JUNB | ENSG00000171223 | NCBI 3726

Details for: JUNB

Gene ID: 3726

Symbol: JUNB

Ensembl ID: ENSG00000171223

Description: JunB proto-oncogene, AP-1 transcription factor subunit

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Cellular response to calcium ion
(GO:0071277)
Chromatin
(GO:0000785)
Decidualization
(GO:0046697)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic process involved in female pregnancy
(GO:0060136)
Integrated stress response signaling
(GO:0140467)
Labyrinthine layer blood vessel development
(GO:0060716)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Osteoblast proliferation
(GO:0033687)
Osteoclast differentiation
(GO:0030316)
Osteoclast proliferation
(GO:0002158)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of cell population proliferation
(GO:0042127)
Regulation of t-helper 17 cell differentiation
(GO:2000319)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to steroid hormone
(GO:0048545)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription factor ap-1 complex
(GO:0035976)
Transcription regulator complex
(GO:0005667)
Trophectodermal cell differentiation
(GO:0001829)
Vasculogenesis
(GO:0001570)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 837.2485
Cell Significance Index: -130.2300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 552.2517
Cell Significance Index: -140.0800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 386.3841
Cell Significance Index: -159.1700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 365.0151
Cell Significance Index: -148.2900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 331.2487
Cell Significance Index: -156.3900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 311.4203
Cell Significance Index: -160.1900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 232.8537
Cell Significance Index: -156.2500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 156.0106
Cell Significance Index: -148.9500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 117.0521
Cell Significance Index: -144.3200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 39.8120
Cell Significance Index: -157.1000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 39.4992
Cell Significance Index: -121.3200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 17.7888
Cell Significance Index: 314.3500
Cell Name: theca cell (CL0000503)
Fold Change: 14.8544
Cell Significance Index: 87.2700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 10.9046
Cell Significance Index: 312.5900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.6478
Cell Significance Index: -25.8500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 8.8191
Cell Significance Index: 163.0000
Cell Name: odontoblast (CL0000060)
Fold Change: 8.7864
Cell Significance Index: 1126.3700
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 6.3795
Cell Significance Index: 17.0900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 5.9123
Cell Significance Index: 811.9200
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 5.7116
Cell Significance Index: 35.1500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.4568
Cell Significance Index: 148.5300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 5.4448
Cell Significance Index: 69.7300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 5.2475
Cell Significance Index: 391.0900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 5.0048
Cell Significance Index: 235.2200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.6678
Cell Significance Index: 841.4600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 4.5783
Cell Significance Index: 2024.1600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.5774
Cell Significance Index: 562.8300
Cell Name: peg cell (CL4033014)
Fold Change: 3.8107
Cell Significance Index: 88.0400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.7643
Cell Significance Index: 266.2300
Cell Name: granulosa cell (CL0000501)
Fold Change: 3.3235
Cell Significance Index: 87.3900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.2843
Cell Significance Index: 44.8100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.2657
Cell Significance Index: 152.2600
Cell Name: lactocyte (CL0002325)
Fold Change: 3.2654
Cell Significance Index: 421.8700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.3945
Cell Significance Index: 50.1200
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.3914
Cell Significance Index: 1306.0000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.1685
Cell Significance Index: 214.5200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.1619
Cell Significance Index: 113.5100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.7642
Cell Significance Index: 122.0000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6760
Cell Significance Index: 108.1300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.2869
Cell Significance Index: 14.6200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2854
Cell Significance Index: 244.6200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.2130
Cell Significance Index: 11.1700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.0036
Cell Significance Index: 118.3600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.6721
Cell Significance Index: 19.7400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6312
Cell Significance Index: 68.6600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.5780
Cell Significance Index: 65.9800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4954
Cell Significance Index: 932.6900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4066
Cell Significance Index: 367.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1679
Cell Significance Index: 127.0700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1225
Cell Significance Index: 188.5700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1150
Cell Significance Index: 1.9300
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0442
Cell Significance Index: 4.5200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0439
Cell Significance Index: 7.5000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0081
Cell Significance Index: -0.4200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0595
Cell Significance Index: -109.7400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0791
Cell Significance Index: -58.6100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0796
Cell Significance Index: -58.3800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0871
Cell Significance Index: -118.4800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0988
Cell Significance Index: -61.7200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1043
Cell Significance Index: -66.2600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2025
Cell Significance Index: -114.1800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2524
Cell Significance Index: -114.5500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2751
Cell Significance Index: -11.2700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3039
Cell Significance Index: -10.5600
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.3137
Cell Significance Index: -4.4000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3397
Cell Significance Index: -71.5500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.3585
Cell Significance Index: -128.5700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.3815
Cell Significance Index: -76.5300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4029
Cell Significance Index: -20.3600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4783
Cell Significance Index: -137.6100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.5459
Cell Significance Index: -88.7800
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.5577
Cell Significance Index: -8.4700
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.5755
Cell Significance Index: -114.2100
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.6492
Cell Significance Index: -13.5400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6803
Cell Significance Index: -77.9400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6993
Cell Significance Index: -101.6500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7178
Cell Significance Index: -20.0600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.8490
Cell Significance Index: -22.7100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.8709
Cell Significance Index: -23.2600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.9005
Cell Significance Index: -104.9400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.3703
Cell Significance Index: -105.1600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.3724
Cell Significance Index: -142.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.7188
Cell Significance Index: -55.0500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.9059
Cell Significance Index: -48.9900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.9316
Cell Significance Index: -152.9800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.1560
Cell Significance Index: -132.1800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -2.1615
Cell Significance Index: -112.5900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -2.1921
Cell Significance Index: -99.3600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.2246
Cell Significance Index: -140.2100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.3422
Cell Significance Index: -157.4900
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -2.3733
Cell Significance Index: -17.0500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.3819
Cell Significance Index: -35.6900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -2.4492
Cell Significance Index: -150.5400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -2.4999
Cell Significance Index: -150.0800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.6917
Cell Significance Index: -151.0500
Cell Name: kidney cell (CL1000497)
Fold Change: -2.9984
Cell Significance Index: -23.9400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -3.1319
Cell Significance Index: -66.7000
Cell Name: preadipocyte (CL0002334)
Fold Change: -3.1460
Cell Significance Index: -61.4000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -3.4207
Cell Significance Index: -125.5700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.4231
Cell Significance Index: -74.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** The JunB gene is a member of the Jun family of proto-oncogenes, which are characterized by their ability to dimerize with other transcription factors to regulate gene expression. JunB is a transcriptional activator that binds to specific DNA sequences, thereby regulating the expression of target genes involved in immune response, cellular differentiation, and cell proliferation. The JunB protein is highly expressed in various cell types, including immune cells, smooth muscle cells, and cancer cells. **Pathways and Functions:** JunB is involved in several signaling pathways, including: 1. **Cytokine Signaling:** JunB regulates the expression of cytokines involved in immune response, such as IL-4 and IL-13, which are crucial for the differentiation of T-helper 22 cells and the development of allergic responses. 2. **Cellular Response to Calcium Ion:** JunB is involved in the regulation of calcium-dependent signaling pathways, which are essential for cellular differentiation and proliferation. 3. **Chromatin Remodeling:** JunB regulates chromatin remodeling, which is critical for the expression of genes involved in immune response and cellular differentiation. 4. **DNA Binding:** JunB binds to specific DNA sequences, thereby regulating the expression of target genes involved in immune response and cellular differentiation. **Functions:** JunB plays a crucial role in various biological processes, including: 1. **Immune Response:** JunB regulates the expression of cytokines and transcription factors involved in immune response, thereby modulating the activity of immune cells. 2. **Cellular Differentiation:** JunB regulates the expression of genes involved in cellular differentiation, including osteoblast and osteoclast differentiation. 3. **Cell Proliferation:** JunB regulates the expression of genes involved in cell proliferation, including the regulation of the cell cycle and cell population proliferation. 4. **Cancer Progression:** JunB is involved in the regulation of cancer progression, including the regulation of cell proliferation, invasion, and metastasis. **Clinical Significance:** The JunB gene has been implicated in various diseases, including: 1. **Cancer:** JunB is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Allergic Diseases:** JunB is involved in the regulation of allergic responses, including the development of asthma and atopic dermatitis. 3. **Autoimmune Diseases:** JunB is involved in the regulation of autoimmune responses, including the development of rheumatoid arthritis and lupus. 4. **Infectious Diseases:** JunB is involved in the regulation of immune responses to infections, including the development of tuberculosis and HIV. In conclusion, the JunB proto-oncogene is a key regulator of immune response and cellular differentiation. Its dysregulation has been implicated in various diseases, including cancer, allergic diseases, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the role of JunB in these diseases and to develop therapeutic strategies to target JunB for the treatment of these conditions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

JUNB_HUMAN

Genular Protein ID: 1486454004

Symbol: JUNB_HUMAN

Name: N/A

UniProtKB Accession Codes:

P17275 Q96GH3

Database IDs:

Citations:

PubMed ID: 2513129

Title: jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun.

PubMed ID: 2513129

DOI: 10.1016/0092-8674(89)90755-1

PubMed ID: 2112242

Title: Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.

PubMed ID: 2112242

DOI: 10.1093/nar/18.10.3047

PubMed ID: 8530030

Title: Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci.

PubMed ID: 8530030

DOI: 10.1006/geno.1995.1135

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16387660

Title: Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

PubMed ID: 16387660

DOI: 10.1016/j.molcel.2005.11.014

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 347
Mass: 35879
Checksum: DF8CD1CD4409C6BE
Sequence:

MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL KAPGARGPGP 
EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT TTPTPPGQYF YPRGGGSGGG 
AGGAGGGVTE EQEGFADGFV KALDDLHKMN HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP 
VYTNLSSYSP ASASSGGAGA AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK 
EEPQTVPEAR SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV 
KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: JUNB

Associated with

Cells (max top 100)

Other Information

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. PubMed ID: 2513129

Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. PubMed ID: 2112242

Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. PubMed ID: 8530030

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. PubMed ID: 16387660

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733