Details for: SLC6A16

Gene ID: 28968

Symbol: SLC6A16

Ensembl ID: ENSG00000063127

Description: solute carrier family 6 member 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.3174
    Cell Significance Index: -7.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.5046
    Cell Significance Index: -7.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9816
    Cell Significance Index: -7.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.1067
    Cell Significance Index: 129.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8854
    Cell Significance Index: -7.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7733
    Cell Significance Index: 38.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6101
    Cell Significance Index: 121.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5744
    Cell Significance Index: 109.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5131
    Cell Significance Index: 184.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4816
    Cell Significance Index: 70.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3723
    Cell Significance Index: 36.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3384
    Cell Significance Index: 5.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3370
    Cell Significance Index: 304.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2422
    Cell Significance Index: 6.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1963
    Cell Significance Index: 39.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1892
    Cell Significance Index: 30.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1569
    Cell Significance Index: 17.0700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1435
    Cell Significance Index: 1.2200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1355
    Cell Significance Index: 1.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1163
    Cell Significance Index: 7.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1148
    Cell Significance Index: 2.8700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1070
    Cell Significance Index: 0.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0828
    Cell Significance Index: 5.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0774
    Cell Significance Index: 2.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0734
    Cell Significance Index: 4.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0729
    Cell Significance Index: 5.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0724
    Cell Significance Index: 2.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0594
    Cell Significance Index: 109.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0573
    Cell Significance Index: 1.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0571
    Cell Significance Index: 87.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0536
    Cell Significance Index: 3.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0475
    Cell Significance Index: 64.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0399
    Cell Significance Index: 1.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0325
    Cell Significance Index: 14.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0293
    Cell Significance Index: 18.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0293
    Cell Significance Index: 3.4100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0268
    Cell Significance Index: 0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0252
    Cell Significance Index: 1.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0246
    Cell Significance Index: 46.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0204
    Cell Significance Index: 3.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0202
    Cell Significance Index: 2.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0105
    Cell Significance Index: 5.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0067
    Cell Significance Index: 0.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0015
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0009
    Cell Significance Index: 0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0019
    Cell Significance Index: -1.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0050
    Cell Significance Index: -0.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0092
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0115
    Cell Significance Index: -7.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0130
    Cell Significance Index: -3.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0137
    Cell Significance Index: -0.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0149
    Cell Significance Index: -0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0152
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0154
    Cell Significance Index: -1.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0165
    Cell Significance Index: -2.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0272
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0339
    Cell Significance Index: -7.1500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0384
    Cell Significance Index: -0.6100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0386
    Cell Significance Index: -0.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0408
    Cell Significance Index: -4.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0412
    Cell Significance Index: -1.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0460
    Cell Significance Index: -0.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0462
    Cell Significance Index: -5.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0512
    Cell Significance Index: -5.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0526
    Cell Significance Index: -3.5400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0640
    Cell Significance Index: -0.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0682
    Cell Significance Index: -4.8200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0768
    Cell Significance Index: -0.8800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0778
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0798
    Cell Significance Index: -6.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0860
    Cell Significance Index: -6.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0887
    Cell Significance Index: -4.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0904
    Cell Significance Index: -4.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0910
    Cell Significance Index: -5.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0929
    Cell Significance Index: -4.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0956
    Cell Significance Index: -3.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0971
    Cell Significance Index: -2.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0980
    Cell Significance Index: -1.2200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0987
    Cell Significance Index: -1.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1007
    Cell Significance Index: -2.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1041
    Cell Significance Index: -5.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1042
    Cell Significance Index: -2.0600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1091
    Cell Significance Index: -1.6600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1165
    Cell Significance Index: -1.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1240
    Cell Significance Index: -4.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1258
    Cell Significance Index: -0.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1330
    Cell Significance Index: -2.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1340
    Cell Significance Index: -6.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1369
    Cell Significance Index: -4.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1398
    Cell Significance Index: -2.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1416
    Cell Significance Index: -2.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1446
    Cell Significance Index: -4.6100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1685
    Cell Significance Index: -5.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1689
    Cell Significance Index: -2.7100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1692
    Cell Significance Index: -1.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1767
    Cell Significance Index: -6.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1773
    Cell Significance Index: -3.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Orphan Gene**: SLC6A16 is an orphan gene, meaning it has no known homolog or functional equivalent. 2. **Sodium- and Chloride-Dependent**: The NTT5 protein is dependent on sodium and chloride ions for its transport function. 3. **Neurotransmitter Transport**: NTT5 is involved in the transport of various neurotransmitters across cellular membranes. 4. **Widespread Expression**: The gene is expressed in multiple tissues, including the nervous system, gastrointestinal tract, and other organs. 5. **Symporter Activity**: NTT5 exhibits symporter activity, suggesting its ability to transport multiple substrates simultaneously. **Pathways and Functions:** 1. **Neurotransmitter Transport**: NTT5 plays a crucial role in the transport of neurotransmitters, such as GABA, glutamate, and aspartate, across the plasma membrane. 2. **Ion Balance Regulation**: The protein helps regulate ion balances by facilitating the transport of sodium and chloride ions. 3. **Cellular Homeostasis**: NTT5 contributes to maintaining cellular homeostasis by regulating the concentration of neurotransmitters and ions. 4. **Membrane Transport**: The protein is involved in the transport of various organic substances across the plasma membrane. 5. **Amino Acid Transport**: NTT5 also participates in the transport of amino acids, such as glutamate and aspartate. **Clinical Significance:** 1. **Neurological Disorders**: Mutations in the NTT5 gene have been associated with neurological disorders, such as epilepsy and schizophrenia. 2. **Gastrointestinal Diseases**: Abnormal expression of NTT5 has been linked to gastrointestinal diseases, including inflammatory bowel disease and colon cancer. 3. **Neurodegenerative Diseases**: The protein's involvement in neurotransmitter transport suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 4. **Cancer Research**: NTT5's expression in various cancer types highlights its potential as a biomarker and therapeutic target. 5. **Pharmacological Applications**: Understanding the function of NTT5 can lead to the development of novel therapeutic agents targeting its activity. In conclusion, SLC6A16, or the orphan sodium- and chloride-dependent neurotransmitter transporter NTT5, is a multifunctional protein involved in various cellular processes, including neurotransmitter transport, ion balance regulation, and cellular homeostasis. Its widespread expression and association with neurological and gastrointestinal disorders make it an important gene for further research and potential therapeutic applications.

Genular Protein ID: 209923296

Symbol: S6A16_HUMAN

Name: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

UniProtKB Accession Codes:

Q9GZN6 Q8IYV4 Q9Y5I9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11112352

Title: Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family.

PubMed ID: 11112352

DOI: 10.1006/geno.2000.6387

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 736
  • Mass: 82200
  • Checksum: E21EA16515446C35
  • Sequence:
    • MKTEAQPSTS LLANTSWTGT VISDSVPGSQ TWEDKGSLTR SATSWTSEAQ VSAARVAEAQ 
ARTSQPKQIS VLEALTASAL NQKPTHEKVQ MTEKKESEVL LARPFWSSKT EYILAQVGFS 
MKPSCLWRFA YLWLNSGGCS FAAIYIFMLF LVGVPLLFLE MAAGQSMRQG GMGVWKIIAP 
WIGGVGYSSF MVCFILGLYF NVVNSWIIFY MSQSFQFPVP WEKCPLTMNS SGFDPECERT 
TPSIYFWYQQ ALKASDRIED GGSPVYSLVL PFFLCWCLVG AFMINGLKST GKVIYVLVLL 
PCFIIVGFFI RTLLLEGAKF GLQQLVVAKI SDVYNMSVWS LAGGQVLSNT GIGLGSVASL 
ASYMPQSNNC LSDAFLVSVI NLLTLLVFTS FNFCVLGFWA TVITHRCCER NAEILLKLIN 
LGKLPPDAKP PVNLLYNPTS IYNAWLSGLP QHIKSMVLRE VTECNIETQF LKASEGPKFA 
FLSFVEAMSF LPPSVFWSFI FFLMLLAMGL SSAIGIMQGI ITPLQDTFSF FRKHTKLLIV 
GVFLLMFVCG LFFTRPSGSY FIRLLSDYWI VFPIIVVVVF ETMAVSWAYG ARRFLADLTI 
LLGHPISPIF GWLWPHLCPV VLLIIFVTMM VHLCMKPITY MSWDSSTSKE VLRPYPPWAL 
LLMITLFAIV ILPIPAYFVY CRIHRIPFRP KSGDGPMTAS TSLPLSHQLT PSKEVQKEEI 
LQVDETKYPS TCNVTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.