Details for: CDH19

Gene ID: 28513

Symbol: CDH19

Ensembl ID: ENSG00000071991

Description: cadherin 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 8.0500
    Cell Significance Index: 115.6000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 4.5013
    Cell Significance Index: 63.9600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 3.8091
    Cell Significance Index: 60.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.8648
    Cell Significance Index: 19.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2816
    Cell Significance Index: 6.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0193
    Cell Significance Index: 12.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0108
    Cell Significance Index: 20.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0081
    Cell Significance Index: 3.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0064
    Cell Significance Index: -4.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0280
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0327
    Cell Significance Index: -24.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0508
    Cell Significance Index: -38.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0520
    Cell Significance Index: -35.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0525
    Cell Significance Index: -96.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0553
    Cell Significance Index: -2.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0583
    Cell Significance Index: -7.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0592
    Cell Significance Index: -33.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0599
    Cell Significance Index: -4.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0628
    Cell Significance Index: -96.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0712
    Cell Significance Index: -96.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0767
    Cell Significance Index: -15.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0771
    Cell Significance Index: -27.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1010
    Cell Significance Index: -21.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1055
    Cell Significance Index: -19.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1059
    Cell Significance Index: -2.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1061
    Cell Significance Index: -30.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1237
    Cell Significance Index: -9.5000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1291
    Cell Significance Index: -3.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1430
    Cell Significance Index: -7.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1575
    Cell Significance Index: -26.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1584
    Cell Significance Index: -31.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1621
    Cell Significance Index: -23.5700
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1644
    Cell Significance Index: -1.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1818
    Cell Significance Index: -22.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1946
    Cell Significance Index: -25.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2196
    Cell Significance Index: -30.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2318
    Cell Significance Index: -6.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2351
    Cell Significance Index: -24.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2463
    Cell Significance Index: -6.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2526
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2654
    Cell Significance Index: -30.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2700
    Cell Significance Index: -11.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2813
    Cell Significance Index: -32.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2853
    Cell Significance Index: -29.7100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2943
    Cell Significance Index: -3.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3629
    Cell Significance Index: -27.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3800
    Cell Significance Index: -6.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4290
    Cell Significance Index: -8.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4594
    Cell Significance Index: -23.9300
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.4645
    Cell Significance Index: -3.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4652
    Cell Significance Index: -9.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4879
    Cell Significance Index: -22.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4944
    Cell Significance Index: -56.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5004
    Cell Significance Index: -23.5200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.5766
    Cell Significance Index: -6.9600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.5808
    Cell Significance Index: -6.3400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.5830
    Cell Significance Index: -6.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6345
    Cell Significance Index: -39.0000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.6389
    Cell Significance Index: -10.2500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.6784
    Cell Significance Index: -7.0300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.7333
    Cell Significance Index: -6.6600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.7363
    Cell Significance Index: -1.6600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.7717
    Cell Significance Index: -9.9700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.7740
    Cell Significance Index: -6.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7839
    Cell Significance Index: -23.0900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.7845
    Cell Significance Index: -6.6200
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.8043
    Cell Significance Index: -7.9500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.8092
    Cell Significance Index: -9.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8306
    Cell Significance Index: -9.0300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8333
    Cell Significance Index: -11.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8435
    Cell Significance Index: -29.5500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.8470
    Cell Significance Index: -9.0500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.8494
    Cell Significance Index: -8.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8511
    Cell Significance Index: -37.6500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.8590
    Cell Significance Index: -7.9500
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.8593
    Cell Significance Index: -11.0000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.8758
    Cell Significance Index: -9.0600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.8785
    Cell Significance Index: -4.6000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.8815
    Cell Significance Index: -9.4400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.8943
    Cell Significance Index: -9.0800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.9106
    Cell Significance Index: -6.5400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9113
    Cell Significance Index: -13.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9161
    Cell Significance Index: -26.2600
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.9443
    Cell Significance Index: -9.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9582
    Cell Significance Index: -53.7700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.9655
    Cell Significance Index: -11.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9673
    Cell Significance Index: -31.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9824
    Cell Significance Index: -37.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.0172
    Cell Significance Index: -27.1600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -1.0386
    Cell Significance Index: -6.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0446
    Cell Significance Index: -33.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0478
    Cell Significance Index: -54.4300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.0620
    Cell Significance Index: -10.9900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -1.0713
    Cell Significance Index: -6.6300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -1.0739
    Cell Significance Index: -12.6900
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -1.0962
    Cell Significance Index: -10.2700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -1.0981
    Cell Significance Index: -7.0100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0982
    Cell Significance Index: -23.4800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.1261
    Cell Significance Index: -8.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.1495
    Cell Significance Index: -28.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Homophilic Cell Adhesion:** CDH19 mediates homophilic cell-cell adhesion, a critical mechanism for maintaining tissue structure and organization. 2. **Calmodulin Binding:** CDH19 interacts with calmodulin, a calcium-binding protein, to regulate its activity and influence cell-cell adhesion. 3. **Regulation of Expression:** CDH19 expression is tightly regulated by various transcriptional and post-transcriptional mechanisms, ensuring its proper localization and function. 4. **Cellular Localization:** CDH19 is primarily expressed in the plasma membrane, where it interacts with catenins and other adhesion molecules to form adherens junctions. **Pathways and Functions:** 1. **Adherens Junction Organization:** CDH19 is essential for the assembly and maintenance of adherens junctions, which regulate cell-cell adhesion and tissue structure. 2. **Cell-Cell Communication:** CDH19 facilitates cell-cell communication by modulating the activity of other adhesion molecules and signaling pathways. 3. **Cell Morphogenesis:** CDH19 plays a critical role in regulating cell shape and morphology, influencing cellular processes such as migration, differentiation, and proliferation. 4. **Regulation of Expression and Function:** CDH19 expression is regulated by various transcriptional and post-transcriptional mechanisms, ensuring its proper localization and function. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in CDH19 have been associated with various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 2. **Cancer:** CDH19 is often dysregulated in various types of cancer, including breast, ovarian, and colon cancer, where it contributes to tumor progression and metastasis. 3. **Cardiovascular Disease:** CDH19 expression is altered in cardiac neurons, suggesting its potential role in cardiovascular disease and heart development. 4. **Immunological Disorders:** CDH19 has been implicated in immunological disorders, including autoimmune diseases and immune-mediated cancer. In conclusion, CDH19 is a critical component of adherens junctions, playing a pivotal role in maintaining cell-cell adhesion, regulating cellular processes, and influencing development and disease. Further research is needed to elucidate the complex mechanisms underlying CDH19's functions and to explore its therapeutic potential in various diseases.

Genular Protein ID: 1454134350

Symbol: CAD19_HUMAN

Name: Cadherin-19

UniProtKB Accession Codes:

Q9H159 B4E1V5 F5H1K0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10995570

Title: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7.

PubMed ID: 10995570

DOI: 10.1006/geno.2000.6305

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 772
  • Mass: 87002
  • Checksum: 650AD27480343C39
  • Sequence:
    • MNCYLLLRFM LGIPLLWPCL GATENSQTKK VKQPVRSHLR VKRGWVWNQF FVPEEMNTTS 
HHIGQLRSDL DNGNNSFQYK LLGAGAGSTF IIDERTGDIY AIQKLDREER SLYILRAQVI 
DIATGRAVEP ESEFVIKVSD INDNEPKFLD EPYEAIVPEM SPEGTLVIQV TASDADDPSS 
GNNARLLYSL LQGQPYFSVE PTTGVIRISS KMDRELQDEY WVIIQAKDMI GQPGALSGTT 
SVLIKLSDVN DNKPIFKESL YRLTVSESAP TGTSIGTIMA YDNDIGENAE MDYSIEEDDS 
QTFDIITNHE TQEGIVILKK KVDFEHQNHY GIRAKVKNHH VPEQLMKYHT EASTTFIKIQ 
VEDVDEPPLF LLPYYVFEVF EETPQGSFVG VVSATDPDNR KSPIRYSITR SKVFNINDNG 
TITTSNSLDR EISAWYNLSI TATEKYNIEQ ISSIPLYVQV LNINDHAPEF SQYYETYVCE 
NAGSGQVIQT ISAVDRDESI EEHHFYFNLS VEDTNNSSFT IIDNQDNTAV ILTNRTGFNL 
QEEPVFYISI LIADNGIPSL TSTNTLTIHV CDCGDSGSTQ TCQYQELVLS MGFKTEVIIA 
ILICIMIIFG FIFLTLGLKQ RRKQILFPEK SEDFRENIFQ YDDEGGGEED TEAFDIAELR 
SSTIMRERKT RKTTSAEIRS LYRQSLQVGP DSAIFRKFIL EKLEEANTDP CAPPFDSLQT 
YAFEGTGSLA GSLSSLESAV SDQDESYDYL NELGPRFKRL ACMFGSAVQS NN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.