Details for: SYN3

Gene ID: 8224

Symbol: SYN3

Ensembl ID: ENSG00000185666

Description: synapsin III

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.7995
    Cell Significance Index: -17.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 7.6821
    Cell Significance Index: 168.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 5.9790
    Cell Significance Index: 869.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.2794
    Cell Significance Index: 1893.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.2373
    Cell Significance Index: 231.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.5947
    Cell Significance Index: 173.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.9035
    Cell Significance Index: 262.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.5014
    Cell Significance Index: 99.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.1831
    Cell Significance Index: 195.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8540
    Cell Significance Index: 572.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.2892
    Cell Significance Index: 54.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.7789
    Cell Significance Index: 34.7200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.7587
    Cell Significance Index: 23.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7533
    Cell Significance Index: 1212.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.4401
    Cell Significance Index: 2655.9000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.3818
    Cell Significance Index: 17.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.2829
    Cell Significance Index: 2415.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0937
    Cell Significance Index: 217.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.0892
    Cell Significance Index: 7.3800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.0672
    Cell Significance Index: 13.8400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.7266
    Cell Significance Index: 9.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6668
    Cell Significance Index: 423.5100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.6519
    Cell Significance Index: 5.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3196
    Cell Significance Index: 492.0000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3031
    Cell Significance Index: 3.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0747
    Cell Significance Index: 1.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0707
    Cell Significance Index: 12.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0285
    Cell Significance Index: 38.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0223
    Cell Significance Index: 20.1200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0063
    Cell Significance Index: 0.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0255
    Cell Significance Index: -1.4300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0303
    Cell Significance Index: -0.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0397
    Cell Significance Index: -7.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0408
    Cell Significance Index: -18.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0681
    Cell Significance Index: -49.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0690
    Cell Significance Index: -51.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0792
    Cell Significance Index: -59.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0947
    Cell Significance Index: -59.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0991
    Cell Significance Index: -12.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0997
    Cell Significance Index: -56.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1014
    Cell Significance Index: -55.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1566
    Cell Significance Index: -45.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1702
    Cell Significance Index: -10.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2309
    Cell Significance Index: -39.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2347
    Cell Significance Index: -38.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2634
    Cell Significance Index: -20.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2647
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2786
    Cell Significance Index: -58.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2957
    Cell Significance Index: -6.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3021
    Cell Significance Index: -13.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3183
    Cell Significance Index: -6.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3323
    Cell Significance Index: -6.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3406
    Cell Significance Index: -35.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3532
    Cell Significance Index: -9.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3605
    Cell Significance Index: -46.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3886
    Cell Significance Index: -38.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3995
    Cell Significance Index: -43.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4045
    Cell Significance Index: -55.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4081
    Cell Significance Index: -52.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4276
    Cell Significance Index: -11.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4502
    Cell Significance Index: -15.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4604
    Cell Significance Index: -54.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4768
    Cell Significance Index: -15.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4882
    Cell Significance Index: -56.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5099
    Cell Significance Index: -58.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5161
    Cell Significance Index: -52.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5843
    Cell Significance Index: -18.7200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6075
    Cell Significance Index: -5.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6390
    Cell Significance Index: -13.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6645
    Cell Significance Index: -30.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6739
    Cell Significance Index: -46.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7056
    Cell Significance Index: -52.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7463
    Cell Significance Index: -23.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7739
    Cell Significance Index: -46.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7801
    Cell Significance Index: -40.9600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7891
    Cell Significance Index: -7.4800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8533
    Cell Significance Index: -10.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8677
    Cell Significance Index: -10.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8737
    Cell Significance Index: -45.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8907
    Cell Significance Index: -56.1400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.9429
    Cell Significance Index: -11.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.9652
    Cell Significance Index: -27.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9734
    Cell Significance Index: -34.1000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9990
    Cell Significance Index: -20.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.0407
    Cell Significance Index: -48.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.0627
    Cell Significance Index: -49.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1312
    Cell Significance Index: -58.7600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.1950
    Cell Significance Index: -16.7500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.2067
    Cell Significance Index: -12.5700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.2127
    Cell Significance Index: -10.0100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.2140
    Cell Significance Index: -17.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.2370
    Cell Significance Index: -25.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2371
    Cell Significance Index: -31.8000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.2504
    Cell Significance Index: -24.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2693
    Cell Significance Index: -31.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.3438
    Cell Significance Index: -33.5200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.3444
    Cell Significance Index: -42.5200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.3447
    Cell Significance Index: -19.3100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -1.4540
    Cell Significance Index: -11.7400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.4831
    Cell Significance Index: -29.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Synapsin III exhibits several distinct characteristics that contribute to its role in neurotransmitter release and synaptic function. These include: 1. **ATP-binding domain**: The presence of an ATP-binding domain suggests that synapsin III is involved in energy-dependent processes, such as the regulation of synaptic vesicle dynamics. 2. **Dopamine and serotonin neurotransmitter release cycle**: Synapsin III is implicated in the regulation of neurotransmitter release cycles involving dopamine and serotonin, highlighting its importance in modulating mood and cognitive functions. 3. **GABAergic and glutamatergic synaptic transmission**: The protein's involvement in GABAergic and glutamatergic synaptic transmission underscores its role in regulating inhibitory and excitatory neurotransmission, respectively. 4. **Postsynaptic density association**: Synapsin III's association with postsynaptic density components suggests that it plays a role in the organization and regulation of synaptic structures. **Pathways and Functions:** Synapsin III is involved in several key pathways and functions, including: 1. **Neurotransmitter release cycle**: Synapsin III regulates the release of neurotransmitters from synaptic vesicles, ensuring precise and regulated neurotransmission. 2. **Synaptic vesicle clustering and mobilization**: The protein facilitates the clustering and mobilization of synaptic vesicles, allowing for efficient neurotransmitter release. 3. **Regulation of synaptic transmission**: Synapsin III modulates synaptic transmission by regulating the release of neurotransmitters and the organization of synaptic structures. 4. **Neurotransmitter secretion**: The protein is involved in the secretion of neurotransmitters from neurons, which is essential for neural communication and behavior. **Clinical Significance:** Dysregulation of synapsin III has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: Alterations in synapsin III expression and function have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Mood disorders**: Dysregulation of synapsin III has been implicated in mood disorders, such as depression and bipolar disorder. 3. **Cognitive dysfunction**: Synapsin III's role in regulating neurotransmitter release and synaptic transmission makes it an important target for understanding cognitive dysfunction and developing therapeutic strategies. In conclusion, synapsin III is a complex protein that plays a critical role in regulating neurotransmitter release and synaptic function. Further research into its functions and regulation is necessary to fully understand its role in neurological disorders and to develop effective therapeutic strategies.

Genular Protein ID: 2398501087

Symbol: SYN3_HUMAN

Name: Synapsin-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9539796

Title: A third member of the synapsin gene family.

PubMed ID: 9539796

DOI: 10.1073/pnas.95.8.4667

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14732590

Title: A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia.

PubMed ID: 14732590

DOI: 10.1016/j.biopsych.2003.07.002

Sequence Information:

  • Length: 580
  • Mass: 63303
  • Checksum: 4F61DE236DE8F3C5
  • Sequence:
  • MNFLRRRLSD SSFMANLPNG YMTDLQRPDS STSSPASPAM ERRHPQPLAA SFSSPGSSLF 
    SSLSSAMKQA PQATSGLMEP PGPSTPIVQR PRILLVIDDA HTDWSKYFHG KKVNGEIEIR 
    VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KVVSRSFKPD FILVRQHAYS MALGEDYRSL 
    VIGLQYGGLP AVNSLYSVYN FCSKPWVFSQ LIKIFHSLGP EKFPLVEQTF FPNHKPMVTA 
    PHFPVVVKLG HAHAGMGKIK VENQLDFQDI TSVVAMAKTY ATTEAFIDSK YDIRIQKIGS 
    NYKAYMRTSI SGNWKANTGS AMLEQVAMTE RYRLWVDSCS EMFGGLDICA VKAVHSKDGR 
    DYIIEVMDSS MPLIGEHVEE DRQLMADLVV SKMSQLPMPG GTAPSPLRPW APQIKSAKSP 
    GQAQLGPQLG QPQPRPPPQG GPRQAQSPQP QRSGSPSQQR LSPQGQQPLS PQSGSPQQQR 
    SPGSPQLSRA SSGSSPNQAS KPGATLASQP RPPVQGRSTS QQGEESKKPA PPHPHLNKSQ 
    SLTNSLSTSD TSQRGTPSED EAKAETIRNL RKSFASLFSD

Genular Protein ID: 4230773029

Symbol: Q17R54_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 579
  • Mass: 63216
  • Checksum: 0150A5E1F5E85A06
  • Sequence:
  • MNFLRRRLSD SSFMANLPNG YMTDLQRPDS STSSPASPAM ERRHPQPLAA SFSSPGSSLF 
    SSLSSAMKQA PQATSGLMEP PGPSTPIVQR PRILLVIDDA HTDWSKYFHG KKVNGEIEIR 
    VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KVVRSFKPDF ILVRQHAYSM ALGEDYRSLV 
    IGLQYGGLPA VNSLYSVYNF CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMVTAP 
    HFPVVVKLGH AHAGMGKIKV ENQLDFQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN 
    YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV KAVHSKDGRD 
    YIIEVMDSSM PLIGEHVEED RQLMADLVVS KMSQLPMPGG TAPSPLRPWA PQIKSAKSPG 
    QAQLGPQLGQ PQPRPPPQGG PRQAQSPQPQ RSGSPSQQRL SPQGQQPLSP QSGSPQQQRS 
    PGSPQLSRAS SGSSPNQASK PGATLASQPR PPVQGRSTSQ QGEESKKPAP PHPHLNKSQS 
    LTNSLSTSDT SQRGTPSEDE AKAETIRNLR KSFASLFSD

Genular Protein ID: 3698848172

Symbol: Q59EX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 611
  • Mass: 66712
  • Checksum: 7CF00D869F6DE901
  • Sequence:
  • SPTTPCTWQQ PVFWASPTHV WVGASHLHPS TAMNFLRRRL SDSSFMANLP NGYMTDLQRP 
    DSSTSSPASP AMERRHPQPL AASFSSPGSS LFSSLSSAMK QAPQATSGLM EPPGPSTPIV 
    QRPRILLVID DAHTDWSKYF HGKKVNGEIE IRVEQAEFSE LNLAAYVTGG CMVDMQVVRN 
    GTKVVRSFKP DFILVRQHAY SMALGEDYRS LVIGLQYGGL PAVNSLYSVY NFCSKPWVFS 
    QLIKIFHSLG PEKFPLVEQT FFPNHKPMVT APHFPVVVKL GHAHAGMGKI KVENQLDFQD 
    ITSVVAMAKT YATTEAFIDS KYDIRIQKIG SNYKAYMRTS ISGNWKANTG SAMLEQVAMT 
    ERYRLWVDSC SEMFGGLDIC AVKAVHSKDG RDYIIEVMDS SMPLIGEHVE EDRQLMADLV 
    VSKMSQLPMP GGTAPSPLRP WAPQIKSAKS PGQAQLGPQL GQPQPRPPPQ GGPRQAQSPQ 
    PQRSGSPSQQ RLSPQGQQPL SPQSGSPQQQ RSPGSPQLSR ASSGSSPNQA SKPGATLASQ 
    PRPPVQGRST SQQGEESKKP APPHPHLNKS QSLTNSLSTS DTSQRGTPSE DEAKAETIRN 
    LRKSFASLFS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.