Details for: RASL12

Gene ID: 51285

Symbol: RASL12

Ensembl ID: ENSG00000103710

Description: RAS like family 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.4396
    Cell Significance Index: -8.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.6392
    Cell Significance Index: -8.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.1333
    Cell Significance Index: -8.7200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.7219
    Cell Significance Index: 35.4000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.3521
    Cell Significance Index: 53.7800
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.4582
    Cell Significance Index: 6.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3942
    Cell Significance Index: 33.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2732
    Cell Significance Index: 40.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0056
    Cell Significance Index: 61.6500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.9433
    Cell Significance Index: 13.1900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.7970
    Cell Significance Index: 3.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5857
    Cell Significance Index: 12.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3187
    Cell Significance Index: 8.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2890
    Cell Significance Index: 13.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2668
    Cell Significance Index: 50.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1514
    Cell Significance Index: 7.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1400
    Cell Significance Index: 126.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1256
    Cell Significance Index: 12.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1242
    Cell Significance Index: 17.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0808
    Cell Significance Index: 1.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0669
    Cell Significance Index: 10.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0601
    Cell Significance Index: 27.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0594
    Cell Significance Index: 37.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0530
    Cell Significance Index: 28.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0324
    Cell Significance Index: 2.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0262
    Cell Significance Index: 2.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0262
    Cell Significance Index: 0.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0219
    Cell Significance Index: 0.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0127
    Cell Significance Index: 0.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0020
    Cell Significance Index: 0.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0019
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0032
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0048
    Cell Significance Index: -8.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0050
    Cell Significance Index: -1.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0116
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -9.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0123
    Cell Significance Index: -5.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0124
    Cell Significance Index: -7.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0182
    Cell Significance Index: -3.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0209
    Cell Significance Index: -2.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0218
    Cell Significance Index: -7.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0281
    Cell Significance Index: -3.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0282
    Cell Significance Index: -4.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0306
    Cell Significance Index: -6.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0372
    Cell Significance Index: -7.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0377
    Cell Significance Index: -6.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0406
    Cell Significance Index: -5.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0457
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0458
    Cell Significance Index: -5.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0593
    Cell Significance Index: -3.5600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0624
    Cell Significance Index: -0.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0654
    Cell Significance Index: -1.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0666
    Cell Significance Index: -8.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0700
    Cell Significance Index: -8.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0723
    Cell Significance Index: -1.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0815
    Cell Significance Index: -8.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0871
    Cell Significance Index: -6.1600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0923
    Cell Significance Index: -1.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1055
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1135
    Cell Significance Index: -1.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1143
    Cell Significance Index: -5.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1264
    Cell Significance Index: -8.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1275
    Cell Significance Index: -9.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1277
    Cell Significance Index: -8.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1294
    Cell Significance Index: -1.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1303
    Cell Significance Index: -8.2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1312
    Cell Significance Index: -2.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1315
    Cell Significance Index: -6.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1376
    Cell Significance Index: -3.9500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1451
    Cell Significance Index: -2.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1599
    Cell Significance Index: -3.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1608
    Cell Significance Index: -8.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1632
    Cell Significance Index: -9.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1673
    Cell Significance Index: -7.8000
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1725
    Cell Significance Index: -1.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1758
    Cell Significance Index: -9.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1891
    Cell Significance Index: -6.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2069
    Cell Significance Index: -9.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2072
    Cell Significance Index: -7.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2153
    Cell Significance Index: -5.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2179
    Cell Significance Index: -4.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2267
    Cell Significance Index: -6.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2296
    Cell Significance Index: -6.2500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.2334
    Cell Significance Index: -2.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2343
    Cell Significance Index: -9.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2414
    Cell Significance Index: -9.1400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2440
    Cell Significance Index: -3.2900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2446
    Cell Significance Index: -1.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2457
    Cell Significance Index: -9.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2633
    Cell Significance Index: -8.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2634
    Cell Significance Index: -3.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2681
    Cell Significance Index: -8.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RASL12 is a Ras-like family member that belongs to the Ras superfamily of small GTPases. The protein is characterized by its small size (approximately 180 amino acids) and the presence of a GTP-binding domain, which is essential for its function. RASL12 is also known to interact with various partners, including G proteins, guanine nucleotide exchange factors (GEFs), and GTPase-activating proteins (GAPs), to modulate its activity. Notably, RASL12 has been shown to be highly expressed in certain cell types, such as mast cells and monocytes, suggesting its involvement in immune cell function and regulation. **Pathways and Functions:** RASL12 has been implicated in several signaling pathways, including: 1. **GDP binding and G protein activity:** RASL12 binds to G proteins, which are essential for transmitting signals from G-protein coupled receptors (GPCRs) to downstream effectors. 2. **GTPase activity:** RASL12 exhibits GTPase activity, which is crucial for its regulation and termination. 3. **GTP binding:** RASL12 binds to GTP, which is necessary for its activation and function. 4. **Protein binding:** RASL12 interacts with various proteins, including GEFs, GAPs, and other signaling molecules, to modulate its activity. RASL12 has been shown to regulate various cellular processes, including: 1. **Immune cell function:** RASL12 is highly expressed in immune cells, such as mast cells and monocytes, and has been implicated in their activation and regulation. 2. **Cellular homeostasis:** RASL12 may play a role in maintaining cellular homeostasis by regulating cell growth, differentiation, and survival. 3. **Signaling pathways:** RASL12 has been shown to interact with various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. **Clinical Significance:** RASL12 has been identified as a potential biomarker for various diseases, including: 1. **Immunological disorders:** RASL12 has been implicated in the regulation of immune cell function and may play a role in immunological disorders, such as allergies and autoimmune diseases. 2. **Cancer:** RASL12 may be involved in the regulation of cell growth and differentiation, making it a potential target for cancer therapy. 3. **Neurological disorders:** RASL12 has been shown to interact with various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RASL12 is a multifaceted gene that plays a crucial role in immune regulation, cellular homeostasis, and potentially, in various diseases. Further studies are necessary to fully elucidate the functions and clinical significance of RASL12, but its identification as a significant gene in the Ras-like superfamily has opened up new avenues for research and potential therapeutic applications.

Genular Protein ID: 1678279058

Symbol: RASLC_HUMAN

Name: Ras-like protein family member 12

UniProtKB Accession Codes:

Q9NYN1 B2RC29 B4DJW2 B4DU82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 2 Rhea 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12107412

Title: Expressed sequence tag analysis of adult human iris for the NEIBank project: steroid-response factors and similarities with retinal pigment epithelium.

PubMed ID: 12107412

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 266
  • Mass: 29662
  • Checksum: CEF9841F94BE9DBA
  • Sequence:
    • MSSVFGKPRA GSGPQSAPLE VNLAILGRRG AGKSALTVKF LTKRFISEYD PNLEDTYSSE 
ETVDHQPVHL RVMDTADLDT PRNCERYLNW AHAFLVVYSV DSRQSFDSSS SYLELLALHA 
KETQRSIPAL LLGNKLDMAQ YRQVTKAEGV ALAGRFGCLF FEVSACLDFE HVQHVFHEAV 
REARRELEKS PLTRPLFISE ERALPHQAPL TARHGLASCT FNTLSTINLK EMPTVAQAKL 
VTVKSSRAQS KRKAPTLTLL KGFKIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.