Details for: HLA C

Gene ID: 3107

Symbol: HLA C

Ensembl ID: ENSG00000204525

Description: major histocompatibility complex, class I, C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.85
    Marker Score: 14860.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.5
    Marker Score: 16051
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.37
    Marker Score: 53193.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.31
    Marker Score: 3750.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 5.08
    Marker Score: 1489
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.04
    Marker Score: 10570
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 5.03
    Marker Score: 4269
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.94
    Marker Score: 20508
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.89
    Marker Score: 3550
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.89
    Marker Score: 8389
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.88
    Marker Score: 15401
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.78
    Marker Score: 3080
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.64
    Marker Score: 245447.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.56
    Marker Score: 6599
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.53
    Marker Score: 2751
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.52
    Marker Score: 3850
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.46
    Marker Score: 249487
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.43
    Marker Score: 2277
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.35
    Marker Score: 50624
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.35
    Marker Score: 12010
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.34
    Marker Score: 1412
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.29
    Marker Score: 12034
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.28
    Marker Score: 4132
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 4.26
    Marker Score: 4174.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.17
    Marker Score: 4630
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.17
    Marker Score: 55976
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 4.12
    Marker Score: 2510
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 4.12
    Marker Score: 3545
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.1
    Marker Score: 17576.5
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.08
    Marker Score: 1755
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.04
    Marker Score: 5942
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.03
    Marker Score: 9838
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 4
    Marker Score: 3962
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.98
    Marker Score: 9714
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.96
    Marker Score: 3896.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.93
    Marker Score: 3505.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.87
    Marker Score: 3442.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.85
    Marker Score: 1987
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.83
    Marker Score: 3266
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.77
    Marker Score: 2956
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.75
    Marker Score: 3159
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.73
    Marker Score: 2294
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.73
    Marker Score: 27761
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.71
    Marker Score: 2809
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.65
    Marker Score: 3432
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.64
    Marker Score: 6509
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.62
    Marker Score: 1932
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.62
    Marker Score: 3228
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.6
    Marker Score: 2006
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.59
    Marker Score: 3157
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.52
    Marker Score: 4853
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.5
    Marker Score: 2863
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.47
    Marker Score: 3972
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.47
    Marker Score: 2624
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.47
    Marker Score: 117981
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.43
    Marker Score: 18030
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.43
    Marker Score: 2509
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.42
    Marker Score: 2080
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.41
    Marker Score: 2462
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.38
    Marker Score: 898
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.36
    Marker Score: 4042
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.35
    Marker Score: 8456
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.34
    Marker Score: 2775
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.34
    Marker Score: 775.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.32
    Marker Score: 3106
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.32
    Marker Score: 6628
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.3
    Marker Score: 911
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.3
    Marker Score: 3551
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.28
    Marker Score: 4509
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 3.28
    Marker Score: 3405
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.28
    Marker Score: 1809
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.27
    Marker Score: 1918
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.27
    Marker Score: 6374
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.27
    Marker Score: 1361
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.26
    Marker Score: 2159
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.26
    Marker Score: 3843
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.26
    Marker Score: 778
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.25
    Marker Score: 3118
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.25
    Marker Score: 8505
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.24
    Marker Score: 3588
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.2
    Marker Score: 1841
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.2
    Marker Score: 1116
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.19
    Marker Score: 5296
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.19
    Marker Score: 2849
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.19
    Marker Score: 1594
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.19
    Marker Score: 1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.18
    Marker Score: 1330
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.17
    Marker Score: 1369
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.17
    Marker Score: 3174
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.17
    Marker Score: 7651
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.16
    Marker Score: 27485
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.15
    Marker Score: 12153.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.14
    Marker Score: 2088
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 3.12
    Marker Score: 1027
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.12
    Marker Score: 960
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.11
    Marker Score: 1612
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 3.11
    Marker Score: 676
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.11
    Marker Score: 9753
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.1
    Marker Score: 5253
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 3.09
    Marker Score: 8012

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The HLA C gene is located on chromosome 6 and contains 21 exons that are spliced together to form a single protein. - The protein is expressed on the surface of all nucleated cells in the body, but its expression is particularly high on cells of the immune system. - The HLA C gene is responsible for producing two different proteins, HLA-A and HLA-B. **Pathways and functions:** - The HLA C gene is involved in the adaptive immune system, where it presents antigens to T cells. - When an antigen is presented by an HLA molecule, it triggers an immune response. - The HLA C gene is also involved in the innate immune system, where it helps to recognize and respond to pathogens. **Clinical significance:** - Mutations in the HLA C gene have been linked to several autoimmune diseases, including rheumatoid arthritis, lupus, and cancer. - These diseases are caused by the immune system attacking the body's own tissues. - HLA C molecules are also used in organ transplantation to match the donor's tissue type to the recipient's tissue type. **Conclusion:** The HLA C gene is a vital gene in the immune system that plays a crucial role in the recognition and response to foreign invaders. Mutations in the HLA C gene can lead to autoimmune diseases, highlighting its importance in human health.

Genular Protein ID: 2954230913

Symbol: HLAC_HUMAN

Name: HLA class I histocompatibility antigen, C alpha chain

UniProtKB Accession Codes:

P10321 O02863 O02864 O02865 O02866 O02958 O19505 O19652 O19676 O62879 O62882 O62883 O62888 O78060 O78061 O78062 O78063 O78067 O78068 O78069 O78072 O78083 O78090 O78091 O78149 O78165 O78166 O78178 O78202 O78203 O78211 O78214 P04222 P30499 P30500 P30501 P30502 P30503 P30504 P30505 P30506 P30507 P30508 P30509 P30510 P79498 Q07000 Q29631 Q29641 Q29643 Q29652 Q29743 Q29768 Q29862 Q29864 Q29865 Q29867 Q29921 Q29959 Q29960 Q29963 Q29986 Q29989 Q29990 Q29991 Q29992 Q29993 Q30192 Q31605 Q31627 Q860R1 Q860R2 Q95463 Q95603 Q95604 Q99528 Q9BD28 Q9GIK4 Q9GIK8 Q9GJ33 Q9MY30 Q9MY31 Q9MY35 Q9MY49 Q9MY74 Q9MYI3 Q9TNN7 Q9TNZ8 Q9TPS4 Q9TPV8 Q9TPX2 Q9TQB4 Q9TQJ5 Q9TQP9 Q9UM32 Q9UM33 Q9UM42 Q9UQS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 33 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 13 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 13 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 15 Pumba 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2914713

Title: Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing.

PubMed ID: 2914713

DOI: 10.1007/bf00395855

PubMed ID: 2714852

Title: Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles.

PubMed ID: 2714852

DOI: 10.1007/bf00352839

PubMed ID: 1711567

Title: Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains.

PubMed ID: 1711567

DOI: 10.1084/jem.174.1.53

PubMed ID: 1317015

Title: Unusual HLA-B alleles in two tribes of Brazilian Indians.

PubMed ID: 1317015

DOI: 10.1038/357326a0

PubMed ID: 1384166

Title: The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes.

PubMed ID: 1384166

DOI: 10.1111/j.1399-0039.1992.tb01943.x

PubMed ID: 7905471

Title: Molecular cloning and polymerase chain reaction-sequence-specific oligonucleotide detection of the allele encoding the novel allospecificity HLA-Cw6.2 (Cw*1502) in Spanish gypsies.

PubMed ID: 7905471

DOI: 10.1016/0198-8859(93)90509-y

PubMed ID: 7482492

Title: Anchored PCR cloning of the novel HLA-Cw*0704 allele detected by PCR-SSP.

PubMed ID: 7482492

DOI: 10.1111/j.1399-0039.1995.tb02471.x

PubMed ID: 8655361

Title: Identification and DNA typing of two Cw7 alleles (Cw*0702 and Cw*0704) in Japanese, with the corrected sequence of Cw*0702.

PubMed ID: 8655361

DOI: 10.1016/0198-8859(95)00150-6

PubMed ID: 9008313

Title: Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706.

PubMed ID: 9008313

DOI: 10.1111/j.1399-0039.1996.tb02694.x

PubMed ID: 9211742

Title: Cw*1701 defines a divergent african HLA-C allelic lineage.

PubMed ID: 9211742

DOI: 10.1007/s002510050259

PubMed ID: 9098935

Title: The complete primary structure of Cw*1701 reveals a highly divergent HLA class I molecule.

PubMed ID: 9098935

DOI: 10.1111/j.1399-0039.1997.tb02749.x

PubMed ID: 10372547

Title: Correction of HLA-Cw*0501 and identification of HLA-Cw*0711.

PubMed ID: 10372547

DOI: 10.1034/j.1399-0039.1999.530508.x

PubMed ID: 2787363

Title: The structure and expression of genes encoding serologically undetected HLA-C locus antigens.

PubMed ID: 2787363

PubMed ID: 2715640

Title: Diversity and diversification of HLA-A,B,C alleles.

PubMed ID: 2715640

PubMed ID: 1598685

Title: Isolation and characterization of a genomic HLA-Cw6 clone.

PubMed ID: 1598685

DOI: 10.1111/j.1399-0039.1992.tb01923.x

PubMed ID: 10488744

Title: There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and 5.

PubMed ID: 10488744

DOI: 10.1034/j.1399-0039.1999.540208.x

PubMed ID: 12622774

Title: Cloning and sequencing full-length HLA-B and -C genes.

PubMed ID: 12622774

DOI: 10.1034/j.1399-0039.2003.610103.x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8265661

Title: Allele-specific peptide ligand motifs of HLA-C molecules.

PubMed ID: 8265661

DOI: 10.1073/pnas.90.24.12005

PubMed ID: 11390610

Title: Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein.

PubMed ID: 11390610

DOI: 10.1128/jvi.75.13.6086-6094.2001

PubMed ID: 11172028

Title: The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.

PubMed ID: 11172028

DOI: 10.1073/pnas.98.4.1781

PubMed ID: 12947002

Title: Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles.

PubMed ID: 12947002

DOI: 10.1182/blood-2003-03-0824

PubMed ID: 16141329

Title: Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.

PubMed ID: 16141329

DOI: 10.1073/pnas.0503594102

PubMed ID: 18420581

Title: N-linked glycosylation selectively regulates the generic folding of HLA-Cw1.

PubMed ID: 18420581

DOI: 10.1074/jbc.m709175200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20104487

Title: Characterization of an HLA-C-restricted CTL response in chronic HIV infection.

PubMed ID: 20104487

DOI: 10.1002/eji.200939634

PubMed ID: 20972337

Title: Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2.

PubMed ID: 20972337

DOI: 10.1172/jci43998

PubMed ID: 20439706

Title: Peptide antagonism as a mechanism for NK cell activation.

PubMed ID: 20439706

DOI: 10.1073/pnas.0913745107

PubMed ID: 20356336

Title: Nomenclature for factors of the HLA system, 2010.

PubMed ID: 20356336

DOI: 10.1111/j.1399-0039.2010.01466.x

PubMed ID: 24091323

Title: Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation.

PubMed ID: 24091323

DOI: 10.1172/jci68991

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25311805

Title: Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule.

PubMed ID: 25311805

DOI: 10.4049/jimmunol.1401689

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29312307

Title: Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8+ T-Cell Repertoire in Older People.

PubMed ID: 29312307

DOI: 10.3389/fimmu.2017.01776

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 10850706

Title: Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand.

PubMed ID: 10850706

DOI: 10.1038/35014520

PubMed ID: 11323700

Title: Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.

PubMed ID: 11323700

DOI: 10.1038/87766

PubMed ID: 24990997

Title: The immunodominant influenza A virus M158-66 cytotoxic T lymphocyte epitope exhibits degenerate class I major histocompatibility complex restriction in humans.

PubMed ID: 24990997

DOI: 10.1128/jvi.00855-14

PubMed ID: 28649982

Title: Structural and regulatory diversity shape HLA-C protein expression levels.

PubMed ID: 28649982

DOI: 10.1038/ncomms15924

PubMed ID: 11122018

Title: HLA-C and guttate psoriasis.

PubMed ID: 11122018

DOI: 10.1046/j.1365-2133.2000.03885.x

PubMed ID: 16235096

Title: Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.

PubMed ID: 16235096

DOI: 10.1007/s00439-005-0048-2

PubMed ID: 16642438

Title: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.

PubMed ID: 16642438

DOI: 10.1086/503821

PubMed ID: 26621454

Title: Melanocyte antigen triggers autoimmunity in human psoriasis.

PubMed ID: 26621454

DOI: 10.1084/jem.20151093

PubMed ID: 28650991

Title: Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.

PubMed ID: 28650991

DOI: 10.1371/journal.pgen.1006862

Sequence Information:

  • Length: 366
  • Mass: 40649
  • Checksum: 59C23D95FD1D0BC8
  • Sequence:
    • MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 
DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ 
RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL 
RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES 
LITCKA

Genular Protein ID: 2073361755

Symbol: O19617_HUMAN

Name: N/A

UniProtKB Accession Codes:

O19617 A0A090KMD8

Database IDs:

ARBA 3 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 16 EPD 1 Ensembl 2 GO 9 Gene3D 2 GenomeRNAi 1 HGNC 1 InterPro 9 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 9177776

Title: Nucleotide sequence analysis of the HLA class I region spanning the 237-kb segment around the HLA-B and -C genes.

PubMed ID: 9177776

DOI: 10.1006/geno.1997.4708

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23714642

Title: Phase-defined complete sequencing of the HLA genes by next-generation sequencing.

PubMed ID: 23714642

DOI: 10.1186/1471-2164-14-355

PubMed ID: 24033148

Title: Advancing allele group-specific amplification of the complete HLA-C gene--isolation of novel alleles from three allele groups (C*04, C*07 and C*08).

PubMed ID: 24033148

DOI: 10.1111/tan.12192

PubMed ID: 28547825

Title: Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.

PubMed ID: 28547825

DOI: 10.1111/tan.13057

PubMed ID: 29327506

Title: Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population.

PubMed ID: 29327506

DOI: .1111/tan.13210

Sequence Information:

  • Length: 366
  • Mass: 40711
  • Checksum: 0B9518E6AA77A609
  • Sequence:
    • MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 
DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ 
RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL 
RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES 
LITCKA

Genular Protein ID: 2548750853

Symbol: Q95HC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q95HC2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 9 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 365
  • Mass: 40517
  • Checksum: 246B3241F2EAB52F
  • Sequence:
    • RVMAPRALLL LLSGGLALTE TWACSHSMRY FDTAVSRPGR GEPRFISVGY VDDTQFVRFD 
SDAASPRGEP RAPWVEQEGP EYWDRETQKY KRQAQADRVS LRNLRGYYNQ SEDGSHTLQR 
MSGCDLGPDG RLLRGYDQSA YDGKDYIALN EDLRSWTAAD TAAQITQRKL EAARAAEQLR 
AYLEGTCVEW LRRYLENGKE TLQRAEPPKT HVTHHPLSDH EATLRCWALG FYPAEITLTW 
QRDGEDQTQD TELVETRPAG DGTFQKWAAV VVPSGQEQRY TCHMQHEGLQ EPLTLSWEPS 
SQPTIPIMGI VAGLAVLVVL AVLGAVVTAM MCRRKSSGGK GGSCSQAACS NSAQGSDESL 
ITCKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.