Details for: UBE2D2

Gene ID: 7322

Symbol: UBE2D2

Ensembl ID: ENSG00000131508

Description: ubiquitin conjugating enzyme E2 D2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 565.7519
    Cell Significance Index: -88.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 335.9638
    Cell Significance Index: -85.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 269.0876
    Cell Significance Index: -110.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 235.1959
    Cell Significance Index: -95.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 233.6681
    Cell Significance Index: -110.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 209.5900
    Cell Significance Index: -107.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 164.5698
    Cell Significance Index: -110.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 101.1895
    Cell Significance Index: -96.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 82.8010
    Cell Significance Index: -102.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.9827
    Cell Significance Index: -106.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.9177
    Cell Significance Index: -69.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.7012
    Cell Significance Index: -78.9400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.9711
    Cell Significance Index: -41.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.9530
    Cell Significance Index: 190.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.7716
    Cell Significance Index: 326.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7504
    Cell Significance Index: 73.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5748
    Cell Significance Index: 75.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1640
    Cell Significance Index: 429.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0973
    Cell Significance Index: 420.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0899
    Cell Significance Index: 1141.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8697
    Cell Significance Index: 104.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8534
    Cell Significance Index: 87.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8246
    Cell Significance Index: 140.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7833
    Cell Significance Index: 48.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.7491
    Cell Significance Index: 44.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7387
    Cell Significance Index: 213.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6605
    Cell Significance Index: 228.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6141
    Cell Significance Index: 290.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5656
    Cell Significance Index: 36.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4202
    Cell Significance Index: 39.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3297
    Cell Significance Index: 99.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2990
    Cell Significance Index: 167.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2366
    Cell Significance Index: 855.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2335
    Cell Significance Index: 16.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2311
    Cell Significance Index: 544.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1737
    Cell Significance Index: 420.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0974
    Cell Significance Index: 22.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9122
    Cell Significance Index: 31.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8392
    Cell Significance Index: 59.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8363
    Cell Significance Index: 21.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7380
    Cell Significance Index: 34.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6929
    Cell Significance Index: 88.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6040
    Cell Significance Index: 31.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5765
    Cell Significance Index: 29.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3340
    Cell Significance Index: 57.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2125
    Cell Significance Index: 400.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1277
    Cell Significance Index: 196.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1162
    Cell Significance Index: 7.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0998
    Cell Significance Index: 19.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0928
    Cell Significance Index: 126.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0652
    Cell Significance Index: 120.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0650
    Cell Significance Index: 41.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0497
    Cell Significance Index: 22.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0137
    Cell Significance Index: 10.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0185
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0348
    Cell Significance Index: -21.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0354
    Cell Significance Index: -25.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0535
    Cell Significance Index: -1.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0605
    Cell Significance Index: -3.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0705
    Cell Significance Index: -1.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0718
    Cell Significance Index: -7.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1050
    Cell Significance Index: -59.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2173
    Cell Significance Index: -35.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2479
    Cell Significance Index: -24.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2554
    Cell Significance Index: -53.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2733
    Cell Significance Index: -78.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2736
    Cell Significance Index: -28.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2759
    Cell Significance Index: -7.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3551
    Cell Significance Index: -51.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3688
    Cell Significance Index: -24.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4242
    Cell Significance Index: -7.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6158
    Cell Significance Index: -71.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6164
    Cell Significance Index: -70.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6938
    Cell Significance Index: -30.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7353
    Cell Significance Index: -13.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7543
    Cell Significance Index: -86.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7701
    Cell Significance Index: -48.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8604
    Cell Significance Index: -23.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8608
    Cell Significance Index: -21.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8609
    Cell Significance Index: -32.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0840
    Cell Significance Index: -85.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1224
    Cell Significance Index: -13.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1471
    Cell Significance Index: -16.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.2086
    Cell Significance Index: -54.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2377
    Cell Significance Index: -30.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.2648
    Cell Significance Index: -13.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3603
    Cell Significance Index: -28.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3753
    Cell Significance Index: -44.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.4118
    Cell Significance Index: -8.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.4331
    Cell Significance Index: -25.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5375
    Cell Significance Index: -33.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7308
    Cell Significance Index: -50.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.7619
    Cell Significance Index: -37.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7751
    Cell Significance Index: -108.8300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.9901
    Cell Significance Index: -20.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.0978
    Cell Significance Index: -56.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.1176
    Cell Significance Index: -41.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.1923
    Cell Significance Index: -62.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.2629
    Cell Significance Index: -54.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UBE2D2 is a member of the ubiquitin-conjugating enzyme (E2) family, which is essential for the ubiquitination of target proteins. The E2 enzymes are responsible for transferring ubiquitin molecules from E3 ligases to target proteins, resulting in the formation of ubiquitin-protein conjugates. UBE2D2 has been shown to interact with various E3 ligases and other proteins to regulate protein degradation, antigen presentation, and immune responses. One of the key characteristics of UBE2D2 is its ability to modulate the activity of E3 ligases, which are responsible for targeting specific proteins for degradation. UBE2D2 can either enhance or inhibit the activity of E3 ligases, depending on the context, thereby regulating the fate of target proteins. **Pathways and Functions** UBE2D2 is involved in various cellular pathways, including: 1. **Adaptive Immune System**: UBE2D2 plays a crucial role in the adaptive immune system by regulating the ubiquitination of target proteins involved in T cell and B cell activation, differentiation, and survival. 2. **Antigen Processing and Presentation**: UBE2D2 is involved in the ubiquitination of antigens, which are then processed and presented to T cells through the major histocompatibility complex (MHC) class I and II molecules. 3. **Cytokine Signaling**: UBE2D2 modulates the activity of cytokine receptors, which are essential for the regulation of immune responses. 4. **Cellular Responses to Stimuli**: UBE2D2 is involved in the regulation of cellular responses to various stimuli, including stress, hypoxia, and oxidative stress. UBE2D2 also interacts with other proteins to regulate various cellular processes, including: 1. **Protein Degradation**: UBE2D2 is involved in the ubiquitination of target proteins, which can lead to their degradation or modification. 2. **Protein Modification**: UBE2D2 can modify proteins through various post-translational modifications, including ubiquitination, phosphorylation, and acetylation. 3. **Cellular Signaling**: UBE2D2 modulates the activity of signaling pathways, including the NF-κB and JAK/STAT pathways. **Clinical Significance** UBE2D2 has been implicated in various diseases, including: 1. **Autoimmune Disorders**: UBE2D2 has been shown to be involved in the regulation of autoimmune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: UBE2D2 has been shown to be involved in the regulation of cancer cell proliferation, survival, and metastasis. 3. **Immunodeficiency Disorders**: UBE2D2 has been implicated in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, UBE2D2 is a crucial gene involved in the regulation of various cellular processes, including protein degradation, antigen presentation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation.

Genular Protein ID: 1684056778

Symbol: UB2D2_HUMAN

Name: Ubiquitin-conjugating enzyme E2 D2

UniProtKB Accession Codes:

P62837 D3DQC9 P51669 Q3MN78 Q96RP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 3 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 11 EMDB 3 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 53 PDBsum 53 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 15 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530467

Title: Identification of a family of closely related human ubiquitin conjugating enzymes.

PubMed ID: 8530467

DOI: 10.1074/jbc.270.51.30408

PubMed ID: 7724550

Title: Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

PubMed ID: 7724550

DOI: 10.1073/pnas.92.8.3264

PubMed ID: 16112646

Title: Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.

PubMed ID: 16112646

DOI: 10.1016/j.bbrc.2005.08.024

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10329681

Title: Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

PubMed ID: 10329681

DOI: 10.1074/jbc.274.21.14823

PubMed ID: 10918611

Title: SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4.

PubMed ID: 10918611

DOI: 10.1038/sj.onc.1203647

PubMed ID: 12036302

Title: PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.

PubMed ID: 12036302

DOI: 10.1006/geno.2002.6770

PubMed ID: 15280377

Title: Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

PubMed ID: 15280377

DOI: 10.1074/jbc.m403362200

PubMed ID: 15001359

Title: An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.

PubMed ID: 15001359

DOI: 10.1016/j.jmb.2004.01.031

PubMed ID: 17588522

Title: E3-independent monoubiquitination of ubiquitin-binding proteins.

PubMed ID: 17588522

DOI: 10.1016/j.molcel.2007.05.014

PubMed ID: 18042044

Title: Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.

PubMed ID: 18042044

DOI: 10.1042/bj20071338

PubMed ID: 18703417

Title: Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation.

PubMed ID: 18703417

DOI: 10.1095/biolreprod.108.071407

PubMed ID: 18359941

Title: Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor.

PubMed ID: 18359941

DOI: 10.1074/jbc.m800402200

PubMed ID: 19854139

Title: Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.

PubMed ID: 19854139

DOI: 10.1016/j.molcel.2009.09.037

PubMed ID: 20403326

Title: Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.

PubMed ID: 20403326

DOI: 10.1016/j.cell.2010.03.029

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 20525694

Title: The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.

PubMed ID: 20525694

DOI: 10.1074/jbc.m109.091157

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28322253

Title: Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

PubMed ID: 28322253

DOI: 10.1038/cr.2017.40

PubMed ID: 15522302

Title: Solution structure of the ubiquitin-conjugating enzyme UbcH5B.

PubMed ID: 15522302

DOI: 10.1016/j.jmb.2004.09.054

PubMed ID: 20152160

Title: Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates.

PubMed ID: 20152160

DOI: 10.1016/j.str.2009.11.007

PubMed ID: 26656854

Title: Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.

PubMed ID: 26656854

DOI: 10.1038/nsmb.3142

PubMed ID: 26475854

Title: Insights into ubiquitination from the unique clamp-like binding of the RING E3 AO7 to the E2 UbcH5B.

PubMed ID: 26475854

DOI: 10.1074/jbc.m115.685867

Sequence Information:

  • Length: 147
  • Mass: 16735
  • Checksum: C942BE7853CBC355
  • Sequence:
    • MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 
PEIARIYKTD REKYNRIARE WTQKYAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.