Details for: KCNAB1

Gene ID: 7881

Symbol: KCNAB1

Ensembl ID: ENSG00000169282

Description: potassium voltage-gated channel subfamily A regulatory beta subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: contractile cell (CL0000183)
    Fold Change: 5.14
    Marker Score: 2784
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.27
    Marker Score: 22925
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 4
    Marker Score: 24053
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.86
    Marker Score: 1733
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.73
    Marker Score: 12636
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.3
    Marker Score: 3855.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.04
    Marker Score: 4698
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.99
    Marker Score: 1897
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.72
    Marker Score: 3492
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168917
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.47
    Marker Score: 21999
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4
    Marker Score: 14441
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.35
    Marker Score: 813
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3068
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.27
    Marker Score: 46860
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.26
    Marker Score: 5206
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19322
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.2
    Marker Score: 396
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.17
    Marker Score: 3336
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4803
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.1
    Marker Score: 347
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.08
    Marker Score: 4517
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 670
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.03
    Marker Score: 490
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.97
    Marker Score: 748
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.96
    Marker Score: 301
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.96
    Marker Score: 3702
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.91
    Marker Score: 381.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9
    Marker Score: 415
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.87
    Marker Score: 1219
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.82
    Marker Score: 1535
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.79
    Marker Score: 2814
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.77
    Marker Score: 260
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.77
    Marker Score: 225
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.76
    Marker Score: 499
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.76
    Marker Score: 758
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.74
    Marker Score: 45445
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.73
    Marker Score: 185
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.72
    Marker Score: 362
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 448
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.68
    Marker Score: 356
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.67
    Marker Score: 823
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.66
    Marker Score: 818
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.65
    Marker Score: 460
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.64
    Marker Score: 423
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.64
    Marker Score: 258
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.64
    Marker Score: 1526
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.62
    Marker Score: 162
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.62
    Marker Score: 177
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.61
    Marker Score: 5277
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 388
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.58
    Marker Score: 11586
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 257
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.58
    Marker Score: 1446
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.56
    Marker Score: 315
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.56
    Marker Score: 369
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.54
    Marker Score: 652
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.53
    Marker Score: 258
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.53
    Marker Score: 1772
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.53
    Marker Score: 253
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.52
    Marker Score: 11583
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.49
    Marker Score: 140
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.49
    Marker Score: 3749
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.49
    Marker Score: 176.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.48
    Marker Score: 457.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.48
    Marker Score: 329
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.48
    Marker Score: 600
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.46
    Marker Score: 17508
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.46
    Marker Score: 225
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 114
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.4
    Marker Score: 442
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.4
    Marker Score: 145
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.4
    Marker Score: 112
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.4
    Marker Score: 222
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4
    Marker Score: 900
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.39
    Marker Score: 165
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.37
    Marker Score: 168
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.37
    Marker Score: 703
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 321

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Other Information

**Key Characteristics** KCNAB1 is a beta subunit of voltage-gated potassium channels, which are essential for controlling the flow of potassium ions across cell membranes. The beta-1 subunit is specifically expressed in neurons, where it interacts with alpha subunits to form functional potassium channels. KCNAB1 is negatively regulated by various signaling pathways, including those involving aldose reductase and NADPH, which modulate its activity. The gene is highly expressed in various cell types, including contractile cells, stellate neurons, and epithelial cells of alveolar tissue. **Pathways and Functions** The KCNAB1 gene is involved in several cellular pathways, including: 1. **Negative regulation of voltage-gated potassium channel activity**: KCNAB1 modulates the activity of voltage-gated potassium channels, which are critical for regulating neuronal excitability and maintaining proper ion balance. 2. **Regulation of delayed rectifier potassium channels**: The beta-1 subunit regulates the activity of delayed rectifier potassium channels, which are involved in controlling the excitability of neurons and the propagation of action potentials. 3. **Voltage-gated potassium channel complex formation**: KCNAB1 interacts with alpha subunits to form functional potassium channels, which are essential for maintaining proper ion balance and neuronal function. 4. **Regulation of potassium ion transmembrane transport**: KCNAB1 modulates the activity of potassium channels, which regulate the flow of potassium ions across cell membranes. **Clinical Significance** Dysregulation of KCNAB1 has been implicated in various neurological and cardiovascular disorders, including: 1. **Neurological disorders**: KCNAB1 mutations have been associated with neurological disorders, such as epilepsy, migraines, and anxiety disorders. 2. **Cardiovascular disorders**: KCNAB1 dysregulation has been implicated in cardiovascular disorders, such as arrhythmias, hypertension, and cardiac conduction disease. 3. **Respiratory disorders**: KCNAB1 mutations have been associated with respiratory disorders, such as chronic obstructive pulmonary disease (COPD) and asthma. In summary, KCNAB1 plays a crucial role in regulating neuronal excitability and ion balance, and its dysregulation has been implicated in various neurological and cardiovascular disorders. Further research is needed to fully understand the mechanisms underlying KCNAB1 function and its role in human disease.

Genular Protein ID: 1277316463

Symbol: KCAB1_HUMAN

Name: Voltage-gated potassium channel subunit beta-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7499366

Title: A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing.

PubMed ID: 7499366

DOI: 10.1074/jbc.270.48.28531

PubMed ID: 7890032

Title: Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium.

PubMed ID: 7890032

DOI: 10.1016/0014-5793(95)00120-x

PubMed ID: 7603988

Title: Characterization of a voltage-gated K+ channel beta subunit expressed in human heart.

PubMed ID: 7603988

DOI: 10.1073/pnas.92.14.6309

PubMed ID: 7649300

Title: Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.

PubMed ID: 7649300

DOI: 10.1016/0014-5793(95)00785-8

PubMed ID: 8938711

Title: Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B).

PubMed ID: 8938711

DOI: 10.1016/0028-3908(96)00133-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7890764

Title: A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits.

PubMed ID: 7890764

DOI: 10.1074/jbc.270.11.6272

PubMed ID: 9763623

Title: Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4.

PubMed ID: 9763623

DOI: 10.1111/j.1469-7793.1998.325be.x

PubMed ID: 12077175

Title: Episodic ataxia type 1 mutations in the human Kv1.1 potassium channel alter hKvbeta 1-induced N-type inactivation.

PubMed ID: 12077175

DOI: 10.1523/jneurosci.22-12-04786.2002

PubMed ID: 12130714

Title: Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit.

PubMed ID: 12130714

DOI: 10.1124/jpet.102.033357

PubMed ID: 15361858

Title: Control of human potassium channel inactivation by editing of a small mRNA hairpin.

PubMed ID: 15361858

DOI: 10.1038/nsmb825

PubMed ID: 17156368

Title: Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2.

PubMed ID: 17156368

DOI: 10.1111/j.1460-9568.2006.05186.x

PubMed ID: 17540341

Title: NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels.

PubMed ID: 17540341

DOI: 10.1016/j.bbrc.2007.05.102

PubMed ID: 19713757

Title: The molecular basis for the actions of Kvbeta1.2 on the opening and closing of the Kv1.2 delayed rectifier channel.

PubMed ID: 19713757

DOI: 10.4161/chan.3.5.9558

Sequence Information:

  • Length: 419
  • Mass: 46563
  • Checksum: EFFDA78568007A7A
  • Sequence:
  • MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS GESQLRARQL 
    ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR VSCLGLGTWV TFGGQISDEV 
    AERLMTIAYE SGVNLFDTAE VYAAGKAEVI LGSIIKKKGW RRSSLVITTK LYWGGKAETE 
    RGLSRKHIIE GLKGSLQRLQ LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS 
    RWSAMEIMEA YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC 
    GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER LGCTLPQLAV 
    AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV NEIDNILRNK PYSKKDYRS

Genular Protein ID: 3482904796

Symbol: B7Z8E5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 390
  • Mass: 43304
  • Checksum: 8F8B29A544671683
  • Sequence:
  • MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS GESQLRARQL 
    ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR VSCLGLGTWV TFGGQISDEV 
    AERLMTIAYE SGVNLFDTAE VYAAGKAEVI LGSIIKKKGW RRSSLVITTK LYWGGKAETE 
    RGLSRKHIIE EIVRAMTHVI NQGMAMYWGT SRWSAMEIME AYSVARQFNM IPPVCEQAEY 
    HLFQREKVEV QLPELYHKIG VGAMTWSPLA CGIISGKYGN GVPESSRASL KCYQWLKERI 
    VSEEGRKQQN KLKDLSPIAE RLGCTLPQLA VAWCLRNEGV SSVLLGSSTP EQLIENLGAI 
    QVLPKMTSHV VNEIDNILRN KPYSKKDYRS

Genular Protein ID: 2779163015

Symbol: B7Z435_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 295
  • Mass: 33198
  • Checksum: CB9AED04942F5A4B
  • Sequence:
  • MTIAYESGVN LFDTAEVYAA GKAEVILGSI IKKKGWRRSS LVITTKLYWG GKAETERGLS 
    RKHIIEGLKG SLQRLQLEYV DVVFANRPDS NTPMEEIVRA MTHVINQGMA MYWGTSRWSA 
    MEIMEAYSVA RQFNMIPPVC EQAEYHLFQR EKVEVQLPEL YHKIGVGAMT WSPLACGIIS 
    GKYGNGVPES SRASLKCYQW LKERIVSEEG RKQQNKLKDL SPIAERLGCT LPQLAVAWCL 
    RNEGVSSVLL GSSTPEQLIE NLGAIQVLPK MTSHVVNEID NILRNKPYSK KDYRS

Genular Protein ID: 1492720506

Symbol: Q5MJQ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 372
  • Mass: 41348
  • Checksum: 397672AFB36DD1BB
  • Sequence:
  • MQVSIACTEH NLKSRNGEDR LLSKQSSTAP NVVNAARAKF RTVAIIARSL GTFAPQHHIS 
    LKESTAKQTG MKYRNLGKSG LRVSCLGLGT WVTFGGQISD EVAERLMTIA YESGVNLFDT 
    AEVYAAGKAE VILGSIIKKK GWRRSSLVIT TKLYWGGKAE TERGLSRKHI IEEIVRAMTH 
    VINQGMAMYW GTSRWSAMEI MEAYSVARQF NMIPPVCEQA EYHLFQREKV EVQLPELYHK 
    IGVGAMTWSP LACGIISGKY GNGVPESSRA SLKCYQWLKE RIVSEEGRKQ QNKLKDLSPI 
    AERLGCTLPQ LAVAWCLRNE GVSSVLLGSS TPEQLIGNLG AIQVLPKMTS HVVNEIDNIL 
    RNKPYSKKDY RS

Genular Protein ID: 3989489124

Symbol: F8W6W4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 372
  • Mass: 41450
  • Checksum: 38C108102454C9CE
  • Sequence:
  • MQVSIACTEH NLKSRNGEDR LLSKQSSTAP NVVNAARAKF RTVAIIARSL GTFTPQHHIS 
    LKESTAKQTG MKYRNLGKSG LRVSCLGLGT WVTFGGQISD EVAERLMTIA YESGVNLFDT 
    AEVYAAGKAE VILGSIIKKK GWRRSSLVIT TKLYWGGKAE TERGLSRKHI IEEIVRAMTH 
    VINQGMAMYW GTSRWSAMEI MEAYSVARQF NMIPPVCEQA EYHLFQREKV EVQLPELYHK 
    IGVGAMTWSP LACGIISGKY GNGVPESSRA SLKCYQWLKE RIVSEEGRKQ QNKLKDLSPI 
    AERLGCTLPQ LAVAWCLRNE GVSSVLLGSS TPEQLIENLG AIQVLPKMTS HVVNEIDNIL 
    RNKPYSKKDY RS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.