678
    Cell Significance Index: -54.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7971
    Cell Significance Index: -11.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8016
    Cell Significance Index: -59.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8164
    Cell Significance Index: -42.5300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.8173
    Cell Significance Index: -9.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8358
    Cell Significance Index: -29.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8463
    Cell Significance Index: -21.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8706
    Cell Significance Index: -24.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8976
    Cell Significance Index: -50.3700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9200
    Cell Significance Index: -11.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9217
    Cell Significance Index: -47.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9683
    Cell Significance Index: -62.4700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.0076
    Cell Significance Index: -12.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.0317
    Cell Significance Index: -9.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.0807
    Cell Significance Index: -50.7900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.1049
    Cell Significance Index: -12.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1700
    Cell Significance Index: -24.2700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.2505
    Cell Significance Index: -39.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.2522
    Cell Significance Index: -58.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.2573
    Cell Significance Index: -26.2400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.2787
    Cell Significance Index: -15.5000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.3003
    Cell Significance Index: -15.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DYNC1I1 is a member of the dynein family of motor proteins, which are characterized by their ability to transport cargo along microtubules. The intermediate chain 1 subunit is specifically involved in the cytoplasmic dynein complex, which plays a crucial role in maintaining cellular homeostasis. DYNC1I1 is also known for its involvement in the regulation of the mitotic spindle, cell cycle checkpoints, and the cellular response to stress. **Pathways and Functions:** DYNC1I1 is implicated in multiple cellular pathways, including: 1. **Adaptive Immune System:** DYNC1I1 is involved in the regulation of immune responses, particularly in the context of viral infections. Studies have shown that DYNC1I1 is essential for the proper functioning of immune cells, such as T cells and macrophages. 2. **Autophagy:** DYNC1I1 is involved in the regulation of autophagy, a process by which cells recycle damaged organelles and proteins. Dysregulation of autophagy has been linked to various diseases, including neurodegenerative disorders. 3. **Cell Cycle Regulation:** DYNC1I1 plays a critical role in the regulation of the cell cycle, particularly during mitosis. It is involved in the formation of the mitotic spindle and the separation of sister chromatids. 4. **Cytoskeletal Dynamics:** DYNC1I1 is a key player in the regulation of cytoskeletal dynamics, including the transport of organelles and the maintenance of cellular shape. **Clinical Significance:** DYNC1I1 dysregulation has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Mutations in DYNC1I1 have been linked to neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Autoimmune Diseases:** Dysregulation of DYNC1I1 has been implicated in autoimmune diseases, such as multiple sclerosis (MS) and rheumatoid arthritis (RA). 3. **Cancer:** DYNC1I1 is often overexpressed in cancer cells, suggesting its potential role in tumorigenesis. In conclusion, DYNC1I1 is a multifunctional gene that plays a critical role in various cellular processes, including the adaptive immune system, autophagy, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functional significance of this gene.

Genular Protein ID: 3966672870

Symbol: DC1I1_HUMAN

Name: Cytoplasmic dynein 1 intermediate chain 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10049579

Title: Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human.

PubMed ID: 10049579

DOI: 10.1006/geno.1998.5665

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19229290

Title: Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.

PubMed ID: 19229290

DOI: 10.1038/emboj.2009.38

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 27502274

Title: Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB.

PubMed ID: 27502274

DOI: 10.1074/jbc.m116.736884

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 645
  • Mass: 72955
  • Checksum: 55A6FF971E632DA0
  • Sequence:
  • MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 
    ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS KSVSTPSEAG SQDSGDLGPL 
    TRTLQWDTDP SVLQLQSDSE LGRRLHKLGV SKVTQVDFLP REVVSYSKET QTPLATHQSE 
    EDEEDEEMVE SKVGQDSELE NQDKKQEVKE APPRELTEEE KQQILHSEEF LIFFDRTIRV 
    IERALAEDSD IFFDYSGREL EEKDGDVQAG ANLSFNRQFY DEHWSKHRVV TCMDWSLQYP 
    ELMVASYNNN EDAPHEPDGV ALVWNMKFKK TTPEYVFHCQ SSVMSVCFAR FHPNLVVGGT 
    YSGQIVLWDN RSHRRTPVQR TPLSAAAHTH PVYCVNVVGT QNAHNLITVS TDGKMCSWSL 
    DMLSTPQESM ELVYNKSKPV AVTGMAFPTG DVNNFVVGSE EGTVYTACRH GSKAGIGEVF 
    EGHQGPVTGI NCHMAVGPID FSHLFVTSSF DWTVKLWTTK HNKPLYSFED NADYVYDVMW 
    SPVHPALFAC VDGMGRLDLW NLNNDTEVPT ASVAIEGASA LNRVRWAQAG KEVAVGDSEG 
    RIWVYDVGEL AVPHNDEWTR FARTLVEIRA NRADSEEEGT VELSA

Genular Protein ID: 3788713155

Symbol: Q8N542_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 628
  • Mass: 70707
  • Checksum: 479FBF78061C8E09
  • Sequence:
  • MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 
    ALLQSIGISP EPPLVPTPMS PSSKSVSTPS EAGSQDSGDL GPLTRTLQWD TDPSVLQLQS 
    DSELGRRLHK LGVSKVTQVD FLPREVVSYS KETQTPLATH QSEEDEEDEE MVESKVGQDS 
    ELENQDKKQE VKEAPPRELT EEEKQQIIHS EEFLIFFDRT IRVIERALAE DSDIFFDYSG 
    RELEEKDGDV QAGANLSFNR QFYDEHCSKH RVVTCMDWSL QYPELMVASY NNNEDAPHEP 
    DGVALVWNMK FKKTTPEYVF HCQSSVMSVC FARFHPNLVV GGTYSGQIVL WDNRSHRRTP 
    VQRTPLSAAA HTHPVYCVNV VGTQNAHNLI TVSTDGKMCS WSLDMLSTPQ ESMELVYNKS 
    KPVAVTGMAF PTGDVNNFVV GSEEGTVYTA CRHGSKAGIG EVFEGHQGPV TGINCHMAVG 
    PIDFSHLFVT SSFDWTVKLW TTKHNKPLYS FEDNADYVYD VMWSPVHPAL FACVDGMGRL 
    DLWNLNNDTE VPTASVAIEG ASALNRVRWA QAGKEVAVGD SEGRIWVYDV GELAVPHNDE 
    WTRFARTLVE IRANRADSEE EGTVELSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.