Details for: MBNL1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 93.27rCSI 100%PRS 5.94
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CSI 78.24rCSI 60.28%PRS 4.36
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CSI 75.25rCSI 100%PRS 4.03
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CSI 48.41rCSI 70.14%PRS 7.1
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CSI 47.13rCSI 81.53%PRS 3.7
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CSI 45.68rCSI 30.44%PRS 13.59
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CSI 41.82rCSI 31.64%PRS 6.78
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CSI 39.87rCSI 66.92%PRS 2.91
-
CSI 39.75rCSI 96.6%PRS 2.83
-
CSI 38.36rCSI 100%PRS 5.63
-
CSI 38.06rCSI 61.22%PRS 3.31
-
CSI 35.86rCSI 77.78%PRS 2.33
-
CSI 35.4rCSI 23.53%PRS 5.75
-
CSI 34.86rCSI 52.59%PRS 4.74
-
CSI 33.82rCSI 42.08%PRS 2.65
-
CSI 33.02rCSI 100%PRS 3.86
-
CSI 29.12rCSI 36.59%PRS 25.69
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CSI 28.15rCSI 88.03%PRS 3.38
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CSI 27.46rCSI 98.82%PRS 2.61
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CSI 27.44rCSI 85.75%PRS 3.1
-
CSI 25.15rCSI 81.84%PRS 7.5
-
CSI 23.89rCSI 29.72%PRS 5.15
-
CSI 22.67rCSI 47.97%PRS 10.72
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CSI 22.34rCSI 16.76%PRS 14.6
-
CSI 20.33rCSI 56.03%PRS 5.48
-
CSI 19.39rCSI 73.27%PRS 3.07
-
CSI 19.28rCSI 90.21%PRS 13.22
-
CSI 19.2rCSI 23.27%PRS 7.25
-
CSI 18.74rCSI 44.83%PRS 2.7
-
CSI 18.21rCSI 73.29%PRS 20.24
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CSI 18.06rCSI 21.57%PRS 2.88
-
CSI 17.71rCSI 22.23%PRS 6.13
-
CSI 17.64rCSI 42.42%PRS 7.51
-
CSI 17.4rCSI 50.38%PRS 5.47
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CSI 16.88rCSI 11.37%PRS 5.86
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CSI 16.83rCSI 53.85%PRS 3.5
-
CSI 16.56rCSI 54.41%PRS 2.43
-
CSI 16.5rCSI 79.04%PRS 2.79
-
CSI 15.95rCSI 93.89%PRS 3.14
-
CSI 15.91rCSI 13.83%PRS 5.94
-
CSI 15.87rCSI 11.15%PRS 14.37
-
CSI 15.75rCSI 16.05%PRS 6.98
-
CSI 15.66rCSI 46.49%PRS 8.17
-
CSI 15.3rCSI 26.17%PRS 10.57
-
CSI 15.17rCSI 27.38%PRS 14.65
-
CSI 14.16rCSI 12.78%PRS 4.25
-
CSI 13.78rCSI 36.71%PRS 4.78
-
CSI 13.42rCSI 19.35%PRS 6.71
-
CSI 13.37rCSI 37.46%PRS 7.6
-
CSI 13.06rCSI 64.36%PRS 6.55
-
CSI 12.86rCSI 36.72%PRS 8.57
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CSI 12.66rCSI 14.87%PRS 43.84
-
CSI 12.47rCSI 7.36%PRS 6.75
-
CSI 12.29rCSI 64.62%PRS 11.37
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CSI 12.21rCSI 21.85%PRS 4.65
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CSI 12.02rCSI 55.53%PRS 10.62
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CSI 11.87rCSI 15.18%PRS 22.22
-
CSI 11.85rCSI 83.78%PRS 8.93
-
CSI 11.72rCSI 61.54%PRS 9.69
-
CSI 11.66rCSI 29.5%PRS 6.1
-
CSI 11.61rCSI 46.85%PRS 5.22
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CSI 11.26rCSI 19.89%PRS 2.88
-
CSI 11.09rCSI 53.1%PRS 7.9
-
CSI 10.93rCSI 14.61%PRS 6.57
-
CSI 10.86rCSI 21.66%PRS 8.29
-
CSI 10.82rCSI 27.44%PRS 3.83
-
CSI 10.72rCSI 17.56%PRS 3.79
-
CSI 10.63rCSI 13.71%PRS 3.08
-
CSI 10.57rCSI 63.96%PRS 11.34
-
CSI 10.48rCSI 33.75%PRS 5.78
-
CSI 10.44rCSI 10.91%PRS 15.52
-
CSI 10.43rCSI 27.1%PRS 7.06
-
CSI 10.37rCSI 8.89%PRS 12.88
-
CSI 10.36rCSI 16.55%PRS 5.25
-
CSI 10.14rCSI 23.64%PRS 12.72
-
CSI 9.95rCSI 17.45%PRS 3.72
-
CSI 9.83rCSI 29.05%PRS 2.93
-
CSI 9.58rCSI 39.05%PRS 7.84
-
CSI 9.47rCSI 7.65%PRS 11.17
-
CSI 9.41rCSI 27.76%PRS 3.48
-
CSI 9.35rCSI 25.45%PRS 23.36
-
CSI 9.2rCSI 67.6%PRS 2.34
-
CSI 9.2rCSI 17.36%PRS 6.02
-
CSI 9.09rCSI 56.8%PRS 3.99
-
CSI 9.05rCSI 46.73%PRS 9.67
-
CSI 8.99rCSI 35.01%PRS 8.02
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CSI 8.94rCSI 7.83%PRS 6.5
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CSI 8.88rCSI 19.92%PRS 3.06
-
CSI 8.71rCSI 7.04%PRS 4.74
-
CSI 8.67rCSI 48.08%PRS 22.21
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CSI 8.45rCSI 9.8%PRS 16.75
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CSI 8.38rCSI 27.42%PRS 15.13
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CSI 8.36rCSI 32.52%PRS 8.04
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CSI 8.19rCSI 45.66%PRS 17.98
-
CSI 8.15rCSI 6.86%PRS 8.09
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CSI 8.02rCSI 6.95%PRS 5.37
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CSI 7.95rCSI 17.49%PRS 1.69
-
CSI 7.89rCSI 12.12%PRS 5.6
-
CSI 7.87rCSI 8.1%PRS 7.89
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CSI 7.81rCSI 9.15%PRS 7.66
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CSI -17.9rCSI -27.7%PRS 4.5%
-
CSI -15.0rCSI -20.8%PRS 5.1%
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CSI -11.4rCSI -64.5%PRS 1.5%
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CSI -9.3rCSI -14.9%PRS 4.2%
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CSI -8.2rCSI -20.9%PRS 4.9%
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CSI -5.6rCSI -6.5%PRS 4.4%
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CSI -5.5rCSI -6.8%PRS 4.2%
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CSI -5.2rCSI -9.8%PRS 3.7%
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CSI -5.2rCSI -7.1%PRS 5.3%
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CSI -3.7rCSI -20.0%PRS 8.8%
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CSI -3.6rCSI -4.4%PRS 6.1%
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CSI -3.1rCSI -3.3%PRS 4.9%
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CSI -3.0rCSI -4.9%PRS 4.9%
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CSI -2.9rCSI -12.6%PRS 9.4%
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CSI -2.4rCSI -4.4%PRS 4.1%
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CSI -2.4rCSI -2.6%PRS 4.5%
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CSI -2.0rCSI -20.9%PRS 4.4%
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CSI -2.0rCSI -2.1%PRS 8.7%
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CSI -2.0rCSI -1.8%PRS 5.0%
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CSI -1.7rCSI -3.4%PRS 3.6%
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CSI -1.7rCSI -2.4%PRS 6.7%
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CSI -1.4rCSI -1.0%PRS 7.0%
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CSI -1.4rCSI -1.2%PRS 4.8%
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CSI -1.3rCSI -2.9%PRS 4.5%
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CSI -1.0rCSI -11.4%PRS 23.8%
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CSI -1.0rCSI -16.4%PRS 24.6%
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CSI -1.0rCSI -8.1%PRS 7.1%
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CSI -0.9rCSI -3.1%PRS 4.2%
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CSI -0.6rCSI -0.9%PRS 4.5%
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CSI -0.5rCSI -4.7%PRS 1.3%
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CSI -0.5rCSI -2.3%PRS 4.9%
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CSI -0.4rCSI -2.0%PRS 18.3%
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CSI -0.3rCSI -0.7%PRS 9.9%
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CSI -0.3rCSI -1.3%PRS 17.7%
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CSI -0.2rCSI -0.4%PRS 13.9%
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CSI 0.0rCSI 0.0%PRS 10.9%
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CSI 0.0rCSI 0.1%PRS 21.7%
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CSI 0.0rCSI 0.1%PRS 7.3%
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CSI 0.0rCSI 0.5%PRS 8.9%
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CSI 0.1rCSI 0.1%PRS 7.4%
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CSI 0.1rCSI 0.9%PRS 17.0%
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CSI 0.1rCSI 1.2%PRS 20.4%
-
CSI 0.1rCSI 0.8%PRS 22.0%
-
CSI 0.1rCSI 1.1%PRS 9.2%
-
CSI 0.1rCSI 0.6%PRS 25.1%
-
CSI 0.1rCSI 0.8%PRS 27.0%
-
CSI 0.1rCSI 0.4%PRS 5.8%
-
CSI 0.1rCSI 0.3%PRS 5.8%
-
CSI 0.1rCSI 1.7%PRS 45.8%
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CSI 0.1rCSI 0.6%PRS 4.1%
-
CSI 0.2rCSI 0.1%PRS 5.3%
-
CSI 0.2rCSI 0.2%PRS 5.3%
-
CSI 0.2rCSI 0.6%PRS 8.3%
-
CSI 0.2rCSI 5.3%PRS 55.7%
-
CSI 0.2rCSI 0.8%PRS 12.1%
-
CSI 0.2rCSI 1.9%PRS 14.8%
-
CSI 0.2rCSI 0.2%PRS 5.2%
-
CSI 0.2rCSI 0.4%PRS 4.9%
-
CSI 0.2rCSI 2.4%PRS 32.3%
-
CSI 0.3rCSI 4.0%PRS 12.7%
-
CSI 0.3rCSI 1.1%PRS 8.7%
-
CSI 0.3rCSI 0.5%PRS 6.4%
-
CSI 0.3rCSI 1.6%PRS 7.5%
-
CSI 0.3rCSI 3.2%PRS 48.8%
-
CSI 0.3rCSI 0.7%PRS 14.0%
-
CSI 0.3rCSI 0.5%PRS 8.5%
-
CSI 0.3rCSI 0.8%PRS 12.1%
-
CSI 0.4rCSI 0.4%PRS 4.8%
-
CSI 0.4rCSI 0.8%PRS 4.7%
-
CSI 0.4rCSI 1.6%PRS 26.2%
-
CSI 0.4rCSI 1.7%PRS 13.4%
-
CSI 0.4rCSI 2.4%PRS 8.8%
-
CSI 0.4rCSI 0.6%PRS 6.4%
-
CSI 0.4rCSI 2.6%PRS 12.8%
-
CSI 0.4rCSI 5.8%PRS 41.5%
-
CSI 0.5rCSI 1.6%PRS 5.7%
-
CSI 0.5rCSI 1.7%PRS 8.8%
-
CSI 0.5rCSI 0.6%PRS 5.6%
-
CSI 0.5rCSI 0.8%PRS 6.3%
-
CSI 0.5rCSI 0.6%PRS 8.1%
-
CSI 0.5rCSI 0.8%PRS 4.8%
-
CSI 0.5rCSI 2.8%PRS 17.1%
-
CSI 0.5rCSI 6.0%PRS 6.9%
-
CSI 0.5rCSI 1.3%PRS 9.2%
-
CSI 0.6rCSI 2.5%PRS 22.1%
-
CSI 0.6rCSI 1.5%PRS 8.2%
-
CSI 0.6rCSI 3.0%PRS 15.7%
-
CSI 0.6rCSI 0.8%PRS 5.6%
-
CSI 0.6rCSI 1.7%PRS 10.9%
-
CSI 0.6rCSI 4.4%PRS 6.1%
-
CSI 0.6rCSI 0.9%PRS 7.9%
-
CSI 0.6rCSI 3.5%PRS 9.6%
-
CSI 0.7rCSI 1.0%PRS 5.1%
-
CSI 0.7rCSI 0.9%PRS 5.6%
-
CSI 0.7rCSI 1.0%PRS 7.8%
-
CSI 0.7rCSI 3.1%PRS 1.5%
-
CSI 0.7rCSI 17.9%PRS 28.2%
-
CSI 0.7rCSI 1.6%PRS 5.1%
-
CSI 0.7rCSI 2.0%PRS 7.0%
-
CSI 0.7rCSI 1.1%PRS 7.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2716243036
Symbol: MBNL1_HUMAN
Name: Muscleblind-like protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9455477
Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 9455477
PubMed ID: 10970838
Title: Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.
PubMed ID: 10970838
PubMed ID: 11590133
Title: Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.
PubMed ID: 11590133
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11929853
Title: Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.
PubMed ID: 11929853
DOI: 10.1093/hmg/11.7.805
PubMed ID: 15257297
Title: Muscleblind proteins regulate alternative splicing.
PubMed ID: 15257297
PubMed ID: 16946708
Title: Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.
PubMed ID: 16946708
PubMed ID: 18335541
Title: MBNL1 associates with YB-1 in cytoplasmic stress granules.
PubMed ID: 18335541
DOI: 10.1002/jnr.21655
PubMed ID: 19470458
Title: The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing.
PubMed ID: 19470458
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25593321
Title: RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy.
PubMed ID: 25593321
PubMed ID: 37548402
Title: Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators.
PubMed ID: 37548402
DOI: 10.1093/nar/gkad652
PubMed ID: 19043415
Title: Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1.
PubMed ID: 19043415
DOI: 10.1038/nsmb.1519
PubMed ID: 27222292
Title: Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype.
PubMed ID: 27222292
DOI: 10.1038/ejhg.2016.41
Sequence Information:
- Length: 388
- Mass: 41817
- Checksum: 118D256A81A86695
- Sequence:
MAVSVTPIRD TKWLTLEVCR EFQRGTCSRP DTECKFAHPS KSCQVENGRV IACFDSLKGR CSRENCKYLH PPPHLKTQLE INGRNNLIQQ KNMAMLAQQM QLANAMMPGA PLQPVPMFSV APSLATNASA AAFNPYLGPV SPSLVPAEIL PTAPMLVTGN PGVPVPAAAA AAAQKLMRTD RLEVCREYQR GNCNRGENDC RFAHPADSTM IDTNDNTVTV CMDYIKGRCS REKCKYFHPP AHLQAKIKAA QYQVNQAAAA QAAATAAAMT QSAVKSLKRP LEATFDLGIP QAVLPPLPKR PALEKTNGAT AVFNTGIFQY QQALANMQLQ QHTAFLPPVP MVHGATPATV SAATTSATSV PFAATATANQ IPIISAEHLT SHKYVTQM
Genular Protein ID: 3802225217
Symbol: Q86VM6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 343
- Mass: 36551
- Checksum: 7F9CE984EB6FB72E
- Sequence:
MGRCSRENCK YLHPPPHLKT QLEINGRNNL IQQKNMAMLA QQMQLANAMM PGAPLQPVPM FSVAPSLATN ASAAAFNPYL GPVSPSLVPA EILPTAPMLV TGNPGVPVPA AAAAAAQKLM RTDRLEVCRE YQRGNCNRGE NDCRFAHPAD STMIDTNDNT VTVCMDYIKG RCSREKCKYF HPPAHLQAKI KAAQYQVNQA AAAQAAATAA AMTQSAVKSL KRPLEATFDL GIPQAVLPPL PKRPALEKTN GATAVFNTGI FQYQQALANM QLQQHTAFLP PGSILCMTPA TSVVPMVHGA TPATVSAATT SATSVPFAAT ATANQIPIIS AEHLTSHKYV TQM