Details for: LOX

Gene ID: 4015

Symbol: LOX

Ensembl ID: ENSG00000113083

Description: lysyl oxidase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.6
    Marker Score: 453
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1159
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.58
    Marker Score: 901
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.39
    Marker Score: 1904
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.38
    Marker Score: 1372.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.29
    Marker Score: 297
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.29
    Marker Score: 1983
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.26
    Marker Score: 1128
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.17
    Marker Score: 3053
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4798
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.04
    Marker Score: 258
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 660.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 381
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.92
    Marker Score: 579.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.92
    Marker Score: 31193.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 393.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 688
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.71
    Marker Score: 7968
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.7
    Marker Score: 156.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.62
    Marker Score: 225
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.61
    Marker Score: 262
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.61
    Marker Score: 326
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 157
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.59
    Marker Score: 1052.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 392
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.58
    Marker Score: 185.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.58
    Marker Score: 360
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.54
    Marker Score: 138
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.53
    Marker Score: 3177
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.52
    Marker Score: 978.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.51
    Marker Score: 250
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.49
    Marker Score: 325
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.46
    Marker Score: 386
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.46
    Marker Score: 164
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.46
    Marker Score: 214
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.45
    Marker Score: 1925
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.43
    Marker Score: 3221
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.43
    Marker Score: 499
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6648
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.42
    Marker Score: 167
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.41
    Marker Score: 103
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 179
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.41
    Marker Score: 103
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 824
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.4
    Marker Score: 727
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.37
    Marker Score: 452
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.36
    Marker Score: 151
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.35
    Marker Score: 90
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.34
    Marker Score: 82
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.33
    Marker Score: 104
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.32
    Marker Score: 277
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.32
    Marker Score: 120
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.32
    Marker Score: 219
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.31
    Marker Score: 119
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.31
    Marker Score: 765
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 82
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.29
    Marker Score: 188
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 176
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.29
    Marker Score: 133
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.29
    Marker Score: 986.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.29
    Marker Score: 136
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.29
    Marker Score: 129
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.29
    Marker Score: 673
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.28
    Marker Score: 3806
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.28
    Marker Score: 436
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 113
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.27
    Marker Score: 66
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.27
    Marker Score: 66
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.26
    Marker Score: 3495
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.26
    Marker Score: 174
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.26
    Marker Score: 125.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 230
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 149
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.25
    Marker Score: 2161
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 117
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.24
    Marker Score: 119
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.23
    Marker Score: 272.5

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Other Information

**Key characteristics:** * LOX is a copper-dependent enzyme that catalyzes the oxidation of lysyl residues in collagen molecules. * It is a key regulator of collagen metabolism and plays a role in tissue development, wound healing, and fibrosis. * Mutations in the LOX gene have been linked to several human diseases, including osteoporosis, rheumatoid arthritis, and cancer. **Pathways and functions:** * LOX is involved in the assembly of collagen fibrils by catalyzing the oxidation of lysyl residues in collagen tropoproteins. * It is also involved in the formation of elastic fibers, which provide elasticity and resilience to tissues. * LOX is essential for the development and maintenance of the extracellular matrix, which provides structural support for cells and tissues. **Clinical significance:** * LOX inhibitors are being investigated as potential therapeutic agents for diseases characterized by excessive collagen deposition, such as osteoporosis, rheumatoid arthritis, and fibrotic diseases. * Targeting LOX has been shown to be effective in reducing tissue damage and improving symptoms. **Additional notes:** * LOX is a highly conserved enzyme that is expressed in organisms from yeast to humans. * It is a multi-functional enzyme that can also bind to and activate other proteins, including B0AZT2 and B7ZAJ4. * Mutations in the LOX gene have been linked to a number of human diseases, including osteoporosis, rheumatoid arthritis, and cancer.

Genular Protein ID: 625606993

Symbol: LYOX_HUMAN

Name: Protein-lysine 6-oxidase

UniProtKB Accession Codes:

P28300 B2R5Q3 Q5FWF0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 10 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 38 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1685472

Title: Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2.

PubMed ID: 1685472

DOI: 10.1016/0888-7543(91)90057-l

PubMed ID: 1357535

Title: The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene).

PubMed ID: 1357535

DOI: 10.1016/s0934-8832(11)80067-3

PubMed ID: 7706256

Title: A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase.

PubMed ID: 7706256

DOI: 10.1074/jbc.270.13.7176

PubMed ID: 10391127

Title: Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene.

PubMed ID: 10391127

DOI: 10.1023/a:1006913122261

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7902322

Title: Structure of the human lysyl oxidase gene.

PubMed ID: 7902322

DOI: 10.1006/geno.1993.1369

PubMed ID: 1352776

Title: Characterization of the human lysyl oxidase gene locus.

PubMed ID: 1352776

DOI: 10.1016/s0021-9258(19)49723-8

PubMed ID: 19570982

Title: Differential regulation of elastic fiber formation by fibulin-4 and -5.

PubMed ID: 19570982

DOI: 10.1074/jbc.m109.019364

PubMed ID: 19855011

Title: Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase.

PubMed ID: 19855011

DOI: 10.1073/pnas.0908268106

PubMed ID: 26601954

Title: Characterization of microfibrillar-associated protein 4 (MFAP4) as a tropoelastin- and fibrillin-binding protein involved in elastic fiber formation.

PubMed ID: 26601954

DOI: 10.1074/jbc.m115.681775

PubMed ID: 31152061

Title: Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.

PubMed ID: 31152061

DOI: 10.1074/jbc.ra119.007806

PubMed ID: 8100215

Title: A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene.

PubMed ID: 8100215

DOI: 10.1006/geno.1993.1203

PubMed ID: 26838787

Title: LOX mutations predispose to thoracic aortic aneurysms and dissections.

PubMed ID: 26838787

DOI: 10.1161/circresaha.115.307130

PubMed ID: 27432961

Title: Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.

PubMed ID: 27432961

DOI: 10.1073/pnas.1601442113

Sequence Information:

  • Length: 417
  • Mass: 46944
  • Checksum: 6412A78443E03F04
  • Sequence:
    • MRFAWTVLLL GPLQLCALVH CAPPAAGQQQ PPREPPAAPG AWRQQIQWEN NGQVFSLLSL 
GSQYQPQRRR DPGAAVPGAA NASAQQPRTP ILLIRDNRTA AARTRTAGSS GVTAGRPRPT 
ARHWFQAGYS TSRAREAGAS RAENQTAPGE VPALSNLRPP SRVDGMVGDD PYNPYKYSDD 
NPYYNYYDTY ERPRPGGRYR PGYGTGYFQY GLPDLVADPY YIQASTYVQK MSMYNLRCAA 
EENCLASTAY RADVRDYDHR VLLRFPQRVK NQGTSDFLPS RPRYSWEWHS CHQHYHSMDE 
FSHYDLLDAN TQRRVAEGHK ASFCLEDTSC DYGYHRRFAC TAHTQGLSPG CYDTYGADID 
CQWIDITDVK PGNYILKVSV NPSYLVPESD YTNNVVRCDI RYTGHHAYAS GCTISPY

Genular Protein ID: 4074307060

Symbol: B0AZT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0AZT2

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 7 DNASU 1 EC 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 Rhea 3 RuleBase 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 120
  • Mass: 13547
  • Checksum: 2C763461592DA50B
  • Sequence:
    • MDEFSHYDLL DANTQRRVAE GHKASFCLED TSCDYGYHRR FACTAHTQGL SPGCYDTYGA 
DIDCQWIDIT DVKPGNYILK VSVNPSYLVP ESDYTNNVVR CDIRYTGHHA YASGCTISPY

Genular Protein ID: 3624044100

Symbol: B7ZAJ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZAJ4

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 7 DNASU 1 EC 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 RefSeq 1 Rhea 3 RuleBase 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 187
  • Mass: 21618
  • Checksum: 8B544A15B0543B73
  • Sequence:
    • MSMYNLRCAA EENCLASTAY RADVRDYDHR VLLRFPQRVK NQGTSDFLPS RPRYSWEWHS 
CHQHYHSMDE FSHYDLLDAN TQRRVAEGHK ASFCLEDTSC DYGYHRRFAC TAHTQGLSPG 
CYDTYGADID CQWIDITDVK PGNYILKVSV NPSYLVPESD YTNNVVRCDI RYTGHHAYAS 
GCTISPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.