Details for: MGST3

Gene ID: 4259

Symbol: MGST3

Ensembl ID: ENSG00000143198

Description: microsomal glutathione S-transferase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 399.3796
    Cell Significance Index: -101.3000
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 386.1899
    Cell Significance Index: -60.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 283.7011
    Cell Significance Index: -116.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 256.4386
    Cell Significance Index: -104.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 252.0637
    Cell Significance Index: -119.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 220.0296
    Cell Significance Index: -113.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 178.5709
    Cell Significance Index: -119.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 109.8306
    Cell Significance Index: -104.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 81.6169
    Cell Significance Index: -100.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.4863
    Cell Significance Index: -89.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 29.2888
    Cell Significance Index: -115.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.0761
    Cell Significance Index: -77.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.0129
    Cell Significance Index: -43.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.0506
    Cell Significance Index: 159.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.8283
    Cell Significance Index: 155.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.2795
    Cell Significance Index: 199.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.3870
    Cell Significance Index: 177.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0479
    Cell Significance Index: 549.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.9916
    Cell Significance Index: 367.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.8636
    Cell Significance Index: 1563.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.7590
    Cell Significance Index: 195.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.7556
    Cell Significance Index: 48.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.7257
    Cell Significance Index: 25.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3766
    Cell Significance Index: 326.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.1858
    Cell Significance Index: 50.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1361
    Cell Significance Index: 273.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0100
    Cell Significance Index: 403.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8539
    Cell Significance Index: 87.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6819
    Cell Significance Index: 743.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6305
    Cell Significance Index: 210.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5880
    Cell Significance Index: 18.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5302
    Cell Significance Index: 548.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4056
    Cell Significance Index: 38.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3740
    Cell Significance Index: 102.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2474
    Cell Significance Index: 26.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1719
    Cell Significance Index: 61.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1594
    Cell Significance Index: 60.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0861
    Cell Significance Index: 107.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0850
    Cell Significance Index: 83.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0147
    Cell Significance Index: 35.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.5910
    Cell Significance Index: 433.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5791
    Cell Significance Index: 8.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5442
    Cell Significance Index: 108.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5033
    Cell Significance Index: 6.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4847
    Cell Significance Index: 29.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4209
    Cell Significance Index: 71.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2641
    Cell Significance Index: 7.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2459
    Cell Significance Index: 186.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1777
    Cell Significance Index: 11.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1458
    Cell Significance Index: 27.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0675
    Cell Significance Index: 127.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0435
    Cell Significance Index: 19.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0271
    Cell Significance Index: -18.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0366
    Cell Significance Index: -67.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0492
    Cell Significance Index: -5.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0498
    Cell Significance Index: -76.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0516
    Cell Significance Index: -1.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0581
    Cell Significance Index: -36.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0611
    Cell Significance Index: -4.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0798
    Cell Significance Index: -108.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0805
    Cell Significance Index: -50.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0979
    Cell Significance Index: -3.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1444
    Cell Significance Index: -81.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2930
    Cell Significance Index: -61.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3064
    Cell Significance Index: -35.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3452
    Cell Significance Index: -99.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4567
    Cell Significance Index: -66.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4955
    Cell Significance Index: -22.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5501
    Cell Significance Index: -64.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6684
    Cell Significance Index: -76.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6977
    Cell Significance Index: -82.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7358
    Cell Significance Index: -21.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7459
    Cell Significance Index: -6.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7556
    Cell Significance Index: -16.3700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.8288
    Cell Significance Index: -5.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8960
    Cell Significance Index: -25.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9018
    Cell Significance Index: -56.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9213
    Cell Significance Index: -22.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9521
    Cell Significance Index: -64.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9751
    Cell Significance Index: -101.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0733
    Cell Significance Index: -60.2300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.1698
    Cell Significance Index: -9.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1813
    Cell Significance Index: -17.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2147
    Cell Significance Index: -22.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2173
    Cell Significance Index: -31.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.2330
    Cell Significance Index: -85.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2561
    Cell Significance Index: -33.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2948
    Cell Significance Index: -57.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3030
    Cell Significance Index: -22.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.3989
    Cell Significance Index: -83.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4490
    Cell Significance Index: -46.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5713
    Cell Significance Index: -59.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6230
    Cell Significance Index: -43.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.7846
    Cell Significance Index: -45.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.8579
    Cell Significance Index: -36.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9057
    Cell Significance Index: -116.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.9133
    Cell Significance Index: -20.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.2179
    Cell Significance Index: -53.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity:** MGST3 exhibits a broad substrate specificity, conjugating glutathione to a variety of electrophiles, including aflatoxins, arachidonic acid metabolites, and prostanoids. 2. **Oxidative stress resistance:** MGST3 helps protect cells against oxidative stress by detoxifying reactive oxygen species (ROS) and conjugating glutathione to electrophilic compounds, rendering them less reactive. 3. **Endoplasmic reticulum localization:** MGST3 is primarily localized in the endoplasmic reticulum, where it participates in the detoxification of xenobiotics and modulation of cellular signaling pathways. 4. **Interactions with other proteins:** MGST3 interacts with various proteins, including glutathione peroxidases, glutathione transferases, and leucotriene synthases, to modulate cellular defense mechanisms. **Pathways and Functions:** 1. **Aflatoxin activation and detoxification:** MGST3 plays a crucial role in detoxifying aflatoxins, which are potent carcinogens produced by Aspergillus species. The enzyme conjugates aflatoxins with glutathione, rendering them less toxic and more soluble for excretion. 2. **Arachidonic acid metabolic process:** MGST3 modulates the metabolism of arachidonic acid, a polyunsaturated fatty acid involved in inflammation and cellular signaling. 3. **Biological oxidations:** MGST3 participates in the detoxification of various electrophilic compounds, including prostanoids and leukotrienes, which are involved in inflammation and cellular signaling. 4. **Cellular oxidant detoxification:** MGST3 helps protect cells against oxidative stress by conjugating glutathione to ROS and other electrophilic compounds, reducing cellular damage. **Clinical Significance:** 1. **Cancer prevention:** MGST3 may play a role in preventing cancer by detoxifying carcinogenic compounds, including aflatoxins and polycyclic aromatic hydrocarbons. 2. **Neurodegenerative diseases:** MGST3 may be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's, by detoxifying neurotoxic compounds and modulating oxidative stress. 3. **Thyroid disorders:** MGST3 expression in thyroid follicular cells may be affected in thyroid disorders, such as hypothyroidism and hyperthyroidism, highlighting the importance of this enzyme in thyroid function. 4. **Kidney disease:** MGST3 expression in kidney epithelial cells may be affected in kidney disease, such as nephrotic syndrome and chronic kidney disease, highlighting the importance of this enzyme in maintaining renal function. In conclusion, MGST3 is a crucial enzyme in cellular defense mechanisms, playing a significant role in detoxifying xenobiotics, modulating oxidative stress, and participating in various cellular signaling pathways. Further research is needed to fully elucidate the role of MGST3 in human health and disease.

Genular Protein ID: 275128912

Symbol: MGST3_HUMAN

Name: N/A

UniProtKB Accession Codes:

O14880 B2R592 Q6ICN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9278457

Title: Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.

PubMed ID: 9278457

DOI: 10.1074/jbc.272.36.22934

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21044946

Title: Site-specific analysis of protein S-acylation by resin-assisted capture.

PubMed ID: 21044946

DOI: 10.1194/jlr.d011106

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27184847

Title: APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest.

PubMed ID: 27184847

DOI: 10.1016/j.celrep.2016.04.064

PubMed ID: 36370807

Title: Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3.

PubMed ID: 36370807

DOI: 10.1016/j.jlr.2022.100310

Sequence Information:

  • Length: 152
  • Mass: 16516
  • Checksum: B721527247415E78
  • Sequence:
    • MAVLSKEYGF VLLTGAASFI MVAHLAINVS KARKKYKVEY PIMYSTDPEN GHIFNCIQRA 
HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY AYGYYTGEPS KRSRGALGSI 
ALLGLVGTTV CSAFQHLGWV KSGLGSGPKC CH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.