Details for: MBNL1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 6.14
Marker Score: 25,583 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 6.02
Marker Score: 15,076 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 5.5
Marker Score: 3,619 - Cell Name: contractile cell (CL0000183)
Fold Change: 4.58
Marker Score: 2,481 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 4.41
Marker Score: 1,594 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 4.36
Marker Score: 5,436 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 4.29
Marker Score: 95,976 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 4.08
Marker Score: 2,270 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.79
Marker Score: 1,886 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.78
Marker Score: 67,137 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.65
Marker Score: 3,483 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.65
Marker Score: 4,133 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.57
Marker Score: 6,872 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.55
Marker Score: 187,838 - Cell Name: lactocyte (CL0002325)
Fold Change: 3.54
Marker Score: 56,850 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 3.46
Marker Score: 1,266 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 3.45
Marker Score: 877 - Cell Name: hepatoblast (CL0005026)
Fold Change: 3.35
Marker Score: 10,960 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.32
Marker Score: 9,304 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.22
Marker Score: 7,068 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.19
Marker Score: 2,413 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.18
Marker Score: 10,032 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 3.13
Marker Score: 812 - Cell Name: blood cell (CL0000081)
Fold Change: 3.12
Marker Score: 36,257 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 3.05
Marker Score: 1,481 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.04
Marker Score: 2,385 - Cell Name: fat cell (CL0000136)
Fold Change: 3.01
Marker Score: 1,682 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 2.99
Marker Score: 2,453 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.99
Marker Score: 2,649 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 2.98
Marker Score: 6,249 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.94
Marker Score: 29,798 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.92
Marker Score: 3,364 - Cell Name: thymocyte (CL0000893)
Fold Change: 2.89
Marker Score: 3,027 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.87
Marker Score: 4,176 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.87
Marker Score: 7,001 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.85
Marker Score: 159,392 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.84
Marker Score: 12,179 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.81
Marker Score: 1,403 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.81
Marker Score: 1,211 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.8
Marker Score: 4,996 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.78
Marker Score: 9,876 - Cell Name: melanocyte (CL0000148)
Fold Change: 2.77
Marker Score: 1,123 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.77
Marker Score: 1,459 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 2.77
Marker Score: 835 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.75
Marker Score: 58,790 - Cell Name: mature T cell (CL0002419)
Fold Change: 2.74
Marker Score: 27,142 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.72
Marker Score: 3,755 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 2.71
Marker Score: 590 - Cell Name: erythroblast (CL0000765)
Fold Change: 2.7
Marker Score: 1,685 - Cell Name: renal principal cell (CL0005009)
Fold Change: 2.68
Marker Score: 2,065 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.66
Marker Score: 4,561 - Cell Name: podocyte (CL0000653)
Fold Change: 2.65
Marker Score: 981 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.65
Marker Score: 17,247 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 2.64
Marker Score: 518 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.64
Marker Score: 631 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.64
Marker Score: 2,844 - Cell Name: astrocyte (CL0000127)
Fold Change: 2.63
Marker Score: 2,276 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.63
Marker Score: 1,568 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.6
Marker Score: 2,126 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.58
Marker Score: 6,186 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.58
Marker Score: 2,269 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.57
Marker Score: 2,742 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.56
Marker Score: 739 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 2.56
Marker Score: 587 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.56
Marker Score: 3,768 - Cell Name: acinar cell (CL0000622)
Fold Change: 2.55
Marker Score: 1,802 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.55
Marker Score: 1,772 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 2.55
Marker Score: 954 - Cell Name: naive T cell (CL0000898)
Fold Change: 2.53
Marker Score: 1,629 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.52
Marker Score: 781 - Cell Name: Unknown (CL0000548)
Fold Change: 2.49
Marker Score: 1,818 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.49
Marker Score: 2,406 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 2.47
Marker Score: 553 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.44
Marker Score: 11,293 - Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.44
Marker Score: 1,787 - Cell Name: muscle precursor cell (CL0000680)
Fold Change: 2.44
Marker Score: 632 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.43
Marker Score: 2,646 - Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 2.43
Marker Score: 598 - Cell Name: naive B cell (CL0000788)
Fold Change: 2.42
Marker Score: 2,162 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 2.41
Marker Score: 868 - Cell Name: pro-B cell (CL0000826)
Fold Change: 2.41
Marker Score: 2,327 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.41
Marker Score: 2,141 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.4
Marker Score: 1,476 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.4
Marker Score: 2,896 - Cell Name: endothelial cell (CL0000115)
Fold Change: 2.4
Marker Score: 2,148 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.39
Marker Score: 2,659 - Cell Name: lung macrophage (CL1001603)
Fold Change: 2.39
Marker Score: 2,731 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.38
Marker Score: 2,529 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.38
Marker Score: 2,018 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.38
Marker Score: 7,051 - Cell Name: Schwann cell (CL0002573)
Fold Change: 2.38
Marker Score: 824 - Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 2.36
Marker Score: 589 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.36
Marker Score: 18,120 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.36
Marker Score: 35,308 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 2.36
Marker Score: 2,168 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.35
Marker Score: 2,214 - Cell Name: memory B cell (CL0000787)
Fold Change: 2.35
Marker Score: 1,779 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 2.35
Marker Score: 1,948 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 2.34
Marker Score: 1,576 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.33
Marker Score: 4,568
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2716243036
Symbol: MBNL1_HUMAN
Name: Muscleblind-like protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9455477
Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 9455477
PubMed ID: 10970838
Title: Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.
PubMed ID: 10970838
PubMed ID: 11590133
Title: Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.
PubMed ID: 11590133
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11929853
Title: Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.
PubMed ID: 11929853
DOI: 10.1093/hmg/11.7.805
PubMed ID: 15257297
Title: Muscleblind proteins regulate alternative splicing.
PubMed ID: 15257297
PubMed ID: 16946708
Title: Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.
PubMed ID: 16946708
PubMed ID: 18335541
Title: MBNL1 associates with YB-1 in cytoplasmic stress granules.
PubMed ID: 18335541
DOI: 10.1002/jnr.21655
PubMed ID: 19470458
Title: The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing.
PubMed ID: 19470458
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25593321
Title: RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy.
PubMed ID: 25593321
PubMed ID: 19043415
Title: Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1.
PubMed ID: 19043415
DOI: 10.1038/nsmb.1519
PubMed ID: 27222292
Title: Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype.
PubMed ID: 27222292
DOI: 10.1038/ejhg.2016.41
Sequence Information:
- Length: 388
- Mass: 41817
- Checksum: 118D256A81A86695
- Sequence:
MAVSVTPIRD TKWLTLEVCR EFQRGTCSRP DTECKFAHPS KSCQVENGRV IACFDSLKGR CSRENCKYLH PPPHLKTQLE INGRNNLIQQ KNMAMLAQQM QLANAMMPGA PLQPVPMFSV APSLATNASA AAFNPYLGPV SPSLVPAEIL PTAPMLVTGN PGVPVPAAAA AAAQKLMRTD RLEVCREYQR GNCNRGENDC RFAHPADSTM IDTNDNTVTV CMDYIKGRCS REKCKYFHPP AHLQAKIKAA QYQVNQAAAA QAAATAAAMT QSAVKSLKRP LEATFDLGIP QAVLPPLPKR PALEKTNGAT AVFNTGIFQY QQALANMQLQ QHTAFLPPVP MVHGATPATV SAATTSATSV PFAATATANQ IPIISAEHLT SHKYVTQM
Genular Protein ID: 3802225217
Symbol: Q86VM6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 343
- Mass: 36551
- Checksum: 7F9CE984EB6FB72E
- Sequence:
MGRCSRENCK YLHPPPHLKT QLEINGRNNL IQQKNMAMLA QQMQLANAMM PGAPLQPVPM FSVAPSLATN ASAAAFNPYL GPVSPSLVPA EILPTAPMLV TGNPGVPVPA AAAAAAQKLM RTDRLEVCRE YQRGNCNRGE NDCRFAHPAD STMIDTNDNT VTVCMDYIKG RCSREKCKYF HPPAHLQAKI KAAQYQVNQA AAAQAAATAA AMTQSAVKSL KRPLEATFDL GIPQAVLPPL PKRPALEKTN GATAVFNTGI FQYQQALANM QLQQHTAFLP PGSILCMTPA TSVVPMVHGA TPATVSAATT SATSVPFAAT ATANQIPIIS AEHLTSHKYV TQM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.