Details for: MFAP2

Gene ID: 4237

Symbol: MFAP2

Ensembl ID: ENSG00000117122

Description: microfibril associated protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.7444
    Cell Significance Index: -17.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 15.3518
    Cell Significance Index: 196.6100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 10.3819
    Cell Significance Index: 64.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.6750
    Cell Significance Index: 160.6500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 7.1481
    Cell Significance Index: 34.7700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 6.6913
    Cell Significance Index: 35.2100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 4.1899
    Cell Significance Index: 24.6000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.7024
    Cell Significance Index: 40.2500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 3.2708
    Cell Significance Index: 19.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.6459
    Cell Significance Index: 84.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6085
    Cell Significance Index: 68.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.4697
    Cell Significance Index: 85.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.4686
    Cell Significance Index: 19.7100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.9281
    Cell Significance Index: 11.9800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.0161
    Cell Significance Index: 16.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8433
    Cell Significance Index: 13.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7333
    Cell Significance Index: 94.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7264
    Cell Significance Index: 99.7500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.6997
    Cell Significance Index: 6.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6721
    Cell Significance Index: 66.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6226
    Cell Significance Index: 10.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6113
    Cell Significance Index: 551.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3698
    Cell Significance Index: 60.1500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3491
    Cell Significance Index: 3.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3207
    Cell Significance Index: 34.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2775
    Cell Significance Index: 5.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1772
    Cell Significance Index: 10.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1690
    Cell Significance Index: 11.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1480
    Cell Significance Index: 29.3700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.1355
    Cell Significance Index: 0.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1113
    Cell Significance Index: 60.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0604
    Cell Significance Index: 1.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0541
    Cell Significance Index: 0.5600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.0509
    Cell Significance Index: 0.3700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0355
    Cell Significance Index: 0.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0320
    Cell Significance Index: 14.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0208
    Cell Significance Index: 39.1500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0207
    Cell Significance Index: 0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0078
    Cell Significance Index: 11.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0062
    Cell Significance Index: 3.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0168
    Cell Significance Index: -0.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0243
    Cell Significance Index: -18.0300
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0255
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0262
    Cell Significance Index: -19.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0276
    Cell Significance Index: -15.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0291
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0324
    Cell Significance Index: -20.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0386
    Cell Significance Index: -7.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0387
    Cell Significance Index: -17.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0434
    Cell Significance Index: -7.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0486
    Cell Significance Index: -17.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0625
    Cell Significance Index: -7.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0629
    Cell Significance Index: -3.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0646
    Cell Significance Index: -18.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0757
    Cell Significance Index: -13.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0785
    Cell Significance Index: -11.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0822
    Cell Significance Index: -10.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0887
    Cell Significance Index: -18.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0926
    Cell Significance Index: -18.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0959
    Cell Significance Index: -2.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1099
    Cell Significance Index: -2.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1113
    Cell Significance Index: -5.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1273
    Cell Significance Index: -15.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1462
    Cell Significance Index: -16.7500
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.1518
    Cell Significance Index: -1.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1592
    Cell Significance Index: -4.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1604
    Cell Significance Index: -16.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1617
    Cell Significance Index: -4.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1680
    Cell Significance Index: -19.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1699
    Cell Significance Index: -17.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1776
    Cell Significance Index: -12.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1801
    Cell Significance Index: -11.0400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2082
    Cell Significance Index: -2.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2517
    Cell Significance Index: -19.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2525
    Cell Significance Index: -16.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2561
    Cell Significance Index: -15.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2661
    Cell Significance Index: -16.7700
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.2666
    Cell Significance Index: -1.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2683
    Cell Significance Index: -20.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2853
    Cell Significance Index: -4.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3106
    Cell Significance Index: -20.0400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.3118
    Cell Significance Index: -1.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3328
    Cell Significance Index: -15.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3331
    Cell Significance Index: -5.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3516
    Cell Significance Index: -10.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3712
    Cell Significance Index: -9.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3942
    Cell Significance Index: -20.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3969
    Cell Significance Index: -20.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4106
    Cell Significance Index: -17.8500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4198
    Cell Significance Index: -3.2300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4233
    Cell Significance Index: -2.6500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4396
    Cell Significance Index: -6.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4702
    Cell Significance Index: -23.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4820
    Cell Significance Index: -12.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MFAP2 is a protein-coding gene that belongs to the microfibril-associated protein family. It is characterized by its ability to interact with collagen, fibrinogen, and fibronectin, which are essential components of the ECM. MFAP2 is highly expressed in various cell types, including enterocytes, skeletal muscle satellite cells, and mesodermal cells. Its expression is also observed in tissues such as the eye, ovary, and respiratory system. **Pathways and Functions:** MFAP2 is involved in several key pathways, including: 1. **Collagen-containing extracellular matrix**: MFAP2 interacts with collagen to form a stable ECM, which provides structural support and maintains tissue integrity. 2. **Elastic fibre formation**: MFAP2 is essential for the assembly and organization of elastic fibres, which are critical for maintaining tissue elasticity and resilience. 3. **Embryonic eye morphogenesis**: MFAP2 plays a crucial role in the development of the eye, particularly in the formation of the lens and retina. 4. **Extracellular matrix organization**: MFAP2 helps to regulate ECM organization and remodeling, ensuring proper tissue function and homeostasis. 5. **Fibrinogen binding**: MFAP2 interacts with fibrinogen, a key component of blood clots, to regulate clot formation and stability. **Clinical Significance:** MFAP2 has been implicated in various human diseases, including: 1. **Ocular diseases**: MFAP2 mutations have been associated with ocular disorders, such as congenital glaucoma and retinal detachment. 2. **Musculoskeletal disorders**: MFAP2 is involved in the development of muscular dystrophy and other muscle-related diseases. 3. **Cancer**: MFAP2 has been implicated in cancer progression and metastasis, particularly in ovarian and breast cancer. 4. **Cardiovascular disease**: MFAP2 is involved in the regulation of blood clotting and thrombosis, making it a potential target for cardiovascular disease prevention and treatment. In conclusion, MFAP2 is a multifaceted gene that plays a critical role in tissue development, ECM organization, and disease prevention. Further research is necessary to fully elucidate the functions and clinical significance of MFAP2, but its implications for human health and disease are clear.

Genular Protein ID: 2279633114

Symbol: MFAP2_HUMAN

Name: Microfibrillar-associated protein 2

UniProtKB Accession Codes:

P55001 Q53X60 Q5JXY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7759096

Title: Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170.

PubMed ID: 7759096

DOI: 10.1016/0888-7543(95)80004-6

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11102756

Title: Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues.

PubMed ID: 11102756

DOI: 10.1016/s0945-053x(00)00115-3

Sequence Information:

  • Length: 183
  • Mass: 20826
  • Checksum: A75BE15DC9629B26
  • Sequence:
    • MRAAYLFLLF LPAGLLAQGQ YDLDPLPPFP DHVQYTHYSD QIDNPDYYDY QEVTPRPSEE 
QFQFQSQQQV QQEVIPAPTP EPGNAELEPT EPGPLDCREE QYPCTRLYSI HRPCKQCLNE 
VCFYSLRRVY VINKEICVRT VCAHEELLRA DLCRDKFSKC GVMASSGLCQ SVAASCARSC 
GSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.