Details for: HLA C

Gene ID: 3107

Symbol: HLA C

Ensembl ID: ENSG00000204525

Description: major histocompatibility complex, class I, C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 915.1679
    Cell Significance Index: -142.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 476.9689
    Cell Significance Index: -120.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 357.1212
    Cell Significance Index: -168.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 355.6673
    Cell Significance Index: -182.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 252.7264
    Cell Significance Index: -169.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 121.4723
    Cell Significance Index: -149.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 48.3452
    Cell Significance Index: -148.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 40.7965
    Cell Significance Index: -160.9900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 40.1809
    Cell Significance Index: 107.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.4920
    Cell Significance Index: -57.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 13.6106
    Cell Significance Index: 251.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.3199
    Cell Significance Index: 164.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.9742
    Cell Significance Index: 79.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 6.4978
    Cell Significance Index: 305.3900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 6.2365
    Cell Significance Index: 44.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.0401
    Cell Significance Index: 177.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.7913
    Cell Significance Index: 309.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.6703
    Cell Significance Index: 598.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.5963
    Cell Significance Index: 342.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.9760
    Cell Significance Index: 513.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.8442
    Cell Significance Index: 527.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.4971
    Cell Significance Index: 630.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.1387
    Cell Significance Index: 385.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.0331
    Cell Significance Index: 357.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7801
    Cell Significance Index: 64.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.6784
    Cell Significance Index: 1184.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.6565
    Cell Significance Index: 262.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6343
    Cell Significance Index: 138.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.5791
    Cell Significance Index: 23.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.3070
    Cell Significance Index: 57.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1673
    Cell Significance Index: 1183.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1580
    Cell Significance Index: 152.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2273
    Cell Significance Index: 35.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 1.1760
    Cell Significance Index: 734.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9804
    Cell Significance Index: 25.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4675
    Cell Significance Index: 53.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4635
    Cell Significance Index: 88.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3888
    Cell Significance Index: 294.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2516
    Cell Significance Index: 42.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1125
    Cell Significance Index: 11.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0158
    Cell Significance Index: 0.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0049
    Cell Significance Index: -3.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0471
    Cell Significance Index: -88.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0663
    Cell Significance Index: -49.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0877
    Cell Significance Index: -161.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1060
    Cell Significance Index: -163.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1313
    Cell Significance Index: -178.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1452
    Cell Significance Index: -28.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2120
    Cell Significance Index: -119.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2272
    Cell Significance Index: -11.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2408
    Cell Significance Index: -26.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2437
    Cell Significance Index: -154.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2695
    Cell Significance Index: -7.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2871
    Cell Significance Index: -32.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3510
    Cell Significance Index: -159.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3613
    Cell Significance Index: -76.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3688
    Cell Significance Index: -15.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.4019
    Cell Significance Index: -144.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.5706
    Cell Significance Index: -114.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6311
    Cell Significance Index: -10.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6936
    Cell Significance Index: -19.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7054
    Cell Significance Index: -32.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7344
    Cell Significance Index: -50.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8299
    Cell Significance Index: -29.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8407
    Cell Significance Index: -122.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8583
    Cell Significance Index: -100.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.8865
    Cell Significance Index: -14.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9436
    Cell Significance Index: -42.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0380
    Cell Significance Index: -33.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2358
    Cell Significance Index: -31.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.4431
    Cell Significance Index: -39.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5455
    Cell Significance Index: -160.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.7672
    Cell Significance Index: -135.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.9401
    Cell Significance Index: -11.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.0510
    Cell Significance Index: -51.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.2294
    Cell Significance Index: -48.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.2307
    Cell Significance Index: -176.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.2571
    Cell Significance Index: -65.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -2.3242
    Cell Significance Index: -62.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.3729
    Cell Significance Index: -50.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.3887
    Cell Significance Index: -150.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.5567
    Cell Significance Index: -143.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.7639
    Cell Significance Index: -169.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.8777
    Cell Significance Index: -43.1200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.9801
    Cell Significance Index: -16.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -3.0237
    Cell Significance Index: -50.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -3.1254
    Cell Significance Index: -63.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.3448
    Cell Significance Index: -45.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.6663
    Cell Significance Index: -162.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.8712
    Cell Significance Index: -142.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.8849
    Cell Significance Index: -135.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.9675
    Cell Significance Index: -116.8600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -4.1370
    Cell Significance Index: -34.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -4.1620
    Cell Significance Index: -81.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -4.1709
    Cell Significance Index: -64.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -4.2801
    Cell Significance Index: -162.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -4.3228
    Cell Significance Index: -141.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -4.4753
    Cell Significance Index: -156.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -4.8108
    Cell Significance Index: -123.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -4.9349
    Cell Significance Index: -157.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HLA-C gene has several key characteristics that make it essential for immune function. These include: 1. **Peptide presentation**: HLA-C presents endogenously synthesized peptides to CTLs, which is critical for the recognition and elimination of infected cells or tumor cells. 2. **MHC class I expression**: HLA-C is a member of the MHC class I family, which is expressed on the surface of nearly all nucleated cells. 3. **Cellular expression**: HLA-C is expressed in various cell types, including those involved in immune responses, such as T cells, monocytes, and dendritic cells. 4. **Alpha chain structure**: The HLA-C protein is composed of three alpha chains (α1, α2, and α3), which are involved in the assembly and loading of peptides onto the MHC class I molecule. **Pathways and Functions** The HLA-C gene is involved in several pathways that are crucial for immune function. These include: 1. **Antigen presentation**: HLA-C presents endogenously synthesized peptides to CTLs, which is critical for the recognition and elimination of infected cells or tumor cells. 2. **Adaptive immune response**: HLA-C is involved in the adaptive immune response, specifically in the recognition and elimination of cells that have been infected or transformed by pathogens or tumor cells. 3. **Cytokine signaling**: HLA-C interacts with the DAP12 adaptor protein, which is involved in cytokine signaling pathways, such as interferon-gamma (IFN-γ) signaling. 4. **Immune system regulation**: HLA-C is involved in the regulation of immune responses, including the modulation of T cell activation and proliferation. **Clinical Significance** The HLA-C gene has significant clinical implications, particularly in the context of infectious diseases and cancer. Some of the key clinical implications include: 1. **Infectious diseases**: HLA-C is involved in the recognition and elimination of infected cells, which is critical for the control of infectious diseases, such as HIV, influenza, and tuberculosis. 2. **Cancer**: HLA-C is involved in the recognition and elimination of tumor cells, which is critical for the control of cancer. 3. **Transplantation**: HLA-C is involved in the rejection of transplanted organs, and mismatches in HLA-C can lead to graft rejection. 4. **Autoimmune diseases**: HLA-C is involved in the regulation of autoimmune responses, and alterations in HLA-C expression can contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, the HLA-C gene is a critical component of the adaptive immune response, and its dysregulation can have significant clinical implications. Further research is needed to fully understand the role of HLA-C in immune function and disease.

Genular Protein ID: 2954230913

Symbol: HLAC_HUMAN

Name: HLA class I histocompatibility antigen, C alpha chain

UniProtKB Accession Codes:

P10321 O02863 O02864 O02865 O02866 O02958 O19505 O19652 O19676 O62879 O62882 O62883 O62888 O78060 O78061 O78062 O78063 O78067 O78068 O78069 O78072 O78083 O78090 O78091 O78149 O78165 O78166 O78178 O78202 O78203 O78211 O78214 P04222 P30499 P30500 P30501 P30502 P30503 P30504 P30505 P30506 P30507 P30508 P30509 P30510 P79498 Q07000 Q29631 Q29641 Q29643 Q29652 Q29743 Q29768 Q29862 Q29864 Q29865 Q29867 Q29921 Q29959 Q29960 Q29963 Q29986 Q29989 Q29990 Q29991 Q29992 Q29993 Q30192 Q31605 Q31627 Q860R1 Q860R2 Q95463 Q95603 Q95604 Q99528 Q9BD28 Q9GIK4 Q9GIK8 Q9GJ33 Q9MY30 Q9MY31 Q9MY35 Q9MY49 Q9MY74 Q9MYI3 Q9TNN7 Q9TNZ8 Q9TPS4 Q9TPV8 Q9TPX2 Q9TQB4 Q9TQJ5 Q9TQP9 Q9UM32 Q9UM33 Q9UM42 Q9UQS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 33 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 13 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 15 Pumba 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2914713

Title: Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing.

PubMed ID: 2914713

DOI: 10.1007/bf00395855

PubMed ID: 2714852

Title: Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles.

PubMed ID: 2714852

DOI: 10.1007/bf00352839

PubMed ID: 1711567

Title: Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains.

PubMed ID: 1711567

DOI: 10.1084/jem.174.1.53

PubMed ID: 1317015

Title: Unusual HLA-B alleles in two tribes of Brazilian Indians.

PubMed ID: 1317015

DOI: 10.1038/357326a0

PubMed ID: 1384166

Title: The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes.

PubMed ID: 1384166

DOI: 10.1111/j.1399-0039.1992.tb01943.x

PubMed ID: 7905471

Title: Molecular cloning and polymerase chain reaction-sequence-specific oligonucleotide detection of the allele encoding the novel allospecificity HLA-Cw6.2 (Cw*1502) in Spanish gypsies.

PubMed ID: 7905471

DOI: 10.1016/0198-8859(93)90509-y

PubMed ID: 7482492

Title: Anchored PCR cloning of the novel HLA-Cw*0704 allele detected by PCR-SSP.

PubMed ID: 7482492

DOI: 10.1111/j.1399-0039.1995.tb02471.x

PubMed ID: 8655361

Title: Identification and DNA typing of two Cw7 alleles (Cw*0702 and Cw*0704) in Japanese, with the corrected sequence of Cw*0702.

PubMed ID: 8655361

DOI: 10.1016/0198-8859(95)00150-6

PubMed ID: 9008313

Title: Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706.

PubMed ID: 9008313

DOI: 10.1111/j.1399-0039.1996.tb02694.x

PubMed ID: 9211742

Title: Cw*1701 defines a divergent african HLA-C allelic lineage.

PubMed ID: 9211742

DOI: 10.1007/s002510050259

PubMed ID: 9098935

Title: The complete primary structure of Cw*1701 reveals a highly divergent HLA class I molecule.

PubMed ID: 9098935

DOI: 10.1111/j.1399-0039.1997.tb02749.x

PubMed ID: 10372547

Title: Correction of HLA-Cw*0501 and identification of HLA-Cw*0711.

PubMed ID: 10372547

DOI: 10.1034/j.1399-0039.1999.530508.x

PubMed ID: 2787363

Title: The structure and expression of genes encoding serologically undetected HLA-C locus antigens.

PubMed ID: 2787363

PubMed ID: 2715640

Title: Diversity and diversification of HLA-A,B,C alleles.

PubMed ID: 2715640

PubMed ID: 1598685

Title: Isolation and characterization of a genomic HLA-Cw6 clone.

PubMed ID: 1598685

DOI: 10.1111/j.1399-0039.1992.tb01923.x

PubMed ID: 10488744

Title: There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and 5.

PubMed ID: 10488744

DOI: 10.1034/j.1399-0039.1999.540208.x

PubMed ID: 12622774

Title: Cloning and sequencing full-length HLA-B and -C genes.

PubMed ID: 12622774

DOI: 10.1034/j.1399-0039.2003.610103.x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8265661

Title: Allele-specific peptide ligand motifs of HLA-C molecules.

PubMed ID: 8265661

DOI: 10.1073/pnas.90.24.12005

PubMed ID: 11390610

Title: Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein.

PubMed ID: 11390610

DOI: 10.1128/jvi.75.13.6086-6094.2001

PubMed ID: 11172028

Title: The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.

PubMed ID: 11172028

DOI: 10.1073/pnas.98.4.1781

PubMed ID: 12947002

Title: Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles.

PubMed ID: 12947002

DOI: 10.1182/blood-2003-03-0824

PubMed ID: 16141329

Title: Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.

PubMed ID: 16141329

DOI: 10.1073/pnas.0503594102

PubMed ID: 18420581

Title: N-linked glycosylation selectively regulates the generic folding of HLA-Cw1.

PubMed ID: 18420581

DOI: 10.1074/jbc.m709175200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20104487

Title: Characterization of an HLA-C-restricted CTL response in chronic HIV infection.

PubMed ID: 20104487

DOI: 10.1002/eji.200939634

PubMed ID: 20972337

Title: Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2.

PubMed ID: 20972337

DOI: 10.1172/jci43998

PubMed ID: 20439706

Title: Peptide antagonism as a mechanism for NK cell activation.

PubMed ID: 20439706

DOI: 10.1073/pnas.0913745107

PubMed ID: 20356336

Title: Nomenclature for factors of the HLA system, 2010.

PubMed ID: 20356336

DOI: 10.1111/j.1399-0039.2010.01466.x

PubMed ID: 24091323

Title: Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation.

PubMed ID: 24091323

DOI: 10.1172/jci68991

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25311805

Title: Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule.

PubMed ID: 25311805

DOI: 10.4049/jimmunol.1401689

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29312307

Title: Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8+ T-Cell Repertoire in Older People.

PubMed ID: 29312307

DOI: 10.3389/fimmu.2017.01776

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 10850706

Title: Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand.

PubMed ID: 10850706

DOI: 10.1038/35014520

PubMed ID: 11323700

Title: Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.

PubMed ID: 11323700

DOI: 10.1038/87766

PubMed ID: 24990997

Title: The immunodominant influenza A virus M158-66 cytotoxic T lymphocyte epitope exhibits degenerate class I major histocompatibility complex restriction in humans.

PubMed ID: 24990997

DOI: 10.1128/jvi.00855-14

PubMed ID: 28649982

Title: Structural and regulatory diversity shape HLA-C protein expression levels.

PubMed ID: 28649982

DOI: 10.1038/ncomms15924

PubMed ID: 11122018

Title: HLA-C and guttate psoriasis.

PubMed ID: 11122018

DOI: 10.1046/j.1365-2133.2000.03885.x

PubMed ID: 16235096

Title: Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.

PubMed ID: 16235096

DOI: 10.1007/s00439-005-0048-2

PubMed ID: 16642438

Title: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.

PubMed ID: 16642438

DOI: 10.1086/503821

PubMed ID: 26621454

Title: Melanocyte antigen triggers autoimmunity in human psoriasis.

PubMed ID: 26621454

DOI: 10.1084/jem.20151093

PubMed ID: 28650991

Title: Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.

PubMed ID: 28650991

DOI: 10.1371/journal.pgen.1006862

Sequence Information:

  • Length: 366
  • Mass: 40649
  • Checksum: 59C23D95FD1D0BC8
  • Sequence:
    • MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 
DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ 
RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL 
RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES 
LITCKA

Genular Protein ID: 2073361755

Symbol: O19617_HUMAN

Name: N/A

UniProtKB Accession Codes:

O19617 A0A090KMD8

Database IDs:

ARBA 3 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 2 GO 8 Gene3D 2 HGNC 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 9177776

Title: Nucleotide sequence analysis of the HLA class I region spanning the 237-kb segment around the HLA-B and -C genes.

PubMed ID: 9177776

DOI: 10.1006/geno.1997.4708

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23714642

Title: Phase-defined complete sequencing of the HLA genes by next-generation sequencing.

PubMed ID: 23714642

DOI: 10.1186/1471-2164-14-355

PubMed ID: 24033148

Title: Advancing allele group-specific amplification of the complete HLA-C gene--isolation of novel alleles from three allele groups (C*04, C*07 and C*08).

PubMed ID: 24033148

DOI: 10.1111/tan.12192

PubMed ID: 28547825

Title: Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.

PubMed ID: 28547825

DOI: 10.1111/tan.13057

PubMed ID: 29327506

Title: Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population.

PubMed ID: 29327506

DOI: .1111/tan.13210

Sequence Information:

  • Length: 366
  • Mass: 40711
  • Checksum: 0B9518E6AA77A609
  • Sequence:
    • MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 
DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ 
RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL 
RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES 
LITCKA

Genular Protein ID: 2548750853

Symbol: Q95HC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q95HC2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 10 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 365
  • Mass: 40517
  • Checksum: 246B3241F2EAB52F
  • Sequence:
    • RVMAPRALLL LLSGGLALTE TWACSHSMRY FDTAVSRPGR GEPRFISVGY VDDTQFVRFD 
SDAASPRGEP RAPWVEQEGP EYWDRETQKY KRQAQADRVS LRNLRGYYNQ SEDGSHTLQR 
MSGCDLGPDG RLLRGYDQSA YDGKDYIALN EDLRSWTAAD TAAQITQRKL EAARAAEQLR 
AYLEGTCVEW LRRYLENGKE TLQRAEPPKT HVTHHPLSDH EATLRCWALG FYPAEITLTW 
QRDGEDQTQD TELVETRPAG DGTFQKWAAV VVPSGQEQRY TCHMQHEGLQ EPLTLSWEPS 
SQPTIPIMGI VAGLAVLVVL AVLGAVVTAM MCRRKSSGGK GGSCSQAACS NSAQGSDESL 
ITCKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.