Details for: SCN3A

Gene ID: 6328

Symbol: SCN3A

Ensembl ID: ENSG00000153253

Description: sodium voltage-gated channel alpha subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 158.3325
    Cell Significance Index: -40.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.5965
    Cell Significance Index: -40.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 5.3870
    Cell Significance Index: 129.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.0874
    Cell Significance Index: 251.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.7794
    Cell Significance Index: 167.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.6149
    Cell Significance Index: 243.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.6118
    Cell Significance Index: 136.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.4499
    Cell Significance Index: 75.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7566
    Cell Significance Index: 552.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.6293
    Cell Significance Index: 943.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8976
    Cell Significance Index: 41.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6455
    Cell Significance Index: 1138.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4844
    Cell Significance Index: 42.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3687
    Cell Significance Index: 62.0400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.1952
    Cell Significance Index: 15.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8835
    Cell Significance Index: 49.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8726
    Cell Significance Index: 7.3300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.5654
    Cell Significance Index: 5.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5616
    Cell Significance Index: 507.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5473
    Cell Significance Index: 54.1400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.4820
    Cell Significance Index: 6.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4733
    Cell Significance Index: 11.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3837
    Cell Significance Index: 12.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2737
    Cell Significance Index: 4.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2515
    Cell Significance Index: 40.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2083
    Cell Significance Index: 39.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0992
    Cell Significance Index: 10.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0860
    Cell Significance Index: 1.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0748
    Cell Significance Index: 2.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0036
    Cell Significance Index: 0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0125
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0197
    Cell Significance Index: -14.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0202
    Cell Significance Index: -37.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0240
    Cell Significance Index: -36.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0270
    Cell Significance Index: -36.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0388
    Cell Significance Index: -2.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0483
    Cell Significance Index: -27.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0500
    Cell Significance Index: -36.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0541
    Cell Significance Index: -40.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0557
    Cell Significance Index: -35.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0624
    Cell Significance Index: -28.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0655
    Cell Significance Index: -12.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0728
    Cell Significance Index: -39.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0822
    Cell Significance Index: -17.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1091
    Cell Significance Index: -31.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1162
    Cell Significance Index: -19.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1368
    Cell Significance Index: -19.8800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1387
    Cell Significance Index: -1.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1459
    Cell Significance Index: -10.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1695
    Cell Significance Index: -30.5600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1852
    Cell Significance Index: -1.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1928
    Cell Significance Index: -2.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2027
    Cell Significance Index: -12.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2337
    Cell Significance Index: -4.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2603
    Cell Significance Index: -32.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2864
    Cell Significance Index: -39.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3035
    Cell Significance Index: -39.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3382
    Cell Significance Index: -39.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3452
    Cell Significance Index: -40.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3454
    Cell Significance Index: -39.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3476
    Cell Significance Index: -3.3000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3480
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3566
    Cell Significance Index: -40.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3582
    Cell Significance Index: -36.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3657
    Cell Significance Index: -38.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4095
    Cell Significance Index: -5.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4159
    Cell Significance Index: -8.9900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4162
    Cell Significance Index: -5.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4193
    Cell Significance Index: -10.4600
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.4270
    Cell Significance Index: -4.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4406
    Cell Significance Index: -6.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4679
    Cell Significance Index: -37.0600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4829
    Cell Significance Index: -5.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4994
    Cell Significance Index: -38.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5023
    Cell Significance Index: -6.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5268
    Cell Significance Index: -39.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5474
    Cell Significance Index: -28.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5666
    Cell Significance Index: -19.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6145
    Cell Significance Index: -39.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6191
    Cell Significance Index: -32.2500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6243
    Cell Significance Index: -7.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7153
    Cell Significance Index: -45.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7283
    Cell Significance Index: -18.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7532
    Cell Significance Index: -21.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7814
    Cell Significance Index: -9.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8059
    Cell Significance Index: -16.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8124
    Cell Significance Index: -38.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8221
    Cell Significance Index: -16.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8605
    Cell Significance Index: -40.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.8645
    Cell Significance Index: -17.2400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.8783
    Cell Significance Index: -9.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8914
    Cell Significance Index: -18.9900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.9505
    Cell Significance Index: -12.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.0445
    Cell Significance Index: -25.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0718
    Cell Significance Index: -22.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0860
    Cell Significance Index: -15.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SCN3A is highly expressed in neuronal populations, including Purkinje cells, chromaffin cells, and GABAergic cortical interneurons. It is also present in muscle cells, thymocytes, and certain sensory neurons. 2. **Function:** SCN3A is a critical component of voltage-gated sodium channels, which regulate the influx of sodium ions into cells. This process is essential for the generation of action potentials in neurons and muscle cells. 3. **Subunit Structure:** SCN3A is a transmembrane protein that forms a pore through which sodium ions pass. It interacts with other subunits to form functional sodium channels. 4. **Regulation:** SCN3A is subject to various regulatory mechanisms, including phosphorylation, ubiquitination, and alternative splicing, which modulate its activity and subunit composition. **Pathways and Functions:** 1. **Neuronal Excitability:** SCN3A plays a critical role in regulating neuronal excitability by controlling the influx of sodium ions during action potential generation. 2. **Muscle Contraction:** SCN3A is essential for muscle contraction, as it regulates the influx of sodium ions that triggers muscle depolarization and contraction. 3. **Sensory Perception:** SCN3A is involved in the sensory perception of taste, particularly the detection of sweet, bitter, and umami (glutamate) tastes. 4. **Cardiac Conduction:** SCN3A is expressed in cardiac muscle cells and plays a role in regulating cardiac conduction and rhythm. 5. **Axon Guidance:** SCN3A is involved in axon guidance during neuronal development, influencing the growth and migration of axons. **Clinical Significance:** 1. **Neuromuscular Disorders:** Mutations in SCN3A have been linked to various neuromuscular disorders, including Lambert-Eaton myasthenic syndrome (LEMS) and congenital myasthenic syndrome (CMS). 2. **Cardiac Arrhythmias:** SCN3A mutations have been associated with cardiac arrhythmias, including long QT syndrome and Brugada syndrome. 3. **Sensory Impairment:** SCN3A dysfunction has been implicated in sensory impairment, including taste and olfactory disorders. 4. **Therapeutic Applications:** SCN3A-targeting therapies have been explored for the treatment of neuromuscular and cardiac disorders. In conclusion, SCN3A is a critical component of voltage-gated sodium channels, playing a pivotal role in regulating neuronal excitability, muscle contraction, and sensory perception. Its widespread expression and involvement in various physiological processes highlight the importance of this gene in maintaining normal physiological function. Further research is needed to elucidate the mechanisms underlying SCN3A dysfunction and to develop effective therapeutic strategies for its associated disorders.

Genular Protein ID: 1091718032

Symbol: SCN3A_HUMAN

Name: Sodium channel protein brain III subunit alpha

UniProtKB Accession Codes:

Q9NY46 Q16142 Q53SX0 Q9BZB3 Q9C006 Q9NYK2 Q9P2J1 Q9UPD1 Q9Y6P4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EMBL 44 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 5 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15548568

Title: Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

PubMed ID: 15548568

DOI: 10.1152/ajpcell.00460.2004

PubMed ID: 11245985

Title: Genomic structures of SCN2A and SCN3A -- candidate genes for deafness at the DFNA16 locus.

PubMed ID: 11245985

DOI: 10.1016/s0378-1119(00)00594-1

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 9589372

Title: Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit.

PubMed ID: 9589372

DOI: 10.1007/bf02737087

PubMed ID: 8159690

Title: Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31.

PubMed ID: 8159690

DOI: 10.1073/pnas.91.8.2975

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 24157691

Title: Novel SCN3A variants associated with focal epilepsy in children.

PubMed ID: 24157691

DOI: 10.1016/j.nbd.2013.10.015

PubMed ID: 24497506

Title: A disulfide tether stabilizes the block of sodium channels by the conotoxin muO[section sign]-GVIIJ.

PubMed ID: 24497506

DOI: 10.1073/pnas.1324189111

PubMed ID: 28235671

Title: SCN3A deficiency associated with increased seizure susceptibility.

PubMed ID: 28235671

DOI: 10.1016/j.nbd.2017.02.006

PubMed ID: 29142310

Title: 1.3 is important for enterochromaffin cell excitability and serotonin release.

PubMed ID: 29142310

DOI: 10.1038/s41598-017-15834-3

PubMed ID: 35277491

Title: Structural basis for modulation of human NaV1.3 by clinical drug and selective antagonist.

PubMed ID: 35277491

DOI: 10.1038/s41467-022-28808-5

PubMed ID: 29466837

Title: Mutations in SCN3A cause early infantile epileptic encephalopathy.

PubMed ID: 29466837

DOI: 10.1002/ana.25188

PubMed ID: 12610651

Title: Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

PubMed ID: 12610651

DOI: 10.1038/sj.mp.4001241

PubMed ID: 26566883

Title: Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family.

PubMed ID: 26566883

DOI: 10.1136/jmedgenet-2015-103179

Sequence Information:

  • Length: 2000
  • Mass: 226294
  • Checksum: F754A1C7D49ECB58
  • Sequence:
    • MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK PNSDLEAGKN 
LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVMNKGKAIF RFSATSALYI LTPLNPVRKI 
AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL 
EDFTFLRDPW NWLDFSVIVM AYVTEFVSLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD 
SNGTFVNVTM STFNWKDYIG DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN 
YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL 
AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGIGGLGE 
LLESSSEASK LSSKSAKEWR NRRKKRRQRE HLEGNNKGER DSFPKSESED SVKRSSFLFS 
MDGNRLTSDK KFCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 
FEDSESRRDS LFVPHRHGER RNSNVSQASM SSRMVPGLPA NGKMHSTVDC NGVVSLVGGP 
SALTSPTGQL PPEGTTTETE VRKRRLSSYQ ISMEMLEDSS GRQRAVSIAS ILTNTMEELE 
ESRQKCPPCW YRFANVFLIW DCCDAWLKVK HLVNLIVMDP FVDLAITICI VLNTLFMAME 
HYPMTEQFSS VLTVGNLVFT GIFTAEMVLK IIAMDPYYYF QEGWNIFDGI IVSLSLMELG 
LSNVEGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG 
MQLFGKSYKE CVCKINDDCT LPRWHMNDFF HSFLIVFRVL CGEWIETMWD CMEVAGQTMC 
LIVFMLVMVI GNLVVLNLFL ALLLSSFSSD NLAATDDDNE MNNLQIAVGR MQKGIDYVKN 
KMRECFQKAF FRKPKVIEIH EGNKIDSCMS NNTGIEISKE LNYLRDGNGT TSGVGTGSSV 
EKYVIDENDY MSFINNPSLT VTVPIAVGES DFENLNTEEF SSESELEESK EKLNATSSSE 
GSTVDVVLPR EGEQAETEPE EDLKPEACFT EGCIKKFPFC QVSTEEGKGK IWWNLRKTCY 
SIVEHNWFET FIVFMILLSS GALAFEDIYI EQRKTIKTML EYADKVFTYI FILEMLLKWV 
AYGFQTYFTN AWCWLDFLIV DVSLVSLVAN ALGYSELGAI KSLRTLRALR PLRALSRFEG 
MRVVVNALVG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK FYHCVNMTTG NMFDISDVNN 
LSDCQALGKQ ARWKNVKVNF DNVGAGYLAL LQVATFKGWM DIMYAAVDSR DVKLQPVYEE 
NLYMYLYFVI FIIFGSFFTL NLFIGVIIDN FNQQKKKFGG QDIFMTEEQK KYYNAMKKLG 
SKKPQKPIPR PANKFQGMVF DFVTRQVFDI SIMILICLNM VTMMVETDDQ GKYMTLVLSR 
INLVFIVLFT GEFVLKLVSL RHYYFTIGWN IFDFVVVILS IVGMFLAEMI EKYFVSPTLF 
RVIRLARIGR ILRLIKGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYA IFGMSNFAYV 
KKEAGIDDMF NFETFGNSMI CLFQITTSAG WDGLLAPILN SAPPDCDPDT IHPGSSVKGD 
CGNPSVGIFF FVSYIIISFL VVVNMYIAVI LENFSVATEE SAEPLSEDDF EMFYEVWEKF 
DPDATQFIEF SKLSDFAAAL DPPLLIAKPN KVQLIAMDLP MVSGDRIHCL DILFAFTKRV 
LGESGEMDAL RIQMEDRFMA SNPSKVSYEP ITTTLKRKQE EVSAAIIQRN FRCYLLKQRL 
KNISSNYNKE AIKGRIDLPI KQDMIIDKLN GNSTPEKTDG SSSTTSPPSY DSVTKPDKEK 
FEKDKPEKES KGKEVRENQK

Genular Protein ID: 784561636

Symbol: Q9C007_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9C007

Database IDs:

ARBA 16 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 4 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 1951
  • Mass: 221520
  • Checksum: 99AD4C032CE124AB
  • Sequence:
    • MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK PNSDLEAGKN 
LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVMNKGKAIF RFSATSALYI LTPLNPVRKI 
AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL 
EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD 
SNGTFVNVTM STFNWKDYIG DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN 
YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL 
AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGVGGLGE 
LLESSSEASK LSSKGAKEWR NRRKKRRQRE HLEGNNKGER DSFPKSESED SVKRSSFLFS 
MDGNRLTSDK KFCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 
FEDSESRRDS LFVPHRHGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS SGRQRAVSIA 
SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV KHLVNLIVMD PFVDLAITIC 
IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG 
IIVSLSLMEL GLSNVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL 
AIIVFIFAVV GMQLFGKSYK ECVCKINDDC TLPRWHMNDF FHSFLIVFRV LCGEWIETMW 
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN EMNNLQIAVG 
RMQKGIDYVK NKMRECFQKA FFRKPKVIEI HEGNKIDSCM SNNTGIEISK ELNYLRDGNG 
TTSGVGTGSS VEKYVIDEND YMSFINNPSL TVTVPIAVGE SDFENLNTEE FSSESELEES 
KEKLNATSSS EGSTVDVVLP REGEQAETEP EEDFKPEACF TEGCIKKFPF CQVSTEEGKG 
KIWWNLRKTC YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY 
IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA IKSLRTLRAL 
RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCVNMTT 
GNMFDISDVN NLSDCQALGK QARWKNVKVN FDNVGAGYLA LLQVATFKGW MDIMYAAVDS 
RDVKLQPVYE ENLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ 
KKYYNAMKKL GSKKPQKPIP RPANKFQGMV FDFVTRQVFD ISIMILICLN MVTMMVETDD 
QGKYMTLVLS RINLVFIVLF TGEFVLKLVS LRHYYFTIGW NIFDFVVVIL SIVGMFLAEM 
IEKYSVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY 
AIFGMSNFAY VKKEAGIDDM FNFETFGNSM ICLFQITTSA GWDGLLAPIL NSAPPDCDPD 
TIHPGSSVKG DRGDPSVGIF FFVSYIIISF LVVVNMYIAV ILENFSVATE ESAEPLSEDD 
FEMFYEVWEK FDPDATQFIE FSKLSDFAAA LDPPLLIAKP NKVQLIAMDL PMVSGDRIHC 
LDILFAFTKR VLCESGEMDA LRIQMEDRFM ASNPSKVSYE PITTTLKRKQ EEVSAAIIQR 
NFRCYLLKQR LKNISSNYNK EAIKGRIDLP IKQDMIIDKL NGNSTPEKTD GSSSTTSPPS 
YDSVTKPDKE KFEKDKPEKE SKGKEVRENQ K

Genular Protein ID: 1488547780

Symbol: A0A590UJH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A590UJH3

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 1086
  • Mass: 122988
  • Checksum: EC074B5807F1B193
  • Sequence:
    • MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK PNSDLEAGKN 
LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVMNKGKAIF RFSATSALYI LTPLNPVRKI 
AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL 
EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD 
SNGTFVNVTM STFNWKDYIG DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN 
YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL 
AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGIGGLGE 
LLESSSEASK LSSKSAKEWR NRRKKRRQRE HLEGNNKGER DSFPKSESED SVKRSSFLFS 
MDGNRLTSDK KFCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 
FEDSESRRDS LFVPHRHGER RNSNVSQGTT TETEVRKRRL SSYQISMEML EDSSGRQRAV 
SIASILTNTM EELEESRQKC PPCWYRFANV FLIWDCCDAW LKVKHLVNLI VMDPFVDLAI 
TICIVLNTLF MAMEHYPMTE QFSSVLTVGN LVFTGIFTAE MVLKIIAMDP YYYFQEGWNI 
FDGIIVSLSL MELGLSNVEG LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT 
LVLAIIVFIF AVVGMQLFGK SYKECVCKIN DDCTLPRWHM NDFFHSFLIV FRVLCGEWIE 
TMWDCMEVAG QTMCLIVFML VMVIGNLVVL NLFLALLLSS FSSDNLAATD DDNEMNNLQI 
AVGRMQKGID YVKNKMRECF QKAFFRKPKV IEIHEGNKID SCMSNNTGIE ISKELNYLRD 
GNGTTSGVGT GSSVEKYVID ENDYMSFINN PSLTVTVPIA VGESDFENLN TEEFSSESEL 
EESKEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.