Details for: LRP4

Gene ID: 4038

Symbol: LRP4

Ensembl ID: ENSG00000134569

Description: LDL receptor related protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 10.01
    Marker Score: 4490
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 6.04
    Marker Score: 3515
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.72
    Marker Score: 3765
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 4.97
    Marker Score: 1797
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.87
    Marker Score: 13760
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.32
    Marker Score: 74201
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.31
    Marker Score: 27967
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.99
    Marker Score: 1092
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.66
    Marker Score: 1439
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.55
    Marker Score: 54431
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.53
    Marker Score: 1662
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.51
    Marker Score: 6280
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.46
    Marker Score: 2180
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.45
    Marker Score: 1238
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.33
    Marker Score: 2643
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.29
    Marker Score: 998
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.17
    Marker Score: 1510
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.03
    Marker Score: 2528
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.89
    Marker Score: 1055
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.79
    Marker Score: 464
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.78
    Marker Score: 3676
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.75
    Marker Score: 2348
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.69
    Marker Score: 1864
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.68
    Marker Score: 26973
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.68
    Marker Score: 2182
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.59
    Marker Score: 822
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.59
    Marker Score: 1963
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168410
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.27
    Marker Score: 1100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.24
    Marker Score: 4814
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.23
    Marker Score: 313
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.16
    Marker Score: 1400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.12
    Marker Score: 317
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 689
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.07
    Marker Score: 405
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16695
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.05
    Marker Score: 4397.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.04
    Marker Score: 1750
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.02
    Marker Score: 2433
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.98
    Marker Score: 977
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.95
    Marker Score: 459
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.93
    Marker Score: 540
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.91
    Marker Score: 314
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5167
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.85
    Marker Score: 390
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.83
    Marker Score: 445
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.81
    Marker Score: 868
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.79
    Marker Score: 392
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.79
    Marker Score: 238
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.78
    Marker Score: 1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3150
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1519
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.72
    Marker Score: 866
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.7
    Marker Score: 142
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.69
    Marker Score: 218
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.66
    Marker Score: 3530
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.65
    Marker Score: 1047
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.64
    Marker Score: 207
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.64
    Marker Score: 827
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.64
    Marker Score: 905
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.61
    Marker Score: 211
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.6
    Marker Score: 336
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.6
    Marker Score: 407
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.59
    Marker Score: 1669
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.58
    Marker Score: 2399
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.57
    Marker Score: 991
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.56
    Marker Score: 3377
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.56
    Marker Score: 157
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.54
    Marker Score: 626
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.52
    Marker Score: 191
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.51
    Marker Score: 410
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.51
    Marker Score: 874
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.51
    Marker Score: 163
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5
    Marker Score: 146
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.49
    Marker Score: 170
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.47
    Marker Score: 189
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.47
    Marker Score: 490
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.46
    Marker Score: 842
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.46
    Marker Score: 468
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.45
    Marker Score: 477
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.44
    Marker Score: 256
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.44
    Marker Score: 404
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.44
    Marker Score: 316

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Other Information

**Key characteristics:** * LRP4 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in epithelial cells of the lung, prostate, and central nervous system. * It is also expressed in astrocytes, microglia, cardiac myocytes, and retinal cells. **Pathways and functions:** * LRP4 is involved in the regulation of cell migration by binding to specific ligands, such as apolipoprotein B. * It also plays a role in cell adhesion by interacting with cadherins on the cell surface. * LRP4 is involved in the regulation of calcium signaling by binding to calcium ions. * It is also involved in the regulation of Ecm proteoglycans, which are a family of extracellular matrix proteins that are involved in cell adhesion and migration. * LRP4 is involved in the regulation of embryonic digit morphogenesis by binding to Wnt proteins. * It is also involved in the regulation of endocytosis by binding to phosphatidylinositol 3-kinase (PI3K) and the epidermal growth factor receptor (EGFR). * LRP4 is involved in the regulation of protein-protein interactions by binding to other proteins, such as cadherins and Ecm proteins. **Clinical significance:** * Mutations in the LRP4 gene have been linked to a number of human diseases, including atherosclerosis, cancer, and diabetes. * LRP4 is a potential target for therapeutic intervention in these diseases. **Additional information:** * LRP4 is a relatively recently discovered protein, with the first sequence being published in 2000. * It is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. * LRP4 is a promising target for therapeutic intervention in a variety of diseases.

Genular Protein ID: 1569486907

Symbol: LRP4_HUMAN

Name: Low-density lipoprotein receptor-related protein 4

UniProtKB Accession Codes:

O75096 B2RN39 Q4AC85 Q5KTZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 39 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 1 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693030

Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

PubMed ID: 9693030

DOI: 10.1006/geno.1998.5341

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20381006

Title: LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome.

PubMed ID: 20381006

DOI: 10.1016/j.ajhg.2010.03.004

PubMed ID: 21471202

Title: Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.

PubMed ID: 21471202

DOI: 10.1074/jbc.m110.190330

PubMed ID: 24234652

Title: LRP4 third beta-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.

PubMed ID: 24234652

DOI: 10.1093/hmg/ddt578

Sequence Information:

  • Length: 1905
  • Mass: 212045
  • Checksum: A39117C18279F9AA
  • Sequence:
    • MRRQWGALLL GALLCAHGLA SSPECACGRS HFTCAVSALG ECTCIPAQWQ CDGDNDCGDH 
SDEDGCILPT CSPLDFHCDN GKCIRRSWVC DGDNDCEDDS DEQDCPPREC EEDEFPCQNG 
YCIRSLWHCD GDNDCGDNSD EQCDMRKCSD KEFRCSDGSC IAEHWYCDGD TDCKDGSDEE 
NCPSAVPAPP CNLEEFQCAY GRCILDIYHC DGDDDCGDWS DESDCSSHQP CRSGEFMCDS 
GLCINAGWRC DGDADCDDQS DERNCTTSMC TAEQFRCHSG RCVRLSWRCD GEDDCADNSD 
EENCENTGSP QCALDQFLCW NGRCIGQRKL CNGVNDCGDN SDESPQQNCR PRTGEENCNV 
NNGGCAQKCQ MVRGAVQCTC HTGYRLTEDG HTCQDVNECA EEGYCSQGCT NSEGAFQCWC 
ETGYELRPDR RSCKALGPEP VLLFANRIDI RQVLPHRSEY TLLLNNLENA IALDFHHRRE 
LVFWSDVTLD RILRANLNGS NVEEVVSTGL ESPGGLAVDW VHDKLYWTDS GTSRIEVANL 
DGAHRKVLLW QNLEKPRAIA LHPMEGTIYW TDWGNTPRIE ASSMDGSGRR IIADTHLFWP 
NGLTIDYAGR RMYWVDAKHH VIERANLDGS HRKAVISQGL PHPFAITVFE DSLYWTDWHT 
KSINSANKFT GKNQEIIRNK LHFPMDIHTL HPQRQPAGKN RCGDNNGGCT HLCLPSGQNY 
TCACPTGFRK ISSHACAQSL DKFLLFARRM DIRRISFDTE DLSDDVIPLA DVRSAVALDW 
DSRDDHVYWT DVSTDTISRA KWDGTGQEVV VDTSLESPAG LAIDWVTNKL YWTDAGTDRI 
EVANTDGSMR TVLIWENLDR PRDIVVEPMG GYMYWTDWGA SPKIERAGMD ASGRQVIISS 
NLTWPNGLAI DYGSQRLYWA DAGMKTIEFA GLDGSKRKVL IGSQLPHPFG LTLYGERIYW 
TDWQTKSIQS ADRLTGLDRE TLQENLENLM DIHVFHRRRP PVSTPCAMEN GGCSHLCLRS 
PNPSGFSCTC PTGINLLSDG KTCSPGMNSF LIFARRIDIR MVSLDIPYFA DVVVPINITM 
KNTIAIGVDP QEGKVYWSDS TLHRISRANL DGSQHEDIIT TGLQTTDGLA VDAIGRKVYW 
TDTGTNRIEV GNLDGSMRKV LVWQNLDSPR AIVLYHEMGF MYWTDWGENA KLERSGMDGS 
DRAVLINNNL GWPNGLTVDK ASSQLLWADA HTERIEAADL NGANRHTLVS PVQHPYGLTL 
LDSYIYWTDW QTRSIHRADK GTGSNVILVR SNLPGLMDMQ AVDRAQPLGF NKCGSRNGGC 
SHLCLPRPSG FSCACPTGIQ LKGDGKTCDP SPETYLLFSS RGSIRRISLD TSDHTDVHVP 
VPELNNVISL DYDSVDGKVY YTDVFLDVIR RADLNGSNME TVIGRGLKTT DGLAVDWVAR 
NLYWTDTGRN TIEASRLDGS CRKVLINNSL DEPRAIAVFP RKGYLFWTDW GHIAKIERAN 
LDGSERKVLI NTDLGWPNGL TLDYDTRRIY WVDAHLDRIE SADLNGKLRQ VLVSHVSHPF 
ALTQQDRWIY WTDWQTKSIQ RVDKYSGRNK ETVLANVEGL MDIIVVSPQR QTGTNACGVN 
NGGCTHLCFA RASDFVCACP DEPDSRPCSL VPGLVPPAPR ATGMSEKSPV LPNTPPTTLY 
SSTTRTRTSL EEVEGRCSER DARLGLCARS NDAVPAAPGE GLHISYAIGG LLSILLILVV 
IAALMLYRHK KSKFTDPGMG NLTYSNPSYR TSTQEVKIEA IPKPAMYNQL CYKKEGGPDH 
NYTKEKIKIV EGICLLSGDD AEWDDLKQLR SSRGGLLRDH VCMKTDTVSI QASSGSLDDT 
ETEQLLQEEQ SECSSVHTAA TPERRGSLPD TGWKHERKLS SESQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.