Details for: CD99

Gene ID: 4267

Symbol: CD99

Ensembl ID: ENSG00000002586

Description: CD99 molecule (Xg blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 9.34
    Marker Score: 26365
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.31
    Marker Score: 4254
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.09
    Marker Score: 67662
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.4
    Marker Score: 43541
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.33
    Marker Score: 13659
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.27
    Marker Score: 9011
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.02
    Marker Score: 10218
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.01
    Marker Score: 3025.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.95
    Marker Score: 11537
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.84
    Marker Score: 2169
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.82
    Marker Score: 2317.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.8
    Marker Score: 5599
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.78
    Marker Score: 1108
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.74
    Marker Score: 3174
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.73
    Marker Score: 6794
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.72
    Marker Score: 4358
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.67
    Marker Score: 3545.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.65
    Marker Score: 15143
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.61
    Marker Score: 5229.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.58
    Marker Score: 10040
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.53
    Marker Score: 15118.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.5
    Marker Score: 40698
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.49
    Marker Score: 46018
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 3.46
    Marker Score: 8971
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.42
    Marker Score: 9459
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.38
    Marker Score: 2386
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.34
    Marker Score: 19809.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.33
    Marker Score: 20250.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.33
    Marker Score: 1939
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.32
    Marker Score: 5442.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.29
    Marker Score: 2835
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.25
    Marker Score: 5502
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.22
    Marker Score: 3804
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.18
    Marker Score: 1374
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.16
    Marker Score: 176724.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.15
    Marker Score: 790
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.1
    Marker Score: 4272
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.09
    Marker Score: 2637
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.05
    Marker Score: 2710
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.01
    Marker Score: 19587
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.99
    Marker Score: 2633
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.98
    Marker Score: 3308
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.96
    Marker Score: 3391
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.95
    Marker Score: 4062
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.95
    Marker Score: 156080.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.92
    Marker Score: 4129
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.9
    Marker Score: 5682
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.86
    Marker Score: 6995
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.86
    Marker Score: 2405
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.86
    Marker Score: 1042
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.84
    Marker Score: 11640
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.84
    Marker Score: 1746
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.83
    Marker Score: 3044
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.83
    Marker Score: 18068
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.82
    Marker Score: 7375
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.8
    Marker Score: 2005.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.78
    Marker Score: 24391.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.77
    Marker Score: 1824.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.77
    Marker Score: 2008
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.76
    Marker Score: 11900
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.75
    Marker Score: 1246
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.71
    Marker Score: 92192.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.7
    Marker Score: 1977
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.69
    Marker Score: 1698
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.63
    Marker Score: 593
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.63
    Marker Score: 1903
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.62
    Marker Score: 4920
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.61
    Marker Score: 1276
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.61
    Marker Score: 29402
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.61
    Marker Score: 2166
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.6
    Marker Score: 897
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.6
    Marker Score: 1833
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.59
    Marker Score: 26276
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.59
    Marker Score: 1887.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.58
    Marker Score: 1484
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.58
    Marker Score: 1863
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.55
    Marker Score: 3319
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.52
    Marker Score: 1329
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.51
    Marker Score: 3646.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.49
    Marker Score: 798
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.48
    Marker Score: 567.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.47
    Marker Score: 1064
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.47
    Marker Score: 4237
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.47
    Marker Score: 18384
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.47
    Marker Score: 1943
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.45
    Marker Score: 1526
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.44
    Marker Score: 1606
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.42
    Marker Score: 2278
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.42
    Marker Score: 1007
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.41
    Marker Score: 1717
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 2.41
    Marker Score: 1048
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.41
    Marker Score: 2324
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.4
    Marker Score: 1234
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.36
    Marker Score: 669
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.36
    Marker Score: 915
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 2.35
    Marker Score: 1601
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.35
    Marker Score: 2527.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.34
    Marker Score: 2189
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.34
    Marker Score: 2522
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.33
    Marker Score: 555.5

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Other Information

**Key characteristics**: * CD99 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is expressed on a variety of cell types, including endothelial cells, immune cells, and stromal cells. * CD99 is a homophilic protein, meaning that it binds to other CD99 molecules. * It is involved in the regulation of immune responses by interacting with other cell surface receptors, such as CD11a and CD11b. * CD99 is also involved in cell adhesion and migration by interacting with extracellular matrix proteins. * It is a negative regulator of inflammation and immune responses. **Pathways and functions**: * CD99 is involved in the regulation of immune responses by interacting with other cell surface receptors. * It is expressed on endothelial cells in blood vessels and regulates the migration of immune cells into tissues. * It is also expressed on tumor cells and can promote tumor growth and metastasis. * CD99 is a potential target for cancer immunotherapy. **Clinical significance**: * Mutations in the CD99 gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and inflammatory diseases. * Targeting CD99 has been shown to be a promising strategy for cancer immunotherapy. * CD99 is a promising target for the development of new drugs for cancer and other diseases that are characterized by abnormal cell adhesion and migration.

Genular Protein ID: 2111858126

Symbol: CD99_HUMAN

Name: CD99 antigen

UniProtKB Accession Codes:

P14209 A6NIW1 O00518 Q6ICV7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 10 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2479542

Title: The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product.

PubMed ID: 2479542

DOI: 10.1002/j.1460-2075.1989.tb08485.x

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3472717

Title: Molecular genetics of MIC2: a gene shared by the human X and Y chromosomes.

PubMed ID: 3472717

DOI: 10.1101/sqb.1986.051.01.025

PubMed ID: 2456574

Title: Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the active X, the inactive X, and the Y chromosome.

PubMed ID: 2456574

DOI: 10.1073/pnas.85.15.5605

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 185
  • Mass: 18848
  • Checksum: C302E09E6B022EAB
  • Sequence:
    • MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG DDFDLGDAVV 
DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS GGEGKGGSDG GGSHRKEGEE 
ADAPGVIPGI VGAVVVAVAG AISSFIAYQK KKLCFKENAE QGEVDMESHR NANAEPAVQR 
TLLEK

Genular Protein ID: 3438970569

Symbol: A0A096LP69_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A096LP69

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12815422

Title: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.

PubMed ID: 12815422

DOI: 10.1038/nature01722

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 184
  • Mass: 18777
  • Checksum: 4982CCD5E69DAE9B
  • Sequence:
    • MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG DDFDLGDAVV 
DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS GGEGKGGSDG GGSHRKEGEE 
ADAPGVIPGI VGAVVVAVAG AISSFIAYQK KKLCFKENEQ GEVDMESHRN ANAEPAVQRT 
LLEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.