DAB1 | ENSG00000173406 | NCBI 1600

Details for: DAB1

Gene ID: 1600

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DAB1

Ensembl ID: ENSG00000173406

Description: DAB adaptor protein 1

Cell Significance Landscape

Display Count:

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Nervous system development
(R-HSA-9675108)
Reelin signalling pathway
(R-HSA-8866376)
Adult walking behavior
(GO:0007628)
Astrocyte differentiation
(GO:0048708)
Axonogenesis
(GO:0007409)
Cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
(GO:0021813)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Cerebellum structural organization
(GO:0021589)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite development
(GO:0016358)
Glutamatergic synapse
(GO:0098978)
Golgi localization
(GO:0051645)
Hippocampus development
(GO:0021766)
Intracellular membrane-bounded organelle
(GO:0043231)
Lateral motor column neuron migration
(GO:0097477)
Layer formation in cerebral cortex
(GO:0021819)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of axonogenesis
(GO:0050771)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Neuron migration
(GO:0001764)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of neuron differentiation
(GO:0045666)
Protein binding
(GO:0005515)
Radial glia-guided pyramidal neuron migration
(GO:0140650)
Radial glia guided migration of purkinje cell
(GO:0021942)
Reelin-mediated signaling pathway
(GO:0038026)
Regulation of synapse maturation
(GO:0090128)
Signaling adaptor activity
(GO:0035591)
Small gtpase-mediated signal transduction
(GO:0007264)
Ventral spinal cord development
(GO:0021517)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

VIP GABAergic cortical interneuron CL4023016

CSI 50.94

rCSI 60.85%

PRS 87.55
pvalb GABAergic cortical interneuron CL4023018

CSI 47.46

rCSI 59.05%

PRS 85.68
sst GABAergic cortical interneuron CL4023017

CSI 46.71

rCSI 60.22%

PRS 88.44
sncg GABAergic cortical interneuron CL4023015

CSI 36.83

rCSI 59.23%

PRS 88.45
lamp5 GABAergic cortical interneuron CL4023011

CSI 34.87

rCSI 58.53%

PRS 87.64
cerebellar granule cell CL0001031

CSI 32

rCSI 47.04%

PRS 92.16
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 31.36

rCSI 55.39%

PRS 87.16
oligodendrocyte precursor cell CL0002453

CSI 27.59

rCSI 60.72%

PRS 82.13
differentiation-committed oligodendrocyte precursor CL4023059

CSI 26.71

rCSI 48.54%

PRS 91.42
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 25.14

rCSI 54.53%

PRS 87.28
interneuron CL0000099

CSI 23.79

rCSI 47.76%

PRS 92.08
retinal bipolar neuron CL0000748

CSI 22.61

rCSI 42.35%

PRS 90
inhibitory interneuron CL0000498

CSI 21.46

rCSI 49.54%

PRS 89.49
glycinergic amacrine cell CL4030028

CSI 20.3

rCSI 52.88%

PRS 90.6
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 19.62

rCSI 47.69%

PRS 85.71
amacrine cell CL0000561

CSI 19.33

rCSI 56.02%

PRS 89.84
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 19.09

rCSI 59.7%

PRS 89.74
neuron CL0000540

CSI 17.67

rCSI 47.04%

PRS 86.04
near-projecting glutamatergic cortical neuron CL4023012

CSI 15.48

rCSI 58.49%

PRS 87.65
radial glial cell CL0000681

CSI 15.03

rCSI 20.89%

PRS 94.28
rod bipolar cell CL0000751

CSI 14.65

rCSI 26.32%

PRS 91.88
adipocyte CL0000136

CSI 14.63

rCSI 18.79%

PRS 89.95
Mueller cell CL0000636

CSI 14.62

rCSI 33.37%

PRS 91.49
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 14.36

rCSI 51.66%

PRS 85.98
GABAergic amacrine cell CL4030027

CSI 13.94

rCSI 47.75%

PRS 86.24
neural crest cell CL0011012

CSI 13.92

rCSI 11%

PRS 91.5
L6b glutamatergic cortical neuron CL4023038

CSI 13.72

rCSI 42.87%

PRS 88.43
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 13.62

rCSI 15.73%

PRS 90.09
glutamatergic neuron CL0000679

CSI 13.48

rCSI 27.69%

PRS 86.84
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 13.34

rCSI 43.86%

PRS 87.19
glioblast CL0000030

CSI 13.18

rCSI 21.03%

PRS 90.21
enterocyte CL0000584

CSI 12.93

rCSI 20.85%

PRS 92.72
vascular leptomeningeal cell CL4023051

CSI 12.89

rCSI 22.6%

PRS 93.56
retinal ganglion cell CL0000740

CSI 12.62

rCSI 27.88%

PRS 88.56
diffuse bipolar 6 cell CL4033032

CSI 12.1

rCSI 63.61%

PRS 87.46
OFFx cell CL4033036

CSI 11.5

rCSI 54.11%

PRS 86.94
neuroblast (sensu Vertebrata) CL0000031

CSI 11.31

rCSI 14.51%

PRS 92.79
GABAergic neuron CL0000617

CSI 11.28

rCSI 37.79%

PRS 85.79
mural cell CL0008034

CSI 11.21

rCSI 37.97%

PRS 92.67
kidney interstitial alternatively activated macrophage CL1000695

CSI 11.12

rCSI 28.98%

PRS 96.66
H1 horizontal cell CL0004217

CSI 11.09

rCSI 43.91%

PRS 90.89
neural cell CL0002319

CSI 10.98

rCSI 41.42%

PRS 85.59
epithelial cell of proximal tubule CL0002306

CSI 10.82

rCSI 26.43%

PRS 90.9
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 10.72

rCSI 15.19%

PRS 94.12
invaginating midget bipolar cell CL4033034

CSI 10.25

rCSI 60.53%

PRS 88.23
H2 horizontal cell CL0004218

CSI 10.11

rCSI 50.27%

PRS 91.37
retinal cone cell CL0000573

CSI 9.48

rCSI 15.26%

PRS 89.9
Schwann cell CL0002573

CSI 9.22

rCSI 26.21%

PRS 92.83
Kupffer cell CL0000091

CSI 9.03

rCSI 20.65%

PRS 96.2
alveolar adventitial fibroblast CL4028006

CSI 8.95

rCSI 14.13%

PRS 96.24
cerebral cortex endothelial cell CL1001602

CSI 8.8

rCSI 15.23%

PRS 92.53
renal principal cell CL0005009

CSI 8.7

rCSI 22.61%

PRS 94.72
retinal pigment epithelial cell CL0002586

CSI 8.7

rCSI 17.27%

PRS 92.98
parietal epithelial cell CL1000452

CSI 8.42

rCSI 22.51%

PRS 92.41
colonocyte CL1000347

CSI 8.42

rCSI 12.07%

PRS 93.72
contractile cell CL0000183

CSI 8.22

rCSI 24.25%

PRS 95.5
melanocyte CL0000148

CSI 8.08

rCSI 5.99%

PRS 93.24
alveolar type 1 fibroblast cell CL4028004

CSI 8.07

rCSI 8.84%

PRS 96.34
podocyte CL0000653

CSI 7.98

rCSI 35.44%

PRS 95.37
intestinal epithelial cell CL0002563

CSI 7.96

rCSI 8.32%

PRS 93.62
retina horizontal cell CL0000745

CSI 7.49

rCSI 11.41%

PRS 93.3
cardiac muscle cell CL0000746

CSI 7.47

rCSI 10.71%

PRS 89.8
kidney connecting tubule epithelial cell CL1000768

CSI 7.45

rCSI 18.9%

PRS 92.07
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 7.4

rCSI 17.69%

PRS 88.32
hepatic stellate cell CL0000632

CSI 6.91

rCSI 25.88%

PRS 93.22
renal interstitial pericyte CL1001318

CSI 6.86

rCSI 18.91%

PRS 94.27
cardiac neuron CL0010022

CSI 6.59

rCSI 21.08%

PRS 94.5
central nervous system neuron CL2000029

CSI 6.49

rCSI 47.74%

PRS 90.41
astrocyte of the cerebral cortex CL0002605

CSI 6.49

rCSI 14.55%

PRS 87.83
cerebral cortex neuron CL0010012

CSI 6.31

rCSI 25.7%

PRS 90.01
serotonergic neuron CL0000850

CSI 6.19

rCSI 27.64%

PRS 84.64
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 6.11

rCSI 35.97%

PRS 87.95
mesothelial cell CL0000077

CSI 6.04

rCSI 23.63%

PRS 84.91
lung ciliated cell CL1000271

CSI 5.96

rCSI 6.89%

PRS 91.65
mature astrocyte CL0002627

CSI 5.91

rCSI 25.1%

PRS 90.75
endocardial cell CL0002350

CSI 5.54

rCSI 26.53%

PRS 93.35
choroid plexus epithelial cell CL0000706

CSI 5.48

rCSI 8.98%

PRS 91.07
dopaminergic neuron CL0000700

CSI 5.38

rCSI 30.4%

PRS 88.12
pulmonary alveolar type 1 cell CL0002062

CSI 5.38

rCSI 31.01%

PRS 93.49
medium spiny neuron CL1001474

CSI 5.37

rCSI 46.27%

PRS 90.06
fibroblast of lung CL0002553

CSI 5.2

rCSI 4.84%

PRS 96.4
neural progenitor cell CL0011020

CSI 5.16

rCSI 22.71%

PRS 87.14
conjunctival epithelial cell CL1000432

CSI 5.16

rCSI 7.88%

PRS 94.49
BEST4+ enteroycte CL4030026

CSI 5

rCSI 6.22%

PRS 94.69
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 4.95

rCSI 42.76%

PRS 91.49
glial cell CL0000125

CSI 4.88

rCSI 18.6%

PRS 90.8
chondrocyte CL0000138

CSI 4.85

rCSI 7.72%

PRS 92.36
epicardial adipocyte CL1000309

CSI 4.81

rCSI 15.66%

PRS 93.45
renal beta-intercalated cell CL0002201

CSI 4.79

rCSI 11.41%

PRS 95.45
Bergmann glial cell CL0000644

CSI 4.73

rCSI 6.47%

PRS 90.4
regular atrial cardiac myocyte CL0002129

CSI 4.72

rCSI 15.19%

PRS 92.48
kidney collecting duct principal cell CL1001431

CSI 4.61

rCSI 23.18%

PRS 91.99
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.41

rCSI 11.41%

PRS 93.83
diffuse bipolar 4 cell CL4033031

CSI 4.35

rCSI 49.78%

PRS 84.33
diffuse bipolar 2 cell CL4033028

CSI 4.09

rCSI 31.68%

PRS 89.25
alveolar macrophage CL0000583

CSI 4.03

rCSI 6.64%

PRS 96.36
cerebellar neuron CL1001611

CSI 3.84

rCSI 33.75%

PRS 86.68
macroglial cell CL0000126

CSI 3.62

rCSI 9.3%

PRS 92.43
lung secretory cell CL1000272

CSI 3.6

rCSI 8.92%

PRS 96.38
basket cell CL0000118

CSI 3.52

rCSI 22.08%

PRS 80.53

diffuse bipolar 3a cell CL4033029

CSI 0.8

rCSI 5.5%

PRS 88.6%
blood vessel smooth muscle cell CL0019018

CSI 1.0

rCSI 8.3%

PRS 94.5%
stromal cell CL0000499

CSI 1.2

rCSI 3.4%

PRS 92.9%
diffuse bipolar 1 cell CL4033027

CSI 1.4

rCSI 10.8%

PRS 86.5%
S cone cell CL0003050

CSI 1.5

rCSI 6.7%

PRS 91.9%
cerebral cortex pyramidal neuron CL4023111

CSI 1.8

rCSI 11.0%

PRS 94.5%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.8

rCSI 19.2%

PRS 92.4%
starburst amacrine cell CL0004232

CSI 2.0

rCSI 16.6%

PRS 84.1%
OFF midget ganglion cell CL4033047

CSI 2.1

rCSI 42.7%

PRS 89.5%
indirect pathway medium spiny neuron CL4023029

CSI 2.1

rCSI 51.6%

PRS 85.1%
ON midget ganglion cell CL4033046

CSI 2.2

rCSI 43.7%

PRS 89.1%
midbrain dopaminergic neuron CL2000097

CSI 2.2

rCSI 13.8%

PRS 90.1%
flat midget bipolar cell CL4033033

CSI 2.2

rCSI 15.7%

PRS 87.7%
direct pathway medium spiny neuron CL4023026

CSI 2.3

rCSI 54.1%

PRS 85.3%
regular ventricular cardiac myocyte CL0002131

CSI 2.3

rCSI 14.2%

PRS 90.8%
ON-bipolar cell CL0000749

CSI 2.7

rCSI 4.0%

PRS 94.0%
ON parasol ganglion cell CL4033052

CSI 2.7

rCSI 38.9%

PRS 89.6%
paneth cell of epithelium of small intestine CL1000343

CSI 2.9

rCSI 8.0%

PRS 96.5%
GABAergic interneuron CL0011005

CSI 3.1

rCSI 49.2%

PRS 95.2%
diffuse bipolar 3b cell CL4033030

CSI 3.2

rCSI 21.4%

PRS 90.3%
hepatocyte CL0000182

CSI 3.3

rCSI 5.9%

PRS 93.7%
lung neuroendocrine cell CL1000223

CSI 3.3

rCSI 4.9%

PRS 95.6%
kidney collecting duct intercalated cell CL1001432

CSI 3.4

rCSI 24.3%

PRS 92.2%
basket cell CL0000118

CSI 3.5

rCSI 22.1%

PRS 80.5%
lung secretory cell CL1000272

CSI 3.6

rCSI 8.9%

PRS 96.4%
macroglial cell CL0000126

CSI 3.6

rCSI 9.3%

PRS 92.4%
cerebellar neuron CL1001611

CSI 3.8

rCSI 33.8%

PRS 86.7%
alveolar macrophage CL0000583

CSI 4.0

rCSI 6.6%

PRS 96.4%
diffuse bipolar 2 cell CL4033028

CSI 4.1

rCSI 31.7%

PRS 89.3%
diffuse bipolar 4 cell CL4033031

CSI 4.4

rCSI 49.8%

PRS 84.3%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.4

rCSI 11.4%

PRS 93.8%
kidney collecting duct principal cell CL1001431

CSI 4.6

rCSI 23.2%

PRS 92.0%
regular atrial cardiac myocyte CL0002129

CSI 4.7

rCSI 15.2%

PRS 92.5%
Bergmann glial cell CL0000644

CSI 4.7

rCSI 6.5%

PRS 90.4%
renal beta-intercalated cell CL0002201

CSI 4.8

rCSI 11.4%

PRS 95.5%
epicardial adipocyte CL1000309

CSI 4.8

rCSI 15.7%

PRS 93.5%
chondrocyte CL0000138

CSI 4.9

rCSI 7.7%

PRS 92.4%
glial cell CL0000125

CSI 4.9

rCSI 18.6%

PRS 90.8%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 5.0

rCSI 42.8%

PRS 91.5%
BEST4+ enteroycte CL4030026

CSI 5.0

rCSI 6.2%

PRS 94.7%
conjunctival epithelial cell CL1000432

CSI 5.2

rCSI 7.9%

PRS 94.5%
neural progenitor cell CL0011020

CSI 5.2

rCSI 22.7%

PRS 87.1%
fibroblast of lung CL0002553

CSI 5.2

rCSI 4.8%

PRS 96.4%
medium spiny neuron CL1001474

CSI 5.4

rCSI 46.3%

PRS 90.1%
pulmonary alveolar type 1 cell CL0002062

CSI 5.4

rCSI 31.0%

PRS 93.5%
dopaminergic neuron CL0000700

CSI 5.4

rCSI 30.4%

PRS 88.1%
choroid plexus epithelial cell CL0000706

CSI 5.5

rCSI 9.0%

PRS 91.1%
endocardial cell CL0002350

CSI 5.5

rCSI 26.5%

PRS 93.4%
mature astrocyte CL0002627

CSI 5.9

rCSI 25.1%

PRS 90.8%
lung ciliated cell CL1000271

CSI 6.0

rCSI 6.9%

PRS 91.7%
mesothelial cell CL0000077

CSI 6.0

rCSI 23.6%

PRS 84.9%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 6.1

rCSI 36.0%

PRS 88.0%
serotonergic neuron CL0000850

CSI 6.2

rCSI 27.6%

PRS 84.6%
cerebral cortex neuron CL0010012

CSI 6.3

rCSI 25.7%

PRS 90.0%
astrocyte of the cerebral cortex CL0002605

CSI 6.5

rCSI 14.6%

PRS 87.8%
central nervous system neuron CL2000029

CSI 6.5

rCSI 47.7%

PRS 90.4%
cardiac neuron CL0010022

CSI 6.6

rCSI 21.1%

PRS 94.5%
renal interstitial pericyte CL1001318

CSI 6.9

rCSI 18.9%

PRS 94.3%
hepatic stellate cell CL0000632

CSI 6.9

rCSI 25.9%

PRS 93.2%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 7.4

rCSI 17.7%

PRS 88.3%
kidney connecting tubule epithelial cell CL1000768

CSI 7.5

rCSI 18.9%

PRS 92.1%
cardiac muscle cell CL0000746

CSI 7.5

rCSI 10.7%

PRS 89.8%
retina horizontal cell CL0000745

CSI 7.5

rCSI 11.4%

PRS 93.3%
intestinal epithelial cell CL0002563

CSI 8.0

rCSI 8.3%

PRS 93.6%
podocyte CL0000653

CSI 8.0

rCSI 35.4%

PRS 95.4%
alveolar type 1 fibroblast cell CL4028004

CSI 8.1

rCSI 8.8%

PRS 96.3%
melanocyte CL0000148

CSI 8.1

rCSI 6.0%

PRS 93.2%
contractile cell CL0000183

CSI 8.2

rCSI 24.3%

PRS 95.5%
colonocyte CL1000347

CSI 8.4

rCSI 12.1%

PRS 93.7%
parietal epithelial cell CL1000452

CSI 8.4

rCSI 22.5%

PRS 92.4%
retinal pigment epithelial cell CL0002586

CSI 8.7

rCSI 17.3%

PRS 93.0%
renal principal cell CL0005009

CSI 8.7

rCSI 22.6%

PRS 94.7%
cerebral cortex endothelial cell CL1001602

CSI 8.8

rCSI 15.2%

PRS 92.5%
alveolar adventitial fibroblast CL4028006

CSI 9.0

rCSI 14.1%

PRS 96.2%
Kupffer cell CL0000091

CSI 9.0

rCSI 20.7%

PRS 96.2%
Schwann cell CL0002573

CSI 9.2

rCSI 26.2%

PRS 92.8%
retinal cone cell CL0000573

CSI 9.5

rCSI 15.3%

PRS 89.9%
H2 horizontal cell CL0004218

CSI 10.1

rCSI 50.3%

PRS 91.4%
invaginating midget bipolar cell CL4033034

CSI 10.3

rCSI 60.5%

PRS 88.2%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 10.7

rCSI 15.2%

PRS 94.1%
epithelial cell of proximal tubule CL0002306

CSI 10.8

rCSI 26.4%

PRS 90.9%
neural cell CL0002319

CSI 11.0

rCSI 41.4%

PRS 85.6%
H1 horizontal cell CL0004217

CSI 11.1

rCSI 43.9%

PRS 90.9%
kidney interstitial alternatively activated macrophage CL1000695

CSI 11.1

rCSI 29.0%

PRS 96.7%
mural cell CL0008034

CSI 11.2

rCSI 38.0%

PRS 92.7%
GABAergic neuron CL0000617

CSI 11.3

rCSI 37.8%

PRS 85.8%
neuroblast (sensu Vertebrata) CL0000031

CSI 11.3

rCSI 14.5%

PRS 92.8%
OFFx cell CL4033036

CSI 11.5

rCSI 54.1%

PRS 86.9%
diffuse bipolar 6 cell CL4033032

CSI 12.1

rCSI 63.6%

PRS 87.5%
retinal ganglion cell CL0000740

CSI 12.6

rCSI 27.9%

PRS 88.6%
vascular leptomeningeal cell CL4023051

CSI 12.9

rCSI 22.6%

PRS 93.6%
enterocyte CL0000584

CSI 12.9

rCSI 20.9%

PRS 92.7%
glioblast CL0000030

CSI 13.2

rCSI 21.0%

PRS 90.2%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 13.3

rCSI 43.9%

PRS 87.2%
glutamatergic neuron CL0000679

CSI 13.5

rCSI 27.7%

PRS 86.8%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 13.6

rCSI 15.7%

PRS 90.1%
L6b glutamatergic cortical neuron CL4023038

CSI 13.7

rCSI 42.9%

PRS 88.4%
neural crest cell CL0011012

CSI 13.9

rCSI 11.0%

PRS 91.5%
GABAergic amacrine cell CL4030027

CSI 13.9

rCSI 47.8%

PRS 86.2%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 14.4

rCSI 51.7%

PRS 86.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

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Node Color (Target Cell CSI, relative to current network):
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- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [DAB1](/details-gene/1600) (DAB adaptor protein 1) is a protein-coding gene located on chromosome 1p32.2-p32.1. It encodes a crucial intracellular adaptor protein that functions as a key component of the Reelin signaling pathway. This pathway is fundamental for correct neuronal migration and the laminar organization of the developing central nervous system, particularly the cerebral cortex and cerebellum. Expression data highlights its significant role in various neuronal populations, especially diverse subtypes of cortical [interneurons](/details-cell/CL0000099) and [cerebellar granule cells](/details-cell/CL0001031). Clinically, mutations in the non-coding region of [DAB1](/details-gene/1600) have been identified as the cause of spinocerebellar ataxia 37 (SCA37), underscoring its importance in maintaining cerebellar function ([Link](https://doi.org/10.1016/j.ajhg.2017.06.007)). ## Cellular Roles and Expression Landscape The expression profile of [DAB1](/details-gene/1600) firmly establishes its role within the central nervous system. **Overall**, it shows exceptionally high significance in a wide array of inhibitory and excitatory neurons. The most significant expression is observed across multiple, distinct subtypes of GABAergic cortical interneurons, including [VIP GABAergic cortical interneurons](/details-cell/CL4023016) (CSI: 50.94), [pvalb GABAergic cortical interneurons](/details-cell/CL4023018) (CSI: 47.46), and [sst GABAergic cortical interneurons](/details-cell/CL4023017) (CSI: 46.71). This suggests that [DAB1](/details-gene/1600)-mediated signaling is not only essential for the initial migration of these cells but may also contribute to their subtype-specific functional integration into cortical circuits. Beyond cortical interneurons, [DAB1](/details-gene/1600) is also a key marker in [cerebellar granule cells](/details-cell/CL0001031) (CSI: 32.00) and various glutamatergic projection neurons, such as [L2/3 intratelencephalic projecting glutamatergic neurons](/details-cell/CL4030059) (CSI: 25.14). Its expression extends to other neuronal types like [retinal bipolar neurons](/details-cell/CL0000748), highlighting a conserved role in neuronal positioning and development across different brain regions. Notably, [DAB1](/details-gene/1600) also shows significant expression in glial progenitor populations, specifically [oligodendrocyte precursor cells](/details-cell/CL0002453) (CSI: 27.59) and [differentiation-committed oligodendrocyte precursors](/details-cell/CL4023059) (CSI: 26.71). This pattern suggests a potential role for Reelin-[DAB1](/details-gene/1600) signaling in the migration, proliferation, or differentiation of the oligodendrocyte lineage, which is critical for myelination. ## Pathways and Molecular Function Functionally, [DAB1](/details-gene/1600) acts as a signaling adaptor protein, as defined by its molecular function in '[Signaling adaptor activity](/details-cell/GO:0035591)'. Its primary and most well-characterized role is within the '[Reelin signalling pathway](/details-cell/R-HSA-8866376)'. Upon binding of the extracellular ligand Reelin to its receptors (VLDLR and LRP8/ApoER2), [DAB1](/details-gene/1600) is recruited to the intracellular domain of the receptor and becomes phosphorylated. This initiates a downstream signaling cascade crucial for cytoskeletal dynamics. This core function is reflected in its involvement in numerous biological processes related to neural development. These include '[Neuron migration](/details-cell/GO:0001764)', '[Axonogenesis](/details-cell/GO:0007409)', '[Layer formation in cerebral cortex](/details-cell/GO:0021819)', and '[Cerebellum structural organization](/details-cell/GO:0021589)'. Its participation in pathways like '[Axon guidance](/details-cell/R-HSA-422475)' and '[Nervous system development](/details-cell/R-HSA-9675108)' is entirely consistent with its high expression in developing and mature neuronal populations. The localization of the protein to the [cytoplasm](/details-cell/GO:0005737) and specifically the [perinuclear region of cytoplasm](/details-cell/GO:0048471) supports its role as an intracellular intermediary in signal transduction. ## Research Directions The well-defined role of [DAB1](/details-gene/1600) in neuronal development and its link to neurodegenerative disease present several avenues for future research. **Proposed Hypotheses:** 1. Given the high CSI scores in diverse, terminally differentiated cortical interneuron subtypes ([VIP](/details-cell/CL4023016), [pvalb](/details-cell/CL4023018)), we hypothesize that [DAB1](/details-gene/1600) signaling in the adult brain is not merely a developmental relic but is actively involved in maintaining synaptic integrity and circuit function, and its dysregulation could contribute to circuit-based neurological disorders beyond ataxia. 2. The significant expression of [DAB1](/details-gene/1600) in [oligodendrocyte precursor cells](/details-cell/CL0002453) (OPCs) suggests a role in glial biology. We hypothesize that Reelin-[DAB1](/details-gene/1600) signaling is a key regulator of OPC migration and differentiation, and its disruption could impair myelination during development or remyelination following injury. 3. The causal link between a pentanucleotide repeat insertion in [DAB1](/details-gene/1600) and spinocerebellar ataxia 37 ([SCA37, OMIM: 614153](https://omim.org/entry/614153)) ([Link](https://doi.org/10.1016/j.ajhg.2017.06.007)) suggests a loss-of-function or haploinsufficiency mechanism. We hypothesize that this repeat expansion leads to reduced [DAB1](/details-gene/1600) transcript or protein levels, specifically in cerebellar cell types like [Purkinje cells](/details-cell/CL0000121) or [cerebellar granule cells](/details-cell/CL0001031), leading to progressive cerebellar degeneration. **Experimental Approach:** To test the hypothesis regarding the role of [DAB1](/details-gene/1600) in the oligodendrocyte lineage (Hypothesis 2), a conditional knockout mouse model could be employed. By crossing a mouse line with floxed *Dab1* alleles with a line expressing Cre recombinase under an OPC-specific promoter (e.g., Olig2-Cre or Pdgfra-CreERT2), [DAB1](/details-gene/1600) can be selectively deleted in these cells. Subsequent analysis of these mice using histology (immunostaining for OPC and mature oligodendrocyte markers like MBP and CC1) and electron microscopy would allow for detailed assessment of OPC proliferation, migration, differentiation, and the structural integrity of myelin sheaths during postnatal development and in models of demyelination. **Therapeutic Potential:** Directly targeting the [DAB1](/details-gene/1600) protein is challenging due to its role as an intracellular adaptor in a critical developmental pathway. However, for SCA37, the therapeutic potential lies in addressing the genetic mutation itself. Strategies such as antisense oligonucleotides (ASOs) or CRISPR-based gene editing designed to either excise the repeat expansion or suppress the expression of the mutant allele could represent a viable therapeutic avenue. Such an approach would aim to restore normal [DAB1](/details-gene/1600) expression levels in the cerebellum, potentially halting or reversing the neurodegenerative process.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Disabled homolog 1

Genular Protein ID: 1425326140

Symbol: DAB1_HUMAN

Name: Disabled homolog 1

UniProtKB Accession Codes:

O75553 A4FU90 B3KTG3 Q4LE59 Q5T6M6 Q5T6M9 Q5T835 Q5T836 Q5T837 Q6NWS9 Q6NWT0 Q6NWT1 Q9NYA8

Database IDs:

Citations:

PubMed ID: 9790777

Title: Cloning of human DAB1 and mapping to chromosome 1p31-p32.

PubMed ID: 9790777

DOI: 10.1006/geno.1998.5523

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15272003

Title: Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.

PubMed ID: 15272003

DOI: 10.1074/jbc.m407592200

PubMed ID: 28686858

Title: A pentanucleotide ATTTC repeat insertion in the non-coding region of DAB1, mapping to SCA37, causes spinocerebellar ataxia.

PubMed ID: 28686858

DOI: 10.1016/j.ajhg.2017.06.007

Sequence Information:

Length: 588
Mass: 63775
Checksum: DAD4024364113AC5
Sequence:

MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 
CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 
TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 
EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV 
SNGYSFEDFE ERFAAATPNR NLPTDFDEIF EATKAVTQLE LFGDMSTPPD ITSPPTPATP 
GDAFIPSSSQ TLPASADVFS SVPFGTAAVP SGYVAMGAVL PSFWGQQPLV QQQMVMGAQP 
PVAQVMPGAQ PIAWGQPGLF PATQQPWPTV AGQFPPAAFM PTQTVMPLPA AMFQGPLTPL 
ATVPGTSDST RSSPQTDKPR QKMGKETFKD FQMAQPPPVP SRKPDQPSLT CTSEAFSSYF 
NKVGVAQDTD DCDDFDISQL NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHASDPTTDD 
IFEEGFESPS KSEEQEAPDG SQASSNSDPF GEPSGEPSGD NISPQAGS

Details for: DAB1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning of human DAB1 and mapping to chromosome 1p31-p32. PubMed ID: 9790777

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334