Details for: TSC22D3

Gene ID: 1831

Symbol: TSC22D3

Ensembl ID: ENSG00000157514

Description: TSC22 domain family member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.96
    Marker Score: 3922
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.82
    Marker Score: 10097
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.14
    Marker Score: 13052
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.07
    Marker Score: 3465
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.05
    Marker Score: 11824
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.98
    Marker Score: 2046
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.98
    Marker Score: 11164
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.98
    Marker Score: 2887
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.98
    Marker Score: 9703.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.97
    Marker Score: 3906
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.96
    Marker Score: 16972.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.85
    Marker Score: 38145
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.85
    Marker Score: 10624
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.85
    Marker Score: 1653
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.81
    Marker Score: 2235
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.8
    Marker Score: 200712
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.71
    Marker Score: 5464.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.6
    Marker Score: 41847
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.54
    Marker Score: 2976
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.53
    Marker Score: 3320.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.5
    Marker Score: 3071
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.45
    Marker Score: 192719
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.41
    Marker Score: 4708
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.35
    Marker Score: 2993
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.33
    Marker Score: 2959
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.32
    Marker Score: 1578.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.3
    Marker Score: 4774
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.29
    Marker Score: 2494.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.25
    Marker Score: 1623
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.24
    Marker Score: 2090
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.23
    Marker Score: 1988
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.15
    Marker Score: 1360
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.13
    Marker Score: 2929
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.13
    Marker Score: 3022.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.13
    Marker Score: 2561
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.11
    Marker Score: 7505
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.09
    Marker Score: 1705
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.05
    Marker Score: 1837
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.02
    Marker Score: 2209
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3
    Marker Score: 5143
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.98
    Marker Score: 1053
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.95
    Marker Score: 29909.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.91
    Marker Score: 903
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.9
    Marker Score: 5658
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.87
    Marker Score: 3069
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.81
    Marker Score: 2129
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.79
    Marker Score: 7097
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.73
    Marker Score: 3127
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.73
    Marker Score: 1597
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.72
    Marker Score: 896
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.68
    Marker Score: 934
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.59
    Marker Score: 671
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.57
    Marker Score: 5043
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.54
    Marker Score: 2737
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.52
    Marker Score: 4740
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.51
    Marker Score: 637
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.51
    Marker Score: 2421
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.5
    Marker Score: 2760
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.49
    Marker Score: 6517
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.49
    Marker Score: 84582.5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.47
    Marker Score: 5551
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.45
    Marker Score: 2111
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.45
    Marker Score: 4373.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.43
    Marker Score: 738
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.4
    Marker Score: 1184
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.4
    Marker Score: 61525.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.4
    Marker Score: 558
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.4
    Marker Score: 1747
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.39
    Marker Score: 1583
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.39
    Marker Score: 1730.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.39
    Marker Score: 589
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.38
    Marker Score: 9979
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.38
    Marker Score: 856
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.32
    Marker Score: 504
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 2.3
    Marker Score: 966
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.3
    Marker Score: 1399
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.29
    Marker Score: 547
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.28
    Marker Score: 1312
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.28
    Marker Score: 1783
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.27
    Marker Score: 2272
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 2.26
    Marker Score: 2926
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.25
    Marker Score: 2447
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.25
    Marker Score: 1982
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.23
    Marker Score: 513
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.23
    Marker Score: 1009
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.22
    Marker Score: 549
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.21
    Marker Score: 2380
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.18
    Marker Score: 2367
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.18
    Marker Score: 759
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.17
    Marker Score: 803
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 2.17
    Marker Score: 750
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 2.17
    Marker Score: 534
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.16
    Marker Score: 1934
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.15
    Marker Score: 979
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.14
    Marker Score: 3738
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.13
    Marker Score: 1434
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.13
    Marker Score: 490
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 2.12
    Marker Score: 645
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.12
    Marker Score: 1240
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.12
    Marker Score: 4232

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of immune cell types. * It is involved in the regulation of immune responses and cell death. **Pathways and functions:** * TSC22D3 is involved in the cytosol, ion channel transport, negative regulation of activation-induced cell death of T cells, nucleus, protein binding, regulation of transcription by RNA polymerase II, response to osmotic stress, stimuli-sensing channels, and transport of small molecules. **Clinical significance:** * Mutations in TSC22D3 have been linked to several human diseases, including autoimmune disorders, neurodegenerative diseases, and cancer. * Targeting TSC22D3 has been investigated as a therapeutic strategy for these diseases. **Additional notes:** * TSC22D3 is a member of the TSC22 domain family of cell surface receptors. * This family of proteins is involved in the regulation of T cell activation and survival. * Mutations in TSC22D3 have been linked to the development of autoimmune disorders, neurodegenerative diseases, and cancer.

Genular Protein ID: 1005956681

Symbol: T22D3_HUMAN

Name: Delta sleep-inducing peptide immunoreactor

UniProtKB Accession Codes:

Q99576 Q5H9S3 Q5JRI9 Q5JRJ2 Q6FIH6 Q8NAI1 Q8WVB9 Q9UBN5 Q9UG13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8982256

Title: hDIP -- a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues.

PubMed ID: 8982256

DOI: 10.1016/s0167-4781(96)00177-7

PubMed ID: 11313722

Title: Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene.

PubMed ID: 11313722

DOI: 10.1038/sj.cdd.4400798

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11468175

Title: Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B.

PubMed ID: 11468175

DOI: 10.1182/blood.v98.3.743

PubMed ID: 12393603

Title: Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.

PubMed ID: 12393603

DOI: 10.1182/blood-2002-02-0538

PubMed ID: 15031210

Title: GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis.

PubMed ID: 15031210

DOI: 10.1182/blood-2003-12-4295

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26752201

Title: TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes.

PubMed ID: 26752201

DOI: 10.1002/jcb.25485

Sequence Information:

  • Length: 134
  • Mass: 14810
  • Checksum: 77B1024969FA8687
  • Sequence:
    • MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAI DNKIEQAMDL 
VKNHLMYAVR EEVEILKEQI RELVEKNSQL ERENTLLKTL ASPEQLEKFQ SCLSPEEPAP 
ESPQVPEAPG GSAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.