TSC22D3 | ENSG00000157514 | NCBI 1831

Details for: TSC22D3

Gene ID: 1831

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TSC22D3

Ensembl ID: ENSG00000157514

Description: TSC22 domain family member 3

Cell Significance Landscape

Display Count:

Associated with

Ion channel transport
(R-HSA-983712)
Stimuli-sensing channels
(R-HSA-2672351)
Transport of small molecules
(R-HSA-382551)
Cytosol
(GO:0005829)
Negative regulation of activation-induced cell death of t cells
(GO:0070236)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to osmotic stress
(GO:0006970)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD4-positive helper T cell CL0000492

CSI 114.04

rCSI 86.27%

PRS 8.43
class switched memory B cell CL0000972

CSI 101.28

rCSI 75.61%

PRS 10.26
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 96.25

rCSI 72.17%

PRS 18
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 91.21

rCSI 61.45%

PRS 7.3
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 87

rCSI 51.38%

PRS 8.4
mature T cell CL0002419

CSI 84.86

rCSI 66.01%

PRS 8.69
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 81.88

rCSI 54.57%

PRS 16.83
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 78.84

rCSI 55.37%

PRS 17.61
naive B cell CL0000788

CSI 77.94

rCSI 66.85%

PRS 14.39
memory B cell CL0000787

CSI 73.86

rCSI 72.94%

PRS 25.96
T follicular helper cell CL0002038

CSI 73.1

rCSI 54.7%

PRS 9.89
mucosal invariant T cell CL0000940

CSI 70.08

rCSI 56.62%

PRS 12.91
activated type II NK T cell CL0000931

CSI 69.63

rCSI 78.37%

PRS 9.99
T-helper 17 cell CL0000899

CSI 68.86

rCSI 54.68%

PRS 10.7
CD14-low, CD16-positive monocyte CL0002396

CSI 68.06

rCSI 52.44%

PRS 5.47
IgA plasma cell CL0000987

CSI 66.17

rCSI 67.74%

PRS 11.47
activated CD4-positive, alpha-beta T cell CL0000896

CSI 65.93

rCSI 60.95%

PRS 11.09
CD8-positive, alpha-beta memory T cell CL0000909

CSI 65.21

rCSI 68.1%

PRS 19.26
group 3 innate lymphoid cell CL0001071

CSI 64.52

rCSI 48.48%

PRS 6.23
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 52.94

rCSI 63.21%

PRS 10.56
gamma-delta T cell CL0000798

CSI 51.9

rCSI 60.96%

PRS 50.25
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 48.9

rCSI 66.61%

PRS 15.14
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 48.8

rCSI 61.33%

PRS 31.17
IgG plasma cell CL0000985

CSI 47.75

rCSI 57.2%

PRS 10.55
bronchus fibroblast of lung CL2000093

CSI 47.5

rCSI 38.59%

PRS 6.48
T-helper 1 cell CL0000545

CSI 46.01

rCSI 83.06%

PRS 17.86
alpha-beta T cell CL0000789

CSI 44.26

rCSI 51.86%

PRS 9.31
mature B cell CL0000785

CSI 44.2

rCSI 38.42%

PRS 7.45
immature B cell CL0000816

CSI 43.46

rCSI 32.29%

PRS 9.07
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 42.44

rCSI 72.6%

PRS 13.08
activated CD8-positive, alpha-beta T cell CL0000906

CSI 41.85

rCSI 41.14%

PRS 17.97
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 41.82

rCSI 50.68%

PRS 8.87
CD4-positive, alpha-beta T cell CL0000624

CSI 40.64

rCSI 52.01%

PRS 76.01
plasma cell CL0000786

CSI 40.5

rCSI 53.08%

PRS 31.38
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 39

rCSI 35.52%

PRS 9.43
hematopoietic stem cell CL0000037

CSI 38.15

rCSI 25.36%

PRS 7.21
mature NK T cell CL0000814

CSI 37.51

rCSI 47.98%

PRS 27.62
elicited macrophage CL0000861

CSI 37.34

rCSI 34.29%

PRS 6.94
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 36.53

rCSI 35.88%

PRS 9.67
skin fibroblast CL0002620

CSI 35.33

rCSI 30.45%

PRS 10.03
memory T cell CL0000813

CSI 35.2

rCSI 67.82%

PRS 13.86
effector CD8-positive, alpha-beta T cell CL0001050

CSI 33.66

rCSI 25.61%

PRS 8
non-classical monocyte CL0000875

CSI 32.75

rCSI 52.49%

PRS 20.09
B cell CL0000236

CSI 32.68

rCSI 43.72%

PRS 32.11
unswitched memory B cell CL0000970

CSI 32.05

rCSI 26.97%

PRS 10.1
alveolar type 1 fibroblast cell CL4028004

CSI 30.9

rCSI 33.85%

PRS 7.06
basophil CL0000767

CSI 30.85

rCSI 65.26%

PRS 13.26
conventional dendritic cell CL0000990

CSI 29.18

rCSI 24.36%

PRS 19.54
CD14-positive, CD16-positive monocyte CL0002397

CSI 29.1

rCSI 38.13%

PRS 8.5
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 29.04

rCSI 39.9%

PRS 12.97
classical monocyte CL0000860

CSI 28.81

rCSI 42.71%

PRS 55.21
CD1c-positive myeloid dendritic cell CL0002399

CSI 28.29

rCSI 34.17%

PRS 7.15
regulatory T cell CL0000815

CSI 28.24

rCSI 32.73%

PRS 20.39
natural T-regulatory cell CL0000903

CSI 26.72

rCSI 50.62%

PRS 17.35
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 26.12

rCSI 52.06%

PRS 10.35
dendritic cell, human CL0001056

CSI 25.7

rCSI 39.48%

PRS 7.04
early lymphoid progenitor CL0000936

CSI 25.05

rCSI 22%

PRS 6.79
pulmonary artery endothelial cell CL1001568

CSI 24.73

rCSI 33.65%

PRS 9.34
transitional stage B cell CL0000818

CSI 24.3

rCSI 79.55%

PRS 18.38
alveolar adventitial fibroblast CL4028006

CSI 23.94

rCSI 37.82%

PRS 6.11
innate lymphoid cell CL0001065

CSI 23.4

rCSI 48.31%

PRS 9.77
adventitial cell CL0002503

CSI 22.49

rCSI 53.71%

PRS 9.83
naive T cell CL0000898

CSI 22.37

rCSI 15.57%

PRS 8.75
fibroblast of lung CL0002553

CSI 22.36

rCSI 20.81%

PRS 6.14
granulocyte monocyte progenitor cell CL0000557

CSI 21.62

rCSI 18.72%

PRS 6.72
follicular B cell CL0000843

CSI 21

rCSI 76.35%

PRS 28.43
T cell CL0000084

CSI 20.77

rCSI 40.6%

PRS 58.28
alveolar macrophage CL0000583

CSI 19.49

rCSI 32.1%

PRS 7.14
CD4-positive, alpha-beta memory T cell CL0000897

CSI 19.08

rCSI 13.69%

PRS 8.24
double-positive, alpha-beta thymocyte CL0000809

CSI 18.64

rCSI 19%

PRS 8.74
myeloid dendritic cell CL0000782

CSI 18.25

rCSI 26.44%

PRS 8.93
pro-B cell CL0000826

CSI 18.22

rCSI 15.09%

PRS 6.06
microcirculation associated smooth muscle cell CL0008035

CSI 18.12

rCSI 52.47%

PRS 6.88
natural killer cell CL0000623

CSI 18.02

rCSI 34.92%

PRS 65.73
dendritic cell CL0000451

CSI 17.73

rCSI 21.84%

PRS 20.57
helper T cell CL0000912

CSI 17.55

rCSI 24.82%

PRS 8.85
mast cell CL0000097

CSI 17.21

rCSI 37.16%

PRS 34.22
precursor B cell CL0000817

CSI 16.58

rCSI 14.52%

PRS 8.18
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 16.51

rCSI 39.72%

PRS 40.3
conjunctival epithelial cell CL1000432

CSI 16.37

rCSI 25%

PRS 6.07
mononuclear phagocyte CL0000113

CSI 16.19

rCSI 35.63%

PRS 6.64
plasmablast CL0000980

CSI 16.18

rCSI 12.73%

PRS 7.2
endothelial cell of artery CL1000413

CSI 16.1

rCSI 23.59%

PRS 34.8
blood vessel endothelial cell CL0000071

CSI 15.11

rCSI 31.36%

PRS 6.04
IgM plasma cell CL0000986

CSI 14.78

rCSI 66.51%

PRS 32.08
ciliated epithelial cell CL0000067

CSI 14.78

rCSI 13%

PRS 4.37
double negative thymocyte CL0002489

CSI 14.74

rCSI 10.25%

PRS 7.09
intermediate monocyte CL0002393

CSI 14.58

rCSI 21.99%

PRS 5.96
perivascular cell CL4033054

CSI 14.46

rCSI 19.77%

PRS 6.88
plasmacytoid dendritic cell CL0000784

CSI 14.26

rCSI 14.44%

PRS 37.44
keratocyte CL0002363

CSI 14.16

rCSI 34.04%

PRS 9.38
pulmonary alveolar type 2 cell CL0002063

CSI 14.11

rCSI 21.88%

PRS 9.54
monocyte CL0000576

CSI 13.99

rCSI 25.29%

PRS 17.31
myeloid leukocyte CL0000766

CSI 13.95

rCSI 12.87%

PRS 6.13
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 13.57

rCSI 68.08%

PRS 7.93
hematopoietic precursor cell CL0008001

CSI 13.49

rCSI 13.88%

PRS 9.83
interneuron CL0000099

CSI 13.45

rCSI 27.01%

PRS 4.48
myofibroblast cell CL0000186

CSI 13.18

rCSI 18.25%

PRS 8.74
epithelial cell of lower respiratory tract CL0002632

CSI 12.68

rCSI 9.83%

PRS 5.78
small pre-B-II cell CL0000954

CSI 12.56

rCSI 12.08%

PRS 13.08

astrocyte of the cerebral cortex CL0002605

CSI -10.5

rCSI -23.5%

PRS 3.7%
ciliated cell CL0000064

CSI -8.5

rCSI -13.8%

PRS 6.1%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -8.5

rCSI -26.6%

PRS 4.1%
goblet cell CL0000160

CSI -2.3

rCSI -2.2%

PRS 6.3%
skeletal muscle satellite cell CL0000594

CSI -1.9

rCSI -5.6%

PRS 23.8%
exhausted T cell CL0011025

CSI -1.8

rCSI -29.6%

PRS 29.9%
pancreatic A cell CL0000171

CSI -1.7

rCSI -1.8%

PRS 6.5%
paneth cell of epithelium of small intestine CL1000343

CSI -0.9

rCSI -2.6%

PRS 9.4%
intestinal crypt stem cell of colon CL0009043

CSI -0.6

rCSI -4.7%

PRS 11.3%
L6b glutamatergic cortical neuron CL4023038

CSI -0.5

rCSI -1.4%

PRS 3.8%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.1

rCSI 0.2%

PRS 3.2%
peptic cell CL0000155

CSI 0.1

rCSI 1.0%

PRS 19.1%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.3

rCSI 1.5%

PRS 12.1%
pancreatic stellate cell CL0002410

CSI 0.3

rCSI 1.8%

PRS 9.1%
ON midget ganglion cell CL4033046

CSI 0.3

rCSI 6.5%

PRS 5.5%
glandular epithelial cell CL0000150

CSI 0.3

rCSI 0.9%

PRS 11.8%
retinal cone cell CL0000573

CSI 0.3

rCSI 0.5%

PRS 4.6%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.4

rCSI 1.3%

PRS 3.3%
group 3 innate lymphoid cell, human CL0001078

CSI 0.5

rCSI 10.4%

PRS 75.5%
kidney granular cell CL0000648

CSI 0.5

rCSI 7.6%

PRS 45.3%
basal cell of epithelium of trachea CL1000348

CSI 0.6

rCSI 3.9%

PRS 19.8%
Cajal-Retzius cell CL0000695

CSI 0.6

rCSI 4.3%

PRS 14.0%
paneth cell CL0000510

CSI 0.6

rCSI 0.8%

PRS 9.6%
lung goblet cell CL1000143

CSI 0.6

rCSI 6.5%

PRS 21.3%
enteroendocrine cell of small intestine CL0009006

CSI 0.6

rCSI 1.3%

PRS 9.3%
OFF-bipolar cell CL0000750

CSI 0.6

rCSI 0.8%

PRS 10.5%
basophil mast progenitor cell CL0002028

CSI 0.7

rCSI 3.5%

PRS 21.4%
Hofbauer cell CL3000001

CSI 0.7

rCSI 1.3%

PRS 7.5%
immature alpha-beta T cell CL0000790

CSI 0.7

rCSI 10.4%

PRS 67.4%
endothelial cell of venule CL1000414

CSI 0.7

rCSI 6.6%

PRS 33.7%
pulmonary ionocyte CL0017000

CSI 0.8

rCSI 0.9%

PRS 7.7%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 0.8

rCSI 0.7%

PRS 5.3%
sst GABAergic cortical interneuron CL4023017

CSI 0.8

rCSI 1.1%

PRS 3.8%
decidual natural killer cell, human CL0002343

CSI 0.9

rCSI 8.6%

PRS 49.6%
endocardial cell CL0002350

CSI 0.9

rCSI 4.2%

PRS 9.4%
erythroid progenitor cell CL0000038

CSI 0.9

rCSI 5.2%

PRS 9.5%
tracheal goblet cell CL1000329

CSI 0.9

rCSI 2.0%

PRS 12.4%
endothelial cell of arteriole CL1000412

CSI 0.9

rCSI 5.1%

PRS 25.2%
contractile cell CL0000183

CSI 1.0

rCSI 2.8%

PRS 4.3%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.1

rCSI 1.9%

PRS 5.5%
enteric smooth muscle cell CL0002504

CSI 1.1

rCSI 1.5%

PRS 6.9%
antibody secreting cell CL0000946

CSI 1.1

rCSI 4.7%

PRS 27.1%
periportal region hepatocyte CL0019026

CSI 1.1

rCSI 4.3%

PRS 9.7%
acinar cell of salivary gland CL0002623

CSI 1.1

rCSI 26.6%

PRS 9.5%
follicular dendritic cell CL0000442

CSI 1.1

rCSI 18.3%

PRS 37.7%
B-1 B cell CL0000819

CSI 1.1

rCSI 29.5%

PRS 34.2%
colonocyte CL1000347

CSI 1.2

rCSI 1.7%

PRS 8.4%
mucous neck cell CL0000651

CSI 1.2

rCSI 1.7%

PRS 9.8%
cytotoxic T cell CL0000910

CSI 1.2

rCSI 6.7%

PRS 9.3%
kidney interstitial cell CL1000500

CSI 1.2

rCSI 20.0%

PRS 50.0%
endothelial cell of uterus CL0009095

CSI 1.2

rCSI 9.0%

PRS 17.2%
intestinal tuft cell CL0019032

CSI 1.2

rCSI 1.9%

PRS 7.0%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.3

rCSI 3.1%

PRS 3.5%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 1.3

rCSI 7.3%

PRS 30.1%
thymocyte CL0000893

CSI 1.3

rCSI 4.6%

PRS 19.6%
mammary gland epithelial cell CL0002327

CSI 1.3

rCSI 4.6%

PRS 11.1%
fast muscle cell CL0000190

CSI 1.3

rCSI 5.2%

PRS 21.8%
corneal epithelial cell CL0000575

CSI 1.4

rCSI 4.0%

PRS 11.5%
intestinal crypt stem cell of small intestine CL0009017

CSI 1.4

rCSI 3.7%

PRS 7.8%
forebrain radial glial cell CL0013000

CSI 1.4

rCSI 4.6%

PRS 9.1%
choroid plexus epithelial cell CL0000706

CSI 1.5

rCSI 2.4%

PRS 4.7%
parietal epithelial cell CL1000452

CSI 1.5

rCSI 3.9%

PRS 5.9%
deuterosomal cell CL4033044

CSI 1.5

rCSI 5.1%

PRS 10.4%
foveolar cell of stomach CL0002179

CSI 1.5

rCSI 3.2%

PRS 9.8%
stratified epithelial cell CL0000079

CSI 1.6

rCSI 9.7%

PRS 29.2%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.6

rCSI 2.8%

PRS 3.6%
pro-T cell CL0000827

CSI 1.7

rCSI 38.5%

PRS 42.3%
type L enteroendocrine cell CL0002279

CSI 1.7

rCSI 3.2%

PRS 12.0%
skeletal muscle satellite stem cell CL0008011

CSI 1.7

rCSI 7.7%

PRS 22.1%
epithelial cell of lung CL0000082

CSI 1.8

rCSI 1.5%

PRS 5.8%
lung microvascular endothelial cell CL2000016

CSI 1.8

rCSI 34.4%

PRS 21.7%
tuft cell of colon CL0009041

CSI 1.8

rCSI 4.2%

PRS 14.2%
lung neuroendocrine cell CL1000223

CSI 1.9

rCSI 2.8%

PRS 7.0%
cerebellar granule cell CL0001031

CSI 1.9

rCSI 2.8%

PRS 6.0%
serous secreting cell CL0000313

CSI 2.0

rCSI 9.9%

PRS 29.1%
B-2 B cell CL0000822

CSI 2.0

rCSI 41.5%

PRS 36.5%
erythroblast CL0000765

CSI 2.0

rCSI 5.3%

PRS 10.3%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 2.0

rCSI 62.1%

PRS 62.1%
vasa recta descending limb cell CL1001285

CSI 2.1

rCSI 16.7%

PRS 27.5%
airway submucosal gland duct basal cell CL4033024

CSI 2.1

rCSI 13.5%

PRS 25.6%
renal interstitial pericyte CL1001318

CSI 2.1

rCSI 5.9%

PRS 6.5%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 2.1

rCSI 6.6%

PRS 11.5%
hepatic pit cell CL2000054

CSI 2.2

rCSI 29.5%

PRS 50.4%
blood vessel smooth muscle cell CL0019018

CSI 2.2

rCSI 17.6%

PRS 6.4%
epicardial adipocyte CL1000309

CSI 2.2

rCSI 7.1%

PRS 8.6%
retinal ganglion cell CL0000740

CSI 2.2

rCSI 4.9%

PRS 4.4%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 2.3

rCSI 5.2%

PRS 6.3%
megakaryocyte progenitor cell CL0000553

CSI 2.3

rCSI 42.3%

PRS 16.4%
chondrocyte CL0000138

CSI 2.3

rCSI 3.7%

PRS 5.4%
bronchiolar smooth muscle cell CL4033017

CSI 2.4

rCSI 35.8%

PRS 20.2%
mucus secreting cell CL0000319

CSI 2.5

rCSI 3.9%

PRS 7.9%
bronchial goblet cell CL1000312

CSI 2.5

rCSI 9.9%

PRS 13.5%
hepatocyte CL0000182

CSI 2.5

rCSI 4.5%

PRS 5.8%
fibroblast of cardiac tissue CL0002548

CSI 2.5

rCSI 12.1%

PRS 3.7%
fraction A pre-pro B cell CL0002045

CSI 2.6

rCSI 2.9%

PRS 12.6%
double negative T regulatory cell CL0011024

CSI 2.6

rCSI 50.2%

PRS 45.2%
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.7

rCSI 4.5%

PRS 3.5%
myelocyte CL0002193

CSI 2.8

rCSI 18.3%

PRS 21.0%
myeloid dendritic cell, human CL0001057

CSI 2.8

rCSI 15.7%

PRS 19.8%
inhibitory interneuron CL0000498

CSI 2.8

rCSI 6.5%

PRS 5.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
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- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [TSC22D3](/details-gene/1831), also known as Glucocorticoid-Induced Leucine Zipper (GILZ), is a protein-coding gene belonging to the TSC22 domain family. It functions as a transcriptional regulator involved in a variety of cellular processes, most notably in the modulation of immune responses and cell survival. As supported by expression data, [TSC22D3](/details-gene/1831) is a prominent marker across numerous lymphocyte populations, including [CD4-positive helper T cell](/details-cell/CL0000492), [class switched memory B cell](/details-cell/CL0000972), and multiple subsets of natural killer and T cells. Its function is closely linked to mediating the anti-inflammatory effects of glucocorticoids and interleukin-10, primarily through the inhibition of key signaling pathways like NF-kappaB ([Link](https://doi.org/10.1182/blood.v98.3.743), [Link](https://doi.org/10.1182/blood-2002-02-0538)). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [TSC22D3](/details-gene/1831) strongly indicates a specialized and crucial role within the hematopoietic system, particularly in adaptive and innate lymphocytes. The gene shows its highest significance in a wide array of immune cells, including [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 114.04), [class switched memory B cell](/details-cell/CL0000972) (CSI: 101.28), [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938) (CSI: 96.25), and both [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 91.21) and [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904) (CSI: 87.00). This widespread high expression across naive, memory, and effector lymphocyte populations suggests its involvement in fundamental processes common to these lineages, such as survival and activation homeostasis. In stark contrast, [TSC22D3](/details-gene/1831) expression is minimal or absent in non-hematopoietic cell types. Its negative significance scores in cells such as [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: -10.47) and various neuronal and epithelial cells, like [ciliated cell](/details-cell/CL0000064) (CSI: -8.54), underscore its high degree of immune cell specificity. Interestingly, despite its high expression in many T cell subsets, it shows a negative significance score in [exhausted T cell](/details-cell/CL0011025) (CSI: -1.75), which may suggest that its downregulation is associated with the acquisition of a terminally dysfunctional state in T lymphocytes. ## Pathways and Molecular Function The functions of [TSC22D3](/details-gene/1831) are consistent with its expression pattern and established role as a transcriptional regulator. It is annotated to the [nucleus](/details-cell/GO:0005634) and [cytosol](/details-cell/GO:0005829) and is known to be involved in the [regulation of transcription by rna polymerase ii](/details-cell/GO:0006357). A key biological process associated with this gene is the [negative regulation of activation-induced cell death of t cells](/details-cell/GO:0070236), a function supported by research demonstrating its ability to protect T lymphocytes from apoptosis following IL-2 withdrawal ([Link](https://doi.org/10.1182/blood-2003-12-4295), [Link](https://doi.org/10.1002/jcb.25485)). This pro-survival role aligns with its high expression in long-lived memory lymphocyte populations. While the connection is less direct, its annotation to Reactome pathways such as [Ion channel transport](/details-cell/R-HSA-983712) and [Transport of small molecules](/details-cell/R-HSA-382551) may reflect downstream consequences of its transcriptional regulatory activities, potentially influencing cellular homeostasis and stress responses, such as the [response to osmotic stress](/details-cell/GO:0006970). The primary mechanism appears to be through protein-protein interactions ([protein binding](/details-cell/GO:0005515)), most notably its interference with transcription factors like NF-kappaB and AP-1 to exert immunosuppressive effects ([Link](https://doi.org/10.1182/blood.v98.3.743)). ## Research Directions The specific expression pattern of [TSC22D3](/details-gene/1831) and its known functions generate several compelling avenues for future research, particularly concerning its role in immune cell fate and function. **Testable Hypotheses:** 1. **Downregulation of [TSC22D3](/details-gene/1831) is a critical step in the development of T cell exhaustion.** The observation that its expression is high across most T cell subtypes but significantly lower in [exhausted T cell](/details-cell/CL0011025) suggests that loss of [TSC22D3](/details-gene/1831) may remove a protective, pro-survival signal, contributing to the dysfunctional phenotype seen in chronic disease and cancer. 2. **[TSC22D3](/details-gene/1831) is indispensable for the maintenance and long-term survival of immunological memory.** Given its high significance in central memory T cells and class-switched memory B cells, its anti-apoptotic functions are likely crucial for sustaining these long-lived cell pools. **Proposed Experimental Approach:** To test the first hypothesis regarding T cell exhaustion, a robust experimental plan would involve both loss-of-function and gain-of-function studies. Using a chronic viral infection model (e.g., LCMV clone 13 in mice), one could employ a conditional knockout approach to specifically delete *Tsc22d3* in antigen-specific CD8+ T cells. The resulting cells could then be analyzed for canonical exhaustion markers (e.g., PD-1, TIM-3, TOX), proliferative capacity, and cytokine production (IFN-gamma, TNF-alpha) via flow cytometry and single-cell RNA sequencing. Conversely, overexpression of [TSC22D3](/details-gene/1831) in T cells prior to adoptive transfer into tumor-bearing mice could be performed to assess whether sustained expression can prevent or delay the onset of exhaustion and improve tumor control. **Therapeutic Potential:** [TSC22D3](/details-gene/1831) represents a complex but promising immunomodulatory target. Its therapeutic manipulation would be highly context-dependent. - **Activation:** In the context of autoimmune or inflammatory diseases, enhancing the function or expression of [TSC22D3](/details-gene/1831) via small molecule agonists could mimic the anti-inflammatory effects of glucocorticoids with potentially greater specificity and fewer side effects. - **Inhibition:** In oncology, transient inhibition of [TSC22D3](/details-gene/1831) within the tumor microenvironment could be a novel strategy for cancer immunotherapy. By blocking its function, it may be possible to lower the threshold for T cell activation and counteract the exhaustion programs that limit anti-tumor immunity, potentially synergizing with existing checkpoint blockade therapies. Given its intracellular location, targeting it would likely require small molecule inhibitors or advanced gene-editing-based cellular therapies.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Delta sleep-inducing peptide immunoreactor

Genular Protein ID: 1005956681

Symbol: T22D3_HUMAN

Name: Delta sleep-inducing peptide immunoreactor

UniProtKB Accession Codes:

Q99576 Q5H9S3 Q5JRI9 Q5JRJ2 Q6FIH6 Q8NAI1 Q8WVB9 Q9UBN5 Q9UG13

Database IDs:

Citations:

PubMed ID: 8982256

Title: hDIP -- a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues.

PubMed ID: 8982256

DOI: 10.1016/s0167-4781(96)00177-7

PubMed ID: 11313722

Title: Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene.

PubMed ID: 11313722

DOI: 10.1038/sj.cdd.4400798

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11468175

Title: Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B.

PubMed ID: 11468175

DOI: 10.1182/blood.v98.3.743

PubMed ID: 12393603

Title: Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.

PubMed ID: 12393603

DOI: 10.1182/blood-2002-02-0538

PubMed ID: 15031210

Title: GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis.

PubMed ID: 15031210

DOI: 10.1182/blood-2003-12-4295

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26752201

Title: TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes.

PubMed ID: 26752201

DOI: 10.1002/jcb.25485

Sequence Information:

Length: 134
Mass: 14810
Checksum: 77B1024969FA8687
Sequence:

MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAI DNKIEQAMDL 
VKNHLMYAVR EEVEILKEQI RELVEKNSQL ERENTLLKTL ASPEQLEKFQ SCLSPEEPAP 
ESPQVPEAPG GSAV

Details for: TSC22D3

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

hDIP -- a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues. PubMed ID: 8982256

Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene. PubMed ID: 11313722

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B. PubMed ID: 11468175

Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10. PubMed ID: 12393603

GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. PubMed ID: 15031210

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes. PubMed ID: 26752201