Details for: HLA B

Gene ID: 3106

Symbol: HLA B

Ensembl ID: ENSG00000234745

Description: major histocompatibility complex, class I, B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 991.2230
    Cell Significance Index: -154.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 466.8760
    Cell Significance Index: -118.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 407.2363
    Cell Significance Index: -167.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 392.9934
    Cell Significance Index: -202.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 390.8306
    Cell Significance Index: -184.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 276.2800
    Cell Significance Index: -185.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 128.6583
    Cell Significance Index: -158.6300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 60.3964
    Cell Significance Index: 161.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 43.2027
    Cell Significance Index: -170.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 39.7727
    Cell Significance Index: -122.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 35.3653
    Cell Significance Index: -77.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 17.9025
    Cell Significance Index: 330.8900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.2174
    Cell Significance Index: 251.2400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 12.9952
    Cell Significance Index: 93.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 11.2812
    Cell Significance Index: 128.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.5598
    Cell Significance Index: 355.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.7520
    Cell Significance Index: 678.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.5601
    Cell Significance Index: 358.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.1840
    Cell Significance Index: 669.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.7337
    Cell Significance Index: 2092.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.6746
    Cell Significance Index: 330.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.8864
    Cell Significance Index: 114.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.6378
    Cell Significance Index: 271.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4077
    Cell Significance Index: 467.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.2122
    Cell Significance Index: 317.7600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.7266
    Cell Significance Index: 23.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.5394
    Cell Significance Index: 325.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1036
    Cell Significance Index: 60.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9856
    Cell Significance Index: 244.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9667
    Cell Significance Index: 354.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.7056
    Cell Significance Index: 194.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3238
    Cell Significance Index: 91.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1257
    Cell Significance Index: 29.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0904
    Cell Significance Index: 595.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0830
    Cell Significance Index: 117.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9755
    Cell Significance Index: 51.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8768
    Cell Significance Index: 23.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5781
    Cell Significance Index: 13.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5368
    Cell Significance Index: 406.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2964
    Cell Significance Index: 56.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0966
    Cell Significance Index: 9.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0254
    Cell Significance Index: -4.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0687
    Cell Significance Index: -129.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0704
    Cell Significance Index: -52.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0716
    Cell Significance Index: -40.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0931
    Cell Significance Index: -171.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1061
    Cell Significance Index: -163.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1308
    Cell Significance Index: -177.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1517
    Cell Significance Index: -111.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1553
    Cell Significance Index: -96.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2274
    Cell Significance Index: -3.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2826
    Cell Significance Index: -56.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2856
    Cell Significance Index: -181.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3189
    Cell Significance Index: -36.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3954
    Cell Significance Index: -179.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4283
    Cell Significance Index: -90.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.4433
    Cell Significance Index: -159.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4452
    Cell Significance Index: -22.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4612
    Cell Significance Index: -23.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5884
    Cell Significance Index: -26.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.6795
    Cell Significance Index: -136.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6871
    Cell Significance Index: -28.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7179
    Cell Significance Index: -18.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7805
    Cell Significance Index: -90.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9538
    Cell Significance Index: -33.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.9725
    Cell Significance Index: -141.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1018
    Cell Significance Index: -35.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1347
    Cell Significance Index: -31.7100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.2892
    Cell Significance Index: -7.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.3813
    Cell Significance Index: -12.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.4261
    Cell Significance Index: -66.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.6321
    Cell Significance Index: -169.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.7250
    Cell Significance Index: -43.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.8454
    Cell Significance Index: -50.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.9155
    Cell Significance Index: -147.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.3979
    Cell Significance Index: -46.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.5096
    Cell Significance Index: -198.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.5955
    Cell Significance Index: -56.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.6081
    Cell Significance Index: -164.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.6305
    Cell Significance Index: -35.8900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -2.7043
    Cell Significance Index: -45.4900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.7940
    Cell Significance Index: -58.2700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.9470
    Cell Significance Index: -59.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.0077
    Cell Significance Index: -184.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -3.0561
    Cell Significance Index: -171.4900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -3.0954
    Cell Significance Index: -53.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.5358
    Cell Significance Index: -52.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -3.5376
    Cell Significance Index: -75.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.8498
    Cell Significance Index: -110.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.9112
    Cell Significance Index: -173.0000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -4.1229
    Cell Significance Index: -24.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.2188
    Cell Significance Index: -154.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -4.2998
    Cell Significance Index: -114.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -4.3517
    Cell Significance Index: -72.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -4.3584
    Cell Significance Index: -112.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -4.4127
    Cell Significance Index: -154.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -4.5678
    Cell Significance Index: -172.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -4.7817
    Cell Significance Index: -68.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -4.7912
    Cell Significance Index: -156.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.8078
    Cell Significance Index: -141.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HLA B gene is a single gene that encodes a protein, HLAB_HUMAN (HLA class I histocompatibility antigen, B alpha chain), which consists of three exons. The HLA B gene is located on chromosome 6p21.3 and is highly polymorphic, resulting in a wide range of allelic variations. This polymorphism allows for the generation of a diverse repertoire of HLA B molecules, which are essential for the recognition of self and non-self antigens by the immune system. **Pathways and Functions** The HLA B gene is involved in several key pathways and functions, including: 1. **Antigen Presentation**: HLA B molecules present endogenous peptides to CD8+ T cells, which are essential for the activation of cytotoxic T cells. 2. **Adaptive Immune Response**: HLA B molecules are involved in the regulation of the adaptive immune response, including the activation of T cells and the production of cytokines. 3. **Viral Infection**: HLA B molecules play a crucial role in the recognition of viral infections, such as SARS-CoV-2, and the activation of immune responses against these pathogens. 4. **Immune Regulation**: HLA B molecules are involved in the regulation of immune responses, including the prevention of autoimmune diseases and the modulation of immune responses to cancer. **Clinical Significance** The HLA B gene has significant clinical implications, including: 1. **Transplantation**: HLA matching is essential for successful organ transplantation, as mismatched HLA molecules can lead to rejection of the transplanted organ. 2. **Vaccine Development**: HLA molecules are involved in the recognition of viral antigens, making them a target for vaccine development. 3. **Autoimmune Diseases**: HLA molecules are involved in the regulation of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cancer**: HLA molecules are involved in the recognition of tumor antigens, making them a target for cancer immunotherapy. In conclusion, the HLA B gene plays a crucial role in the adaptive immune response, and its dysregulation can lead to various diseases. Understanding the function and regulation of the HLA B gene is essential for the development of novel therapeutic strategies for various diseases, including viral infections and autoimmune diseases. **Significantly Expressed Cells** The HLA B gene is expressed on the surface of various cells, including: 1. **Alveolar Capillary Type 1 Endothelial Cells**: These cells are involved in the regulation of immune responses in the lungs. 2. **CD38-Negative Naive B Cells**: These cells are involved in the regulation of the adaptive immune response. 3. **NKp46-Positive Innate Lymphoid Cells**: These cells are involved in the recognition of viral infections. 4. **Human Neutrophils**: These cells are involved in the regulation of immune responses, including the production of cytokines. 5. **Professional Antigen-Presenting Cells**: These cells, such as dendritic cells and macrophages, are involved in the presentation of antigens to T cells. Overall, the HLA B gene is a critical component of the adaptive immune response, and its dysregulation can lead to various diseases. Further research is needed to fully understand the function and regulation of the HLA B gene and its role in various diseases.

Genular Protein ID: 2018360851

Symbol: HLAB_HUMAN

Name: HLA class I histocompatibility antigen, B alpha chain

UniProtKB Accession Codes:

P01889 A0A2I6Q7B5 B0V0B8 G3GN01 O02862 O02956 O02957 O02960 O19555 O19556 O19595 O19615 O19624 O19625 O19627 O19641 O19651 O19675 O19692 O19758 O19779 O19783 O46702 O62897 O62901 O62915 O62917 O62919 O77933 O77959 O78053 O78138 O78160 O78163 O78172 O78173 O78180 O78217 O95730 O98140 P01890 P03989 P10317 P10318 P10319 P10320 P18463 P18464 P18465 P19373 P30460 P30461 P30462 P30463 P30464 P30465 P30466 P30467 P30468 P30469 P30470 P30471 P30472 P30473 P30474 P30475 P30476 P30477 P30478 P30479 P30480 P30481 P30482 P30483 P30484 P30485 P30486 P30487 P30488 P30489 P30490 P30491 P30492 P30493 P30494 P30495 P30496 P30497 P30498 P30513 P30685 P79489 P79490 P79496 P79504 P79523 P79524 P79542 P79555 Q04826

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 87 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 21 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 35 Pumba 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2437025

Title: A transposable epitope of HLA-B7, B40 molecules.

PubMed ID: 2437025

DOI: 10.1007/bf00404425

PubMed ID: 2320591

Title: Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification.

PubMed ID: 2320591

DOI: 10.1073/pnas.87.7.2833

PubMed ID: 1737933

Title: HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha 1-helix.

PubMed ID: 1737933

PubMed ID: 1431115

Title: Distinctive HLA-A,B antigens of black populations formed by interallelic conversion.

PubMed ID: 1431115

PubMed ID: 1385528

Title: Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix.

PubMed ID: 1385528

PubMed ID: 1317015

Title: Unusual HLA-B alleles in two tribes of Brazilian Indians.

PubMed ID: 1317015

DOI: 10.1038/357326a0

PubMed ID: 1362296

Title: The B*4002 allele encodes the B61 antigen: B40* is identical to B61.

PubMed ID: 1362296

DOI: 10.1111/j.1399-0039.1992.tb02053.x

PubMed ID: 1481202

Title: A common Japanese haplotype HLA-A26-Cw3-B61-DR9-DQ3 carries HLA-B*4002.

PubMed ID: 1481202

DOI: 10.1111/j.1399-0039.1992.tb02054.x

PubMed ID: 8423049

Title: Allelic variations clustered in the antigen binding sites of HLA-Bw62 molecules.

PubMed ID: 8423049

DOI: 10.1007/bf00216833

PubMed ID: 8362411

Title: Primary structure shows HLA-B59 to be a hybrid of HLA-B55 and HLA-B51, and not a subtype of HLA-B8.

PubMed ID: 8362411

DOI: 10.1111/j.1399-0039.1993.tb02001.x

PubMed ID: 7517915

Title: HLA-B73: an atypical HLA-B molecule carrying a Bw6-epitope motif variant and a B pocket identical to HLA-B27.

PubMed ID: 7517915

DOI: 10.1007/bf00188185

PubMed ID: 7521976

Title: HLA-B15: a widespread and diverse family of HLA-B alleles.

PubMed ID: 7521976

DOI: 10.1111/j.1399-0039.1994.tb02327.x

PubMed ID: 7524186

Title: The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B alleles.

PubMed ID: 7524186

DOI: 10.1111/j.1399-0039.1994.tb02344.x

PubMed ID: 8547229

Title: Antigenic characteristics and cDNA sequences of HLA-B73.

PubMed ID: 8547229

DOI: 10.1111/j.1744-313x.1995.tb00237.x

PubMed ID: 7558929

Title: Both HLA-B*1301 and B*1302 exist in Asian populations and are associated with different haplotypes.

PubMed ID: 7558929

DOI: 10.1016/0198-8859(94)00120-f

PubMed ID: 8847228

Title: Nucleotide sequence analysis of HLA-B*1523 and B*8101. Dominant alpha-helical motifs produce complex serologic recognition patterns for the HLA-B''DT'' and HLA-B''NM5'' antigens.

PubMed ID: 8847228

DOI: 10.1016/0198-8859(95)00082-f

PubMed ID: 7725307

Title: HLA-B16 antigens: sequence of the ST-16 antigen, further definition of two B38 subtypes and evidence for convergent evolution of B*3902.

PubMed ID: 7725307

DOI: 10.1111/j.1399-0039.1995.tb02410.x

PubMed ID: 8851728

Title: Molecular characterization of the new alleles HLA-B*8101 and B*4407.

PubMed ID: 8851728

DOI: 10.1111/j.1399-0039.1996.tb02527.x

PubMed ID: 8740766

Title: Novel HLA-B alleles, B*8201, B*3515 and B*5106, add to the complexity of serologic identification of HLA types.

PubMed ID: 8740766

DOI: 10.1111/j.1399-0039.1996.tb02538.x

PubMed ID: 8773315

Title: Further molecular diversity in the HLA-B15 group.

PubMed ID: 8773315

DOI: 10.1111/j.1399-0039.1996.tb02553.x

PubMed ID: 10395103

Title: Diversity of HLA-B17 alleles and haplotypes in East Asians and a novel Cw6 allele (Cw*0604) associated with B*5701.

PubMed ID: 10395103

DOI: 10.1034/j.1399-0039.1999.530603.x

PubMed ID: 2995352

Title: The complete primary structure of HLA-Bw58.

PubMed ID: 2995352

DOI: 10.1016/s0021-9258(17)38967-6

PubMed ID: 3011411

Title: Gene conversion-like mechanisms may generate polymorphism in human class I genes.

PubMed ID: 3011411

DOI: 10.1002/j.1460-2075.1986.tb04245.x

PubMed ID: 3489755

Title: Absence of polymorphism between HLA-B27 genomic exon sequences isolated from normal donors and ankylosing spondylitis patients.

PubMed ID: 3489755

PubMed ID: 3257938

Title: Comparison of the structure of HLA-Bw47 to HLA-B13 and its relationship to 21-hydroxylase deficiency.

PubMed ID: 3257938

DOI: 10.1007/bf00376123

PubMed ID: 2788131

Title: The structure of HLA-B35 suggests that it is derived from HLA-Bw58 by two genetic mechanisms.

PubMed ID: 2788131

DOI: 10.1007/bf02421534

PubMed ID: 2714852

Title: Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles.

PubMed ID: 2714852

DOI: 10.1007/bf00352839

PubMed ID: 2715640

Title: Diversity and diversification of HLA-A,B,C alleles.

PubMed ID: 2715640

PubMed ID: 1699887

Title: Allospecificities between HLA-Bw53 and HLA-B35 are generated by substitution of the residues associated with HLA-Bw4/Bw6 public epitopes.

PubMed ID: 1699887

DOI: 10.1007/bf02114973

PubMed ID: 1691230

Title: Allodeterminants and evolution of a novel HLA-B5 CREG antigen, HLA-B SNA.

PubMed ID: 1691230

PubMed ID: 2251138

Title: Nucleotide sequence of an HLA-Bw57 gene.

PubMed ID: 2251138

DOI: 10.1093/nar/18.22.6702

PubMed ID: 8420828

Title: Molecular analysis of HLA-B39 subtypes.

PubMed ID: 8420828

DOI: 10.1007/bf00191887

PubMed ID: 7517584

Title: HLA-B67: a member of the HLA-B16 family that expresses the ME1 epitope.

PubMed ID: 7517584

DOI: 10.1111/j.1399-0039.1994.tb02294.x

PubMed ID: 12622774

Title: Cloning and sequencing full-length HLA-B and -C genes.

PubMed ID: 12622774

DOI: 10.1034/j.1399-0039.2003.610103.x

PubMed ID: 21585707

Title: Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the Chinese Han population.

PubMed ID: 21585707

DOI: 10.1111/j.1744-313x.2011.01016.x

PubMed ID: 21868630

Title: The shaping of modern human immune systems by multiregional admixture with archaic humans.

PubMed ID: 21868630

DOI: 10.1126/science.1209202

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 518865

Title: Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies.

PubMed ID: 518865

DOI: 10.1021/bi00592a030

PubMed ID: 1922338

Title: Identification of self peptides bound to purified HLA-B27.

PubMed ID: 1922338

DOI: 10.1038/353326a0

PubMed ID: 7743181

Title: Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes.

PubMed ID: 7743181

DOI: 10.1016/s0960-9822(95)00039-x

PubMed ID: 8879234

Title: A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B*2705.

PubMed ID: 8879234

DOI: 10.1084/jem.184.4.1585

PubMed ID: 9036970

Title: Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing.

PubMed ID: 9036970

PubMed ID: 9620674

Title: HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.

PubMed ID: 9620674

DOI: 10.1016/s1074-7613(00)80558-0

PubMed ID: 11390610

Title: Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein.

PubMed ID: 11390610

DOI: 10.1128/jvi.75.13.6086-6094.2001

PubMed ID: 12366779

Title: A MAGE-3 peptide presented by HLA-B44 is also recognized by cytolytic T lymphocytes on HLA-B18.

PubMed ID: 12366779

DOI: 10.1034/j.1399-0039.2002.600103.x

PubMed ID: 14978097

Title: Toward a definition of self: proteomic evaluation of the class I peptide repertoire.

PubMed ID: 14978097

DOI: 10.4049/jimmunol.172.5.2944

PubMed ID: 15113903

Title: A mutation in the HLA-B*2705-restricted NP383-391 epitope affects the human influenza A virus-specific cytotoxic T-lymphocyte response in vitro.

PubMed ID: 15113903

DOI: 10.1128/jvi.78.10.5216-5222.2004

PubMed ID: 17251285

Title: Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.

PubMed ID: 17251285

DOI: 10.1128/jvi.02689-06

PubMed ID: 18991276

Title: Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA-B44 supertype.

PubMed ID: 18991276

DOI: 10.1002/eji.200838632

PubMed ID: 18385228

Title: Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.

PubMed ID: 18385228

DOI: 10.1128/jvi.02356-07

PubMed ID: 19139562

Title: Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.

PubMed ID: 19139562

DOI: 10.1172/jci36587

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20356336

Title: Nomenclature for factors of the HLA system, 2010.

PubMed ID: 20356336

DOI: 10.1111/j.1399-0039.2010.01466.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23209413

Title: Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.

PubMed ID: 23209413

DOI: 10.1371/journal.ppat.1003042

PubMed ID: 23749632

Title: HLA peptide length preferences control CD8+ T cell responses.

PubMed ID: 23749632

DOI: 10.4049/jimmunol.1300292

PubMed ID: 26439010

Title: TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst.

PubMed ID: 26439010

DOI: 10.7554/elife.09617

PubMed ID: 25480565

Title: The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope.

PubMed ID: 25480565

DOI: 10.4049/jimmunol.1402542

PubMed ID: 26416272

Title: Mechanistic Basis for Epitope Proofreading in the Peptide-Loading Complex.

PubMed ID: 26416272

DOI: 10.4049/jimmunol.1501515

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28514659

Title: The Intergenic Recombinant HLA-B*46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.

PubMed ID: 28514659

DOI: 10.1016/j.celrep.2017.04.059

PubMed ID: 32887977

Title: Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.

PubMed ID: 32887977

DOI: 10.1038/s41590-020-0782-6

PubMed ID: 34228645

Title: HLA-E-restricted HIV-1-specific CD8+ T cell responses in natural infection.

PubMed ID: 34228645

DOI: 10.1172/jci148979

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 15657948

Title: Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705.

PubMed ID: 15657948

DOI: 10.1002/eji.200425724

PubMed ID: 17057332

Title: Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype.

PubMed ID: 17057332

DOI: 10.1107/s0907444906027636

PubMed ID: 22020283

Title: Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B.

PubMed ID: 22020283

DOI: 10.1038/nature10517

PubMed ID: 24600035

Title: Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01.

PubMed ID: 24600035

DOI: 10.4049/jimmunol.1302667

PubMed ID: 25808313

Title: A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.

PubMed ID: 25808313

DOI: 10.1186/s12977-015-0149-5

PubMed ID: 29531227

Title: Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.

PubMed ID: 29531227

DOI: 10.1038/s41467-018-03321-w

PubMed ID: 11888582

Title: Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir.

PubMed ID: 11888582

DOI: 10.1016/s0140-6736(02)07873-x

PubMed ID: 15603872

Title: HLA-B27 in the Greek Cypriot population: distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707.

PubMed ID: 15603872

DOI: 10.1016/j.humimm.2004.08.177

PubMed ID: 15057820

Title: Medical genetics: a marker for Stevens-Johnson syndrome.

PubMed ID: 15057820

DOI: 10.1038/428486a

PubMed ID: 22286218

Title: Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.

PubMed ID: 22286218

DOI: 10.1038/ng.1076

PubMed ID: 23291587

Title: Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1.

PubMed ID: 23291587

DOI: 10.1038/ng.2520

PubMed ID: 28650991

Title: Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.

PubMed ID: 28650991

DOI: 10.1371/journal.pgen.1006862

Sequence Information:

  • Length: 362
  • Mass: 40460
  • Checksum: 5E5A7BDE031403D6
  • Sequence:
    • MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 
SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR 
RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 
TA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.