Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 75.9265
Cell Significance Index: -11.8100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 42.2246
Cell Significance Index: -10.7100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 26.0102
Cell Significance Index: -12.2800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.9650
Cell Significance Index: -11.7000 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.6153
Cell Significance Index: 25.9200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.4856
Cell Significance Index: 37.1400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.3610
Cell Significance Index: 83.4400 - Cell Name: preosteoblast (CL0007010)
Fold Change: 1.1977
Cell Significance Index: 10.8700 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.0232
Cell Significance Index: 15.8300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.0181
Cell Significance Index: 21.3100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.9401
Cell Significance Index: 26.9500 - Cell Name: chondroblast (CL0000058)
Fold Change: 0.6337
Cell Significance Index: 3.7200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5634
Cell Significance Index: 12.2100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.4468
Cell Significance Index: 8.7200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3786
Cell Significance Index: 72.0500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3613
Cell Significance Index: 49.6200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.3469
Cell Significance Index: 11.1100 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.3257
Cell Significance Index: 2.0200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2255
Cell Significance Index: 22.3100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2176
Cell Significance Index: 196.5200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1862
Cell Significance Index: 23.8700 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.1299
Cell Significance Index: 0.8800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1095
Cell Significance Index: 17.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0950
Cell Significance Index: 51.8800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.0933
Cell Significance Index: 2.2600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0809
Cell Significance Index: 0.8800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0552
Cell Significance Index: 34.4500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0511
Cell Significance Index: 2.4000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0376
Cell Significance Index: 0.6300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0348
Cell Significance Index: 3.7900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0190
Cell Significance Index: 13.1700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0153
Cell Significance Index: 3.0400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0138
Cell Significance Index: 1.5700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0014
Cell Significance Index: -0.0400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0015
Cell Significance Index: -2.8100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0046
Cell Significance Index: -0.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0065
Cell Significance Index: -4.8000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0076
Cell Significance Index: -14.0000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0088
Cell Significance Index: -13.5000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0089
Cell Significance Index: -12.1300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0089
Cell Significance Index: -3.9400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0120
Cell Significance Index: -6.7500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0144
Cell Significance Index: -10.9300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0152
Cell Significance Index: -1.5500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0169
Cell Significance Index: -12.3600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0170
Cell Significance Index: -4.8900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0175
Cell Significance Index: -11.1200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0227
Cell Significance Index: -8.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0240
Cell Significance Index: -4.1000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0265
Cell Significance Index: -1.8300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0273
Cell Significance Index: -12.3800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0275
Cell Significance Index: -5.7900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0373
Cell Significance Index: -1.6900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0378
Cell Significance Index: -4.4100 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0384
Cell Significance Index: -0.3700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0435
Cell Significance Index: -7.8400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0446
Cell Significance Index: -8.9500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0464
Cell Significance Index: -6.0000 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0580
Cell Significance Index: -0.9200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0670
Cell Significance Index: -8.2400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0674
Cell Significance Index: -9.8000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0893
Cell Significance Index: -10.2300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0980
Cell Significance Index: -6.9300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1031
Cell Significance Index: -6.1900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1121
Cell Significance Index: -11.6700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1187
Cell Significance Index: -3.1700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1354
Cell Significance Index: -6.8400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1385
Cell Significance Index: -8.5200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1413
Cell Significance Index: -4.9100 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.1432
Cell Significance Index: -0.8900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1591
Cell Significance Index: -12.2100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1603
Cell Significance Index: -4.4800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1624
Cell Significance Index: -7.5700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1678
Cell Significance Index: -3.4800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1722
Cell Significance Index: -11.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1733
Cell Significance Index: -10.9200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1754
Cell Significance Index: -13.0700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2277
Cell Significance Index: -12.7800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2322
Cell Significance Index: -4.9500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2564
Cell Significance Index: -11.3400 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.2577
Cell Significance Index: -2.1900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2608
Cell Significance Index: -3.9300 - Cell Name: osteoblast (CL0000062)
Fold Change: -0.2762
Cell Significance Index: -2.6800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2805
Cell Significance Index: -7.2100 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2807
Cell Significance Index: -7.0000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2830
Cell Significance Index: -14.8600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2870
Cell Significance Index: -10.5400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2893
Cell Significance Index: -15.0300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2930
Cell Significance Index: -7.9800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3026
Cell Significance Index: -11.4600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3034
Cell Significance Index: -10.6300 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.3203
Cell Significance Index: -3.5800 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.3345
Cell Significance Index: -1.6000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3415
Cell Significance Index: -11.1800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3424
Cell Significance Index: -9.1600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3487
Cell Significance Index: -10.2700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3489
Cell Significance Index: -9.3500 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3641
Cell Significance Index: -9.1000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3654
Cell Significance Index: -14.9700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3696
Cell Significance Index: -9.2200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 625606993
Symbol: LYOX_HUMAN
Name: Protein-lysine 6-oxidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1685472
Title: Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2.
PubMed ID: 1685472
PubMed ID: 1357535
Title: The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene).
PubMed ID: 1357535
PubMed ID: 7706256
Title: A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase.
PubMed ID: 7706256
PubMed ID: 10391127
Title: Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene.
PubMed ID: 10391127
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7902322
PubMed ID: 1352776
Title: Characterization of the human lysyl oxidase gene locus.
PubMed ID: 1352776
PubMed ID: 19570982
Title: Differential regulation of elastic fiber formation by fibulin-4 and -5.
PubMed ID: 19570982
PubMed ID: 19855011
Title: Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase.
PubMed ID: 19855011
PubMed ID: 26601954
Title: Characterization of microfibrillar-associated protein 4 (MFAP4) as a tropoelastin- and fibrillin-binding protein involved in elastic fiber formation.
PubMed ID: 26601954
PubMed ID: 31152061
Title: Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.
PubMed ID: 31152061
PubMed ID: 8100215
Title: A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene.
PubMed ID: 8100215
PubMed ID: 26838787
Title: LOX mutations predispose to thoracic aortic aneurysms and dissections.
PubMed ID: 26838787
PubMed ID: 27432961
Title: Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.
PubMed ID: 27432961
Sequence Information:
- Length: 417
- Mass: 46944
- Checksum: 6412A78443E03F04
- Sequence:
MRFAWTVLLL GPLQLCALVH CAPPAAGQQQ PPREPPAAPG AWRQQIQWEN NGQVFSLLSL GSQYQPQRRR DPGAAVPGAA NASAQQPRTP ILLIRDNRTA AARTRTAGSS GVTAGRPRPT ARHWFQAGYS TSRAREAGAS RAENQTAPGE VPALSNLRPP SRVDGMVGDD PYNPYKYSDD NPYYNYYDTY ERPRPGGRYR PGYGTGYFQY GLPDLVADPY YIQASTYVQK MSMYNLRCAA EENCLASTAY RADVRDYDHR VLLRFPQRVK NQGTSDFLPS RPRYSWEWHS CHQHYHSMDE FSHYDLLDAN TQRRVAEGHK ASFCLEDTSC DYGYHRRFAC TAHTQGLSPG CYDTYGADID CQWIDITDVK PGNYILKVSV NPSYLVPESD YTNNVVRCDI RYTGHHAYAS GCTISPY
Genular Protein ID: 4074307060
Symbol: B0AZT2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 120
- Mass: 13547
- Checksum: 2C763461592DA50B
- Sequence:
MDEFSHYDLL DANTQRRVAE GHKASFCLED TSCDYGYHRR FACTAHTQGL SPGCYDTYGA DIDCQWIDIT DVKPGNYILK VSVNPSYLVP ESDYTNNVVR CDIRYTGHHA YASGCTISPY
Genular Protein ID: 3624044100
Symbol: B7ZAJ4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 187
- Mass: 21618
- Checksum: 8B544A15B0543B73
- Sequence:
MSMYNLRCAA EENCLASTAY RADVRDYDHR VLLRFPQRVK NQGTSDFLPS RPRYSWEWHS CHQHYHSMDE FSHYDLLDAN TQRRVAEGHK ASFCLEDTSC DYGYHRRFAC TAHTQGLSPG CYDTYGADID CQWIDITDVK PGNYILKVSV NPSYLVPESD YTNNVVRCDI RYTGHHAYAS GCTISPY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.