Details for: HEYL

Gene ID: 26508

Symbol: HEYL

Ensembl ID: ENSG00000163909

Description: hes related family bHLH transcription factor with YRPW motif like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.6874
    Cell Significance Index: -7.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0667
    Cell Significance Index: -7.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.9624
    Cell Significance Index: 28.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9184
    Cell Significance Index: -7.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0020
    Cell Significance Index: 61.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7892
    Cell Significance Index: 8.5800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.7342
    Cell Significance Index: 3.3900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6196
    Cell Significance Index: 10.2100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5259
    Cell Significance Index: 5.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3949
    Cell Significance Index: 75.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3662
    Cell Significance Index: 4.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2517
    Cell Significance Index: 5.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2482
    Cell Significance Index: 13.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2320
    Cell Significance Index: 22.9500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2292
    Cell Significance Index: 2.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1777
    Cell Significance Index: 11.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1767
    Cell Significance Index: 20.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1664
    Cell Significance Index: 150.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1641
    Cell Significance Index: 9.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1531
    Cell Significance Index: 4.5100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1463
    Cell Significance Index: 2.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1369
    Cell Significance Index: 14.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1250
    Cell Significance Index: 1.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1183
    Cell Significance Index: 19.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0694
    Cell Significance Index: 106.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0639
    Cell Significance Index: 4.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0624
    Cell Significance Index: 38.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0538
    Cell Significance Index: 7.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0423
    Cell Significance Index: 5.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0340
    Cell Significance Index: 5.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0225
    Cell Significance Index: 2.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0191
    Cell Significance Index: 0.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0118
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0030
    Cell Significance Index: 5.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0024
    Cell Significance Index: 0.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0003
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0021
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0057
    Cell Significance Index: -1.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0090
    Cell Significance Index: -5.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0092
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0106
    Cell Significance Index: -0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0111
    Cell Significance Index: -3.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0112
    Cell Significance Index: -6.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0117
    Cell Significance Index: -4.2100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0131
    Cell Significance Index: -0.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0131
    Cell Significance Index: -0.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0156
    Cell Significance Index: -1.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0165
    Cell Significance Index: -3.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0207
    Cell Significance Index: -0.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0217
    Cell Significance Index: -0.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0235
    Cell Significance Index: -0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0237
    Cell Significance Index: -4.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0239
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0245
    Cell Significance Index: -2.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0298
    Cell Significance Index: -3.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0345
    Cell Significance Index: -4.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0437
    Cell Significance Index: -4.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0461
    Cell Significance Index: -3.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0512
    Cell Significance Index: -6.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0512
    Cell Significance Index: -6.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0693
    Cell Significance Index: -7.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0726
    Cell Significance Index: -0.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0831
    Cell Significance Index: -3.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0863
    Cell Significance Index: -2.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0899
    Cell Significance Index: -6.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0935
    Cell Significance Index: -4.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0984
    Cell Significance Index: -6.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1004
    Cell Significance Index: -6.1700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1027
    Cell Significance Index: -0.9900
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1038
    Cell Significance Index: -0.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1135
    Cell Significance Index: -1.7100
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.1143
    Cell Significance Index: -0.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1144
    Cell Significance Index: -2.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1243
    Cell Significance Index: -5.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1295
    Cell Significance Index: -2.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1343
    Cell Significance Index: -2.1300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1364
    Cell Significance Index: -1.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1376
    Cell Significance Index: -7.1500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1440
    Cell Significance Index: -2.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1451
    Cell Significance Index: -4.1600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1471
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1481
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1568
    Cell Significance Index: -1.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1596
    Cell Significance Index: -4.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1629
    Cell Significance Index: -2.5200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1641
    Cell Significance Index: -1.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1666
    Cell Significance Index: -7.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1732
    Cell Significance Index: -4.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1756
    Cell Significance Index: -6.1500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1766
    Cell Significance Index: -0.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1841
    Cell Significance Index: -4.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1865
    Cell Significance Index: -6.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1909
    Cell Significance Index: -7.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** HEYL belongs to the BHLH transcription factor family, which is known for regulating gene expression in response to various signaling pathways. 2. **YRPW Motif:** The presence of a YRPW motif in HEYL is essential for its transcriptional activity and interaction with other proteins. 3. **Cell-Type Specificity:** HEYL expression is observed in multiple cell types, including contractile cells, mural cells, and neural crest cells, indicating its role in development and tissue homeostasis. 4. **Regulatory Pathways:** HEYL regulates various signaling pathways, including Notch1, Notch3, and BMP, which are critical for cardiac development and morphogenesis. **Pathways and Functions:** The HEYL gene is involved in various cellular processes, including: 1. **Adherens Junctions:** HEYL regulates the formation and maintenance of adherens junctions, which are essential for cell-cell communication and tissue integrity. 2. **Notch Signaling:** HEYL interacts with Notch receptors, regulating the transcriptional activity of Notch1 and Notch3. 3. **BMP Signaling:** HEYL is involved in the regulation of BMP signaling, which is critical for cardiac development and morphogenesis. 4. **Cell-Cell Communication:** HEYL regulates the expression of genes involved in cell-cell communication, including CDH11 and type II classical cadherins. 5. **Morphogenesis:** HEYL is involved in the regulation of morphogenesis in the cardiovascular system, including cardiac ventricle morphogenesis, aortic valve morphogenesis, and pulmonary valve morphogenesis. **Clinical Significance:** The HEYL gene has been implicated in various cardiovascular diseases, including: 1. **Cardiac Hypertrophy:** HEYL has been shown to be downregulated in cardiac hypertrophy, suggesting its role in regulating cardiac development and function. 2. **Valvular Heart Disease:** HEYL has been implicated in the regulation of valve morphogenesis, and its dysregulation may contribute to valvular heart disease. 3. **Cancer:** HEYL has been shown to be involved in the regulation of Notch signaling, which is often dysregulated in cancer. In conclusion, the HEYL gene plays a critical role in regulating cell-cell communication and development in the cardiovascular system. Its dysregulation may contribute to various cardiovascular diseases, highlighting the importance of HEYL in maintaining cardiac homeostasis and function. Further research is needed to fully elucidate the mechanisms by which HEYL regulates cellular processes and to explore its therapeutic potential in cardiovascular disease.

Genular Protein ID: 3560546770

Symbol: HEYL_HUMAN

Name: Hairy/enhancer-of-split related with YRPW motif-like protein

UniProtKB Accession Codes:

Q9NQ87 Q5TG99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 36 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10860664

Title: Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.

PubMed ID: 10860664

DOI: 10.1006/geno.2000.6200

PubMed ID: 11095750

Title: Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.

PubMed ID: 11095750

DOI: 10.1073/pnas.250485597

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10964718

Title: Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.

PubMed ID: 10964718

DOI: 10.1006/bbrc.2000.3354

PubMed ID: 15485867

Title: Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.

PubMed ID: 15485867

DOI: 10.1074/jbc.m409879200

Sequence Information:

  • Length: 328
  • Mass: 35087
  • Checksum: C11A1EAB18611F43
  • Sequence:
    • MKRPKEPSGS DGESDGPIDV GQEGQLSQMA RPLSTPSSSQ MQARKKHRGI IEKRRRDRIN 
SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA TGGTGFFDAR ALAVDFRSIG 
FRECLTEVIR YLGVLEGPSS RADPVRIRLL SHLNSYAAEM EPSPTPTGPL AFPAWPWSFF 
HSCPGLPALS NQLAILGRVP SPVLPGVSSP AYPIPALRTA PLRRATGIIL PARRNVLPSR 
GASSTRRARP LERPATPVPV APSSRAARSS HIAPLLQSSS PTPPGPTGSA AYVAVPTPNS 
SSPGPAGRPA GAMLYHSWVS EITEIGAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.