Details for: GSTM1

Gene ID: 2944

Symbol: GSTM1

Ensembl ID: ENSG00000134184

Description: glutathione S-transferase mu 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 22.0515
    Cell Significance Index: -3.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.2272
    Cell Significance Index: -3.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.1272
    Cell Significance Index: 47.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8306
    Cell Significance Index: -3.4900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.7890
    Cell Significance Index: 17.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.4038
    Cell Significance Index: 30.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1454
    Cell Significance Index: 111.4500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.8096
    Cell Significance Index: 27.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6500
    Cell Significance Index: 297.4400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.6444
    Cell Significance Index: 23.0700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.1338
    Cell Significance Index: 7.1300
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.9261
    Cell Significance Index: 4.6200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.9150
    Cell Significance Index: 4.4500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8868
    Cell Significance Index: 5.2100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.8761
    Cell Significance Index: 5.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8021
    Cell Significance Index: 20.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7435
    Cell Significance Index: 91.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7081
    Cell Significance Index: 20.8000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.4893
    Cell Significance Index: 2.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4852
    Cell Significance Index: 13.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4734
    Cell Significance Index: 76.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4300
    Cell Significance Index: 50.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4133
    Cell Significance Index: 24.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3956
    Cell Significance Index: 8.2800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.3260
    Cell Significance Index: 0.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2921
    Cell Significance Index: 28.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1927
    Cell Significance Index: 36.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1610
    Cell Significance Index: 1.7500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1317
    Cell Significance Index: 2.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1237
    Cell Significance Index: 13.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0852
    Cell Significance Index: 46.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0851
    Cell Significance Index: 0.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0766
    Cell Significance Index: 1.5900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0580
    Cell Significance Index: 0.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0544
    Cell Significance Index: 3.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0540
    Cell Significance Index: 1.1700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.0219
    Cell Significance Index: 0.2400
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.0203
    Cell Significance Index: 0.0900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0146
    Cell Significance Index: 0.0900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0142
    Cell Significance Index: 0.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0095
    Cell Significance Index: 1.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0090
    Cell Significance Index: 3.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0057
    Cell Significance Index: 0.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0041
    Cell Significance Index: 0.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0033
    Cell Significance Index: 0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0019
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -2.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0043
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0051
    Cell Significance Index: -0.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0054
    Cell Significance Index: -3.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0058
    Cell Significance Index: -3.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0087
    Cell Significance Index: -0.2800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0090
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0093
    Cell Significance Index: -4.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0096
    Cell Significance Index: -3.4500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0097
    Cell Significance Index: -0.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0105
    Cell Significance Index: -0.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0143
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0152
    Cell Significance Index: -3.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0169
    Cell Significance Index: -3.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0200
    Cell Significance Index: -2.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0266
    Cell Significance Index: -3.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0274
    Cell Significance Index: -0.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0277
    Cell Significance Index: -4.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0288
    Cell Significance Index: -1.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0297
    Cell Significance Index: -0.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0305
    Cell Significance Index: -0.5100
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0364
    Cell Significance Index: -0.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0393
    Cell Significance Index: -0.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0408
    Cell Significance Index: -3.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0423
    Cell Significance Index: -2.9900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0427
    Cell Significance Index: -0.7200
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0436
    Cell Significance Index: -0.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0511
    Cell Significance Index: -4.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0545
    Cell Significance Index: -1.3300
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0546
    Cell Significance Index: -0.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0581
    Cell Significance Index: -3.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0601
    Cell Significance Index: -3.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0608
    Cell Significance Index: -3.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0610
    Cell Significance Index: -3.7400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0624
    Cell Significance Index: -0.2400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0625
    Cell Significance Index: -0.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0643
    Cell Significance Index: -2.3600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0647
    Cell Significance Index: -0.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0670
    Cell Significance Index: -3.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0675
    Cell Significance Index: -1.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0676
    Cell Significance Index: -2.9400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0682
    Cell Significance Index: -1.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GSTM1 is a dimeric enzyme composed of two identical subunits, each consisting of approximately 220 amino acids. The enzyme is primarily expressed in the cytosol of cells and exhibits a wide range of substrate specificity, including xenobiotics, electrophiles, and other reactive compounds. GSTM1 is also known to interact with other proteins, such as glutathione and other glutathione S-transferases, to regulate its activity and stability. **Pathways and Functions:** GSTM1 is involved in various cellular pathways, including: 1. **Glutathione conjugation**: GSTM1 catalyzes the conjugation of glutathione to electrophilic compounds, such as xenobiotics and reactive oxygen species, which are then eliminated from the body. 2. **Cellular detoxification**: GSTM1 plays a role in the detoxification of nitrogen and sulfur compounds, such as nitrobenzene and paracetamol, which are metabolized into less toxic compounds. 3. **Oxidative stress response**: GSTM1 helps to protect cells against oxidative stress by conjugating glutathione to reactive oxygen species, thereby neutralizing their toxic effects. 4. **Cancer prevention**: GSTM1 has been shown to have anti-cancer properties by conjugating glutathione to carcinogenic compounds, thereby reducing their carcinogenic potential. **Clinical Significance:** The absence or deficiency of GSTM1 has been associated with various diseases, including: 1. **Cancer**: GSTM1 deficiency has been linked to an increased risk of certain cancers, such as lung, breast, and colon cancer. 2. **Neurological disorders**: GSTM1 deficiency has been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Metabolic disorders**: GSTM1 deficiency has been linked to metabolic disorders, such as diabetes and obesity. 4. **Toxicity**: GSTM1 deficiency can also lead to increased toxicity from certain chemicals, such as pesticides and heavy metals. In conclusion, GSTM1 plays a critical role in cellular defense mechanisms, and its absence or deficiency can have significant implications for human health. Further research is needed to fully understand the mechanisms of GSTM1 and its clinical significance.

Genular Protein ID: 3671911742

Symbol: GSTM1_HUMAN

Name: GST HB subunit 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3419925

Title: The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA.

PubMed ID: 3419925

DOI: 10.1093/nar/16.17.8541

PubMed ID: 3174634

Title: Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.

PubMed ID: 3174634

DOI: 10.1073/pnas.85.19.7293

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8471052

Title: Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4.

PubMed ID: 8471052

DOI: 10.1042/bj2910041

PubMed ID: 7822249

Title: Immunochemical evidence for the occurrence of Mu class glutathione S-transferase in human fetal livers.

PubMed ID: 7822249

DOI: 10.1093/oxfordjournals.jbchem.a124525

PubMed ID: 2110160

Title: Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms.

PubMed ID: 2110160

DOI: 10.1016/s0021-9258(19)39092-1

PubMed ID: 3979555

Title: Structural evidence for three different types of glutathione transferase in human tissues.

PubMed ID: 3979555

DOI: 10.1016/0014-5793(85)80324-0

PubMed ID: 3864155

Title: Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

PubMed ID: 3864155

DOI: 10.1073/pnas.82.21.7202

PubMed ID: 1846734

Title: Purification and characterization of human muscle glutathione S-transferases: evidence that glutathione S-transferase zeta corresponds to a locus distinct from GST1, GST2, and GST3.

PubMed ID: 1846734

DOI: 10.1016/0003-9861(91)90329-h

PubMed ID: 1420361

Title: Gender related differences in the expression and characteristics of glutathione S-transferases of human colon.

PubMed ID: 1420361

DOI: 10.1016/0167-4781(92)90135-m

PubMed ID: 11271497

Title: Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.

PubMed ID: 11271497

DOI: 10.1002/1522-2683(200011)21:17<3785::aid-elps3785>3.0.co;2-2

PubMed ID: 2362832

Title: GST1 gene deletion determined by polymerase chain reaction.

PubMed ID: 2362832

DOI: 10.1093/nar/18.12.3670

PubMed ID: 8317488

Title: Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13.

PubMed ID: 8317488

PubMed ID: 9084911

Title: Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.

PubMed ID: 9084911

DOI: 10.1021/tx9601770

PubMed ID: 21046276

Title: Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.

PubMed ID: 21046276

DOI: 10.1007/s11745-010-3485-1

PubMed ID: 9930979

Title: Functions of His107 in the catalytic mechanism of human glutathione S-transferase hGSTM1a-1a.

PubMed ID: 9930979

DOI: 10.1021/bi982164m

PubMed ID: 16548513

Title: Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a.

PubMed ID: 16548513

DOI: 10.1021/bi051823+

Sequence Information:

  • Length: 218
  • Mass: 25712
  • Checksum: 98FB03E87B83A31B
  • Sequence:
  • MPMILGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL 
    PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQTMDNHMQ LGMICYNPEF 
    EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG NKITFVDFLV YDVLDLHRIF EPKCLDAFPN 
    LKDFISRFEG LEKISAYMKS SRFLPRPVFS KMAVWGNK

Genular Protein ID: 4258128084

Symbol: X5D932_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 181
  • Mass: 21253
  • Checksum: 1FB16A0418115A26
  • Sequence:
  • MPMILGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL 
    PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQTMDNHMQ LGMICYNPEF 
    EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG NKGLEKISAY MKSSRFLPRP VFSKMAVWGN 
    K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.