Details for: TSC22D3

Gene ID: 1831

Symbol: TSC22D3

Ensembl ID: ENSG00000157514

Description: TSC22 domain family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 477.7389
    Cell Significance Index: -74.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 187.8622
    Cell Significance Index: -47.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 177.2407
    Cell Significance Index: -91.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 174.3403
    Cell Significance Index: -82.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 123.3789
    Cell Significance Index: -82.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 60.1481
    Cell Significance Index: -74.1600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 26.9011
    Cell Significance Index: 72.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.4900
    Cell Significance Index: -75.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.2722
    Cell Significance Index: -80.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.7570
    Cell Significance Index: -43.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 18.3683
    Cell Significance Index: 124.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.1151
    Cell Significance Index: -43.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.7001
    Cell Significance Index: 432.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.9114
    Cell Significance Index: 90.7800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.8182
    Cell Significance Index: 17.0800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 3.7392
    Cell Significance Index: 8.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.9675
    Cell Significance Index: 52.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.9435
    Cell Significance Index: 347.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.7545
    Cell Significance Index: 78.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0283
    Cell Significance Index: 54.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2123
    Cell Significance Index: 155.4100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.0961
    Cell Significance Index: 22.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5977
    Cell Significance Index: 1125.4300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.5496
    Cell Significance Index: 1.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5473
    Cell Significance Index: 75.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4797
    Cell Significance Index: 261.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4394
    Cell Significance Index: 88.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3939
    Cell Significance Index: 20.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3812
    Cell Significance Index: 62.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3683
    Cell Significance Index: 40.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3575
    Cell Significance Index: 16.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3455
    Cell Significance Index: 8.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3282
    Cell Significance Index: 8.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2606
    Cell Significance Index: 2.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2358
    Cell Significance Index: 212.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2167
    Cell Significance Index: 21.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2149
    Cell Significance Index: 77.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2058
    Cell Significance Index: 90.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2028
    Cell Significance Index: 36.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1921
    Cell Significance Index: 11.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1235
    Cell Significance Index: 15.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1178
    Cell Significance Index: 89.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0949
    Cell Significance Index: 7.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0944
    Cell Significance Index: 12.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0775
    Cell Significance Index: 7.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0370
    Cell Significance Index: 23.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0306
    Cell Significance Index: 22.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0102
    Cell Significance Index: 0.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0065
    Cell Significance Index: -1.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0436
    Cell Significance Index: -80.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0527
    Cell Significance Index: -81.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0560
    Cell Significance Index: -41.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0614
    Cell Significance Index: -83.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0672
    Cell Significance Index: -46.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0727
    Cell Significance Index: -45.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0879
    Cell Significance Index: -3.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1107
    Cell Significance Index: -62.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1197
    Cell Significance Index: -5.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1236
    Cell Significance Index: -56.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1436
    Cell Significance Index: -6.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2454
    Cell Significance Index: -70.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2840
    Cell Significance Index: -48.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2872
    Cell Significance Index: -60.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2935
    Cell Significance Index: -34.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2959
    Cell Significance Index: -20.9300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3012
    Cell Significance Index: -4.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3096
    Cell Significance Index: -61.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3505
    Cell Significance Index: -6.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3509
    Cell Significance Index: -51.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4607
    Cell Significance Index: -9.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4987
    Cell Significance Index: -25.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5587
    Cell Significance Index: -64.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5649
    Cell Significance Index: -58.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5876
    Cell Significance Index: -20.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6666
    Cell Significance Index: -18.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7274
    Cell Significance Index: -83.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7396
    Cell Significance Index: -20.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7548
    Cell Significance Index: -57.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7772
    Cell Significance Index: -61.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8434
    Cell Significance Index: -43.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8715
    Cell Significance Index: -25.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8820
    Cell Significance Index: -23.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9391
    Cell Significance Index: -23.9900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9589
    Cell Significance Index: -13.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9908
    Cell Significance Index: -60.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0072
    Cell Significance Index: -67.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0318
    Cell Significance Index: -63.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1261
    Cell Significance Index: -28.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1502
    Cell Significance Index: -19.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2251
    Cell Significance Index: -50.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2736
    Cell Significance Index: -80.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4317
    Cell Significance Index: -24.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4581
    Cell Significance Index: -81.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.5131
    Cell Significance Index: -12.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.5962
    Cell Significance Index: -33.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6064
    Cell Significance Index: -51.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.6905
    Cell Significance Index: -21.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7462
    Cell Significance Index: -77.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.8618
    Cell Significance Index: -54.6800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -1.9204
    Cell Significance Index: -12.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TSC22D3 exhibits several distinct characteristics that set it apart from other genes. Its expression is characterized by: 1. **Widespread expression**: TSC22D3 is expressed in a diverse range of cell types, including immune cells, non-immune cells, and tissues such as skeletal muscle. 2. **Cell-type-specific expression**: The gene's expression is cell-type specific, with varying levels of expression in different immune cells and tissues. 3. **Ion channel transport**: TSC22D3 is involved in ion channel transport, which is crucial for maintaining cellular homeostasis and responding to environmental changes. 4. **Regulation of transcription**: The gene plays a role in regulating transcription, influencing the expression of other genes and proteins. **Pathways and Functions** TSC22D3 is involved in several key pathways and functions, including: 1. **Cytosol and ion channel transport**: TSC22D3 participates in ion channel transport, regulating the movement of ions across cell membranes. 2. **Negative regulation of activation-induced cell death**: The gene plays a role in preventing excessive cell death in response to immune activation. 3. **Regulation of transcription by RNA polymerase II**: TSC22D3 influences the expression of other genes and proteins by regulating transcription. 4. **Stimuli-sensing channels**: The gene is involved in stimuli-sensing channels, allowing cells to respond to environmental changes. 5. **Response to osmotic stress**: TSC22D3 helps cells respond to osmotic stress, maintaining cellular homeostasis in the face of changing environmental conditions. **Clinical Significance** The clinical significance of TSC22D3 is multifaceted and far-reaching. Its involvement in immune regulation and cellular homeostasis makes it a potential target for the treatment of various diseases, including: 1. **Autoimmune disorders**: TSC22D3's role in regulating immune cell activation and preventing excessive cell death makes it a potential target for autoimmune disorders such as multiple sclerosis. 2. **Cancer**: The gene's involvement in cellular homeostasis and response to environmental changes makes it a potential target for cancer therapy. 3. **Neurological disorders**: TSC22D3's role in stimuli-sensing channels and response to osmotic stress makes it a potential target for neurological disorders such as Alzheimer's disease. In conclusion, TSC22D3 is a complex gene with a multifaceted role in immune regulation, cellular homeostasis, and response to environmental changes. Its clinical significance is vast, and further research is needed to fully understand its implications in various diseases.

Genular Protein ID: 1005956681

Symbol: T22D3_HUMAN

Name: Delta sleep-inducing peptide immunoreactor

UniProtKB Accession Codes:

Q99576 Q5H9S3 Q5JRI9 Q5JRJ2 Q6FIH6 Q8NAI1 Q8WVB9 Q9UBN5 Q9UG13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 6 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8982256

Title: hDIP -- a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues.

PubMed ID: 8982256

DOI: 10.1016/s0167-4781(96)00177-7

PubMed ID: 11313722

Title: Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene.

PubMed ID: 11313722

DOI: 10.1038/sj.cdd.4400798

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11468175

Title: Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B.

PubMed ID: 11468175

DOI: 10.1182/blood.v98.3.743

PubMed ID: 12393603

Title: Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.

PubMed ID: 12393603

DOI: 10.1182/blood-2002-02-0538

PubMed ID: 15031210

Title: GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis.

PubMed ID: 15031210

DOI: 10.1182/blood-2003-12-4295

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26752201

Title: TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes.

PubMed ID: 26752201

DOI: 10.1002/jcb.25485

Sequence Information:

  • Length: 134
  • Mass: 14810
  • Checksum: 77B1024969FA8687
  • Sequence:
    • MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAI DNKIEQAMDL 
VKNHLMYAVR EEVEILKEQI RELVEKNSQL ERENTLLKTL ASPEQLEKFQ SCLSPEEPAP 
ESPQVPEAPG GSAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.