Details for: JUND

Gene ID: 3727

Symbol: JUND

Ensembl ID: ENSG00000130522

Description: JunD proto-oncogene, AP-1 transcription factor subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 948.9844
    Cell Significance Index: -147.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 577.8586
    Cell Significance Index: -146.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 372.0133
    Cell Significance Index: -153.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 332.8161
    Cell Significance Index: -157.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 325.9266
    Cell Significance Index: -132.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 292.2323
    Cell Significance Index: -150.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 234.4483
    Cell Significance Index: -157.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 138.8856
    Cell Significance Index: -132.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 124.6841
    Cell Significance Index: -153.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 53.8662
    Cell Significance Index: -144.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 39.7847
    Cell Significance Index: -156.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.9876
    Cell Significance Index: -101.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.5050
    Cell Significance Index: -55.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 14.8566
    Cell Significance Index: 425.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.7008
    Cell Significance Index: 432.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.4066
    Cell Significance Index: 879.8100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.3753
    Cell Significance Index: 39.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.6896
    Cell Significance Index: 2515.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 5.5234
    Cell Significance Index: 390.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.1180
    Cell Significance Index: 112.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0374
    Cell Significance Index: 2204.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.8488
    Cell Significance Index: 180.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.6296
    Cell Significance Index: 270.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.5574
    Cell Significance Index: 437.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.2091
    Cell Significance Index: 74.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.1560
    Cell Significance Index: 568.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.9406
    Cell Significance Index: 137.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3564
    Cell Significance Index: 304.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2794
    Cell Significance Index: 292.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6815
    Cell Significance Index: 87.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5958
    Cell Significance Index: 14.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.4887
    Cell Significance Index: 254.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4554
    Cell Significance Index: 26.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4336
    Cell Significance Index: 287.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3533
    Cell Significance Index: 38.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1213
    Cell Significance Index: 222.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9498
    Cell Significance Index: 25.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8816
    Cell Significance Index: 39.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7978
    Cell Significance Index: 286.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6711
    Cell Significance Index: 11.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4629
    Cell Significance Index: 88.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4477
    Cell Significance Index: 44.2900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3572
    Cell Significance Index: 5.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2791
    Cell Significance Index: 32.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2774
    Cell Significance Index: 522.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1129
    Cell Significance Index: 153.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0691
    Cell Significance Index: 50.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0659
    Cell Significance Index: 59.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0216
    Cell Significance Index: 33.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0301
    Cell Significance Index: -22.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0441
    Cell Significance Index: -3.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0485
    Cell Significance Index: -89.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0601
    Cell Significance Index: -38.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0620
    Cell Significance Index: -45.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0871
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0961
    Cell Significance Index: -60.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1649
    Cell Significance Index: -74.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1813
    Cell Significance Index: -18.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1938
    Cell Significance Index: -109.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3888
    Cell Significance Index: -81.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3889
    Cell Significance Index: -63.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4556
    Cell Significance Index: -131.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5356
    Cell Significance Index: -61.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6627
    Cell Significance Index: -40.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6690
    Cell Significance Index: -76.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7483
    Cell Significance Index: -108.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8599
    Cell Significance Index: -30.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8655
    Cell Significance Index: -100.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0726
    Cell Significance Index: -72.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2173
    Cell Significance Index: -32.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3816
    Cell Significance Index: -143.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3947
    Cell Significance Index: -110.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.3963
    Cell Significance Index: -19.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.4277
    Cell Significance Index: -109.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.5244
    Cell Significance Index: -62.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.5912
    Cell Significance Index: -26.6300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.5962
    Cell Significance Index: -7.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.6533
    Cell Significance Index: -104.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.6890
    Cell Significance Index: -85.3600
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -1.9689
    Cell Significance Index: -8.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.9772
    Cell Significance Index: -103.8100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.0167
    Cell Significance Index: -42.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.1304
    Cell Significance Index: -127.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.1745
    Cell Significance Index: -60.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.2077
    Cell Significance Index: -47.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.3092
    Cell Significance Index: -61.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.3261
    Cell Significance Index: -130.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.3427
    Cell Significance Index: -122.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.4799
    Cell Significance Index: -52.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.5184
    Cell Significance Index: -154.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.5322
    Cell Significance Index: -67.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.5445
    Cell Significance Index: -63.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.6746
    Cell Significance Index: -52.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.6945
    Cell Significance Index: -16.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -2.8201
    Cell Significance Index: -59.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.8731
    Cell Significance Index: -43.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.0423
    Cell Significance Index: -134.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.1216
    Cell Significance Index: -114.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.3410
    Cell Significance Index: -116.1000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -3.3453
    Cell Significance Index: -25.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** JunD shares significant structural homology with other AP-1 subunits, including c-Fos, c-Jun, and ATF. 2. **Transcriptional Regulation:** JunD acts as a transcriptional activator, binding to specific DNA sequences and modulating the expression of target genes. 3. **Cellular Expression:** JunD is highly expressed in various cell types, including fibroblasts, epithelial cells, immune cells, and stem cells. 4. **Signaling Pathways:** JunD is involved in multiple signaling pathways, including those mediated by growth factors, hormones, and stress signals. **Pathways and Functions:** 1. **Cell Proliferation and Differentiation:** JunD regulates the expression of genes involved in cell proliferation and differentiation, particularly in the context of osteoblast development and differentiation. 2. **Apoptosis and Survival:** JunD modulates the expression of genes involved in apoptosis and survival, influencing the response to stress signals and cellular damage. 3. **Immune Response:** JunD is involved in the regulation of immune cell function, including the activation and differentiation of T cells and B cells. 4. **Stress Response:** JunD is activated in response to various stress signals, including oxidative stress and inflammation, and regulates the expression of genes involved in stress response and adaptation. **Clinical Significance:** 1. **Cancer:** JunD is often overexpressed in various types of cancer, including breast, lung, and prostate cancer, and is associated with poor prognosis and aggressive disease. 2. **Autoimmune Diseases:** JunD is involved in the regulation of immune cell function and is implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders:** JunD is involved in the regulation of neuronal function and is implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Regenerative Medicine:** JunD is involved in the regulation of stem cell function and is a potential target for regenerative therapies, including tissue engineering and cell therapy. In conclusion, the JunD proto-oncogene plays a critical role in regulating various cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation is implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders. Understanding the mechanisms of JunD regulation and its role in different cellular contexts is essential for the development of novel therapeutic strategies.

Genular Protein ID: 3214316131

Symbol: JUND_HUMAN

Name: N/A

UniProtKB Accession Codes:

P17535 Q53EK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1903194

Title: Structure and function of human jun-D.

PubMed ID: 1903194

PubMed ID: 2112242

Title: Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.

PubMed ID: 2112242

DOI: 10.1093/nar/18.10.3047

PubMed ID: 9989505

Title: Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.

PubMed ID: 9989505

DOI: 10.1016/s0092-8674(00)80967-8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22327296

Title: The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

PubMed ID: 22327296

DOI: 10.1038/nature10806

PubMed ID: 28981703

Title: Activator Protein-1: redox switch controlling structure and DNA-binding.

PubMed ID: 28981703

DOI: 10.1093/nar/gkx795

Sequence Information:

  • Length: 347
  • Mass: 35174
  • Checksum: FE85A1AA2B5B9597
  • Sequence:
    • METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL TLSLSEQVAA 
ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS PELERLIIQS NGLVTTTPTS 
SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ NQLGAGAAAA AAAAAAGGPS GTATGSAPPG 
ELAPAAAAPE APVYANLSSY AGGAGGAGGA ATVAFAAEPV PFPPPPPPGA LGPPRLAALK 
DEPQTVPDVP SFGESPPLSP IDMDTQERIK AERKRLRNRI AASKCRKRKL ERISRLEEKV 
KTLKSQNTEL ASTASLLREQ VAQLKQKVLS HVNSGCQLLP QHQVPAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.