Details for: SFPQ

Gene ID: 6421

Symbol: SFPQ

Ensembl ID: ENSG00000116560

Description: splicing factor proline and glutamine rich

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 747.3711
    Cell Significance Index: -116.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 458.2812
    Cell Significance Index: -116.2400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 320.1863
    Cell Significance Index: -131.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 286.7158
    Cell Significance Index: -135.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 280.2782
    Cell Significance Index: -113.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 251.1931
    Cell Significance Index: -129.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 202.0425
    Cell Significance Index: -135.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 120.5115
    Cell Significance Index: -115.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 106.1595
    Cell Significance Index: -130.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 46.8931
    Cell Significance Index: -125.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 34.1088
    Cell Significance Index: -134.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 31.5681
    Cell Significance Index: -96.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.7009
    Cell Significance Index: -54.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.5667
    Cell Significance Index: 123.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3649
    Cell Significance Index: 217.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9184
    Cell Significance Index: 137.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.9175
    Cell Significance Index: 76.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7415
    Cell Significance Index: 376.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.7049
    Cell Significance Index: 439.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4875
    Cell Significance Index: 129.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3465
    Cell Significance Index: 288.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1966
    Cell Significance Index: 59.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1940
    Cell Significance Index: 440.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1751
    Cell Significance Index: 62.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1038
    Cell Significance Index: 58.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0218
    Cell Significance Index: 364.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9604
    Cell Significance Index: 110.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9535
    Cell Significance Index: 117.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9307
    Cell Significance Index: 87.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8858
    Cell Significance Index: 241.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8825
    Cell Significance Index: 832.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8424
    Cell Significance Index: 365.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8408
    Cell Significance Index: 1005.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7805
    Cell Significance Index: 51.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5762
    Cell Significance Index: 96.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5354
    Cell Significance Index: 550.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5155
    Cell Significance Index: 178.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4216
    Cell Significance Index: 183.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3845
    Cell Significance Index: 28.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2474
    Cell Significance Index: 862.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2149
    Cell Significance Index: 85.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1332
    Cell Significance Index: 78.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0679
    Cell Significance Index: 964.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0495
    Cell Significance Index: 78.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7163
    Cell Significance Index: 37.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6935
    Cell Significance Index: 75.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6780
    Cell Significance Index: 52.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6308
    Cell Significance Index: 32.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5336
    Cell Significance Index: 11.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4697
    Cell Significance Index: 21.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3914
    Cell Significance Index: 10.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3054
    Cell Significance Index: 58.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2497
    Cell Significance Index: 42.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2243
    Cell Significance Index: 101.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1935
    Cell Significance Index: 122.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1926
    Cell Significance Index: 362.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1183
    Cell Significance Index: 182.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0921
    Cell Significance Index: 169.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0625
    Cell Significance Index: 0.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0471
    Cell Significance Index: 3.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0261
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0148
    Cell Significance Index: 20.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0058
    Cell Significance Index: 4.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0613
    Cell Significance Index: -45.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0846
    Cell Significance Index: -64.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1276
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1342
    Cell Significance Index: -83.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1822
    Cell Significance Index: -102.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1930
    Cell Significance Index: -19.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2911
    Cell Significance Index: -33.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3398
    Cell Significance Index: -71.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3411
    Cell Significance Index: -7.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3629
    Cell Significance Index: -16.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3933
    Cell Significance Index: -113.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3978
    Cell Significance Index: -57.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4225
    Cell Significance Index: -41.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4357
    Cell Significance Index: -7.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6442
    Cell Significance Index: -75.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6687
    Cell Significance Index: -76.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6746
    Cell Significance Index: -25.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7252
    Cell Significance Index: -45.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7547
    Cell Significance Index: -18.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8213
    Cell Significance Index: -9.7900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9082
    Cell Significance Index: -7.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0093
    Cell Significance Index: -13.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0499
    Cell Significance Index: -19.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0791
    Cell Significance Index: -112.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1617
    Cell Significance Index: -29.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.2966
    Cell Significance Index: -38.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.3845
    Cell Significance Index: -35.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4014
    Cell Significance Index: -110.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4705
    Cell Significance Index: -25.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4861
    Cell Significance Index: -31.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.6658
    Cell Significance Index: -58.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9710
    Cell Significance Index: -120.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.9763
    Cell Significance Index: -52.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.0344
    Cell Significance Index: -43.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.1915
    Cell Significance Index: -70.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -2.1980
    Cell Significance Index: -24.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -2.2826
    Cell Significance Index: -21.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Alternative Splicing**: SFPQ is a splicing factor that regulates alternative mRNA splicing via the spliceosome, a complex responsible for the removal of introns and joining of exons in pre-mRNA. 2. **Transcriptional Regulation**: SFPQ binds to specific sequences in the DNA, regulating transcription by RNA polymerase II and other transcription factors. 3. **Protein-Protein Interactions**: SFPQ interacts with various proteins, including histone deacetylases, transcription factors, and non-receptor tyrosine kinases, modulating their activity. 4. **Cell Type-Specific Expression**: SFPQ is highly expressed in immune cells, epithelial cells, and stem cells, indicating its importance in these cell types. **Pathways and Functions** 1. **Activation of Innate Immune Response**: SFPQ regulates the activation of innate immune response by modulating the activity of transcription factors and signaling pathways involved in immune response. 2. **Alternative mRNA Splicing**: SFPQ is involved in the regulation of alternative mRNA splicing via the spliceosome, leading to the production of diverse protein isoforms. 3. **Transcriptional Regulation**: SFPQ regulates transcription by binding to specific sequences in the DNA, influencing the expression of target genes. 4. **Circadian Rhythm Regulation**: SFPQ is involved in the regulation of circadian rhythm, modulating the expression of clock genes and other circadian-related genes. 5. **Apoptosis Suppression**: SFPQ suppresses apoptosis by regulating the activity of pro-apoptotic proteins and promoting the expression of anti-apoptotic genes. **Clinical Significance** 1. **Infectious Diseases**: SFPQ dysregulation has been implicated in infectious diseases, such as tuberculosis, where it may contribute to the evasion of host immune response. 2. **Autoimmune Disorders**: SFPQ may play a role in autoimmune disorders, such as rheumatoid arthritis, where it may contribute to the dysregulation of immune response. 3. **Cancer**: SFPQ expression has been altered in various cancers, suggesting its potential role in tumorigenesis and cancer progression. 4. **Neurological Disorders**: SFPQ may be involved in neurological disorders, such as Alzheimer's disease, where it may contribute to the dysregulation of immune response and neuronal function. In conclusion, SFPQ is a multifunctional gene that plays a critical role in various cellular processes, including alternative mRNA splicing, transcriptional regulation, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of SFPQ in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the functions and clinical significance of SFPQ.

Genular Protein ID: 1869018394

Symbol: SFPQ_HUMAN

Name: Splicing factor, proline- and glutamine-rich

UniProtKB Accession Codes:

P23246 P30808 Q5SZ71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8449401

Title: Cloning and characterization of PSF, a novel pre-mRNA splicing factor.

PubMed ID: 8449401

DOI: 10.1101/gad.7.3.393

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8439294

Title: Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells.

PubMed ID: 8439294

DOI: 10.1042/bj2900267

PubMed ID: 9409622

Title: The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p.

PubMed ID: 9409622

PubMed ID: 2480877

Title: Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody.

PubMed ID: 2480877

DOI: 10.1242/dev.105.4.723

PubMed ID: 9848648

Title: The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor.

PubMed ID: 9848648

DOI: 10.1017/s1355838298981183

PubMed ID: 10653975

Title: Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB.

PubMed ID: 10653975

DOI: 10.1002/(sici)1097-4644(20000315)76:4<559::aid-jcb4>3.3.co;2-l

PubMed ID: 8045264

Title: A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction.

PubMed ID: 8045264

DOI: 10.1002/j.1460-2075.1994.tb06638.x

PubMed ID: 9393982

Title: Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.

PubMed ID: 9393982

DOI: 10.1038/sj.onc.1201394

PubMed ID: 9756848

Title: The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.

PubMed ID: 9756848

DOI: 10.1074/jbc.273.41.26261

PubMed ID: 10858305

Title: PSF/p54(nrb) stimulates 'jumping' of DNA topoisomerase I between separate DNA helices.

PubMed ID: 10858305

DOI: 10.1021/bi992898e

PubMed ID: 10847580

Title: Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response element.

PubMed ID: 10847580

DOI: 10.1210/mend.14.6.0485

PubMed ID: 10931916

Title: Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion.

PubMed ID: 10931916

DOI: 10.1093/nar/28.16.3022

PubMed ID: 11525732

Title: The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.

PubMed ID: 11525732

DOI: 10.1016/s0092-8674(01)00466-4

PubMed ID: 11514619

Title: Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions.

PubMed ID: 11514619

DOI: 10.1091/mbc.12.8.2328

PubMed ID: 11259580

Title: PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.

PubMed ID: 11259580

DOI: 10.1128/mcb.21.7.2298-2311.2001

PubMed ID: 11897684

Title: Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription.

PubMed ID: 11897684

DOI: 10.1210/endo.143.4.8748

PubMed ID: 12403470

Title: PSF and p54nrb bind a conserved stem in U5 snRNA.

PubMed ID: 12403470

DOI: 10.1017/s1355838202022070

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15590677

Title: Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor.

PubMed ID: 15590677

DOI: 10.1074/jbc.m412758200

PubMed ID: 16767080

Title: Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.

PubMed ID: 16767080

DOI: 10.1038/ncb1433

PubMed ID: 17537995

Title: NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma.

PubMed ID: 17537995

DOI: 10.1182/blood-2006-01-028647

PubMed ID: 17965020

Title: The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha.

PubMed ID: 17965020

DOI: 10.1074/jbc.m705286200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18655028

Title: Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins.

PubMed ID: 18655028

DOI: 10.1002/pmic.200800083

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19439179

Title: BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.

PubMed ID: 19439179

DOI: 10.1016/j.cellsig.2009.04.008

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20932480

Title: Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

PubMed ID: 20932480

DOI: 10.1016/j.molcel.2010.09.013

PubMed ID: 20454556

Title: Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis.

PubMed ID: 20454556

DOI: 10.1371/journal.pone.0010474

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21933836

Title: The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.

PubMed ID: 21933836

DOI: 10.1093/hmg/ddr430

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28712728

Title: HEXIM1 and NEAT1 Long non-coding RNA form a multi-subunit complex that regulates DNA-mediated innate immune response.

PubMed ID: 28712728

DOI: 10.1016/j.molcel.2017.06.020

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25765647

Title: The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation.

PubMed ID: 25765647

DOI: 10.1093/nar/gkv156

Sequence Information:

  • Length: 707
  • Mass: 76149
  • Checksum: 6D8D5EA95E235847
  • Sequence:
    • MSRDRFRSRG GGGGGFHRRG GGGGRGGLHD FRSPPPGMGL NQNRGPMGPG PGQSGPKPPI 
PPPPPHQQQQ QPPPQQPPPQ QPPPHQPPPH PQPHQQQQPP PPPQDSSKPV VAQGPGPAPG 
VGSAPPASSS APPATPPTSG APPGSGPGPT PTPPPAVTSA PPGAPPPTPP SSGVPTTPPQ 
AGGPPPPPAA VPGPGPGPKQ GPGPGGPKGG KMPGGPKPGG GPGLSTPGGH PKPPHRGGGE 
PRGGRQHHPP YHQQHHQGPP PGGPGGRSEE KISDSEGFKA NLSLLRRPGE KTYTQRCRLF 
VGNLPADITE DEFKRLFAKY GEPGEVFINK GKGFGFIKLE SRALAEIAKA ELDDTPMRGR 
QLRVRFATHA AALSVRNLSP YVSNELLEEA FSQFGPIERA VVIVDDRGRS TGKGIVEFAS 
KPAARKAFER CSEGVFLLTT TPRPVIVEPL EQLDDEDGLP EKLAQKNPMY QKERETPPRF 
AQHGTFEYEY SQRWKSLDEM EKQQREQVEK NMKDAKDKLE SEMEDAYHEH QANLLRQDLM 
RRQEELRRME ELHNQEMQKR KEMQLRQEEE RRRREEEMMI RQREMEEQMR RQREESYSRM 
GYMDPRERDM RMGGGGAMNM GDPYGSGGQK FPPLGGGGGI GYEANPGVPP ATMSGSMMGS 
DMRTERFGQG GAGPVGGQGP RGMGPGTPAG YGRGREEYEG PNKKPRF

Genular Protein ID: 799024824

Symbol: Q86VG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86VG2

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 IntAct 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 707
  • Mass: 76188
  • Checksum: B5C287EF61FD1811
  • Sequence:
    • MSRDRFRSRG GGGGGFHRRG GGGGRGGLHD FRSPPPGMGL NQNRGPMGPG PGQSGPKPPI 
PPPPPHQQQQ QPPPQQPPPQ QPPPHQPPPH PQPHQQQQPP PPPQDSSKPV VAQGPGPAPG 
VGSTPPASSS APPATPPTSG APPGSGPGPT PTPPPAVTSA PPGAPPPTPP SSGVPTTPPQ 
AGGPPPPPAA VPGPGPGPKQ GPGPGGPKGG KMPGGPKPGG GPGLSTPGGH PKPPRRGGGE 
PRGGRQHHPP YHQQHHQGPP PGGPGGRSEE KISDSEGFKA NLSLLRRPGE KTYTQRCRLF 
VGNLPADITE DEFKRLFAKY GEPGEVFINK GKGFGFIKLE SRALAEIAKA ELDDTPMRGR 
QLRVRFATHA AALSVRNLSP YVSNELLEEA FSQFGPIERA VVIVDDRGRS TGKGIVEFAS 
KPAARKAFER CSEGVFLLTT TPRPVIVEPL EQLDDEDGLP EKLAQKNPMY QKERETPTRF 
AQHGTFEYEY SQRWKSLDEM EKQQREQVEK NMKDAKDKLE SEMEDAYHEH QANLLRQDLM 
RRQEELRRME ELHNQEMQKR KEMQLRQEEE RRRREEEMMI RQREMEDQMR RQREESYSRM 
GYMDPRERDM RMGGGGAMNM GDPYGSGGQK FPPLGGGGGI GYEANPGVPP ATMSGSMMGS 
DMRTERFGQG GAGPVGGQGP RGMGPGTPAG YGRGREEYEG PNKKPRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.