Details for: TTC3

Gene ID: 7267

Symbol: TTC3

Ensembl ID: ENSG00000182670

Description: tetratricopeptide repeat domain 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.88
    Marker Score: 86667.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.29
    Marker Score: 144997
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.94
    Marker Score: 20670
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.88
    Marker Score: 17961
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.85
    Marker Score: 12908
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.62
    Marker Score: 5089
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.51
    Marker Score: 18835
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.32
    Marker Score: 1717.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.3
    Marker Score: 43519
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.15
    Marker Score: 2369
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.14
    Marker Score: 23645
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.13
    Marker Score: 1633
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.1
    Marker Score: 12944.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.01
    Marker Score: 3641
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.01
    Marker Score: 3638
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.95
    Marker Score: 7066
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.95
    Marker Score: 102099
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.91
    Marker Score: 12187.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.89
    Marker Score: 5874
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.88
    Marker Score: 18734.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.81
    Marker Score: 8027
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.8
    Marker Score: 2641
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.79
    Marker Score: 55566
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.78
    Marker Score: 6380
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.77
    Marker Score: 1329
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.76
    Marker Score: 3707
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.73
    Marker Score: 20892
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.71
    Marker Score: 1573
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.7
    Marker Score: 790
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.7
    Marker Score: 5700.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.68
    Marker Score: 40008
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.64
    Marker Score: 100293.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.64
    Marker Score: 4433
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6
    Marker Score: 5913
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.58
    Marker Score: 2891
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.57
    Marker Score: 54939
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.57
    Marker Score: 1811.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.56
    Marker Score: 6855
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.56
    Marker Score: 845
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.55
    Marker Score: 4915.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.54
    Marker Score: 2418
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.49
    Marker Score: 1920
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.48
    Marker Score: 1391
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.48
    Marker Score: 10270
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.47
    Marker Score: 3052
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.45
    Marker Score: 5776
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.43
    Marker Score: 701
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.41
    Marker Score: 2084
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.41
    Marker Score: 5291
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.39
    Marker Score: 1661.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.39
    Marker Score: 88245.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.39
    Marker Score: 26885
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.38
    Marker Score: 4353
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.38
    Marker Score: 1411
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.38
    Marker Score: 1174
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.37
    Marker Score: 2554
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.36
    Marker Score: 894
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.36
    Marker Score: 792
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.35
    Marker Score: 2006
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.34
    Marker Score: 1364
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.33
    Marker Score: 2884
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.33
    Marker Score: 52027
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.33
    Marker Score: 1361
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.29
    Marker Score: 1440
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.29
    Marker Score: 7495.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.29
    Marker Score: 1079
  • Cell Name: glial cell (CL0000125)
    Fold Change: 2.28
    Marker Score: 2502
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.27
    Marker Score: 3121
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.27
    Marker Score: 1515.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.27
    Marker Score: 719
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.25
    Marker Score: 2591
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.25
    Marker Score: 1185
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.24
    Marker Score: 2399
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.24
    Marker Score: 5652
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.22
    Marker Score: 8601
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.22
    Marker Score: 1291
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.21
    Marker Score: 1915
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.18
    Marker Score: 521
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.17
    Marker Score: 4521
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.16
    Marker Score: 551
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.15
    Marker Score: 2774
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.15
    Marker Score: 1058.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.14
    Marker Score: 775
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.14
    Marker Score: 8773
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.14
    Marker Score: 866
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.14
    Marker Score: 894.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 20057
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.13
    Marker Score: 2003
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.13
    Marker Score: 2261.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.12
    Marker Score: 783
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.09
    Marker Score: 670
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.08
    Marker Score: 1036
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.08
    Marker Score: 2217
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.07
    Marker Score: 796
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.07
    Marker Score: 585
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.06
    Marker Score: 1357
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126477.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.06
    Marker Score: 3493
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.04
    Marker Score: 20492
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.03
    Marker Score: 818.5

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Other Information

**Key Characteristics:** 1. **Ubiquitin-Protein Ligase Activity:** TTC3 is an E3 ubiquitin-protein ligase, which catalyzes the transfer of ubiquitin molecules to specific lysine residues on target proteins, marking them for degradation. 2. **Tetratricopeptide Repeat Domain:** The gene encodes a tetratricopeptide repeat (TPR) domain, a protein-protein interaction motif that facilitates the recognition and binding of target proteins. 3. **High Expression in Immune-Related Cells:** TTC3 is significantly expressed in cells of the immune system, including cortical cells of the adrenal gland, Purkinje cells, and inhibitory interneurons, suggesting its role in immune regulation and tolerance. 4. **Metal Ion Binding:** TTC3 has been shown to bind metal ions, which may influence its ubiquitination activity and protein-protein interactions. **Pathways and Functions:** TTC3 is involved in various cellular processes, including: 1. **Protein Degradation:** TTC3 regulates protein degradation through the ubiquitination pathway, which is essential for maintaining cellular homeostasis and eliminating damaged or misfolded proteins. 2. **Immune Regulation:** TTC3 plays a crucial role in immune regulation, including the suppression of autoimmune responses and the maintenance of immune tolerance. 3. **Neurotransmission:** TTC3 is involved in neurotransmission, particularly in the regulation of inhibitory neurotransmitters, such as GABA and glycine. 4. **Cell Signaling:** TTC3 may participate in cell signaling pathways, including the regulation of cell growth, differentiation, and apoptosis. **Clinical Significance:** Dysregulation of TTC3 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** TTC3 has been linked to autoimmune diseases, such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, where it may contribute to the development of autoimmunity. 2. **Neurodegenerative Disorders:** TTC3 has been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, where it may play a role in protein degradation and neuroinflammation. 3. **Cancer:** TTC3 has been implicated in cancer, where it may contribute to tumorigenesis, metastasis, and resistance to therapy. In conclusion, TTC3 is a complex gene with multifaceted functions, playing a crucial role in protein degradation, immune regulation, and neurotransmission. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TTC3 and its potential as a therapeutic target.

Genular Protein ID: 275226711

Symbol: TTC3_HUMAN

Name: E3 ubiquitin-protein ligase TTC3

UniProtKB Accession Codes:

P53804 A8K7H7 B2RPA7 D3DSG9 D3DSH2 D3DSH3 O60767 P78476 P78477 Q569I2 Q6P578 Q9UEK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 20 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 2 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8724848

Title: Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21.

PubMed ID: 8724848

DOI: 10.1093/dnares/3.1.9

PubMed ID: 8947847

Title: Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2.

PubMed ID: 8947847

DOI: 10.1093/oxfordjournals.jbchem.a021485

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 9254009

Title: Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2.

PubMed ID: 9254009

DOI: 10.3109/10425179709034031

PubMed ID: 9503011

Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.

PubMed ID: 9503011

DOI: 10.1006/geno.1997.5146

PubMed ID: 17488780

Title: The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.

PubMed ID: 17488780

DOI: 10.1242/jcs.000703

PubMed ID: 20059950

Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

PubMed ID: 20059950

DOI: 10.1016/j.devcel.2009.09.007

PubMed ID: 24695496

Title: The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways.

PubMed ID: 24695496

DOI: 10.1371/journal.pone.0093721

PubMed ID: 29290964

Title: Tetratricopeptide repeat domain 3 overexpression tends to form aggregates and inhibit ubiquitination and degradation of DNA polymerase gamma.

PubMed ID: 29290964

DOI: 10.18632/oncotarget.22476

PubMed ID: 30696809

Title: TTC3 contributes to TGF-beta1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.

PubMed ID: 30696809

DOI: 10.1038/s41419-019-1308-8

PubMed ID: 30203323

Title: Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and Form Aggregates in the Nucleus.

PubMed ID: 30203323

DOI: 10.1007/s12017-018-8509-7

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27066578

Title: Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease.

PubMed ID: 27066578

DOI: 10.1212/nxg.0000000000000041

Sequence Information:

  • Length: 2025
  • Mass: 229869
  • Checksum: C80BC8E1970B6725
  • Sequence:
    • MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV QYKDYIQSER 
NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS SVISRLHPCV DANNSRASEI 
NLKKLQHLEL MEDIVDLAKK VANDSFLIGG LLRIGCKIEN KILAMEEALN WIKYAGDVTI 
LTKLGSIDNC WPMLSIFFTE YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE 
EFSKERFDIA IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK 
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI EDLQGRTANK 
DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH EMANGGNQNL KVADEALKVD 
DCDCHPEFSP PSSQPPKHKG KQKSRNNESE KFSSSSPLTL PADLKNILEK QFSKSSRAAH 
QDFANIMKML RSLIQDGYMA LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY 
GLAISLLGIG QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE 
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI CCYQKCHGYS 
KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF NDKIDKDFLQ GICLTPDCEG 
VISKIIIFSS GGEVKCEFEH KVIKEKVPPR PILKQKCSSL EKLRLKEDKK LKRKIQKKEA 
KKLAQERMEE DLRESNPPKN EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM 
LLKELLSWKV LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE 
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD SIEGKQLDYF 
SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR CTVLRKQDSG EAPFSSTKVK 
NKSKKKKPKD SKPMLVGSGT TSVTSNNEII TSSEDHSNRN SDSAGPFAVP DHLRQDVEEF 
EALYDQHSNE YVVRNKKLWD MNPKQKCSTL YDYFSQFLEE HGPLDMSNKM FSAEYEFFPE 
ETRQILEKAG GLKPFLLGCP RFVVIDNCIA LKKVASRLKK KRKKKNIKTK VEEISKAGEY 
VRVKLQLNPA AREFKPDVKS KPVSDSSSAP AFENVKPKPV SANSPKPACE DVKAKPVSDN 
SSRQVSEDGQ PKGVSSNSPK PGSEDANYKR VSCNSPKPVL EDVKPTYWAQ SHLVTGYCTY 
LPFQRFDITQ TPPAYINVLP GLPQYTSIYT PLASLSPEYQ LPRSVPVVPS FVANDRADKN 
AAAYFEGHHL NAENVAGHQI ASETQILEGS LGISVKSHCS TGDAHTVLSE SNRNDEHCGN 
SNNKCEVIPE STSAVTNIPH VQMVAIQVSW NIIHQEVNTE PYNPFEERQG EISRIEKEHQ 
VLQDQLQEVY ENYEQIKLKG LEETRDLEEK LKRHLEENKI SKTELDWFLQ DLEREIKKWQ 
QEKKEIQERL KSLKKKIKKV SNASEMYTQK NDGKEKEHEL HLDQSLEISN TLTNEKMKIE 
EYIKKGKEDY EESHQRAVAA EVSVLENWKE SEVYKLQIME SQAEAFLKKL GLISRDPAAY 
PDMESDIRSW ELFLSNVTKE IEKAKSQFEE QIKAIKNGSR LSELSKVQIS ELSFPACNTV 
HPELLPESSG DDGQGLVTSA SDVTGNHAAL HRDPSVFSAG DSPGEAPSAL LPGPPPGQPE 
ATQLTGPKRA GQAALSERSP VADRKQPVPP GRAARSSQSP KKPFNSIIEH LSVVFPCYNS 
TELAGFIKKV RSKNKNSLSG LSIDEIVQRV TEHILDEQKK KKPNPGKDKR TYEPSSATPV 
TRSSQGSPSV VVAPSPKTKG QKAEDVPVRI ALGASSCEIC HEVFKSKNVR VLKCGHKYHK 
GCFKQWLKGQ SACPACQGRD LLTEESPSGR GWPSQNQELP SCSSR

Genular Protein ID: 3203210506

Symbol: H7BZ57_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7BZ57

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 EC 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 2043
  • Mass: 231968
  • Checksum: E454D8BF42D27B5E
  • Sequence:
    • MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV QYKDYIQSER 
NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS SVISRLHPCV DANNSRASEI 
NLKKLQHLEL MEDIVDLAKK VANDSFLIGG LLRIGCKIEN KILAMEEALN WIKYAGDVTI 
LTKLGSIDNC WPMLSIFFTE YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE 
EFSKERFDIA IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK 
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI EDLQGRTANK 
DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH EMANGGNQNL KVADEALKVD 
DCDCHPEFSP PSSQPPKHKG KQKSRNNESE KFSSSSPLTL PADLKNILEK QFSKSSRAAH 
QDFANIMKML RSLIQDGYMA LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY 
GLAISLLGIG QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE 
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI CCYQKCHGYS 
KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF NDKIDKDFLQ GICLTPDCEG 
VISKIIIFSS GGEVKCEFEH KVIKEKVPPR PILKQKCSSL EKLRLKEDKK LKRKIQKKEA 
KKLAQERMEE DLRESNPPKN EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM 
LLKELLSWKV LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE 
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD SIEGKQLDYF 
SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDIF TASWERLHVT LTESINSRCT 
VLRKQDSGEA PFSSTKVKNK SKKKKPKDSK PMLVGSGTTS VTSNNEIITS SEDHSNRNSD 
SAGPFAVPDH LRQDVEEFEA LYDQHSNEYV VRNKKLWDMN PKQKCSTLYD YFSQFLEEHG 
PLDMSNKMFS AEYEFFPEET RQILEKAGGL KPFLLGCPRF VVIDNCIALK KVASRLKKKR 
KKKNIKTKVE EISKAGEYVR VKLQLNPAAR EFKPDVKSKP VSDSSSAPAF ENVKPKPVSA 
NSPKPACEDV KAKPVSDNSS RQVSEDGQPK GVSSNSPKPG SEDANYKRVS CNSPKPVLED 
VKPTYWAQSH LVTGYCTYLP FQRFDITQTP PAYINVLPGL PQYTSIYTPL ASLSPEYQLP 
RSVPVVPSFV ANDRADKNAA AYFEGHHLNA ENVAGHQIAS ETQILEGSLG ISVKSHCSTG 
DAHTVLSESN RNDEHCGNSN NKCEVIPEST SAVTNIPHVQ MVAIQVSWNI IHQEVNTEPY 
NPFEERQGEI SRIEKEHQVL QDQLQEVYEN YEQIKLKGLE ETRDLEEKLK RHLEENKISK 
TELDWFLQDL EREIKKWQQE KKEIQERLKS LKKKIKKVSN ASEMYTQKND GKEKEHELHL 
DQSLEISNTL TNEKMKIEEY IKKGKEDYEE SHQRAVAAEV SVLENWKESE VYKLQIMESQ 
AEAFLKKLGL ISRDPAAYPD MESDIRSWEL FLSNVTKEIE KAKSQFEEQI KAIKNGSRLS 
ELSKVQISEL SFPACNTVHP ELLPESSGDD GQGLVTSASD VTGNHAALHR DPSVFSAGDS 
PGEAPSALLP GPPPGQPEAT QLTGPKRAGQ AALSERSPVA DRKQPVPPGR AARSSQSPKK 
PFNSIIEHLS VVFPCYNSTE LAGFIKKVRS KNKNSLSGLS IDEIVQRVTE HILDEQKKKK 
PNPGKDKRTY EPSSATPVTR SSQGSPSVVV APSPKTKGQK AEDVPVRIAL GASSCEICHE 
VFKSKNVRVL KCGHKYHKGC FKQWLKGQSA CPACQGRDLL TEESPSGRGW PSQNQELPSC 
SSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.