Details for: SRSF2

Gene ID: 6427

Symbol: SRSF2

Ensembl ID: ENSG00000161547

Description: serine and arginine rich splicing factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 464.4308
    Cell Significance Index: -72.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 330.1091
    Cell Significance Index: -83.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 274.2825
    Cell Significance Index: -112.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 235.2697
    Cell Significance Index: -95.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 231.8677
    Cell Significance Index: -109.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 208.3264
    Cell Significance Index: -107.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 163.3031
    Cell Significance Index: -109.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 100.4983
    Cell Significance Index: -95.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 81.4547
    Cell Significance Index: -100.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.4804
    Cell Significance Index: -76.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.2247
    Cell Significance Index: -107.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.6300
    Cell Significance Index: -75.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.1056
    Cell Significance Index: -33.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.8006
    Cell Significance Index: 166.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.2946
    Cell Significance Index: 120.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.1120
    Cell Significance Index: 193.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.1074
    Cell Significance Index: 111.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.9299
    Cell Significance Index: 503.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3645
    Cell Significance Index: 217.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.2769
    Cell Significance Index: 68.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.9306
    Cell Significance Index: 31.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7836
    Cell Significance Index: 207.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6871
    Cell Significance Index: 316.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5624
    Cell Significance Index: 331.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.4182
    Cell Significance Index: 1069.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3437
    Cell Significance Index: 165.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.3164
    Cell Significance Index: 60.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8912
    Cell Significance Index: 1032.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8287
    Cell Significance Index: 48.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7728
    Cell Significance Index: 217.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6498
    Cell Significance Index: 74.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6096
    Cell Significance Index: 290.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5998
    Cell Significance Index: 219.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5841
    Cell Significance Index: 45.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.5061
    Cell Significance Index: 26.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4905
    Cell Significance Index: 295.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4633
    Cell Significance Index: 238.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3258
    Cell Significance Index: 74.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1734
    Cell Significance Index: 34.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0863
    Cell Significance Index: 31.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.0830
    Cell Significance Index: 12.9100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.0554
    Cell Significance Index: 6.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9331
    Cell Significance Index: 48.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8285
    Cell Significance Index: 166.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7955
    Cell Significance Index: 78.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7891
    Cell Significance Index: 41.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7863
    Cell Significance Index: 36.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6725
    Cell Significance Index: 7.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.5198
    Cell Significance Index: 59.3400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4516
    Cell Significance Index: 3.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3625
    Cell Significance Index: 68.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3050
    Cell Significance Index: 275.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2969
    Cell Significance Index: 106.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1575
    Cell Significance Index: 108.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0968
    Cell Significance Index: 16.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0642
    Cell Significance Index: 1.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0479
    Cell Significance Index: 90.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0466
    Cell Significance Index: 35.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0242
    Cell Significance Index: 44.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0122
    Cell Significance Index: 0.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0067
    Cell Significance Index: 4.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0062
    Cell Significance Index: 9.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0141
    Cell Significance Index: -10.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0499
    Cell Significance Index: -67.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0561
    Cell Significance Index: -35.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0569
    Cell Significance Index: -5.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0818
    Cell Significance Index: -37.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1354
    Cell Significance Index: -76.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1453
    Cell Significance Index: -9.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1552
    Cell Significance Index: -16.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1869
    Cell Significance Index: -14.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2283
    Cell Significance Index: -48.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3086
    Cell Significance Index: -7.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3218
    Cell Significance Index: -92.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3451
    Cell Significance Index: -39.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3500
    Cell Significance Index: -11.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3733
    Cell Significance Index: -54.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3879
    Cell Significance Index: -9.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5239
    Cell Significance Index: -7.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5691
    Cell Significance Index: -12.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6303
    Cell Significance Index: -73.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8613
    Cell Significance Index: -52.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8693
    Cell Significance Index: -11.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9580
    Cell Significance Index: -99.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0090
    Cell Significance Index: -26.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0555
    Cell Significance Index: -70.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0626
    Cell Significance Index: -23.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0938
    Cell Significance Index: -86.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.1548
    Cell Significance Index: -60.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.2116
    Cell Significance Index: -11.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3387
    Cell Significance Index: -35.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3649
    Cell Significance Index: -23.3900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.5506
    Cell Significance Index: -12.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.7538
    Cell Significance Index: -22.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7550
    Cell Significance Index: -107.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.7574
    Cell Significance Index: -42.8800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.8511
    Cell Significance Index: -31.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9691
    Cell Significance Index: -87.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.1566
    Cell Significance Index: -63.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine and Arginine-Rich Domain**: SRSF2 contains two distinct domains: a serine-rich domain and an arginine-rich domain. These domains are essential for its RNA-binding properties and interaction with other proteins. 2. **Spliceosome Component**: SRSF2 is a critical component of the spliceosome, a complex that facilitates the removal of introns and the joining of exons in pre-mRNA. It coordinates the assembly and disassembly of the spliceosome to ensure accurate splicing. 3. **Alternative Splicing Regulator**: SRSF2 regulates alternative splicing by interacting with specific RNA sequences and influencing the recruitment of other splicing factors. 4. **RNA Binding**: SRSF2 binds to various RNA sequences, including those involved in alternative splicing, and facilitates the recognition and binding of these sequences by other proteins. **Pathways and Functions** 1. **Alternative Splicing**: SRSF2 regulates alternative splicing by interacting with specific RNA sequences and influencing the recruitment of other splicing factors. 2. **Gene Expression**: SRSF2 plays a crucial role in regulating gene expression by controlling the splicing of pre-mRNA, which affects the translation of messenger RNA into protein. 3. **Immune Response**: SRSF2 is highly expressed in immune cells, such as T cells and natural killer cells, where it plays a critical role in regulating the splicing of genes involved in immune responses. 4. **Cellular Homeostasis**: SRSF2 maintains cellular homeostasis by regulating the splicing of genes involved in cell growth, differentiation, and survival. **Clinical Significance** 1. **Cancer**: Alterations in SRSF2 expression have been observed in various types of cancer, including leukemia, lymphoma, and solid tumors. These alterations can lead to the dysregulation of alternative splicing, resulting in the production of aberrant proteins that contribute to tumorigenesis. 2. **Immune-Mediated Disorders**: SRSF2 has been implicated in the pathogenesis of immune-mediated disorders, such as autoimmune diseases and immune-related cancers. 3. **Spliceosome-Related Disorders**: Mutations in SRSF2 have been associated with spliceosome-related disorders, including myelodysplastic syndromes and lymphomas. 4. **Hematological Malignancies**: SRSF2 expression is often reduced in hematological malignancies, such as acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL), where it plays a critical role in regulating the splicing of genes involved in cell survival and proliferation. In conclusion, SRSF2 is a multifunctional protein that plays a critical role in regulating alternative mRNA splicing, gene expression, and immune responses. Its dysregulation has been implicated in various diseases, including cancer, immune-mediated disorders, and spliceosome-related disorders, highlighting the importance of SRSF2 in maintaining cellular homeostasis and responding to environmental cues.

Genular Protein ID: 2452740727

Symbol: SRSF2_HUMAN

Name: Serine/arginine-rich splicing factor 2

UniProtKB Accession Codes:

Q01130 B3KWD5 B4DN89 H0YG49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1373910

Title: Isolation of a complementary DNA that encodes the mammalian splicing factor SC35.

PubMed ID: 1373910

DOI: 10.1126/science.1373910

PubMed ID: 1557353

Title: A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.

PubMed ID: 1557353

DOI: 10.1073/pnas.89.7.2511

PubMed ID: 8302870

Title: Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor.

PubMed ID: 8302870

DOI: 10.1073/pnas.91.3.932

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1465383

Title: The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene.

PubMed ID: 1465383

DOI: 10.1073/pnas.89.24.11683

PubMed ID: 1577277

Title: SR proteins: a conserved family of pre-mRNA splicing factors.

PubMed ID: 1577277

DOI: 10.1101/gad.6.5.837

PubMed ID: 8261509

Title: Specific interactions between proteins implicated in splice site selection and regulated alternative splicing.

PubMed ID: 8261509

DOI: 10.1016/0092-8674(93)90316-i

PubMed ID: 8361546

Title: Specific commitment of different pre-mRNAs to splicing by single SR proteins.

PubMed ID: 8361546

DOI: 10.1038/365082a0

PubMed ID: 8139654

Title: Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.

PubMed ID: 8139654

DOI: 10.1038/368119a0

PubMed ID: 7543047

Title: The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.

PubMed ID: 7543047

DOI: 10.1002/j.1460-2075.1995.tb07360.x

PubMed ID: 9237760

Title: A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.

PubMed ID: 9237760

DOI: 10.1038/41137

PubMed ID: 9447963

Title: Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.

PubMed ID: 9447963

DOI: 10.1128/mcb.18.2.676

PubMed ID: 10757789

Title: Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

PubMed ID: 10757789

DOI: 10.1128/mcb.20.9.3049-3057.2000

PubMed ID: 11980906

Title: Cyclin L is an RS domain protein involved in pre-mRNA splicing.

PubMed ID: 11980906

DOI: 10.1074/jbc.m202266200

PubMed ID: 14684736

Title: Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.

PubMed ID: 14684736

DOI: 10.1074/jbc.m312895200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19592491

Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

PubMed ID: 19592491

DOI: 10.1074/jbc.m109.026237

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21157427

Title: Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.

PubMed ID: 21157427

DOI: 10.1038/emboj.2010.333

PubMed ID: 21296756

Title: NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo.

PubMed ID: 21296756

DOI: 10.1093/nar/gkq1267

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 221
  • Mass: 25476
  • Checksum: 68121AC4D35714FA
  • Sequence:
    • MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY TKESRGFAFV 
RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH SRRGPPPRRY GGGGYGRRSR 
SPRRRRRSRS RSRSRSRSRS RSRYSRSKSR SRTRSRSRST SKSRSARRSK SKSSSVSRSR 
SRSRSRSRSR SPPPVSKRES KSRSRSKSPP KSPEEEGAVS S

Genular Protein ID: 1257120289

Symbol: Q53FN0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FN0

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 221
  • Mass: 25502
  • Checksum: 68047614D35714FA
  • Sequence:
    • MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY TKESRGFAFV 
RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH SRRGPPPRRY GGGGYGRRSR 
SPRRRRRSRS RSRSRSRSRS RSRYSRSKSR SRTRSRSRST SKSRSARRSK SKSSSVSRSR 
SRSRSRSRSR SPPPVSKRES KSRLRSKSPP KSPEEEGAVS S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.