Details for: TCAP

Gene ID: 8557

Symbol: TCAP

Ensembl ID: ENSG00000173991

Description: titin-cap

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.7458
    Cell Significance Index: -6.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.1247
    Cell Significance Index: -6.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 10.3550
    Cell Significance Index: 252.6600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 10.0674
    Cell Significance Index: 162.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 8.9782
    Cell Significance Index: 132.5500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 5.7183
    Cell Significance Index: 90.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6774
    Cell Significance Index: -7.0000
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 4.5746
    Cell Significance Index: 13.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.1353
    Cell Significance Index: 240.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3144
    Cell Significance Index: -6.2000
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 2.2961
    Cell Significance Index: 16.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6874
    Cell Significance Index: 103.4600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8477
    Cell Significance Index: 8.8500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8420
    Cell Significance Index: 12.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7223
    Cell Significance Index: 19.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6611
    Cell Significance Index: 29.9700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6044
    Cell Significance Index: 8.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2767
    Cell Significance Index: 52.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2714
    Cell Significance Index: 26.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2625
    Cell Significance Index: 237.0200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.2596
    Cell Significance Index: 3.4000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.2320
    Cell Significance Index: 3.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2062
    Cell Significance Index: 5.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1413
    Cell Significance Index: 22.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1277
    Cell Significance Index: 13.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1198
    Cell Significance Index: 34.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0959
    Cell Significance Index: 19.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0810
    Cell Significance Index: 4.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0768
    Cell Significance Index: 1.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0647
    Cell Significance Index: 23.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0567
    Cell Significance Index: 3.9200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0372
    Cell Significance Index: 0.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0298
    Cell Significance Index: 0.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0119
    Cell Significance Index: 8.2200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0091
    Cell Significance Index: 0.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0082
    Cell Significance Index: 0.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0041
    Cell Significance Index: 0.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0037
    Cell Significance Index: 0.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0007
    Cell Significance Index: 0.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0028
    Cell Significance Index: -1.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0038
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0136
    Cell Significance Index: -1.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0140
    Cell Significance Index: -0.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0159
    Cell Significance Index: -1.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0173
    Cell Significance Index: -2.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0210
    Cell Significance Index: -3.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0211
    Cell Significance Index: -0.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0222
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0272
    Cell Significance Index: -4.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0283
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0287
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0331
    Cell Significance Index: -3.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0358
    Cell Significance Index: -2.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0398
    Cell Significance Index: -4.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0431
    Cell Significance Index: -2.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0440
    Cell Significance Index: -5.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0488
    Cell Significance Index: -1.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0503
    Cell Significance Index: -5.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0539
    Cell Significance Index: -1.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0541
    Cell Significance Index: -3.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0551
    Cell Significance Index: -2.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0569
    Cell Significance Index: -2.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0602
    Cell Significance Index: -3.7000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0604
    Cell Significance Index: -0.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0619
    Cell Significance Index: -4.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0623
    Cell Significance Index: -3.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0628
    Cell Significance Index: -2.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0645
    Cell Significance Index: -1.3700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0670
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0687
    Cell Significance Index: -5.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0694
    Cell Significance Index: -7.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0759
    Cell Significance Index: -4.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0843
    Cell Significance Index: -1.2700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0887
    Cell Significance Index: -1.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0927
    Cell Significance Index: -1.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0930
    Cell Significance Index: -3.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0987
    Cell Significance Index: -4.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0989
    Cell Significance Index: -3.1500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1033
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1046
    Cell Significance Index: -2.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1073
    Cell Significance Index: -3.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1124
    Cell Significance Index: -3.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1149
    Cell Significance Index: -3.6800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1180
    Cell Significance Index: -2.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1219
    Cell Significance Index: -3.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1223
    Cell Significance Index: -3.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1259
    Cell Significance Index: -1.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1381
    Cell Significance Index: -5.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1407
    Cell Significance Index: -3.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1410
    Cell Significance Index: -4.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1482
    Cell Significance Index: -2.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TCAP is expressed in a wide range of cell types, including cardiac muscle cells, neural progenitor cells, and kidney epithelial cells. 2. **Function:** TCAP is a molecular adaptor protein that interacts with titin, a giant protein that spans the sarcomere, to regulate muscle contraction and relaxation. 3. **Signaling Pathways:** TCAP is implicated in various signaling pathways, including those involved in cardiac development, muscle contraction, and hypertrophy. 4. **Structural Component:** TCAP is a component of the titin complex, which is essential for maintaining the structural integrity of sarcomeres. **Pathways and Functions:** 1. **Cardiac Development:** TCAP is involved in the development of cardiac muscle cells, particularly during somitogenesis and cardiac muscle tissue morphogenesis. 2. **Muscle Contraction:** TCAP regulates muscle contraction by interacting with titin and other proteins to modulate the mechanical properties of sarcomeres. 3. **Hypertrophy:** TCAP is involved in the regulation of cardiac muscle hypertrophy, particularly in response to stress or mechanical overload. 4. **Mechanical Stimulus Detection:** TCAP is also involved in the detection of mechanical stimuli, such as muscle stretch, which is essential for regulating muscle contraction and relaxation. **Clinical Significance:** 1. **Hypertrophic Cardiomyopathy:** TCAP mutations have been associated with hypertrophic cardiomyopathy, a condition characterized by abnormal thickening of the heart muscle. 2. **Cardiac Arrhythmias:** TCAP dysregulation may contribute to cardiac arrhythmias, such as atrial fibrillation, by disrupting normal cardiac electrical activity. 3. **Muscle-Wasting Disorders:** TCAP mutations may also be involved in muscle-wasting disorders, such as muscular dystrophy, by impairing muscle contraction and relaxation. In conclusion, the titin-cap gene (TCAP) is a critical regulator of cardiac muscle function and development. Its dysregulation may contribute to various cardiac disorders, highlighting the importance of further research into the molecular mechanisms underlying cardiac function and disease.

Genular Protein ID: 338867475

Symbol: TELT_HUMAN

Name: Telethonin

UniProtKB Accession Codes:

O15273 Q96L27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9350988

Title: Telethonin, a novel sarcomeric protein of heart and skeletal muscle.

PubMed ID: 9350988

DOI: 10.1016/s0014-5793(97)01108-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9645487

Title: Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin.

PubMed ID: 9645487

DOI: 10.1016/s0014-5793(98)00501-8

PubMed ID: 10984498

Title: FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle.

PubMed ID: 10984498

DOI: 10.1074/jbc.m007493200

PubMed ID: 11842093

Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PubMed ID: 11842093

DOI: 10.1074/jbc.m200712200

PubMed ID: 15136035

Title: The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.

PubMed ID: 15136035

DOI: 10.1016/j.jmb.2004.03.071

PubMed ID: 24860983

Title: Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.

PubMed ID: 24860983

DOI: 10.1111/febs.12859

PubMed ID: 16407954

Title: Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk.

PubMed ID: 16407954

DOI: 10.1038/nature04343

PubMed ID: 16713295

Title: Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus.

PubMed ID: 16713295

DOI: 10.1016/j.jsb.2006.03.028

PubMed ID: 10655062

Title: Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin.

PubMed ID: 10655062

DOI: 10.1038/72822

PubMed ID: 12507422

Title: The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.

PubMed ID: 12507422

DOI: 10.1016/s0092-8674(02)01226-6

PubMed ID: 16352453

Title: Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin.

PubMed ID: 16352453

DOI: 10.1016/j.ymgme.2005.10.008

PubMed ID: 16490376

Title: Deletion of Glu at codon 13 in the TCAP gene encoding the Z-disc protein titin-cap/telethonin is a rare non-synonymous polymorphism.

PubMed ID: 16490376

DOI: 10.1016/j.ymgme.2006.01.004

PubMed ID: 16650785

Title: Deletion of Glu at codon 13 of the TCAP gene encoding the titin-cap-telethonin is a rare polymorphism in a large Italian population.

PubMed ID: 16650785

DOI: 10.1016/j.ymgme.2006.03.012

PubMed ID: 15582318

Title: Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy.

PubMed ID: 15582318

DOI: 10.1016/j.jacc.2004.08.058

Sequence Information:

  • Length: 167
  • Mass: 19052
  • Checksum: A3B0E27D8C84F6C5
  • Sequence:
    • MATSELSCEV SEENCERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHQQGQCQVL 
VQRSPWLMMR MGILGRGLQE YQLPYQRVLP LPIFTPAKMG ATKEEREDTP IQLQELLALE 
TALGGQCVDR QEVAEITKQL PPVVPVSKPG ALRRSLSRSM SQEAQRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.