Details for: GSTM1

Gene ID: 2944

Symbol: GSTM1

Ensembl ID: ENSG00000134184

Description: glutathione S-transferase mu 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.49
    Marker Score: 2795
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.87
    Marker Score: 1923
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.96
    Marker Score: 574
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.7
    Marker Score: 1161
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1156
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.32
    Marker Score: 3738
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.29
    Marker Score: 782
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.16
    Marker Score: 1233
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7420
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.11
    Marker Score: 510
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.09
    Marker Score: 7106
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1
    Marker Score: 709
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71804
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.94
    Marker Score: 682
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5277
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.91
    Marker Score: 1339
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 615
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.9
    Marker Score: 498
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.9
    Marker Score: 1479
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.84
    Marker Score: 452.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.84
    Marker Score: 268
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.75
    Marker Score: 357
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 291
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.72
    Marker Score: 1117
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.72
    Marker Score: 773
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.7
    Marker Score: 926
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.67
    Marker Score: 355
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.66
    Marker Score: 289
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.66
    Marker Score: 3921
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.64
    Marker Score: 1323
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.64
    Marker Score: 181
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.61
    Marker Score: 1671
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.61
    Marker Score: 4536
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.59
    Marker Score: 1760
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.57
    Marker Score: 1564
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.56
    Marker Score: 3594
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.55
    Marker Score: 549
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.55
    Marker Score: 552
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.55
    Marker Score: 5505.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.55
    Marker Score: 557
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 338
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.51
    Marker Score: 448.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.49
    Marker Score: 707
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.49
    Marker Score: 611
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.48
    Marker Score: 348
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.46
    Marker Score: 5219
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.44
    Marker Score: 5058
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.42
    Marker Score: 205
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.42
    Marker Score: 731
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.41
    Marker Score: 160
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.4
    Marker Score: 183
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.39
    Marker Score: 687
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.39
    Marker Score: 97
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.39
    Marker Score: 761
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.37
    Marker Score: 728
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.37
    Marker Score: 275
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.36
    Marker Score: 1524
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.35
    Marker Score: 632
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.35
    Marker Score: 224
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.35
    Marker Score: 253
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.35
    Marker Score: 263
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.34
    Marker Score: 168
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 214.5
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.32
    Marker Score: 96
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.32
    Marker Score: 794
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.31
    Marker Score: 184
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.31
    Marker Score: 123
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.3
    Marker Score: 104
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.29
    Marker Score: 300.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.29
    Marker Score: 192
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.28
    Marker Score: 140
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 159
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.28
    Marker Score: 4305
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.27
    Marker Score: 225
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.27
    Marker Score: 81
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.27
    Marker Score: 82
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.27
    Marker Score: 259
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.27
    Marker Score: 258

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Other Information

**Key characteristics:** * GSTM1 is a large protein with a molecular weight of approximately 130 kDa. * It is a thiol-dependent enzyme, meaning that it requires a thiol group for its catalytic activity. * GSTM1 is a member of the glutathione S-transferase (GST) family of enzymes, which are responsible for the detoxification of electrophilic compounds. * It is expressed in high levels in tissues that are exposed to oxidative stress, such as the lungs, liver, and kidneys. * GSTM1 is also expressed in cells that are involved in inflammation and immune responses. **Pathways and functions:** * GSTM1 is involved in several important pathways, including: * Azathioprine adme: GSTM1 is a key enzyme in the metabolism of the anticancer drug azathioprine. * Biological oxidations: GSTM1 is involved in the detoxification of various endogenous and exogenous compounds, including hydrogen peroxide, hydroxyl radicals, and lipid peroxides. * Cellular detoxification of nitrogen compounds: GSTM1 is responsible for the detoxification of certain nitrogenous compounds, such as nitric oxide and nitrate. * Drug adme: GSTM1 is involved in the metabolism of several drugs, including paracetamol and methotrexate. * Enzyme binding: GSTM1 binds to a variety of proteins, including glutathione, proteins involved in inflammation and immune responses, and drugs. * Glutathione conjugation: GSTM1 conjugates with glutathione to form glutathione S-transferase complex, which protects cells from oxidative damage. * Glutathione derivative biosynthetic process: GSTM1 is involved in the biosynthesis of glutathione, a key antioxidant molecule. * Glutathione metabolic process: GSTM1 participates in the metabolism of various substrates, including hydrogen peroxide, nitric oxide, and amino acids. * Glutathione transferase activity: GSTM1 is a key enzyme in the transfer of glutathione between different molecules. **Clinical significance:** GSTM1 gene mutations have been linked to an increased risk of certain diseases, including liver disease, cancer, and inflammation. Studies have shown that mutations in the GSTM1 gene can lead to the accumulation of damaged proteins and cell death. This can be seen in conditions such as liver cirrhosis, liver cancer, and rheumatoid arthritis. GSTM1 is a promising target for the treatment of diseases that are characterized by oxidative stress and inflammation. By inhibiting GSTM1, it may be possible to protect cells from damage and slow the progression of these diseases.

Genular Protein ID: 3671911742

Symbol: GSTM1_HUMAN

Name: GST HB subunit 4

UniProtKB Accession Codes:

P09488 Q5GHG0 Q6FH88 Q8TC98 Q9UC96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTC 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 19 EC 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 12 SABIO-RK 1 SFLD 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3419925

Title: The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA.

PubMed ID: 3419925

DOI: 10.1093/nar/16.17.8541

PubMed ID: 3174634

Title: Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.

PubMed ID: 3174634

DOI: 10.1073/pnas.85.19.7293

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8471052

Title: Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4.

PubMed ID: 8471052

DOI: 10.1042/bj2910041

PubMed ID: 7822249

Title: Immunochemical evidence for the occurrence of Mu class glutathione S-transferase in human fetal livers.

PubMed ID: 7822249

DOI: 10.1093/oxfordjournals.jbchem.a124525

PubMed ID: 2110160

Title: Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms.

PubMed ID: 2110160

DOI: 10.1016/s0021-9258(19)39092-1

PubMed ID: 3979555

Title: Structural evidence for three different types of glutathione transferase in human tissues.

PubMed ID: 3979555

DOI: 10.1016/0014-5793(85)80324-0

PubMed ID: 3864155

Title: Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

PubMed ID: 3864155

DOI: 10.1073/pnas.82.21.7202

PubMed ID: 1846734

Title: Purification and characterization of human muscle glutathione S-transferases: evidence that glutathione S-transferase zeta corresponds to a locus distinct from GST1, GST2, and GST3.

PubMed ID: 1846734

DOI: 10.1016/0003-9861(91)90329-h

PubMed ID: 1420361

Title: Gender related differences in the expression and characteristics of glutathione S-transferases of human colon.

PubMed ID: 1420361

DOI: 10.1016/0167-4781(92)90135-m

PubMed ID: 11271497

Title: Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.

PubMed ID: 11271497

DOI: 10.1002/1522-2683(200011)21:17<3785::aid-elps3785>3.0.co;2-2

PubMed ID: 2362832

Title: GST1 gene deletion determined by polymerase chain reaction.

PubMed ID: 2362832

DOI: 10.1093/nar/18.12.3670

PubMed ID: 8317488

Title: Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13.

PubMed ID: 8317488

PubMed ID: 9084911

Title: Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.

PubMed ID: 9084911

DOI: 10.1021/tx9601770

PubMed ID: 21046276

Title: Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.

PubMed ID: 21046276

DOI: 10.1007/s11745-010-3485-1

PubMed ID: 9930979

Title: Functions of His107 in the catalytic mechanism of human glutathione S-transferase hGSTM1a-1a.

PubMed ID: 9930979

DOI: 10.1021/bi982164m

PubMed ID: 16548513

Title: Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a.

PubMed ID: 16548513

DOI: 10.1021/bi051823+

Sequence Information:

  • Length: 218
  • Mass: 25712
  • Checksum: 98FB03E87B83A31B
  • Sequence:
    • MPMILGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL 
PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQTMDNHMQ LGMICYNPEF 
EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG NKITFVDFLV YDVLDLHRIF EPKCLDAFPN 
LKDFISRFEG LEKISAYMKS SRFLPRPVFS KMAVWGNK

Genular Protein ID: 4258128084

Symbol: X5D932_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5D932

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 7 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 2 RefSeq 1 Rhea 1 RuleBase 1 SFLD 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 181
  • Mass: 21253
  • Checksum: 1FB16A0418115A26
  • Sequence:
    • MPMILGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL 
PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQTMDNHMQ LGMICYNPEF 
EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG NKGLEKISAY MKSSRFLPRP VFSKMAVWGN 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.