Details for: SLC35F1

Gene ID: 222553

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SLC35F1

Ensembl ID: ENSG00000196376

Description: solute carrier family 35 member F1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 49.78
    rCSI 61.93%
    PRS 96.28
  • VIP GABAergic cortical interneuron CL4023016
    CSI 46.26
    rCSI 55.26%
    PRS 96.64
  • sst GABAergic cortical interneuron CL4023017
    CSI 43.69
    rCSI 56.32%
    PRS 97.14
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 40.41
    rCSI 73.42%
    PRS 97.25
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 37.44
    rCSI 62.85%
    PRS 97.05
  • sncg GABAergic cortical interneuron CL4023015
    CSI 37.44
    rCSI 60.2%
    PRS 96.57
  • Bergmann glial cell CL0000644
    CSI 37.26
    rCSI 50.98%
    PRS 97.11
  • oligodendrocyte precursor cell CL0002453
    CSI 35.84
    rCSI 78.87%
    PRS 92.87
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 32.87
    rCSI 58.05%
    PRS 96.73
  • neural crest cell CL0011012
    CSI 32.1
    rCSI 25.37%
    PRS 98.54
  • cardiac neuron CL0010022
    CSI 25.06
    rCSI 80.2%
    PRS 98.73
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 24.71
    rCSI 59.11%
    PRS 95.61
  • astrocyte of the cerebral cortex CL0002605
    CSI 22.36
    rCSI 50.13%
    PRS 96.82
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 21.56
    rCSI 52.39%
    PRS 95.7
  • peripheral nervous system neuron CL2000032
    CSI 21
    rCSI 28.61%
    PRS 97.94
  • glycinergic amacrine cell CL4030028
    CSI 20.18
    rCSI 52.57%
    PRS 96.46
  • renal interstitial pericyte CL1001318
    CSI 20.02
    rCSI 55.18%
    PRS 98.84
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 19.87
    rCSI 25.5%
    PRS 98.23
  • L6b glutamatergic cortical neuron CL4023038
    CSI 19.72
    rCSI 61.64%
    PRS 96.72
  • inhibitory interneuron CL0000498
    CSI 19.65
    rCSI 45.37%
    PRS 96.81
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 19.44
    rCSI 60.8%
    PRS 97.06
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 19.21
    rCSI 63.15%
    PRS 95.19
  • radial glial cell CL0000681
    CSI 18.39
    rCSI 25.54%
    PRS 99.06
  • neuron CL0000540
    CSI 18.32
    rCSI 48.79%
    PRS 94.54
  • rod bipolar cell CL0000751
    CSI 18.24
    rCSI 32.78%
    PRS 97.63
  • cerebral cortex endothelial cell CL1001602
    CSI 18.09
    rCSI 31.3%
    PRS 97.86
  • interneuron CL0000099
    CSI 17.93
    rCSI 35.99%
    PRS 97.95
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 17.73
    rCSI 20.47%
    PRS 97.36
  • macroglial cell CL0000126
    CSI 17.6
    rCSI 45.25%
    PRS 97.68
  • vascular leptomeningeal cell CL4023051
    CSI 16.56
    rCSI 29.03%
    PRS 97.97
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 16.37
    rCSI 58.89%
    PRS 96.08
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 16.24
    rCSI 61.39%
    PRS 96.17
  • retina horizontal cell CL0000745
    CSI 15.69
    rCSI 23.92%
    PRS 98.19
  • retinal ganglion cell CL0000740
    CSI 15.55
    rCSI 34.35%
    PRS 96.7
  • glioblast CL0000030
    CSI 15.37
    rCSI 24.52%
    PRS 97.3
  • neural cell CL0002319
    CSI 15.36
    rCSI 57.95%
    PRS 94.64
  • retinal bipolar neuron CL0000748
    CSI 15.13
    rCSI 28.33%
    PRS 97.07
  • ON-bipolar cell CL0000749
    CSI 14.37
    rCSI 21.36%
    PRS 98.2
  • Schwann cell CL0002573
    CSI 14.09
    rCSI 40.04%
    PRS 98.02
  • cerebral cortex neuron CL0010012
    CSI 14
    rCSI 57.05%
    PRS 96.45
  • cerebellar granule cell CL0001031
    CSI 13.28
    rCSI 19.52%
    PRS 97.34
  • Mueller cell CL0000636
    CSI 11.95
    rCSI 27.26%
    PRS 97.58
  • glutamatergic neuron CL0000679
    CSI 11.16
    rCSI 22.93%
    PRS 94.75
  • enteroglial cell CL4040002
    CSI 10.55
    rCSI 55.45%
    PRS 98.8
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 10.53
    rCSI 62.01%
    PRS 96.26
  • cardiac muscle cell CL0000746
    CSI 10.1
    rCSI 14.49%
    PRS 97
  • GABAergic amacrine cell CL4030027
    CSI 9.98
    rCSI 34.19%
    PRS 94.81
  • mature astrocyte CL0002627
    CSI 9.12
    rCSI 38.78%
    PRS 97.1
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 8.93
    rCSI 19.38%
    PRS 94.81
  • glial cell CL0000125
    CSI 8.71
    rCSI 33.17%
    PRS 96.97
  • invaginating midget bipolar cell CL4033034
    CSI 8.59
    rCSI 50.75%
    PRS 95.21
  • GABAergic neuron CL0000617
    CSI 8.18
    rCSI 27.41%
    PRS 94.53
  • amacrine cell CL0000561
    CSI 8.15
    rCSI 23.62%
    PRS 96.79
  • lung pericyte CL0009089
    CSI 8
    rCSI 21.12%
    PRS 99.5
  • central nervous system neuron CL2000029
    CSI 7.91
    rCSI 58.11%
    PRS 97.1
  • dopaminergic neuron CL0000700
    CSI 7.28
    rCSI 41.13%
    PRS 95.88
  • medium spiny neuron CL1001474
    CSI 6.99
    rCSI 60.22%
    PRS 96.58
  • contractile cell CL0000183
    CSI 6.77
    rCSI 19.97%
    PRS 99.26
  • serotonergic neuron CL0000850
    CSI 6.55
    rCSI 29.25%
    PRS 93.75
  • diffuse bipolar 6 cell CL4033032
    CSI 6.47
    rCSI 34.03%
    PRS 94.5
  • OFFx cell CL4033036
    CSI 5.15
    rCSI 24.24%
    PRS 94.57
  • cerebellar neuron CL1001611
    CSI 5.08
    rCSI 44.66%
    PRS 94.75
  • basket cell CL0000118
    CSI 5.04
    rCSI 31.6%
    PRS 91.59
  • medial ganglionic eminence derived interneuron CL4023063
    CSI 5.04
    rCSI 50.33%
    PRS 79.31
  • regular ventricular cardiac myocyte CL0002131
    CSI 4.89
    rCSI 30.52%
    PRS 97.23
  • H1 horizontal cell CL0004217
    CSI 4.62
    rCSI 18.32%
    PRS 96.52
  • retinal cone cell CL0000573
    CSI 4.34
    rCSI 6.98%
    PRS 96.98
  • ON parasol ganglion cell CL4033052
    CSI 3.79
    rCSI 53.77%
    PRS 96.08
  • diffuse bipolar 1 cell CL4033027
    CSI 3.67
    rCSI 27.6%
    PRS 94.36
  • forebrain radial glial cell CL0013000
    CSI 3.43
    rCSI 11.01%
    PRS 98.94
  • cerebral cortex pyramidal neuron CL4023111
    CSI 3.35
    rCSI 20.65%
    PRS 98.2
  • GABAergic interneuron CL0011005
    CSI 3.24
    rCSI 51.11%
    PRS 98.7
  • elicited macrophage CL0000861
    CSI 3.11
    rCSI 2.86%
    PRS 99.67
  • neural progenitor cell CL0011020
    CSI 3.02
    rCSI 13.29%
    PRS 94.99
  • flat midget bipolar cell CL4033033
    CSI 2.79
    rCSI 19.96%
    PRS 95.17
  • midbrain dopaminergic neuron CL2000097
    CSI 2.77
    rCSI 17.74%
    PRS 96.58
  • starburst amacrine cell CL0004232
    CSI 2.55
    rCSI 21.48%
    PRS 93.32
  • alveolar macrophage CL0000583
    CSI 2.54
    rCSI 4.19%
    PRS 99.22
  • OFF midget ganglion cell CL4033047
    CSI 2.52
    rCSI 51.21%
    PRS 96.22
  • ON midget ganglion cell CL4033046
    CSI 2.33
    rCSI 47.41%
    PRS 96.29
  • H2 horizontal cell CL0004218
    CSI 2.25
    rCSI 11.2%
    PRS 96.87
  • diffuse bipolar 2 cell CL4033028
    CSI 2.24
    rCSI 17.37%
    PRS 95.56
  • direct pathway medium spiny neuron CL4023026
    CSI 2.24
    rCSI 53.59%
    PRS 95.06
  • diffuse bipolar 3b cell CL4033030
    CSI 2.13
    rCSI 14.15%
    PRS 96
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.11
    rCSI 50.92%
    PRS 94.85
  • blood vessel smooth muscle cell CL0019018
    CSI 1.74
    rCSI 14.19%
    PRS 98.94
  • diffuse bipolar 4 cell CL4033031
    CSI 1.64
    rCSI 18.77%
    PRS 92.58

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SLC35F1](/details-gene/222553) is a protein-coding gene located on chromosome 6 that encodes Solute carrier family 35 member F1, a transmembrane transporter. Functional annotations and expression data strongly suggest its involvement in molecular transport across membranes, particularly within the central nervous system. Expression analysis reveals that **Overall**, [SLC35F1](/details-gene/222553) is a highly significant marker for various neuronal and glial cell populations, with especially prominent expression in GABAergic cortical interneurons and oligodendrocyte lineage cells. A recent study has identified it as a putative vesicular transporter for UDP-glucose, pointing towards a role in glycobiology and energy metabolism within the synapse ([Link](https://doi.org/10.7554/elife.65417)). ## Cellular Roles and Expression Landscape The expression profile of [SLC35F1](/details-gene/222553) demonstrates a highly specialized role within the nervous system. The gene exhibits its highest significance scores in multiple subtypes of inhibitory interneurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 49.78), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 46.26), and [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 43.69). This consistent high-level expression across diverse interneuron classes suggests a fundamental role in the function or maintenance of inhibitory circuits in the cortex. In addition to its neuronal expression, [SLC35F1](/details-gene/222553) is also a key marker for glial cells, particularly those of the oligodendrocyte lineage. It shows high significance in both [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) (CSI: 40.41) and [oligodendrocyte precursor cell](/details-cell/CL0002453)s (CSI: 35.84). This pattern suggests a potential involvement in the processes of oligodendrocyte development, maturation, or myelination. Significant expression is also noted in other neural cell types such as [Bergmann glial cell](/details-cell/CL0000644)s and [astrocyte of the cerebral cortex](/details-cell/CL0002605), reinforcing its broad importance in CNS cell biology. ## Pathways and Molecular Function The functional annotations for [SLC35F1](/details-gene/222553) are consistent with its identity as a solute carrier. It is associated with the Gene Ontology terms `[transmembrane transport](/details-go/GO:0055085)` and `[transmembrane transporter activity](/details-go/GO:0022857)`. Crucially, its annotated localization to the `[synaptic vesicle membrane](/details-go/GO:0030672)` provides a specific cellular context for its transport function. This localization, combined with its high expression in neurons, strongly implies a role in synaptic transmission. A key study provided direct evidence for this function, demonstrating that [SLC35F1](/details-gene/222553) likely operates as a vesicular transporter for UDP-glucose ([Link](https://doi.org/10.7554/elife.65417)). This function suggests it could be involved in supplying substrate for glycosylation reactions within the synaptic vesicle or in regulating energy metabolism at the presynaptic terminal. ## Research Directions The specific expression pattern and putative function of [SLC35F1](/details-gene/222553) open up several avenues for future research into neurological function and disease. **Proposed Hypotheses:** 1. Given its localization to synaptic vesicles and high expression in inhibitory interneurons, [SLC35F1](/details-gene/222553) is essential for maintaining the metabolic state or signaling capacity of GABAergic synapses. Its transport of UDP-glucose may be a rate-limiting step for the glycosylation of synaptic vesicle proteins, thereby modulating neurotransmitter release dynamics and inhibitory circuit function. 2. The high significance of [SLC35F1](/details-gene/222553) in [oligodendrocyte precursor cell](/details-cell/CL0002453)s suggests it plays a critical role in myelination. The gene may be responsible for transporting UDP-glucose into a cellular compartment essential for synthesizing the complex glycolipids and glycoproteins that constitute the myelin sheath. **Key Experimental Approach:** To test the hypothesis regarding its role in myelination, a conditional knockout of `Slc35f1` could be generated in the oligodendrocyte lineage of mice (e.g., using an *Olig2-Cre* driver). The resulting phenotype could be analyzed for myelination defects using electron microscopy and immunohistochemistry for myelin basic protein (MBP). In vitro, primary oligodendrocyte precursor cells could be isolated from these mice or treated with shRNA against `Slc35f1`. The impact on their differentiation and ability to wrap synthetic nanofibers or co-cultured dorsal root ganglion axons would provide direct evidence of its function in myelin sheath formation. **Therapeutic Potential:** Given its specific role in oligodendrocyte precursors and its potential function in myelination, [SLC35F1](/details-gene/222553) may represent a novel therapeutic target for demyelinating diseases such as multiple sclerosis. A strategy focused on the **activation** or enhancement of its transporter function could potentially promote remyelination by boosting the metabolic and biosynthetic capacity of oligodendrocyte precursor cells. Its restricted expression primarily within the CNS would likely minimize off-target effects, making it an attractive candidate for targeted therapeutic development.

Genular Protein ID: 286973278

Symbol: S35F1_HUMAN

Name: Solute carrier family 35 member F1

UniProtKB Accession Codes:

Q5T1Q4 B4DJ02 E1P564 Q1RMG1 Q4G0U9 Q4G167 Q6N007

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 2 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 34269178

Title: Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose.

PubMed ID: 34269178

DOI: 10.7554/elife.65417

Sequence Information:

  • Length: 408
  • Mass: 45346
  • Checksum: 2E459610FC84ECD8
  • Sequence:
    • MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ RIRKVLNREM 
LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN YILLFLVYTT TLAVRQGEEN 
LLAILRRRWW KYMILGLIDL EANYLVVKAY QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR 
YKAVHFIGIV VCILGMGCMV GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI 
IRTLSRVEFL GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM 
PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL VLYSSTSTYI 
AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE EEPHVRVA