Details for: ZNF385D

Gene ID: 79750

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF385D

Ensembl ID: ENSG00000151789

Description: zinc finger protein 385D

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cerebellar granule cell CL0001031
    CSI 57.01
    rCSI 83.8%
    PRS 90.49
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 56.35
    rCSI 70.1%
    PRS 82.97
  • VIP GABAergic cortical interneuron CL4023016
    CSI 53.19
    rCSI 63.53%
    PRS 85.04
  • sst GABAergic cortical interneuron CL4023017
    CSI 52.68
    rCSI 67.91%
    PRS 85.99
  • sncg GABAergic cortical interneuron CL4023015
    CSI 42.27
    rCSI 67.98%
    PRS 85.94
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 38.28
    rCSI 64.25%
    PRS 85.18
  • retina horizontal cell CL0000745
    CSI 33.37
    rCSI 50.87%
    PRS 91.73
  • retinal blood vessel endothelial cell CL0002585
    CSI 30.93
    rCSI 49.39%
    PRS 95.69
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 30.59
    rCSI 54.03%
    PRS 84.54
  • inhibitory interneuron CL0000498
    CSI 25.88
    rCSI 59.74%
    PRS 87.47
  • amacrine cell CL0000561
    CSI 23.94
    rCSI 69.38%
    PRS 87.89
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 22.02
    rCSI 68.86%
    PRS 87.67
  • neuron CL0000540
    CSI 20.49
    rCSI 54.57%
    PRS 84.16
  • L6b glutamatergic cortical neuron CL4023038
    CSI 18.31
    rCSI 57.23%
    PRS 86.06
  • retinal ganglion cell CL0000740
    CSI 17.3
    rCSI 38.21%
    PRS 86.48
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 16.98
    rCSI 64.15%
    PRS 85.22
  • tracheobronchial smooth muscle cell CL0019019
    CSI 16.9
    rCSI 29.8%
    PRS 96.02
  • retinal bipolar neuron CL0000748
    CSI 16.57
    rCSI 31.03%
    PRS 88.17
  • Bergmann glial cell CL0000644
    CSI 16.48
    rCSI 22.55%
    PRS 88.54
  • GABAergic amacrine cell CL4030027
    CSI 15.68
    rCSI 53.7%
    PRS 84.06
  • glioblast CL0000030
    CSI 15.66
    rCSI 24.97%
    PRS 88.33
  • H1 horizontal cell CL0004217
    CSI 15.65
    rCSI 61.99%
    PRS 89.34
  • cardiac muscle cell CL0000746
    CSI 15.51
    rCSI 22.26%
    PRS 87.88
  • Mueller cell CL0000636
    CSI 14.47
    rCSI 33.03%
    PRS 89.44
  • glycinergic amacrine cell CL4030028
    CSI 12.71
    rCSI 33.11%
    PRS 89.34
  • enteric smooth muscle cell CL0002504
    CSI 12.67
    rCSI 18.08%
    PRS 94.13
  • neural cell CL0002319
    CSI 12.47
    rCSI 47.08%
    PRS 82.77
  • GABAergic neuron CL0000617
    CSI 12.41
    rCSI 41.58%
    PRS 83.58
  • interneuron CL0000099
    CSI 12.19
    rCSI 24.48%
    PRS 90.01
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 11.68
    rCSI 13.49%
    PRS 88.05
  • cerebral cortex endothelial cell CL1001602
    CSI 11.59
    rCSI 20.05%
    PRS 90.69
  • H2 horizontal cell CL0004218
    CSI 11.44
    rCSI 56.88%
    PRS 89.84
  • adipocyte CL0000136
    CSI 11.36
    rCSI 14.59%
    PRS 87.8
  • capillary endothelial cell CL0002144
    CSI 11.16
    rCSI 20.45%
    PRS 93.38
  • hematopoietic precursor cell CL0008001
    CSI 10.88
    rCSI 11.2%
    PRS 97.33
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 10.6
    rCSI 9.57%
    PRS 93.32
  • astrocyte of the cerebral cortex CL0002605
    CSI 10.57
    rCSI 23.71%
    PRS 85.34
  • basal cell CL0000646
    CSI 10.38
    rCSI 13.87%
    PRS 91.8
  • retinal rod cell CL0000604
    CSI 10.1
    rCSI 17.81%
    PRS 90.8
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 9.91
    rCSI 14.05%
    PRS 92.87
  • epithelial cell of proximal tubule CL0002306
    CSI 9.8
    rCSI 23.93%
    PRS 89.3
  • ependymal cell CL0000065
    CSI 9.56
    rCSI 19.4%
    PRS 79.87
  • blood vessel endothelial cell CL0000071
    CSI 9.45
    rCSI 19.62%
    PRS 92.88
  • diffuse bipolar 3b cell CL4033030
    CSI 9.23
    rCSI 61.29%
    PRS 88.72
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 8.84
    rCSI 11.34%
    PRS 91.1
  • hematopoietic stem cell CL0000037
    CSI 8.73
    rCSI 5.8%
    PRS 95.09
  • vascular leptomeningeal cell CL4023051
    CSI 8.73
    rCSI 15.3%
    PRS 92.07
  • cardiac endothelial cell CL0010008
    CSI 8.68
    rCSI 35%
    PRS 94.78
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 8.04
    rCSI 47.36%
    PRS 85.46
  • diffuse bipolar 2 cell CL4033028
    CSI 7.99
    rCSI 61.91%
    PRS 87.69
  • central nervous system neuron CL2000029
    CSI 7.87
    rCSI 57.81%
    PRS 88.48
  • diffuse bipolar 3a cell CL4033029
    CSI 7.7
    rCSI 52.41%
    PRS 87.1
  • glial cell CL0000125
    CSI 7.68
    rCSI 29.24%
    PRS 89.07
  • retinal pigment epithelial cell CL0002586
    CSI 7.54
    rCSI 14.97%
    PRS 91.65
  • smooth muscle cell CL0000192
    CSI 7.49
    rCSI 17.86%
    PRS 89.82
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 7.34
    rCSI 24.14%
    PRS 85.12
  • starburst amacrine cell CL0004232
    CSI 7.19
    rCSI 60.51%
    PRS 82.47
  • contractile cell CL0000183
    CSI 7.19
    rCSI 21.21%
    PRS 94.25
  • vein endothelial cell CL0002543
    CSI 7.1
    rCSI 19.39%
    PRS 95.65
  • mesenchymal cell CL0008019
    CSI 7.06
    rCSI 17.92%
    PRS 90.79
  • mural cell CL0008034
    CSI 7.04
    rCSI 23.85%
    PRS 91.09
  • glutamatergic neuron CL0000679
    CSI 6.99
    rCSI 14.36%
    PRS 84.71
  • skin fibroblast CL0002620
    CSI 6.98
    rCSI 6.01%
    PRS 93.71
  • myofibroblast cell CL0000186
    CSI 6.91
    rCSI 9.57%
    PRS 91.83
  • cerebral cortex neuron CL0010012
    CSI 6.87
    rCSI 28.01%
    PRS 88.38
  • kidney connecting tubule epithelial cell CL1000768
    CSI 6.74
    rCSI 17.09%
    PRS 90.4
  • retinal cone cell CL0000573
    CSI 6.71
    rCSI 10.79%
    PRS 87.94
  • renal interstitial pericyte CL1001318
    CSI 6.66
    rCSI 18.35%
    PRS 92.88
  • mesodermal cell CL0000222
    CSI 6.65
    rCSI 7.98%
    PRS 93.49
  • diffuse bipolar 1 cell CL4033027
    CSI 6.54
    rCSI 49.19%
    PRS 84.64
  • neural crest cell CL0011012
    CSI 6.38
    rCSI 5.05%
    PRS 89.44
  • S cone cell CL0003050
    CSI 6.07
    rCSI 26.67%
    PRS 90.79
  • microcirculation associated smooth muscle cell CL0008035
    CSI 5.99
    rCSI 17.33%
    PRS 93.63
  • endothelial cell of lymphatic vessel CL0002138
    CSI 5.97
    rCSI 11.84%
    PRS 94.55
  • keratocyte CL0002363
    CSI 5.95
    rCSI 14.29%
    PRS 94.68
  • chondrocyte CL0000138
    CSI 5.76
    rCSI 9.16%
    PRS 90.97
  • midbrain dopaminergic neuron CL2000097
    CSI 5.72
    rCSI 36.65%
    PRS 88.63
  • OFF-bipolar cell CL0000750
    CSI 5.7
    rCSI 7.8%
    PRS 92.19
  • regular ventricular cardiac myocyte CL0002131
    CSI 5.66
    rCSI 35.38%
    PRS 89.26
  • vein endothelial cell of respiratory system CL4033008
    CSI 5.55
    rCSI 38.11%
    PRS 96.26
  • medium spiny neuron CL1001474
    CSI 5.42
    rCSI 46.67%
    PRS 88.21
  • basal cell of epidermis CL0002187
    CSI 5.23
    rCSI 9.27%
    PRS 69.47
  • parietal epithelial cell CL1000452
    CSI 4.93
    rCSI 13.17%
    PRS 90.67
  • myoepithelial cell CL0000185
    CSI 4.81
    rCSI 12.18%
    PRS 95.58
  • conjunctival epithelial cell CL1000432
    CSI 4.75
    rCSI 7.25%
    PRS 93.26
  • endothelial cell of venule CL1000414
    CSI 4.37
    rCSI 38.76%
    PRS 96.99
  • dopaminergic neuron CL0000700
    CSI 4.29
    rCSI 24.22%
    PRS 85.95
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 4.27
    rCSI 7.75%
    PRS 89.62
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 4.13
    rCSI 9.88%
    PRS 86.27
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 4.01
    rCSI 9.65%
    PRS 98.03
  • serotonergic neuron CL0000850
    CSI 3.92
    rCSI 17.51%
    PRS 82.12
  • neural progenitor cell CL0011020
    CSI 3.9
    rCSI 17.14%
    PRS 85.26
  • ON parasol ganglion cell CL4033052
    CSI 3.78
    rCSI 53.62%
    PRS 88.12
  • flat midget bipolar cell CL4033033
    CSI 3.65
    rCSI 26.11%
    PRS 85.96
  • ON-bipolar cell CL0000749
    CSI 3.63
    rCSI 5.4%
    PRS 92.74
  • stromal cell CL0000499
    CSI 3.63
    rCSI 10.22%
    PRS 91.27
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.58
    rCSI 8.69%
    PRS 83.1
  • fibroblast of cardiac tissue CL0002548
    CSI 3.51
    rCSI 16.8%
    PRS 95.01
  • cerebellar neuron CL1001611
    CSI 3.49
    rCSI 30.71%
    PRS 84.25
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.47
    rCSI 8.97%
    PRS 92.55
  • mesenchymal stem cell CL0000134
    CSI 0.3
    rCSI 3.7%
    PRS 95.5%
  • cone retinal bipolar cell CL0000752
    CSI 0.7
    rCSI 8.6%
    PRS 90.4%
  • diffuse bipolar 4 cell CL4033031
    CSI 1.0
    rCSI 11.5%
    PRS 83.1%
  • type B pancreatic cell CL0000169
    CSI 1.1
    rCSI 2.5%
    PRS 94.1%
  • diffuse bipolar 6 cell CL4033032
    CSI 1.6
    rCSI 8.3%
    PRS 85.7%
  • neuroplacodal cell CL0000032
    CSI 1.6
    rCSI 15.0%
    PRS 90.1%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 1.8
    rCSI 12.6%
    PRS 89.5%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.9
    rCSI 15.0%
    PRS 93.1%
  • endothelial cell of uterus CL0009095
    CSI 1.9
    rCSI 13.7%
    PRS 97.2%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 2.0
    rCSI 48.0%
    PRS 96.2%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.1
    rCSI 50.7%
    PRS 82.7%
  • basket cell CL0000118
    CSI 2.1
    rCSI 13.2%
    PRS 77.6%
  • mesangial cell CL0000650
    CSI 2.2
    rCSI 8.9%
    PRS 97.3%
  • neutrophil CL0000775
    CSI 2.3
    rCSI 12.7%
    PRS 91.8%
  • muscle cell CL0000187
    CSI 2.3
    rCSI 4.8%
    PRS 95.4%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.4
    rCSI 57.7%
    PRS 82.9%
  • melanocyte of skin CL1000458
    CSI 2.4
    rCSI 3.3%
    PRS 69.2%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 2.5
    rCSI 26.9%
    PRS 91.2%
  • hepatocyte CL0000182
    CSI 2.6
    rCSI 4.7%
    PRS 92.7%
  • adventitial cell CL0002503
    CSI 2.7
    rCSI 6.5%
    PRS 95.9%
  • alveolar adventitial fibroblast CL4028006
    CSI 2.8
    rCSI 4.4%
    PRS 95.0%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 2.9
    rCSI 3.5%
    PRS 77.2%
  • eye photoreceptor cell CL0000287
    CSI 3.0
    rCSI 33.3%
    PRS 94.7%
  • macroglial cell CL0000126
    CSI 3.0
    rCSI 7.7%
    PRS 91.0%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 3.1
    rCSI 11.1%
    PRS 83.4%
  • OFF midget ganglion cell CL4033047
    CSI 3.1
    rCSI 62.9%
    PRS 87.8%
  • ON midget ganglion cell CL4033046
    CSI 3.1
    rCSI 63.3%
    PRS 87.3%
  • OFFx cell CL4033036
    CSI 3.2
    rCSI 14.9%
    PRS 85.4%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.3
    rCSI 28.6%
    PRS 89.9%
  • endothelial cell of vascular tree CL0002139
    CSI 3.4
    rCSI 18.4%
    PRS 90.8%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.5
    rCSI 9.0%
    PRS 92.6%
  • cerebellar neuron CL1001611
    CSI 3.5
    rCSI 30.7%
    PRS 84.3%
  • fibroblast of cardiac tissue CL0002548
    CSI 3.5
    rCSI 16.8%
    PRS 95.0%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.6
    rCSI 8.7%
    PRS 83.1%
  • stromal cell CL0000499
    CSI 3.6
    rCSI 10.2%
    PRS 91.3%
  • ON-bipolar cell CL0000749
    CSI 3.6
    rCSI 5.4%
    PRS 92.7%
  • flat midget bipolar cell CL4033033
    CSI 3.7
    rCSI 26.1%
    PRS 86.0%
  • ON parasol ganglion cell CL4033052
    CSI 3.8
    rCSI 53.6%
    PRS 88.1%
  • neural progenitor cell CL0011020
    CSI 3.9
    rCSI 17.1%
    PRS 85.3%
  • serotonergic neuron CL0000850
    CSI 3.9
    rCSI 17.5%
    PRS 82.1%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 4.0
    rCSI 9.7%
    PRS 98.0%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 4.1
    rCSI 9.9%
    PRS 86.3%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 4.3
    rCSI 7.8%
    PRS 89.6%
  • dopaminergic neuron CL0000700
    CSI 4.3
    rCSI 24.2%
    PRS 86.0%
  • endothelial cell of venule CL1000414
    CSI 4.4
    rCSI 38.8%
    PRS 97.0%
  • conjunctival epithelial cell CL1000432
    CSI 4.8
    rCSI 7.3%
    PRS 93.3%
  • myoepithelial cell CL0000185
    CSI 4.8
    rCSI 12.2%
    PRS 95.6%
  • parietal epithelial cell CL1000452
    CSI 4.9
    rCSI 13.2%
    PRS 90.7%
  • basal cell of epidermis CL0002187
    CSI 5.2
    rCSI 9.3%
    PRS 69.5%
  • medium spiny neuron CL1001474
    CSI 5.4
    rCSI 46.7%
    PRS 88.2%
  • vein endothelial cell of respiratory system CL4033008
    CSI 5.6
    rCSI 38.1%
    PRS 96.3%
  • regular ventricular cardiac myocyte CL0002131
    CSI 5.7
    rCSI 35.4%
    PRS 89.3%
  • OFF-bipolar cell CL0000750
    CSI 5.7
    rCSI 7.8%
    PRS 92.2%
  • midbrain dopaminergic neuron CL2000097
    CSI 5.7
    rCSI 36.7%
    PRS 88.6%
  • chondrocyte CL0000138
    CSI 5.8
    rCSI 9.2%
    PRS 91.0%
  • keratocyte CL0002363
    CSI 6.0
    rCSI 14.3%
    PRS 94.7%
  • endothelial cell of lymphatic vessel CL0002138
    CSI 6.0
    rCSI 11.8%
    PRS 94.6%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 6.0
    rCSI 17.3%
    PRS 93.6%
  • S cone cell CL0003050
    CSI 6.1
    rCSI 26.7%
    PRS 90.8%
  • neural crest cell CL0011012
    CSI 6.4
    rCSI 5.1%
    PRS 89.4%
  • diffuse bipolar 1 cell CL4033027
    CSI 6.5
    rCSI 49.2%
    PRS 84.6%
  • mesodermal cell CL0000222
    CSI 6.7
    rCSI 8.0%
    PRS 93.5%
  • renal interstitial pericyte CL1001318
    CSI 6.7
    rCSI 18.4%
    PRS 92.9%
  • retinal cone cell CL0000573
    CSI 6.7
    rCSI 10.8%
    PRS 87.9%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 6.7
    rCSI 17.1%
    PRS 90.4%
  • cerebral cortex neuron CL0010012
    CSI 6.9
    rCSI 28.0%
    PRS 88.4%
  • myofibroblast cell CL0000186
    CSI 6.9
    rCSI 9.6%
    PRS 91.8%
  • skin fibroblast CL0002620
    CSI 7.0
    rCSI 6.0%
    PRS 93.7%
  • glutamatergic neuron CL0000679
    CSI 7.0
    rCSI 14.4%
    PRS 84.7%
  • mural cell CL0008034
    CSI 7.0
    rCSI 23.9%
    PRS 91.1%
  • mesenchymal cell CL0008019
    CSI 7.1
    rCSI 17.9%
    PRS 90.8%
  • vein endothelial cell CL0002543
    CSI 7.1
    rCSI 19.4%
    PRS 95.7%
  • contractile cell CL0000183
    CSI 7.2
    rCSI 21.2%
    PRS 94.3%
  • starburst amacrine cell CL0004232
    CSI 7.2
    rCSI 60.5%
    PRS 82.5%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 7.3
    rCSI 24.1%
    PRS 85.1%
  • smooth muscle cell CL0000192
    CSI 7.5
    rCSI 17.9%
    PRS 89.8%
  • retinal pigment epithelial cell CL0002586
    CSI 7.5
    rCSI 15.0%
    PRS 91.7%
  • glial cell CL0000125
    CSI 7.7
    rCSI 29.2%
    PRS 89.1%
  • diffuse bipolar 3a cell CL4033029
    CSI 7.7
    rCSI 52.4%
    PRS 87.1%
  • central nervous system neuron CL2000029
    CSI 7.9
    rCSI 57.8%
    PRS 88.5%
  • diffuse bipolar 2 cell CL4033028
    CSI 8.0
    rCSI 61.9%
    PRS 87.7%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 8.0
    rCSI 47.4%
    PRS 85.5%
  • cardiac endothelial cell CL0010008
    CSI 8.7
    rCSI 35.0%
    PRS 94.8%
  • vascular leptomeningeal cell CL4023051
    CSI 8.7
    rCSI 15.3%
    PRS 92.1%
  • hematopoietic stem cell CL0000037
    CSI 8.7
    rCSI 5.8%
    PRS 95.1%
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 8.8
    rCSI 11.3%
    PRS 91.1%
  • diffuse bipolar 3b cell CL4033030
    CSI 9.2
    rCSI 61.3%
    PRS 88.7%
  • blood vessel endothelial cell CL0000071
    CSI 9.5
    rCSI 19.6%
    PRS 92.9%
  • ependymal cell CL0000065
    CSI 9.6
    rCSI 19.4%
    PRS 79.9%
  • epithelial cell of proximal tubule CL0002306
    CSI 9.8
    rCSI 23.9%
    PRS 89.3%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 9.9
    rCSI 14.1%
    PRS 92.9%
  • retinal rod cell CL0000604
    CSI 10.1
    rCSI 17.8%
    PRS 90.8%
  • basal cell CL0000646
    CSI 10.4
    rCSI 13.9%
    PRS 91.8%
  • astrocyte of the cerebral cortex CL0002605
    CSI 10.6
    rCSI 23.7%
    PRS 85.3%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 10.6
    rCSI 9.6%
    PRS 93.3%
  • hematopoietic precursor cell CL0008001
    CSI 10.9
    rCSI 11.2%
    PRS 97.3%
  • capillary endothelial cell CL0002144
    CSI 11.2
    rCSI 20.5%
    PRS 93.4%
  • adipocyte CL0000136
    CSI 11.4
    rCSI 14.6%
    PRS 87.8%
  • H2 horizontal cell CL0004218
    CSI 11.4
    rCSI 56.9%
    PRS 89.8%
  • cerebral cortex endothelial cell CL1001602
    CSI 11.6
    rCSI 20.1%
    PRS 90.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZNF385D](/details-gene/79750) is a protein-coding gene located on chromosome 3p24.3 that encodes Zinc Finger Protein 385D. Functional annotations indicate that this protein is localized to the [nucleus](/details-go/GO:0005634) where it likely functions as a transcription factor, based on its predicted roles in [sequence-specific double-stranded dna binding](/details-go/GO:1990837) and [zinc ion binding](/details-go/GO:0008270). **Overall**, expression data reveals that [ZNF385D](/details-gene/79750) is a highly specific marker for various neuronal subtypes within the central nervous system. It shows the highest significance in [cerebellar granule cells](/details-cell/CL0001031) and multiple classes of GABAergic cortical interneurons, suggesting a crucial role in the development, specification, or function of these neural circuits. ## Cellular Roles and Expression Landscape The expression profile of [ZNF385D](/details-gene/79750) strongly points to a specialized function within the nervous system. The gene exhibits its highest significance scores in a distinct set of neuronal populations, establishing it as a key marker for these cell types. **Overall**, the most significant expression is observed in: * **Cerebellar Neurons:** [ZNF385D](/details-gene/79750) is a top marker for [cerebellar granule cells](/details-cell/CL0001031) (CSI: 57.01), which are fundamental to motor learning and coordination. * **Cortical Inhibitory Interneurons:** The gene is highly significant across a broad range of GABAergic interneurons, including [pvalb GABAergic cortical interneurons](/details-cell/CL4023018) (CSI: 56.35), [VIP GABAergic cortical interneurons](/details-cell/CL4023016) (CSI: 53.19), and [sst GABAergic cortical interneurons](/details-cell/CL4023017) (CSI: 52.68). This consistent high expression across multiple inhibitory neuron subtypes suggests a fundamental role in regulating cortical inhibitory tone. * **Retinal Neurons:** Significant expression is also noted in cells critical for visual processing, such as [retina horizontal cells](/details-cell/CL0000745) (CSI: 33.37), [amacrine cells](/details-cell/CL0000561) (CSI: 23.94), and [retinal ganglion cells](/details-cell/CL0000740) (CSI: 17.30). This highly specific expression pattern within diverse neuronal populations involved in sensory processing, cortical computation, and motor control suggests that [ZNF385D](/details-gene/79750) may be a core transcriptional regulator involved in establishing or maintaining the specialized functional identities of these cells. ## Pathways and Molecular Function The functional annotations for [ZNF385D](/details-gene/79750) are consistent with its role as a transcriptional regulator. Its designation as a zinc finger protein, coupled with its annotated molecular functions of [zinc ion binding](/details-go/GO:0008270) and [sequence-specific double-stranded dna binding](/details-go/GO:1990837), strongly supports its classification as a DNA-binding protein. Its localization within the [nucleus](/details-go/GO:0005634) is the expected subcellular compartment for a protein involved in gene regulation. Although not linked to specific Reactome pathways in the provided data, its function as a putative transcription factor in highly specialized neurons suggests it likely orchestrates the expression of gene programs essential for neuronal identity, synaptic connectivity, and neurotransmitter phenotype. For instance, in [pvalb GABAergic cortical interneurons](/details-cell/CL4023018), it may regulate genes involved in fast-spiking behavior and the synthesis of GABA, while in [retinal ganglion cells](/details-cell/CL0000740), it could control genes related to axon guidance and the formation of the optic nerve. These roles are supported by foundational genomic studies that have characterized human cDNAs and the human genome sequence ([Link](https://doi.org/10.1038/ng1285), [Link](https://doi.org/10.1038/nature03001)). ## Research Directions The specific expression of [ZNF385D](/details-gene/79750) in discrete neuronal populations, particularly inhibitory interneurons, positions it as a gene of interest for neurological and psychiatric disorders characterized by excitatory/inhibitory imbalance. ### Proposed Hypotheses 1. **[ZNF385D](/details-gene/79750) is a master regulator of cortical interneuron identity and function.** Its loss or dysregulation during neurodevelopment could lead to improperly specified interneuron subtypes, resulting in circuit hyperexcitability and predisposing individuals to conditions such as epilepsy or schizophrenia. 2. **The gene plays a critical role in the maintenance of mature neuronal phenotypes.** In the adult brain, downregulation of [ZNF385D](/details-gene/79750) in response to injury or disease could contribute to neuronal dysfunction or dedifferentiation, potentially exacerbating neurodegenerative processes. ### Experimental Approach To test the hypothesis that [ZNF385D](/details-gene/79750) is a master regulator of interneuron identity, a compelling experiment would involve its conditional knockout in the developing mouse brain. One could use a Cre-Lox system with a driver line specific to interneuron progenitors (e.g., *Nkx2-1*-Cre). The resulting phenotype could be analyzed using a combination of single-cell RNA sequencing (scRNA-seq) on the cortical cells to determine if interneuron subtypes fail to differentiate properly, and *in vivo* two-photon calcium imaging or electrophysiology to assess whether the loss of [ZNF385D](/details-gene/79750) leads to aberrant network activity and a shift in the cortical excitatory/inhibitory balance. ### Therapeutic Potential As an intracellular transcription factor, [ZNF385D](/details-gene/79750) presents a challenging target for traditional small-molecule drugs. However, if its loss-of-function is linked to neurological disorders, it could be a candidate for gene therapy approaches aimed at restoring its expression in affected neuronal populations. Conversely, if its aberrant gain-of-function were identified in a specific disease context, targeted degradation (e.g., using proteolysis-targeting chimeras, or PROTACs) or oligonucleotide-based therapies (e.g., ASOs) to reduce its expression might be viable strategies. Given its highly specific expression profile, therapies targeting [ZNF385D](/details-gene/79750) could potentially offer high cellular specificity with fewer off-target effects compared to broadly acting neuromodulatory drugs.

Genular Protein ID: 2012492750

Symbol: Z385D_HUMAN

Name: Zinc finger protein 385D

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 395
  • Mass: 42296
  • Checksum: D16D251A935776AA
  • Sequence:
  • MRNIMYFGGT CQSPALPALV RPPAPPLQPS LDIKPFLPFP LDTAAAVNLF PNFNAMDPIQ 
    KAVINHTFGV PLPHRRKQII SCNICQLRFN SDSQAAAHYK GTKHAKKLKA LEAMKNKQKS 
    VTAKDSAKTT FTSITTNTIN TSSDKTDGTA GTPAISTTTT VEIRKSSVMT TEITSKVEKS 
    PTTATGNSSC PSTETEEEKA KRLLYCSLCK VAVNSASQLE AHNSGTKHKT MLEARNGSGT 
    IKAFPRAGVK GKGPVNKGNT GLQNKTFHCE ICDVHVNSET QLKQHISSRR HKDRAAGKPP 
    KPKYSPYNKL QKTAHPLGVK LVFSKEPSKP LAPRILPNPL AAAAAAAAVA VSSPFSLRTA 
    PAATLFQTSA LPPALLRPAP GPIRTAHTPV LFAPY

Genular Protein ID: 3976925087

Symbol: A0A2R8YG37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 496
  • Mass: 53364
  • Checksum: 46406217E83ECAF8
  • Sequence:
  • MPGPGRRAAA SRRMKSSVGG RREKLLGAPK AQPSRDFTCV HDGESEAELI PDDFEEKPER 
    EKKHTNFTLC NVCNIQLNSA AQAQIHYNGK SHQKRLKQLS NGTLKNDNGG TCQSPALPAL 
    VRPPAPPLQP SLDIKPFLPF PLDTAAAVNL FPNFNAMDPI QKAVINHTFG VPLPHRRKQI 
    ISCNICQLRF NSDSQAAAHY KGTKHAKKLK ALEAMKNKQK SVTAKDSAKT TFTSITTNTI 
    NTSSDKTDGT AGTPAISTTT TVEIRKSSVM TTEITSKVEK SPTTATGNSS CPSTETEEEK 
    AKRLLYCSLC KVAVNSASQL EAHNSGTKHK TMLEARNGSG TIKAFPRAGV KGKGPVNKGN 
    TGLQNKTFHC EICDVHVNSE TQLKQHISSR RHKDRAAGKP PKPKYSPYNK LQKTAHPLGV 
    KLVFSKEPSK PLAPRILPNP LAAAAAAAAV AVSSPFSLRT APAATLFQTS ALPPALLRPA 
    PGPIRTAHTP VLFAPY

Genular Protein ID: 3806666742

Symbol: A0A994J5P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 515
  • Mass: 55358
  • Checksum: F9785D2F30F34E8B
  • Sequence:
  • MPGPGRRAAA SRRMKSSVGG RREKLLGAPK AQPSRDFTCV HDGESEAELI PDDFEEKPER 
    EKKHTNFTLC NVCNIQLNSA AQAQIHYNGK SHQKRLKQLS NGTLKNDNGG TCQSPALPAL 
    VRPPAPPLQP SLDIKPFLPF PLDTAAAVNL FPNFNAMDPI QKAVINHTFG VPLPHRRKQI 
    ISCNICQLRF NSDSQAAAHY KGTKHAKKLK ALEAMKNKQK SVTAKDSAKT TFTSITTNTI 
    NTSSDKTGGK KGAMKPCGLF LPFCTRDGTA GTPAISTTTT VEIRKSSVMT TEITSKVEKS 
    PTTATGNSSC PSTETEEEKA KRLLYCSLCK VAVNSASQLE AHNSGTKHKT MLEARNGSGT 
    IKAFPRAGVK GKGPVNKGNT GLQNKTFHCE ICDVHVNSET QLKQHISSRR HKDRAAGKPP 
    KPKYSPYNKL QKTAHPLGVK LVFSKEPSKP LAPRILPNPL AAAAAAAAVA VSSPFSLRTA 
    PAATLFQTSA LPPALLRPAP GPIRTAHTPV LFAPY