Gene JUNB - ENSG00000171223 | NCBI Gene ID: 3726

Details for: JUNB

Gene ID: 3726

Symbol: JUNB

Ensembl ID: ENSG00000171223

Description: JunB proto-oncogene, AP-1 transcription factor subunit

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Cellular response to calcium ion
(GO:0071277)
Chromatin
(GO:0000785)
Decidualization
(GO:0046697)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic process involved in female pregnancy
(GO:0060136)
Integrated stress response signaling
(GO:0140467)
Labyrinthine layer blood vessel development
(GO:0060716)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Osteoblast proliferation
(GO:0033687)
Osteoclast differentiation
(GO:0030316)
Osteoclast proliferation
(GO:0002158)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of cell population proliferation
(GO:0042127)
Regulation of t-helper 17 cell differentiation
(GO:2000319)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription factor ap-1 complex
(GO:0035976)
Transcription factor binding
(GO:0008134)
Transcription regulator complex
(GO:0005667)
Trophectodermal cell differentiation
(GO:0001829)
Vasculogenesis
(GO:0001570)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.27
Marker Score: 6864
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.54
Marker Score: 154529
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.46
Marker Score: 9346
Cell Name: naive T cell (CL0000898)
Fold Change: 4.21
Marker Score: 2709
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.19
Marker Score: 2154.5
Cell Name: mature T cell (CL0002419)
Fold Change: 4.18
Marker Score: 41437
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.11
Marker Score: 229902
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.07
Marker Score: 17444
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.02
Marker Score: 11286
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.02
Marker Score: 11096.5
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 4
Marker Score: 2899
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.95
Marker Score: 10051.5
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.9
Marker Score: 3322
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.87
Marker Score: 9438
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.84
Marker Score: 3277
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 3.83
Marker Score: 6578
Cell Name: theca cell (CL0000503)
Fold Change: 3.83
Marker Score: 2742
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.82
Marker Score: 3287
Cell Name: naive B cell (CL0000788)
Fold Change: 3.79
Marker Score: 3388
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.77
Marker Score: 11894
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.77
Marker Score: 10994.5
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.77
Marker Score: 199086
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.69
Marker Score: 2796
Cell Name: supporting cell (CL0000630)
Fold Change: 3.68
Marker Score: 6913
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.61
Marker Score: 3858
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.61
Marker Score: 3553
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.53
Marker Score: 2974
Cell Name: acinar cell (CL0000622)
Fold Change: 3.5
Marker Score: 2467
Cell Name: memory T cell (CL0000813)
Fold Change: 3.48
Marker Score: 1495
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.46
Marker Score: 5008
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.45
Marker Score: 5086.5
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.44
Marker Score: 3941
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.42
Marker Score: 8342
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.39
Marker Score: 4096
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.38
Marker Score: 6745
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.37
Marker Score: 3169
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.37
Marker Score: 8133
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.32
Marker Score: 1946
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.29
Marker Score: 1417
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.29
Marker Score: 5561
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.27
Marker Score: 3088.5
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.27
Marker Score: 4510
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.27
Marker Score: 1632.5
Cell Name: basophil (CL0000767)
Fold Change: 3.25
Marker Score: 1543
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.25
Marker Score: 2660
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.25
Marker Score: 2548
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.22
Marker Score: 2827
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.22
Marker Score: 1978
Cell Name: fibroblast (CL0000057)
Fold Change: 3.21
Marker Score: 3105
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.2
Marker Score: 8375
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.18
Marker Score: 5209
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.16
Marker Score: 2316
Cell Name: reticular cell (CL0000432)
Fold Change: 3.13
Marker Score: 1144
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.1
Marker Score: 24195
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.09
Marker Score: 6029
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.08
Marker Score: 11879
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.07
Marker Score: 7003
Cell Name: neutrophil (CL0000775)
Fold Change: 3.05
Marker Score: 1859
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.03
Marker Score: 2837
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.02
Marker Score: 721
Cell Name: basal cell (CL0000646)
Fold Change: 3.01
Marker Score: 3888
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.01
Marker Score: 1253
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.98
Marker Score: 1717
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.93
Marker Score: 1010.5
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.92
Marker Score: 19022
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.91
Marker Score: 903
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.9
Marker Score: 1186
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.88
Marker Score: 2764
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 2.88
Marker Score: 2395
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.88
Marker Score: 4178
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.87
Marker Score: 2866
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.86
Marker Score: 970
Cell Name: club cell (CL0000158)
Fold Change: 2.86
Marker Score: 3344
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.86
Marker Score: 15026
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.86
Marker Score: 3159
Cell Name: decidual cell (CL2000002)
Fold Change: 2.85
Marker Score: 12294
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.85
Marker Score: 1667
Cell Name: immature B cell (CL0000816)
Fold Change: 2.84
Marker Score: 1882
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.84
Marker Score: 3087
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.83
Marker Score: 6433
Cell Name: stromal cell (CL0000499)
Fold Change: 2.83
Marker Score: 3320
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.83
Marker Score: 1707
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.83
Marker Score: 1467
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.83
Marker Score: 2538
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.82
Marker Score: 13850
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.81
Marker Score: 2034
Cell Name: pericyte (CL0000669)
Fold Change: 2.81
Marker Score: 1641
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.8
Marker Score: 1272
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.8
Marker Score: 3108.5
Cell Name: memory B cell (CL0000787)
Fold Change: 2.78
Marker Score: 2107
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.77
Marker Score: 968
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.77
Marker Score: 1902
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.77
Marker Score: 18078
Cell Name: granulocyte (CL0000094)
Fold Change: 2.76
Marker Score: 1235
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.75
Marker Score: 31011
Cell Name: oocyte (CL0000023)
Fold Change: 2.75
Marker Score: 680
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.74
Marker Score: 2951
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.74
Marker Score: 17452
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.73
Marker Score: 967
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.73
Marker Score: 1033

Hover over a box to see details here...

**Key characteristics:** * JUNB is a member of the Jun family of transcription factors. * It is a key regulator of cytokine signaling in the immune system. * It is also involved in the regulation of cell growth and differentiation. **Pathways and functions:** * JUNB is a key regulator of inflammation. It is expressed in high levels in inflammatory cells, such as macrophages and dendritic cells. * In inflammatory responses, JUNB binds to DNA sequences called AP-1 response elements (AP-1REs) on the promoters of inflammatory genes. * This binding activates the transcription of these genes, promoting inflammation. * JUNB also plays a role in cell growth and differentiation. It is expressed in high levels in proliferating cells and is involved in the regulation of cell cycle progression and apoptosis. **Clinical significance:** * Mutations in JUNB have been linked to the development of several human cancers, including breast cancer, lung cancer, and ovarian cancer. * Inhibition of JUNB has been shown to inhibit cancer cell growth and migration. * Therefore, JUNB is a potential target for cancer therapy. **Additional notes:** * JUNB is a highly conserved gene, with a similar gene called JUNB1 in mice. * JUNB is a key regulator of the immune system. It is expressed in high levels in cells of the immune system, including T cells, B cells, and macrophages. * JUNB binds to DNA sequences called AP-1REs on the promoters of inflammatory genes. * This binding activates the transcription of these genes, promoting inflammation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

JUNB_HUMAN

Genular Protein ID: 1486454004

Symbol: JUNB_HUMAN

Name: N/A

UniProtKB Accession Codes:

P17275 Q96GH3

Database IDs:

Citations:

PubMed ID: 2513129

Title: jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun.

PubMed ID: 2513129

DOI: 10.1016/0092-8674(89)90755-1

PubMed ID: 2112242

Title: Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.

PubMed ID: 2112242

DOI: 10.1093/nar/18.10.3047

PubMed ID: 8530030

Title: Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci.

PubMed ID: 8530030

DOI: 10.1006/geno.1995.1135

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16387660

Title: Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

PubMed ID: 16387660

DOI: 10.1016/j.molcel.2005.11.014

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 347
Mass: 35879
Checksum: DF8CD1CD4409C6BE
Sequence:

MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL KAPGARGPGP 
EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT TTPTPPGQYF YPRGGGSGGG 
AGGAGGGVTE EQEGFADGFV KALDDLHKMN HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP 
VYTNLSSYSP ASASSGGAGA AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK 
EEPQTVPEAR SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV 
KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: JUNB

Associated with

Cells (max top 100)

Other Information

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. PubMed ID: 2513129

Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. PubMed ID: 2112242

Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. PubMed ID: 8530030

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. PubMed ID: 16387660

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733