Details for: RBM3

Gene ID: 5935

Symbol: RBM3

Ensembl ID: ENSG00000102317

Description: RNA binding motif protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 452.5050
    Cell Significance Index: -70.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 248.8180
    Cell Significance Index: -102.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 242.1116
    Cell Significance Index: -61.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 237.3743
    Cell Significance Index: -96.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 221.2349
    Cell Significance Index: -104.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 202.1637
    Cell Significance Index: -103.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 156.1945
    Cell Significance Index: -104.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 101.0115
    Cell Significance Index: -96.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 72.7966
    Cell Significance Index: -89.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.6753
    Cell Significance Index: -97.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.9207
    Cell Significance Index: -70.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.6925
    Cell Significance Index: -60.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.2587
    Cell Significance Index: -33.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.7357
    Cell Significance Index: 168.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 5.6831
    Cell Significance Index: 401.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.4607
    Cell Significance Index: 96.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.2094
    Cell Significance Index: 88.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.9826
    Cell Significance Index: 256.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.9055
    Cell Significance Index: 1726.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.8667
    Cell Significance Index: 288.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.7045
    Cell Significance Index: 478.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.3709
    Cell Significance Index: 397.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.0616
    Cell Significance Index: 420.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.0370
    Cell Significance Index: 142.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.9086
    Cell Significance Index: 31.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.9057
    Cell Significance Index: 33.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.8028
    Cell Significance Index: 344.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6632
    Cell Significance Index: 480.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.5547
    Cell Significance Index: 23.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.4629
    Cell Significance Index: 85.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2282
    Cell Significance Index: 58.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1555
    Cell Significance Index: 39.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0390
    Cell Significance Index: 95.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6812
    Cell Significance Index: 918.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6665
    Cell Significance Index: 47.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6620
    Cell Significance Index: 213.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7260
    Cell Significance Index: 123.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5755
    Cell Significance Index: 56.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5376
    Cell Significance Index: 6.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5097
    Cell Significance Index: 11.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4778
    Cell Significance Index: 94.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4668
    Cell Significance Index: 24.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4496
    Cell Significance Index: 85.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4272
    Cell Significance Index: 11.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3716
    Cell Significance Index: 281.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3040
    Cell Significance Index: 60.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2230
    Cell Significance Index: 154.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1495
    Cell Significance Index: 135.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1266
    Cell Significance Index: 45.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0217
    Cell Significance Index: 0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0295
    Cell Significance Index: -3.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0359
    Cell Significance Index: -66.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0441
    Cell Significance Index: -67.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0501
    Cell Significance Index: -2.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0528
    Cell Significance Index: -38.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0582
    Cell Significance Index: -36.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0661
    Cell Significance Index: -89.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0933
    Cell Significance Index: -59.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1089
    Cell Significance Index: -61.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1904
    Cell Significance Index: -86.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2103
    Cell Significance Index: -44.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3013
    Cell Significance Index: -35.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3355
    Cell Significance Index: -54.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3589
    Cell Significance Index: -22.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3806
    Cell Significance Index: -43.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4333
    Cell Significance Index: -62.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4573
    Cell Significance Index: -13.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4642
    Cell Significance Index: -11.8600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5210
    Cell Significance Index: -4.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5565
    Cell Significance Index: -14.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5863
    Cell Significance Index: -66.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6113
    Cell Significance Index: -10.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6328
    Cell Significance Index: -17.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6955
    Cell Significance Index: -22.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7679
    Cell Significance Index: -58.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.7812
    Cell Significance Index: -84.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8279
    Cell Significance Index: -8.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8785
    Cell Significance Index: -10.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8932
    Cell Significance Index: -50.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9424
    Cell Significance Index: -98.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9594
    Cell Significance Index: -50.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0869
    Cell Significance Index: -86.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1947
    Cell Significance Index: -73.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2730
    Cell Significance Index: -85.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4978
    Cell Significance Index: -32.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.5304
    Cell Significance Index: -29.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6147
    Cell Significance Index: -22.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6920
    Cell Significance Index: -103.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.7774
    Cell Significance Index: -14.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.8467
    Cell Significance Index: -96.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.8560
    Cell Significance Index: -27.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8975
    Cell Significance Index: -83.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.9930
    Cell Significance Index: -51.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -2.0732
    Cell Significance Index: -34.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0992
    Cell Significance Index: -61.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.1140
    Cell Significance Index: -13.0100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -2.1285
    Cell Significance Index: -18.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.1400
    Cell Significance Index: -45.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RBM3 is a small, highly conserved RNA-binding protein with a characteristic RNA-binding motif (RBM). Its primary characteristics include: 1. **RNA-binding specificity**: RBM3 exhibits specific binding affinity for certain RNA sequences, particularly those involved in alternative splicing and translation regulation. 2. **Regulation of mrna splicing**: RBM3 acts as a positive regulator of mRNA splicing, influencing the inclusion or exclusion of specific exons and thereby modulating the final protein product. 3. **Regulation of translation**: RBM3 also modulates translation initiation and elongation, affecting the levels and localization of target mRNAs. 4. **Cell-type specificity**: RBM3 expression is highly restricted to specific cell types, including immune cells, muscle cells, and trophoblasts, highlighting its importance in distinct biological contexts. **Pathways and Functions** RBM3 is involved in multiple cellular pathways and processes, including: 1. **Positive regulation of mrna splicing via spliceosome**: RBM3 interacts with the spliceosome complex to facilitate the recognition and processing of specific RNA sequences. 2. **Positive regulation of translation**: RBM3 modulates translation initiation and elongation, influencing the levels and localization of target mRNAs. 3. **Protein binding**: RBM3 interacts with various proteins, including other RNA-binding proteins, to regulate RNA processing and translation. 4. **Regulation of translation**: RBM3 influences translation initiation and elongation, affecting the levels and localization of target mRNAs. **Clinical Significance** RBM3 has been implicated in various human diseases, including: 1. **Immune disorders**: RBM3 has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation leads to impaired immune tolerance and excessive inflammation. 2. **Cancer**: RBM3 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it contributes to tumorigenesis and cancer progression. 3. **Muscular dystrophy**: RBM3 has been implicated in muscular dystrophy, where its dysregulation leads to impaired muscle cell differentiation and function. 4. **Reproductive disorders**: RBM3 has been associated with reproductive disorders, such as miscarriage and preterm birth, where its dysregulation affects trophoblast development and function. In conclusion, RBM3 is a critical RNA-binding protein that regulates post-transcriptional gene expression in various cell types. Its dysregulation has been implicated in numerous human diseases, highlighting the importance of RBM3 in maintaining cellular homeostasis and preventing disease. Further research is needed to elucidate the molecular mechanisms underlying RBM3's role in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1758443640

Symbol: RBM3_HUMAN

Name: RNA-binding protein 3

UniProtKB Accession Codes:

P98179

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8634703

Title: RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain.

PubMed ID: 8634703

DOI: 10.1093/hmg/4.12.2307

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15075239

Title: Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism.

PubMed ID: 15075239

DOI: 10.1242/jcs.01026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 157
  • Mass: 17170
  • Checksum: 91C12E2A3E32CFA4
  • Sequence:
    • MSSEEGKLFV GGLNFNTDEQ ALEDHFSSFG PISEVVVVKD RETQRSRGFG FITFTNPEHA 
SVAMRAMNGE SLDGRQIRVD HAGKSARGTR GGGFGAHGRG RSYSRGGGDQ GYGSGRYYDS 
RPGGYGYGYG RSRDYNGRNQ GGYDRYSGGN YRDNYDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.