Details for: TTC3

Gene ID: 7267

Symbol: TTC3

Ensembl ID: ENSG00000182670

Description: tetratricopeptide repeat domain 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 889.1948
    Cell Significance Index: -138.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 492.3448
    Cell Significance Index: -124.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 330.2362
    Cell Significance Index: -136.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 293.7372
    Cell Significance Index: -138.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 284.2289
    Cell Significance Index: -115.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 256.1504
    Cell Significance Index: -131.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 121.2578
    Cell Significance Index: -115.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 115.3813
    Cell Significance Index: -142.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 48.2369
    Cell Significance Index: -129.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 40.3066
    Cell Significance Index: -123.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 36.3617
    Cell Significance Index: -143.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 27.6480
    Cell Significance Index: -60.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.7855
    Cell Significance Index: 294.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.5529
    Cell Significance Index: 109.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.8231
    Cell Significance Index: 1371.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.6191
    Cell Significance Index: 243.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2207
    Cell Significance Index: 646.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1866
    Cell Significance Index: 140.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1215
    Cell Significance Index: 145.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.0514
    Cell Significance Index: 115.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9264
    Cell Significance Index: 1598.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8473
    Cell Significance Index: 391.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7383
    Cell Significance Index: 493.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.7202
    Cell Significance Index: 1881.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.7189
    Cell Significance Index: 152.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6181
    Cell Significance Index: 137.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3816
    Cell Significance Index: 472.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3528
    Cell Significance Index: 289.3000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.8397
    Cell Significance Index: 14.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6077
    Cell Significance Index: 123.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2938
    Cell Significance Index: 36.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.2652
    Cell Significance Index: 803.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.1517
    Cell Significance Index: 2168.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0006
    Cell Significance Index: 128.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9893
    Cell Significance Index: 437.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9220
    Cell Significance Index: 26.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7399
    Cell Significance Index: 12.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7324
    Cell Significance Index: 15.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6628
    Cell Significance Index: 598.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5629
    Cell Significance Index: 866.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4103
    Cell Significance Index: 8.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3941
    Cell Significance Index: 726.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3807
    Cell Significance Index: 10.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3191
    Cell Significance Index: 11.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2786
    Cell Significance Index: 7.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2695
    Cell Significance Index: 5.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2153
    Cell Significance Index: 10.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2113
    Cell Significance Index: 22.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1964
    Cell Significance Index: 12.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1822
    Cell Significance Index: 247.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1475
    Cell Significance Index: 66.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1223
    Cell Significance Index: 15.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1114
    Cell Significance Index: 81.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0648
    Cell Significance Index: 11.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0546
    Cell Significance Index: 10.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0496
    Cell Significance Index: 8.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0013
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0013
    Cell Significance Index: 0.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0423
    Cell Significance Index: -1.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1031
    Cell Significance Index: -1.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1113
    Cell Significance Index: -84.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1329
    Cell Significance Index: -98.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1628
    Cell Significance Index: -12.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2002
    Cell Significance Index: -14.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2052
    Cell Significance Index: -24.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2278
    Cell Significance Index: -128.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2549
    Cell Significance Index: -26.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2711
    Cell Significance Index: -169.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3621
    Cell Significance Index: -35.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4129
    Cell Significance Index: -60.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4379
    Cell Significance Index: -125.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5411
    Cell Significance Index: -28.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5489
    Cell Significance Index: -14.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7215
    Cell Significance Index: -151.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7845
    Cell Significance Index: -91.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9764
    Cell Significance Index: -61.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.0282
    Cell Significance Index: -36.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0396
    Cell Significance Index: -119.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0659
    Cell Significance Index: -110.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0789
    Cell Significance Index: -28.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.1462
    Cell Significance Index: -26.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2499
    Cell Significance Index: -98.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.3438
    Cell Significance Index: -92.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.3786
    Cell Significance Index: -17.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.5135
    Cell Significance Index: -33.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.8086
    Cell Significance Index: -21.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.8491
    Cell Significance Index: -50.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8566
    Cell Significance Index: -47.4300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.9356
    Cell Significance Index: -27.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0171
    Cell Significance Index: -123.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.0956
    Cell Significance Index: -67.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -2.1132
    Cell Significance Index: -19.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.2051
    Cell Significance Index: -63.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.5137
    Cell Significance Index: -82.3000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -2.5610
    Cell Significance Index: -43.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -2.6339
    Cell Significance Index: -52.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.6629
    Cell Significance Index: -84.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.8790
    Cell Significance Index: -84.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9426
    Cell Significance Index: -63.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -2.9745
    Cell Significance Index: -63.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin-Protein Ligase Activity:** TTC3 is an E3 ubiquitin-protein ligase, which catalyzes the transfer of ubiquitin molecules to specific lysine residues on target proteins, marking them for degradation. 2. **Tetratricopeptide Repeat Domain:** The gene encodes a tetratricopeptide repeat (TPR) domain, a protein-protein interaction motif that facilitates the recognition and binding of target proteins. 3. **High Expression in Immune-Related Cells:** TTC3 is significantly expressed in cells of the immune system, including cortical cells of the adrenal gland, Purkinje cells, and inhibitory interneurons, suggesting its role in immune regulation and tolerance. 4. **Metal Ion Binding:** TTC3 has been shown to bind metal ions, which may influence its ubiquitination activity and protein-protein interactions. **Pathways and Functions:** TTC3 is involved in various cellular processes, including: 1. **Protein Degradation:** TTC3 regulates protein degradation through the ubiquitination pathway, which is essential for maintaining cellular homeostasis and eliminating damaged or misfolded proteins. 2. **Immune Regulation:** TTC3 plays a crucial role in immune regulation, including the suppression of autoimmune responses and the maintenance of immune tolerance. 3. **Neurotransmission:** TTC3 is involved in neurotransmission, particularly in the regulation of inhibitory neurotransmitters, such as GABA and glycine. 4. **Cell Signaling:** TTC3 may participate in cell signaling pathways, including the regulation of cell growth, differentiation, and apoptosis. **Clinical Significance:** Dysregulation of TTC3 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** TTC3 has been linked to autoimmune diseases, such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, where it may contribute to the development of autoimmunity. 2. **Neurodegenerative Disorders:** TTC3 has been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, where it may play a role in protein degradation and neuroinflammation. 3. **Cancer:** TTC3 has been implicated in cancer, where it may contribute to tumorigenesis, metastasis, and resistance to therapy. In conclusion, TTC3 is a complex gene with multifaceted functions, playing a crucial role in protein degradation, immune regulation, and neurotransmission. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TTC3 and its potential as a therapeutic target.

Genular Protein ID: 275226711

Symbol: TTC3_HUMAN

Name: E3 ubiquitin-protein ligase TTC3

UniProtKB Accession Codes:

P53804 A8K7H7 B2RPA7 D3DSG9 D3DSH2 D3DSH3 O60767 P78476 P78477 Q569I2 Q6P578 Q9UEK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 20 Ensembl 6 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 7 SIGNOR 1 SMART 2 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8724848

Title: Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21.

PubMed ID: 8724848

DOI: 10.1093/dnares/3.1.9

PubMed ID: 8947847

Title: Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2.

PubMed ID: 8947847

DOI: 10.1093/oxfordjournals.jbchem.a021485

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 9254009

Title: Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2.

PubMed ID: 9254009

DOI: 10.3109/10425179709034031

PubMed ID: 9503011

Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.

PubMed ID: 9503011

DOI: 10.1006/geno.1997.5146

PubMed ID: 17488780

Title: The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.

PubMed ID: 17488780

DOI: 10.1242/jcs.000703

PubMed ID: 20059950

Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

PubMed ID: 20059950

DOI: 10.1016/j.devcel.2009.09.007

PubMed ID: 24695496

Title: The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways.

PubMed ID: 24695496

DOI: 10.1371/journal.pone.0093721

PubMed ID: 29290964

Title: Tetratricopeptide repeat domain 3 overexpression tends to form aggregates and inhibit ubiquitination and degradation of DNA polymerase gamma.

PubMed ID: 29290964

DOI: 10.18632/oncotarget.22476

PubMed ID: 30696809

Title: TTC3 contributes to TGF-beta1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.

PubMed ID: 30696809

DOI: 10.1038/s41419-019-1308-8

PubMed ID: 30203323

Title: Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and Form Aggregates in the Nucleus.

PubMed ID: 30203323

DOI: 10.1007/s12017-018-8509-7

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27066578

Title: Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease.

PubMed ID: 27066578

DOI: 10.1212/nxg.0000000000000041

Sequence Information:

  • Length: 2025
  • Mass: 229869
  • Checksum: C80BC8E1970B6725
  • Sequence:
    • MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV QYKDYIQSER 
NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS SVISRLHPCV DANNSRASEI 
NLKKLQHLEL MEDIVDLAKK VANDSFLIGG LLRIGCKIEN KILAMEEALN WIKYAGDVTI 
LTKLGSIDNC WPMLSIFFTE YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE 
EFSKERFDIA IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK 
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI EDLQGRTANK 
DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH EMANGGNQNL KVADEALKVD 
DCDCHPEFSP PSSQPPKHKG KQKSRNNESE KFSSSSPLTL PADLKNILEK QFSKSSRAAH 
QDFANIMKML RSLIQDGYMA LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY 
GLAISLLGIG QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE 
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI CCYQKCHGYS 
KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF NDKIDKDFLQ GICLTPDCEG 
VISKIIIFSS GGEVKCEFEH KVIKEKVPPR PILKQKCSSL EKLRLKEDKK LKRKIQKKEA 
KKLAQERMEE DLRESNPPKN EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM 
LLKELLSWKV LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE 
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD SIEGKQLDYF 
SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR CTVLRKQDSG EAPFSSTKVK 
NKSKKKKPKD SKPMLVGSGT TSVTSNNEII TSSEDHSNRN SDSAGPFAVP DHLRQDVEEF 
EALYDQHSNE YVVRNKKLWD MNPKQKCSTL YDYFSQFLEE HGPLDMSNKM FSAEYEFFPE 
ETRQILEKAG GLKPFLLGCP RFVVIDNCIA LKKVASRLKK KRKKKNIKTK VEEISKAGEY 
VRVKLQLNPA AREFKPDVKS KPVSDSSSAP AFENVKPKPV SANSPKPACE DVKAKPVSDN 
SSRQVSEDGQ PKGVSSNSPK PGSEDANYKR VSCNSPKPVL EDVKPTYWAQ SHLVTGYCTY 
LPFQRFDITQ TPPAYINVLP GLPQYTSIYT PLASLSPEYQ LPRSVPVVPS FVANDRADKN 
AAAYFEGHHL NAENVAGHQI ASETQILEGS LGISVKSHCS TGDAHTVLSE SNRNDEHCGN 
SNNKCEVIPE STSAVTNIPH VQMVAIQVSW NIIHQEVNTE PYNPFEERQG EISRIEKEHQ 
VLQDQLQEVY ENYEQIKLKG LEETRDLEEK LKRHLEENKI SKTELDWFLQ DLEREIKKWQ 
QEKKEIQERL KSLKKKIKKV SNASEMYTQK NDGKEKEHEL HLDQSLEISN TLTNEKMKIE 
EYIKKGKEDY EESHQRAVAA EVSVLENWKE SEVYKLQIME SQAEAFLKKL GLISRDPAAY 
PDMESDIRSW ELFLSNVTKE IEKAKSQFEE QIKAIKNGSR LSELSKVQIS ELSFPACNTV 
HPELLPESSG DDGQGLVTSA SDVTGNHAAL HRDPSVFSAG DSPGEAPSAL LPGPPPGQPE 
ATQLTGPKRA GQAALSERSP VADRKQPVPP GRAARSSQSP KKPFNSIIEH LSVVFPCYNS 
TELAGFIKKV RSKNKNSLSG LSIDEIVQRV TEHILDEQKK KKPNPGKDKR TYEPSSATPV 
TRSSQGSPSV VVAPSPKTKG QKAEDVPVRI ALGASSCEIC HEVFKSKNVR VLKCGHKYHK 
GCFKQWLKGQ SACPACQGRD LLTEESPSGR GWPSQNQELP SCSSR

Genular Protein ID: 3203210506

Symbol: H7BZ57_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7BZ57

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 3 SAM 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 2043
  • Mass: 231968
  • Checksum: E454D8BF42D27B5E
  • Sequence:
    • MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV QYKDYIQSER 
NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS SVISRLHPCV DANNSRASEI 
NLKKLQHLEL MEDIVDLAKK VANDSFLIGG LLRIGCKIEN KILAMEEALN WIKYAGDVTI 
LTKLGSIDNC WPMLSIFFTE YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE 
EFSKERFDIA IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK 
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI EDLQGRTANK 
DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH EMANGGNQNL KVADEALKVD 
DCDCHPEFSP PSSQPPKHKG KQKSRNNESE KFSSSSPLTL PADLKNILEK QFSKSSRAAH 
QDFANIMKML RSLIQDGYMA LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY 
GLAISLLGIG QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE 
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI CCYQKCHGYS 
KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF NDKIDKDFLQ GICLTPDCEG 
VISKIIIFSS GGEVKCEFEH KVIKEKVPPR PILKQKCSSL EKLRLKEDKK LKRKIQKKEA 
KKLAQERMEE DLRESNPPKN EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM 
LLKELLSWKV LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE 
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD SIEGKQLDYF 
SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDIF TASWERLHVT LTESINSRCT 
VLRKQDSGEA PFSSTKVKNK SKKKKPKDSK PMLVGSGTTS VTSNNEIITS SEDHSNRNSD 
SAGPFAVPDH LRQDVEEFEA LYDQHSNEYV VRNKKLWDMN PKQKCSTLYD YFSQFLEEHG 
PLDMSNKMFS AEYEFFPEET RQILEKAGGL KPFLLGCPRF VVIDNCIALK KVASRLKKKR 
KKKNIKTKVE EISKAGEYVR VKLQLNPAAR EFKPDVKSKP VSDSSSAPAF ENVKPKPVSA 
NSPKPACEDV KAKPVSDNSS RQVSEDGQPK GVSSNSPKPG SEDANYKRVS CNSPKPVLED 
VKPTYWAQSH LVTGYCTYLP FQRFDITQTP PAYINVLPGL PQYTSIYTPL ASLSPEYQLP 
RSVPVVPSFV ANDRADKNAA AYFEGHHLNA ENVAGHQIAS ETQILEGSLG ISVKSHCSTG 
DAHTVLSESN RNDEHCGNSN NKCEVIPEST SAVTNIPHVQ MVAIQVSWNI IHQEVNTEPY 
NPFEERQGEI SRIEKEHQVL QDQLQEVYEN YEQIKLKGLE ETRDLEEKLK RHLEENKISK 
TELDWFLQDL EREIKKWQQE KKEIQERLKS LKKKIKKVSN ASEMYTQKND GKEKEHELHL 
DQSLEISNTL TNEKMKIEEY IKKGKEDYEE SHQRAVAAEV SVLENWKESE VYKLQIMESQ 
AEAFLKKLGL ISRDPAAYPD MESDIRSWEL FLSNVTKEIE KAKSQFEEQI KAIKNGSRLS 
ELSKVQISEL SFPACNTVHP ELLPESSGDD GQGLVTSASD VTGNHAALHR DPSVFSAGDS 
PGEAPSALLP GPPPGQPEAT QLTGPKRAGQ AALSERSPVA DRKQPVPPGR AARSSQSPKK 
PFNSIIEHLS VVFPCYNSTE LAGFIKKVRS KNKNSLSGLS IDEIVQRVTE HILDEQKKKK 
PNPGKDKRTY EPSSATPVTR SSQGSPSVVV APSPKTKGQK AEDVPVRIAL GASSCEICHE 
VFKSKNVRVL KCGHKYHKGC FKQWLKGQSA CPACQGRDLL TEESPSGRGW PSQNQELPSC 
SSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.