Details for: SRSF3

Gene ID: 6428

Symbol: SRSF3

Ensembl ID: ENSG00000112081

Description: serine and arginine rich splicing factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 642.0641
    Cell Significance Index: -99.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 391.0214
    Cell Significance Index: -99.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 314.9187
    Cell Significance Index: -129.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 282.6808
    Cell Significance Index: -133.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 249.1518
    Cell Significance Index: -128.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 199.2855
    Cell Significance Index: -133.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 105.0078
    Cell Significance Index: -129.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 35.1415
    Cell Significance Index: -138.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.0182
    Cell Significance Index: -91.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.2207
    Cell Significance Index: -89.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.6598
    Cell Significance Index: -38.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.6738
    Cell Significance Index: 191.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.2625
    Cell Significance Index: 217.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.6628
    Cell Significance Index: 725.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.6586
    Cell Significance Index: 265.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.3094
    Cell Significance Index: 57.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.0675
    Cell Significance Index: 106.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0748
    Cell Significance Index: 262.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.5468
    Cell Significance Index: 96.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5437
    Cell Significance Index: 93.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4860
    Cell Significance Index: 478.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.3083
    Cell Significance Index: 1462.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.0801
    Cell Significance Index: 217.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8716
    Cell Significance Index: 338.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.5621
    Cell Significance Index: 315.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4569
    Cell Significance Index: 442.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3337
    Cell Significance Index: 1274.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.3214
    Cell Significance Index: 105.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.0064
    Cell Significance Index: 35.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9440
    Cell Significance Index: 90.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9316
    Cell Significance Index: 249.5500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8912
    Cell Significance Index: 15.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5660
    Cell Significance Index: 17.7900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.5045
    Cell Significance Index: 22.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4504
    Cell Significance Index: 108.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3935
    Cell Significance Index: 40.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3138
    Cell Significance Index: 35.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2737
    Cell Significance Index: 252.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8814
    Cell Significance Index: 25.4000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8034
    Cell Significance Index: 4.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7007
    Cell Significance Index: 36.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5685
    Cell Significance Index: 61.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5628
    Cell Significance Index: 29.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5360
    Cell Significance Index: 14.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5124
    Cell Significance Index: 102.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4117
    Cell Significance Index: 46.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3736
    Cell Significance Index: 63.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2813
    Cell Significance Index: 27.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1680
    Cell Significance Index: 127.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1601
    Cell Significance Index: 57.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1548
    Cell Significance Index: 29.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1404
    Cell Significance Index: 2.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0665
    Cell Significance Index: 1.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0641
    Cell Significance Index: 120.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0205
    Cell Significance Index: 13.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0151
    Cell Significance Index: 2.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0025
    Cell Significance Index: 1.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0284
    Cell Significance Index: -25.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0447
    Cell Significance Index: -68.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0502
    Cell Significance Index: -68.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0517
    Cell Significance Index: -38.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0545
    Cell Significance Index: -100.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0792
    Cell Significance Index: -49.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1251
    Cell Significance Index: -12.7800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1357
    Cell Significance Index: -0.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1464
    Cell Significance Index: -66.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1805
    Cell Significance Index: -101.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2142
    Cell Significance Index: -13.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2340
    Cell Significance Index: -67.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2847
    Cell Significance Index: -59.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2944
    Cell Significance Index: -16.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3290
    Cell Significance Index: -11.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4542
    Cell Significance Index: -34.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4860
    Cell Significance Index: -70.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5163
    Cell Significance Index: -13.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6247
    Cell Significance Index: -72.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7304
    Cell Significance Index: -83.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7771
    Cell Significance Index: -24.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9337
    Cell Significance Index: -57.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0854
    Cell Significance Index: -13.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0905
    Cell Significance Index: -86.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1221
    Cell Significance Index: -15.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2631
    Cell Significance Index: -131.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.4872
    Cell Significance Index: -13.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.6014
    Cell Significance Index: -107.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.7946
    Cell Significance Index: -38.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.8533
    Cell Significance Index: -49.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -2.0854
    Cell Significance Index: -14.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1545
    Cell Significance Index: -132.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -2.2222
    Cell Significance Index: -51.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.3029
    Cell Significance Index: -39.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.4692
    Cell Significance Index: -63.4700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.6298
    Cell Significance Index: -36.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.6481
    Cell Significance Index: -39.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.7028
    Cell Significance Index: -79.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.7521
    Cell Significance Index: -121.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.7826
    Cell Significance Index: -33.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.8096
    Cell Significance Index: -16.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.8300
    Cell Significance Index: -60.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.9997
    Cell Significance Index: -110.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRSF3 is a serine and arginine-rich protein that belongs to the family of splicing factors, which are essential for the proper processing of pre-mRNAs. The gene is characterized by its high expression levels in cells involved in immune responses, such as hematopoietic stem cells and natural killer cells. SRSF3 is also involved in the regulation of alternative splicing, which is a complex process that involves the recognition and excision of introns, as well as the joining of exons. The gene's ability to regulate splicing is mediated through its interactions with other proteins and RNA molecules, including the spliceosome, a complex that facilitates the splicing process. **Pathways and Functions** SRSF3 is involved in several key pathways, including: 1. **mRNA splicing**: SRSF3 plays a crucial role in the regulation of alternative splicing, which is essential for the production of diverse isoforms of proteins. The gene's ability to regulate splicing is mediated through its interactions with the spliceosome. 2. **Gene expression (transcription)**: SRSF3 is involved in the regulation of gene expression, particularly in cells involved in immune responses. 3. **Metabolism of RNA**: The gene is involved in the regulation of RNA metabolism, including the processing of pre-mRNAs and the export of mature mRNAs from the nucleus. 4. **Regulation of mRNA splicing via spliceosome**: SRSF3 is a key component of the spliceosome, a complex that facilitates the splicing process. **Clinical Significance** The dysregulation of SRSF3 has been implicated in various diseases, including: 1. **Leukemia**: Mutations in SRSF3 have been associated with certain types of leukemia, highlighting the gene's importance in immune cell development. 2. **Immune-related disorders**: The dysregulation of SRSF3 has been implicated in various immune-related disorders, including autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: The gene's ability to regulate splicing has been exploited in cancer, where it can contribute to the development of cancerous cells. In conclusion, SRSF3 is a crucial gene involved in the regulation of alternative splicing, a process that is essential for the proper functioning of genes involved in immune responses. The gene's dysregulation has been implicated in various diseases, highlighting its importance in human health and disease. Further research is needed to fully understand the mechanisms by which SRSF3 regulates splicing and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2900487551

Symbol: SRSF3_HUMAN

Name: Serine/arginine-rich splicing factor 3

UniProtKB Accession Codes:

P84103 B4E241 O08831 P23152 Q5R3K0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1577277

Title: SR proteins: a conserved family of pre-mRNA splicing factors.

PubMed ID: 1577277

DOI: 10.1101/gad.6.5.837

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10757789

Title: Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

PubMed ID: 10757789

DOI: 10.1128/mcb.20.9.3049-3057.2000

PubMed ID: 11336712

Title: Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA.

PubMed ID: 11336712

DOI: 10.1016/s1097-2765(01)00233-7

PubMed ID: 12667464

Title: SR splicing factors serve as adapter proteins for TAP-dependent mRNA export.

PubMed ID: 12667464

DOI: 10.1016/s1097-2765(03)00089-3

PubMed ID: 15595951

Title: The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.

PubMed ID: 15595951

DOI: 10.1111/j.1365-2605.2004.00496.x

PubMed ID: 15169763

Title: Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.

PubMed ID: 15169763

DOI: 10.1074/jbc.m403927200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18364396

Title: Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.

PubMed ID: 18364396

DOI: 10.1073/pnas.0709167105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32440474

Title: Small protein hidden in lncRNA LOC90024 promotes 'cancerous' RNA splicing and tumorigenesis.

PubMed ID: 32440474

DOI: 10.1002/advs.201903233

PubMed ID: 17036044

Title: Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.

PubMed ID: 17036044

DOI: 10.1038/sj.emboj.7601385

PubMed ID: 26876937

Title: Nuclear m(6)A reader YTHDC1 regulates mRNA splicing.

PubMed ID: 26876937

DOI: 10.1016/j.molcel.2016.01.012

PubMed ID: 28984244

Title: YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.

PubMed ID: 28984244

DOI: 10.7554/elife.31311

Sequence Information:

  • Length: 164
  • Mass: 19330
  • Checksum: 02F0A5EE33FF28A0
  • Sequence:
    • MHRDSCPLDC KVYVGNLGNN GNKTELERAF GYYGPLRSVW VARNPPGFAF VEFEDPRDAA 
DAVRELDGRT LCGCRVRVEL SNGEKRSRNR GPPPSWGRRP RDDYRRRSPP PRRRSPRRRS 
FSRSRSRSLS RDRRRERSLS RERNHKPSRS FSRSRSRSRS NERK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.