Gene JUND - ENSG00000130522 | NCBI Gene ID: 3727

Details for: JUND

Gene ID: 3727

Symbol: JUND

Ensembl ID: ENSG00000130522

Description: JunD proto-oncogene, AP-1 transcription factor subunit

Associated with

Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Cellular response to calcium ion
(GO:0071277)
Chromatin
(GO:0000785)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Enzyme binding
(GO:0019899)
Gene expression
(GO:0010467)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast development
(GO:0002076)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of cell population proliferation
(GO:0042127)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transcription factor ap-1 complex
(GO:0035976)
Transcription factor binding
(GO:0008134)
Transcription regulator complex
(GO:0005667)
Transcription repressor complex
(GO:0017053)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.06
Marker Score: 172229.5
Cell Name: acinar cell (CL0000622)
Fold Change: 4.09
Marker Score: 2888
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4.08
Marker Score: 4023
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4
Marker Score: 25522
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.94
Marker Score: 4204
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.83
Marker Score: 3264
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.71
Marker Score: 4830.5
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.7
Marker Score: 4113
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.63
Marker Score: 1865
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.62
Marker Score: 10159
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.5
Marker Score: 8828
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.43
Marker Score: 16856.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.25
Marker Score: 1621
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.18
Marker Score: 2978
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.18
Marker Score: 109992
Cell Name: memory T cell (CL0000813)
Fold Change: 3.15
Marker Score: 1354
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.13
Marker Score: 2229
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.09
Marker Score: 2240
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.09
Marker Score: 7006
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 3.08
Marker Score: 1858
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.08
Marker Score: 2334
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.08
Marker Score: 1327
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.07
Marker Score: 2584
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.05
Marker Score: 30926
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.02
Marker Score: 2574
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 3.02
Marker Score: 1069
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3
Marker Score: 1048
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3
Marker Score: 11552
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.99
Marker Score: 3420
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.96
Marker Score: 165782.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 2.94
Marker Score: 2875
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.93
Marker Score: 907
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.92
Marker Score: 1007
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.88
Marker Score: 1089
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.87
Marker Score: 7923
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.81
Marker Score: 9991.5
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.78
Marker Score: 915.5
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.77
Marker Score: 4595
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.77
Marker Score: 2656
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.77
Marker Score: 8689
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.77
Marker Score: 14534
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.76
Marker Score: 6299
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.76
Marker Score: 17985
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.73
Marker Score: 2599
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.72
Marker Score: 1410
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 2.71
Marker Score: 740
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.7
Marker Score: 2336
Cell Name: reticular cell (CL0000432)
Fold Change: 2.69
Marker Score: 980
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.68
Marker Score: 5361.5
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.67
Marker Score: 2815
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.67
Marker Score: 638
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.67
Marker Score: 30049
Cell Name: supporting cell (CL0000630)
Fold Change: 2.66
Marker Score: 4990
Cell Name: naive T cell (CL0000898)
Fold Change: 2.66
Marker Score: 1710.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.65
Marker Score: 2683.5
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.64
Marker Score: 2201
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.63
Marker Score: 3727
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.62
Marker Score: 2352
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.62
Marker Score: 1092
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.62
Marker Score: 2831
Cell Name: fibroblast (CL0000057)
Fold Change: 2.59
Marker Score: 2500
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.58
Marker Score: 10705
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.58
Marker Score: 3103
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.56
Marker Score: 911
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.54
Marker Score: 3738
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.53
Marker Score: 6770
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.52
Marker Score: 723
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.51
Marker Score: 1463
Cell Name: paneth cell (CL0000510)
Fold Change: 2.51
Marker Score: 1745
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 2.49
Marker Score: 1015
Cell Name: oocyte (CL0000023)
Fold Change: 2.48
Marker Score: 614
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.47
Marker Score: 751
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.47
Marker Score: 1271.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.46
Marker Score: 5999.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.45
Marker Score: 3900
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 2.45
Marker Score: 648
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.44
Marker Score: 2073
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.44
Marker Score: 605
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.44
Marker Score: 602
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.42
Marker Score: 4295
Cell Name: enterocyte (CL0000584)
Fold Change: 2.42
Marker Score: 11620
Cell Name: PP cell (CL0000696)
Fold Change: 2.42
Marker Score: 544
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.4
Marker Score: 1186
Cell Name: ependymal cell (CL0000065)
Fold Change: 2.4
Marker Score: 838
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 2.39
Marker Score: 1006
Cell Name: granulocyte (CL0000094)
Fold Change: 2.39
Marker Score: 1071
Cell Name: leukocyte (CL0000738)
Fold Change: 2.39
Marker Score: 1370
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 2.39
Marker Score: 519
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.38
Marker Score: 2592.5
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.37
Marker Score: 1108.5
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.36
Marker Score: 682
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.36
Marker Score: 3997.5
Cell Name: stromal cell (CL0000499)
Fold Change: 2.36
Marker Score: 2765.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.34
Marker Score: 8653
Cell Name: ionocyte (CL0005006)
Fold Change: 2.34
Marker Score: 709
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.32
Marker Score: 865
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.32
Marker Score: 13759
Cell Name: keratocyte (CL0002363)
Fold Change: 2.32
Marker Score: 533
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.32
Marker Score: 1198
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 2.3
Marker Score: 647

Hover over a box to see details here...

**Key characteristics:** * JUND is a nuclear protein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of cell types, including fibroblasts, acinar cells, immune cells, and stem cells. * JUND is a key regulator of cell growth and differentiation in these cells. **Pathways and functions:** * JUND is a key regulator of the Notch signaling pathway in mammary gland fibroblasts. * It is also involved in the regulation of osteoblast development, cell cycle regulation, and apoptosis. * JUND is a key regulator of the estrogen-dependent gene expression. * It is involved in the regulation of the nuclear events pathway, which is involved in cell cycle regulation and apoptosis. * JUND is a key regulator of the Ngf signaling pathway, which is involved in the regulation of cell growth and differentiation. **Clinical significance:** * Mutations in the JUND gene have been linked to a number of human cancers, including breast cancer, lung cancer, and prostate cancer. * Targeting JUND has been shown to be a promising therapeutic strategy for cancer. **Additional notes:** * JUND is a highly conserved gene, with a similar gene found in other mammals. * It is a key regulator of cell growth and differentiation in a variety of tissues. * JUND is a promising target for cancer treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

JUND_HUMAN

Genular Protein ID: 3214316131

Symbol: JUND_HUMAN

Name: N/A

UniProtKB Accession Codes:

P17535 Q53EK9

Database IDs:

Citations:

PubMed ID: 1903194

Title: Structure and function of human jun-D.

PubMed ID: 1903194

PubMed ID: 2112242

Title: Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.

PubMed ID: 2112242

DOI: 10.1093/nar/18.10.3047

PubMed ID: 9989505

Title: Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.

PubMed ID: 9989505

DOI: 10.1016/s0092-8674(00)80967-8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22327296

Title: The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

PubMed ID: 22327296

DOI: 10.1038/nature10806

PubMed ID: 28981703

Title: Activator Protein-1: redox switch controlling structure and DNA-binding.

PubMed ID: 28981703

DOI: 10.1093/nar/gkx795

Sequence Information:

Length: 347
Mass: 35174
Checksum: FE85A1AA2B5B9597
Sequence:

METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL TLSLSEQVAA 
ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS PELERLIIQS NGLVTTTPTS 
SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ NQLGAGAAAA AAAAAAGGPS GTATGSAPPG 
ELAPAAAAPE APVYANLSSY AGGAGGAGGA ATVAFAAEPV PFPPPPPPGA LGPPRLAALK 
DEPQTVPDVP SFGESPPLSP IDMDTQERIK AERKRLRNRI AASKCRKRKL ERISRLEEKV 
KTLKSQNTEL ASTASLLREQ VAQLKQKVLS HVNSGCQLLP QHQVPAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: JUND

Associated with

Cells (max top 100)

Other Information

Structure and function of human jun-D. PubMed ID: 1903194

Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. PubMed ID: 2112242

Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. PubMed ID: 9989505

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. PubMed ID: 22327296

Activator Protein-1: redox switch controlling structure and DNA-binding. PubMed ID: 28981703