Details for: MBNL1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 752.8036
Cell Significance Index: -117.1000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 461.1987
Cell Significance Index: -116.9800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 272.9164
Cell Significance Index: -128.8500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 272.5121
Cell Significance Index: -110.7100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 245.1470
Cell Significance Index: -126.1000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 117.7071
Cell Significance Index: -112.3800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 101.1756
Cell Significance Index: -124.7500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 43.1415
Cell Significance Index: -115.5700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 39.9306
Cell Significance Index: -122.6500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 35.8953
Cell Significance Index: -78.5600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 32.5471
Cell Significance Index: -128.4300 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 9.5934
Cell Significance Index: 65.0000 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 9.4986
Cell Significance Index: 231.7600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 8.5661
Cell Significance Index: 220.1900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 6.9057
Cell Significance Index: 134.7800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 6.1131
Cell Significance Index: 469.1100 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 5.9776
Cell Significance Index: 96.4500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 4.5011
Cell Significance Index: 125.7900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.2659
Cell Significance Index: 275.2100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 3.8221
Cell Significance Index: 445.4200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.7956
Cell Significance Index: 54.5900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.7927
Cell Significance Index: 554.2200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6424
Cell Significance Index: 530.0600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.2342
Cell Significance Index: 263.4800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.1164
Cell Significance Index: 759.1000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.8834
Cell Significance Index: 71.3200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.8698
Cell Significance Index: 46.7400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.8373
Cell Significance Index: 81.2700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.6681
Cell Significance Index: 86.8900 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.5136
Cell Significance Index: 19.0600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.4832
Cell Significance Index: 83.2300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.2231
Cell Significance Index: 82.2500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1801
Cell Significance Index: 145.1100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.1534
Cell Significance Index: 797.7400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.0810
Cell Significance Index: 477.9400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.0653
Cell Significance Index: 28.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0054
Cell Significance Index: 907.7900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9915
Cell Significance Index: 178.7500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6466
Cell Significance Index: 88.8000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6141
Cell Significance Index: 99.8800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.4745
Cell Significance Index: 8.7700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.4676
Cell Significance Index: 212.2100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.4672
Cell Significance Index: 7.8700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.4039
Cell Significance Index: 5.8000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3559
Cell Significance Index: 10.2600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3275
Cell Significance Index: 178.8300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3224
Cell Significance Index: 607.0400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3091
Cell Significance Index: 14.0100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2302
Cell Significance Index: 146.2100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2000
Cell Significance Index: 9.4000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1269
Cell Significance Index: 13.8100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1175
Cell Significance Index: 0.7100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1041
Cell Significance Index: 192.0600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1022
Cell Significance Index: 157.3900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0620
Cell Significance Index: 1.8200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0117
Cell Significance Index: -15.8500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0546
Cell Significance Index: -34.1200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0600
Cell Significance Index: -45.3900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0637
Cell Significance Index: -47.2000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1079
Cell Significance Index: -79.1100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.1237
Cell Significance Index: -23.5400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1260
Cell Significance Index: -2.1600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1313
Cell Significance Index: -74.0500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1403
Cell Significance Index: -23.9500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1733
Cell Significance Index: -6.0900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2794
Cell Significance Index: -28.5400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2919
Cell Significance Index: -4.3100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3124
Cell Significance Index: -19.2000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3889
Cell Significance Index: -111.8900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3932
Cell Significance Index: -57.1600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.4034
Cell Significance Index: -51.7100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4171
Cell Significance Index: -87.8500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5046
Cell Significance Index: -14.4000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.5241
Cell Significance Index: -51.8500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5324
Cell Significance Index: -14.2200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.6267
Cell Significance Index: -13.4000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6482
Cell Significance Index: -45.8400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.6601
Cell Significance Index: -85.2900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8351
Cell Significance Index: -95.3300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8554
Cell Significance Index: -89.0700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.9288
Cell Significance Index: -106.4100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.9624
Cell Significance Index: -60.6600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.0609
Cell Significance Index: -30.4100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.0638
Cell Significance Index: -28.5100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.2886
Cell Significance Index: -96.0400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.4499
Cell Significance Index: -21.4000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.4520
Cell Significance Index: -115.0000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.4923
Cell Significance Index: -75.4200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.5794
Cell Significance Index: -73.6400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.6124
Cell Significance Index: -83.7600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.8385
Cell Significance Index: -39.8300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.8924
Cell Significance Index: -99.3600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.9400
Cell Significance Index: -118.9400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.1827
Cell Significance Index: -69.9100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -2.3127
Cell Significance Index: -47.9800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -2.5369
Cell Significance Index: -64.8100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -2.5835
Cell Significance Index: -61.9600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.6607
Cell Significance Index: -84.7400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.6753
Cell Significance Index: -87.5900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -2.7464
Cell Significance Index: -74.7600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2716243036
Symbol: MBNL1_HUMAN
Name: Muscleblind-like protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9455477
Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 9455477
PubMed ID: 10970838
Title: Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.
PubMed ID: 10970838
PubMed ID: 11590133
Title: Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.
PubMed ID: 11590133
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11929853
Title: Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.
PubMed ID: 11929853
DOI: 10.1093/hmg/11.7.805
PubMed ID: 15257297
Title: Muscleblind proteins regulate alternative splicing.
PubMed ID: 15257297
PubMed ID: 16946708
Title: Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.
PubMed ID: 16946708
PubMed ID: 18335541
Title: MBNL1 associates with YB-1 in cytoplasmic stress granules.
PubMed ID: 18335541
DOI: 10.1002/jnr.21655
PubMed ID: 19470458
Title: The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing.
PubMed ID: 19470458
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25593321
Title: RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy.
PubMed ID: 25593321
PubMed ID: 37548402
Title: Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators.
PubMed ID: 37548402
DOI: 10.1093/nar/gkad652
PubMed ID: 19043415
Title: Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1.
PubMed ID: 19043415
DOI: 10.1038/nsmb.1519
PubMed ID: 27222292
Title: Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype.
PubMed ID: 27222292
DOI: 10.1038/ejhg.2016.41
Sequence Information:
- Length: 388
- Mass: 41817
- Checksum: 118D256A81A86695
- Sequence:
MAVSVTPIRD TKWLTLEVCR EFQRGTCSRP DTECKFAHPS KSCQVENGRV IACFDSLKGR CSRENCKYLH PPPHLKTQLE INGRNNLIQQ KNMAMLAQQM QLANAMMPGA PLQPVPMFSV APSLATNASA AAFNPYLGPV SPSLVPAEIL PTAPMLVTGN PGVPVPAAAA AAAQKLMRTD RLEVCREYQR GNCNRGENDC RFAHPADSTM IDTNDNTVTV CMDYIKGRCS REKCKYFHPP AHLQAKIKAA QYQVNQAAAA QAAATAAAMT QSAVKSLKRP LEATFDLGIP QAVLPPLPKR PALEKTNGAT AVFNTGIFQY QQALANMQLQ QHTAFLPPVP MVHGATPATV SAATTSATSV PFAATATANQ IPIISAEHLT SHKYVTQM
Genular Protein ID: 3802225217
Symbol: Q86VM6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 343
- Mass: 36551
- Checksum: 7F9CE984EB6FB72E
- Sequence:
MGRCSRENCK YLHPPPHLKT QLEINGRNNL IQQKNMAMLA QQMQLANAMM PGAPLQPVPM FSVAPSLATN ASAAAFNPYL GPVSPSLVPA EILPTAPMLV TGNPGVPVPA AAAAAAQKLM RTDRLEVCRE YQRGNCNRGE NDCRFAHPAD STMIDTNDNT VTVCMDYIKG RCSREKCKYF HPPAHLQAKI KAAQYQVNQA AAAQAAATAA AMTQSAVKSL KRPLEATFDL GIPQAVLPPL PKRPALEKTN GATAVFNTGI FQYQQALANM QLQQHTAFLP PGSILCMTPA TSVVPMVHGA TPATVSAATT SATSVPFAAT ATANQIPIIS AEHLTSHKYV TQM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.