Details for: LIN7A

Gene ID: 8825

Symbol: LIN7A

Ensembl ID: ENSG00000111052

Description: lin-7 homolog A, crumbs cell polarity complex component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 186.1195
    Cell Significance Index: -28.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.6097
    Cell Significance Index: -29.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.4883
    Cell Significance Index: -28.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.3618
    Cell Significance Index: -29.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9706
    Cell Significance Index: -8.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.6383
    Cell Significance Index: 62.3500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.9489
    Cell Significance Index: 22.7300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.5660
    Cell Significance Index: 37.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.4199
    Cell Significance Index: 30.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1908
    Cell Significance Index: 439.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.1872
    Cell Significance Index: 62.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0999
    Cell Significance Index: 416.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.5689
    Cell Significance Index: 105.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2801
    Cell Significance Index: 98.2400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.1885
    Cell Significance Index: 12.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1659
    Cell Significance Index: 19.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0531
    Cell Significance Index: 39.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9317
    Cell Significance Index: 644.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4953
    Cell Significance Index: 21.9100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.2310
    Cell Significance Index: 2.8000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.2107
    Cell Significance Index: 2.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1990
    Cell Significance Index: 37.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1988
    Cell Significance Index: 12.2200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1532
    Cell Significance Index: 1.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1233
    Cell Significance Index: 1.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1137
    Cell Significance Index: 51.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1072
    Cell Significance Index: 38.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0889
    Cell Significance Index: 167.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0773
    Cell Significance Index: 69.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0581
    Cell Significance Index: 7.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0571
    Cell Significance Index: 1.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0554
    Cell Significance Index: 2.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0314
    Cell Significance Index: 5.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0044
    Cell Significance Index: -0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0076
    Cell Significance Index: -14.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0090
    Cell Significance Index: -12.2100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0125
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0230
    Cell Significance Index: -16.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0286
    Cell Significance Index: -21.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0368
    Cell Significance Index: -27.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0370
    Cell Significance Index: -1.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0437
    Cell Significance Index: -24.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0463
    Cell Significance Index: -28.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0479
    Cell Significance Index: -26.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0498
    Cell Significance Index: -22.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0504
    Cell Significance Index: -6.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0588
    Cell Significance Index: -9.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0740
    Cell Significance Index: -10.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0744
    Cell Significance Index: -9.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0759
    Cell Significance Index: -4.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0770
    Cell Significance Index: -22.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0852
    Cell Significance Index: -8.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0853
    Cell Significance Index: -1.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0938
    Cell Significance Index: -9.5800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1074
    Cell Significance Index: -1.3600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1143
    Cell Significance Index: -1.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1266
    Cell Significance Index: -13.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1269
    Cell Significance Index: -26.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1281
    Cell Significance Index: -3.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1538
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1562
    Cell Significance Index: -26.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1659
    Cell Significance Index: -3.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1680
    Cell Significance Index: -5.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1857
    Cell Significance Index: -8.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1881
    Cell Significance Index: -1.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1914
    Cell Significance Index: -24.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1973
    Cell Significance Index: -20.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2010
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2014
    Cell Significance Index: -23.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2074
    Cell Significance Index: -6.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2144
    Cell Significance Index: -24.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2152
    Cell Significance Index: -6.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2218
    Cell Significance Index: -26.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2242
    Cell Significance Index: -3.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2391
    Cell Significance Index: -6.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2415
    Cell Significance Index: -14.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2433
    Cell Significance Index: -16.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2512
    Cell Significance Index: -15.4000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2570
    Cell Significance Index: -3.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2745
    Cell Significance Index: -21.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2916
    Cell Significance Index: -6.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3190
    Cell Significance Index: -16.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3200
    Cell Significance Index: -22.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3428
    Cell Significance Index: -8.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3521
    Cell Significance Index: -8.7800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3718
    Cell Significance Index: -4.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4216
    Cell Significance Index: -26.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4220
    Cell Significance Index: -21.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4273
    Cell Significance Index: -10.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4708
    Cell Significance Index: -10.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4778
    Cell Significance Index: -16.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4791
    Cell Significance Index: -13.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4839
    Cell Significance Index: -10.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5048
    Cell Significance Index: -23.7300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.5149
    Cell Significance Index: -4.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5264
    Cell Significance Index: -4.9900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5318
    Cell Significance Index: -3.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5431
    Cell Significance Index: -25.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LIN7A is a small, cytoplasmic protein that interacts with other Crumbs complex components to regulate cell polarity and synaptic function. Its primary function is to maintain the apical-basal polarity of epithelial cells by regulating the localization of proteins and lipids to the apical surface. LIN7A also interacts with other proteins, such as NMDA receptors, to regulate synaptic function and neurotransmitter release. **Pathways and Functions** LIN7A is involved in several key pathways, including: 1. **Activation of NMDA receptors and postsynaptic events**: LIN7A interacts with NMDA receptors to regulate their assembly and presentation at the postsynaptic density, thereby modulating synaptic function and neurotransmitter release. 2. **Assembly and cell surface presentation of NMDA receptors**: LIN7A is essential for the proper assembly and presentation of NMDA receptors at the cell surface, ensuring proper synaptic transmission. 3. **Maintenance of epithelial cell apical/basal polarity**: LIN7A regulates the localization of proteins and lipids to the apical surface of epithelial cells, maintaining their apical-basal polarity. 4. **Neurotransmitter release cycle**: LIN7A interacts with other proteins to regulate the release of neurotransmitters, such as dopamine, at the presynaptic terminal. **Clinical Significance** Dysregulation of LIN7A has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: LIN7A's role in regulating synaptic function and cell polarity makes it a potential therapeutic target for neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative diseases**: LIN7A's involvement in maintaining epithelial cell polarity and regulating synaptic function may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: LIN7A's role in regulating cell polarity and cell-cell junctions makes it a potential target for cancer therapy, particularly in epithelial-derived cancers. In conclusion, LIN7A is a crucial protein that plays a pivotal role in maintaining cell polarity and regulating synaptic function. Its dysregulation has been implicated in various neurological disorders and cancer, making it a promising therapeutic target for the treatment of these diseases. Further research is needed to fully elucidate the mechanisms by which LIN7A regulates cell polarity and synaptic function, as well as its potential therapeutic applications.

Genular Protein ID: 2077000691

Symbol: LIN7A_HUMAN

Name: Protein lin-7 homolog A

UniProtKB Accession Codes:

O14910 A4FTY3 Q147W1 Q6LES3 Q7LDS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9753324

Title: A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.

PubMed ID: 9753324

DOI: 10.1016/s0092-8674(00)81736-5

PubMed ID: 10341223

Title: Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex.

PubMed ID: 10341223

DOI: 10.1523/jneurosci.19-11-04189.1999

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9482110

Title: The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.

PubMed ID: 9482110

DOI: 10.1038/sj.onc.1201567

PubMed ID: 11311936

Title: VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain.

PubMed ID: 11311936

DOI: 10.1016/s0167-4781(01)00191-9

PubMed ID: 12967566

Title: Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7.

PubMed ID: 12967566

DOI: 10.1016/j.devcel.2003.08.001

PubMed ID: 17237226

Title: The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions.

PubMed ID: 17237226

DOI: 10.1074/jbc.m610002200

Sequence Information:

  • Length: 233
  • Mass: 25997
  • Checksum: D8D05EF16A93BE7B
  • Sequence:
    • MLKPSVTSAP TADMATLTVV QPLTLDRDVA RAIELLEKLQ ESGEVPVHKL QSLKKVLQSE 
FCTAIREVYQ YMHETITVNG CPEFRARATA KATVAAFAAS EGHSHPRVVE LPKTDEGLGF 
NVMGGKEQNS PIYISRIIPG GVAERHGGLK RGDQLLSVNG VSVEGEHHEK AVELLKAAKD 
SVKLVVRYTP KVLEEMEARF EKLRTARRRQ QQQLLIQQQQ QQQQQQTQQN HMS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.