Details for: MCL1

Gene ID: 4170

Symbol: MCL1

Ensembl ID: ENSG00000143384

Description: MCL1 apoptosis regulator, BCL2 family member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 532.4496
    Cell Significance Index: -82.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 275.8992
    Cell Significance Index: -69.9800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 218.5958
    Cell Significance Index: -90.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 193.9327
    Cell Significance Index: -91.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 180.3512
    Cell Significance Index: -92.7700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 136.1058
    Cell Significance Index: -91.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 69.9214
    Cell Significance Index: -86.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.6569
    Cell Significance Index: -71.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.5844
    Cell Significance Index: -75.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.3527
    Cell Significance Index: -88.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.8628
    Cell Significance Index: -30.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.6558
    Cell Significance Index: 141.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.2540
    Cell Significance Index: 150.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.2955
    Cell Significance Index: 116.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.0773
    Cell Significance Index: 394.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.6593
    Cell Significance Index: 46.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2677
    Cell Significance Index: 59.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1698
    Cell Significance Index: 161.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0543
    Cell Significance Index: 252.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9020
    Cell Significance Index: 89.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8735
    Cell Significance Index: 53.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5067
    Cell Significance Index: 271.6100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.4553
    Cell Significance Index: 8.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4286
    Cell Significance Index: 184.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4006
    Cell Significance Index: 1264.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3804
    Cell Significance Index: 71.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3683
    Cell Significance Index: 604.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3292
    Cell Significance Index: 725.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3288
    Cell Significance Index: 85.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3118
    Cell Significance Index: 28.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1118
    Cell Significance Index: 152.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9280
    Cell Significance Index: 100.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8763
    Cell Significance Index: 30.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7186
    Cell Significance Index: 12.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7143
    Cell Significance Index: 32.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6907
    Cell Significance Index: 18.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6760
    Cell Significance Index: 18.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6063
    Cell Significance Index: 42.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5727
    Cell Significance Index: 56.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5121
    Cell Significance Index: 101.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5113
    Cell Significance Index: 60.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4328
    Cell Significance Index: 20.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3258
    Cell Significance Index: 55.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3046
    Cell Significance Index: 57.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3016
    Cell Significance Index: 20.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0736
    Cell Significance Index: 113.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0259
    Cell Significance Index: 19.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0079
    Cell Significance Index: 1.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0058
    Cell Significance Index: 0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0031
    Cell Significance Index: 5.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0035
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0118
    Cell Significance Index: -1.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0242
    Cell Significance Index: -8.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0472
    Cell Significance Index: -34.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0569
    Cell Significance Index: -36.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0589
    Cell Significance Index: -43.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0602
    Cell Significance Index: -81.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0630
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0656
    Cell Significance Index: -40.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0839
    Cell Significance Index: -58.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1215
    Cell Significance Index: -68.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1227
    Cell Significance Index: -3.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1281
    Cell Significance Index: -3.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1421
    Cell Significance Index: -64.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2453
    Cell Significance Index: -51.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2462
    Cell Significance Index: -18.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2477
    Cell Significance Index: -71.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2878
    Cell Significance Index: -3.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3113
    Cell Significance Index: -50.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3480
    Cell Significance Index: -17.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3938
    Cell Significance Index: -57.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4204
    Cell Significance Index: -2.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4508
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4537
    Cell Significance Index: -51.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4849
    Cell Significance Index: -56.5100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7946
    Cell Significance Index: -4.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8014
    Cell Significance Index: -83.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8228
    Cell Significance Index: -51.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8685
    Cell Significance Index: -18.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8717
    Cell Significance Index: -48.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9430
    Cell Significance Index: -49.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9757
    Cell Significance Index: -39.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0081
    Cell Significance Index: -79.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0150
    Cell Significance Index: -19.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0269
    Cell Significance Index: -25.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0915
    Cell Significance Index: -16.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1039
    Cell Significance Index: -67.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1321
    Cell Significance Index: -76.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2067
    Cell Significance Index: -73.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3457
    Cell Significance Index: -43.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4750
    Cell Significance Index: -43.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5154
    Cell Significance Index: -40.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.5925
    Cell Significance Index: -14.6700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -1.7847
    Cell Significance Index: -11.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8459
    Cell Significance Index: -81.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8805
    Cell Significance Index: -48.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.9082
    Cell Significance Index: -46.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9589
    Cell Significance Index: -71.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.9723
    Cell Significance Index: -42.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MCL1 is a long-lived, anti-apoptotic protein that counteracts the pro-apoptotic effects of BAX and BAK, two members of the BCL2 family. Its unique structure, consisting of a BH3-only domain, allows it to interact with BAX and BAK, preventing their oligomerization and activation. This interaction is crucial for preventing cell death in response to DNA damage, stress, and other forms of cellular insult. MCL1 is also involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components, and negative regulation of anoikis, a form of programmed cell death that occurs in response to loss of cell-cell or cell-matrix adhesion. **Pathways and Functions:** MCL1 is involved in various cellular pathways, including: 1. **Apoptosis regulation**: MCL1 counteracts the pro-apoptotic effects of BAX and BAK, preventing cell death in response to DNA damage, stress, and other forms of cellular insult. 2. **Autophagy regulation**: MCL1 interacts with ATG5, a key protein involved in autophagy, and regulates its activity. 3. **Cytokine signaling**: MCL1 interacts with various cytokines, including interleukins, and regulates their signaling pathways. 4. **Cellular homeostasis**: MCL1 maintains cellular homeostasis by regulating the activity of other proteins involved in cell survival and death. 5. **Mitochondrial function**: MCL1 regulates mitochondrial function by interacting with mitochondrial proteins, such as BAX and BAK. **Clinical Significance:** Dysregulation of MCL1 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of MCL1 has been observed in various types of cancer, including leukemia, lymphoma, and solid tumors, where it contributes to cancer cell survival and resistance to chemotherapy. 2. **Autoimmune diseases**: MCL1 has been implicated in autoimmune diseases, such as rheumatoid arthritis, where it contributes to the regulation of immune cell function and survival. 3. **Neurodegenerative diseases**: MCL1 has been shown to play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it contributes to the regulation of neuronal survival and death. In conclusion, MCL1 is a critical regulator of apoptosis and cellular homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which MCL1 regulates cellular processes and to develop therapeutic strategies targeting this gene in the treatment of diseases.

Genular Protein ID: 1429048038

Symbol: MCL1_HUMAN

Name: Induced myeloid leukemia cell differentiation protein Mcl-1

UniProtKB Accession Codes:

Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 ELM 1 EMBL 22 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7682708

Title: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

PubMed ID: 7682708

DOI: 10.1073/pnas.90.8.3516

PubMed ID: 8790944

Title: Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3.

PubMed ID: 8790944

DOI: 10.1247/csf.21.143

PubMed ID: 11130466

Title: Functional analysis of the human MCL-1 gene.

PubMed ID: 11130466

DOI: 10.1007/pl00000728

PubMed ID: 10766760

Title: Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death.

PubMed ID: 10766760

DOI: 10.1074/jbc.m909572199

PubMed ID: 10837489

Title: MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.

PubMed ID: 10837489

DOI: 10.1074/jbc.m909826199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10634649

Title: Acute myeloid leukemia possessing jumping translocation is related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions.

PubMed ID: 10634649

DOI: 10.1016/s0145-2126(99)00137-x

PubMed ID: 15122313

Title: Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

PubMed ID: 15122313

DOI: 10.1038/sj.onc.1207648

PubMed ID: 9671497

Title: Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response.

PubMed ID: 9671497

DOI: 10.1128/mcb.18.8.4883

PubMed ID: 12149273

Title: Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone.

PubMed ID: 12149273

DOI: 10.1074/jbc.m207413200

PubMed ID: 12223490

Title: Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress.

PubMed ID: 12223490

DOI: 10.1074/jbc.m207951200

PubMed ID: 15077116

Title: Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

PubMed ID: 15077116

DOI: 10.1038/ncb1123

PubMed ID: 15241487

Title: MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.

PubMed ID: 15241487

DOI: 10.1038/sj.onc.1207692

PubMed ID: 15989957

Title: Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.

PubMed ID: 15989957

DOI: 10.1016/j.cell.2005.06.009

PubMed ID: 16543145

Title: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.

PubMed ID: 16543145

DOI: 10.1016/j.molcel.2006.02.009

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23024798

Title: Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1.

PubMed ID: 23024798

DOI: 10.1371/journal.pone.0045088

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 35063767

Title: The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein.

PubMed ID: 35063767

DOI: 10.1016/j.bbrc.2022.01.019

PubMed ID: 17389404

Title: Structural insights into the degradation of Mcl-1 induced by BH3 domains.

PubMed ID: 17389404

DOI: 10.1073/pnas.0701297104

PubMed ID: 20562877

Title: The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.

PubMed ID: 20562877

DOI: 10.1038/nchembio.391

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 350
  • Mass: 37337
  • Checksum: D85821AC59275F1F
  • Sequence:
    • MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG GEAGAVIGGS 
AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA PTRRAAPLEE MEAPAADAIM 
SPEEELDGYE PEPLGKRPAV LPLLELVGES GNNTSTDGSL PSTPPPAEEE EDELYRQSLE 
IISRYLREQA TGAKDTKPMG RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE 
DDVKSLSRVM IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR 
TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR

Genular Protein ID: 3589846339

Symbol: A0A087WT64_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WT64

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 197
  • Mass: 21226
  • Checksum: D4F1953A5EEB09D7
  • Sequence:
    • MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATGA KDTKPMGRSG ATSRKALETL 
RRVGDGVQRN HETAFQGMLR KLDIKNEDDV KSLSRVMIHV FSDGVTNWGR IVTLISFGAF 
VAKHLKTINQ ESCIEPLAES ITDVLVRTKR DWLVKQRGWD GFVEFFHVED LEGGIRNVLL 
AFAGVAGVGA GLAYLIR

Genular Protein ID: 1170852192

Symbol: C8YZ26_HUMAN

Name: N/A

UniProtKB Accession Codes:

C8YZ26

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 19683529

Title: MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death.

PubMed ID: 19683529

DOI: 10.1016/j.febslet.2009.08.006

Sequence Information:

  • Length: 197
  • Mass: 21261
  • Checksum: F0C2EC3A54653A2B
  • Sequence:
    • MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATGA KDTKPMGRSG ATSRKALETL 
RRVGDGVQRN HETAFQGMLR RLDIKNEDDV KSLSRVMIHV FSDGVTNWGR IVTLISFGAF 
VAKHLKTINQ ESCIEPLAES ITDVLVRTKR DWLVKQRGWD GFVEFFQVED LEGGIRNVLL 
AFAGVAGVGA GLAYLKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.