Gene FGF7 - ENSG00000140285 | NCBI Gene ID: 2252

Details for: FGF7

Gene ID: 2252

Symbol: FGF7

Ensembl ID: ENSG00000140285

Description: fibroblast growth factor 7

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2b ligand binding and activation
(R-HSA-190377)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Actin cytoskeleton organization
(GO:0030036)
Animal organ morphogenesis
(GO:0009887)
Branching involved in salivary gland morphogenesis
(GO:0060445)
Cell differentiation
(GO:0030154)
Chemoattractant activity
(GO:0042056)
Cytoplasm
(GO:0005737)
Endothelial cell proliferation
(GO:0001935)
Epidermis development
(GO:0008544)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Golgi apparatus
(GO:0005794)
Growth factor activity
(GO:0008083)
Hair follicle morphogenesis
(GO:0031069)
Heparin binding
(GO:0008201)
Lung development
(GO:0030324)
Mesenchymal cell proliferation
(GO:0010463)
Myoblast proliferation
(GO:0051450)
Positive chemotaxis
(GO:0050918)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of epithelial cell proliferation involved in lung morphogenesis
(GO:0060501)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of keratinocyte migration
(GO:0051549)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Positive regulation of myoblast proliferation
(GO:2000288)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Protein binding
(GO:0005515)
Protein localization to cell surface
(GO:0034394)
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
(GO:0060665)
Regulation of cell migration
(GO:0030334)
Response to wounding
(GO:0009611)
Secretion by lung epithelial cell involved in lung growth
(GO:0061033)
Signal transduction
(GO:0007165)
Type 2 fibroblast growth factor receptor binding
(GO:0005111)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.61
Marker Score: 1490
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.42
Marker Score: 914
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.21
Marker Score: 5790
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.15
Marker Score: 1193
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.07
Marker Score: 70383
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.04
Marker Score: 4796
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.9
Marker Score: 428
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.9
Marker Score: 790
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.87
Marker Score: 465
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.86
Marker Score: 1081
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.85
Marker Score: 465
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1163
Cell Name: keratocyte (CL0002363)
Fold Change: 1.59
Marker Score: 365
Cell Name: decidual cell (CL2000002)
Fold Change: 1.58
Marker Score: 6815
Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.5
Marker Score: 645
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169101
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.44
Marker Score: 1439
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.4
Marker Score: 2161
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.38
Marker Score: 1175
Cell Name: theca cell (CL0000503)
Fold Change: 1.34
Marker Score: 961
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.32
Marker Score: 2187
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.24
Marker Score: 306
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.24
Marker Score: 1529
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.23
Marker Score: 2375
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.18
Marker Score: 1896
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.16
Marker Score: 15313
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4802
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.14
Marker Score: 1561
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.09
Marker Score: 7074
Cell Name: fibroblast (CL0000057)
Fold Change: 1.08
Marker Score: 1046
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.04
Marker Score: 16240
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251790
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71809
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48033
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.98
Marker Score: 253
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.97
Marker Score: 657
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: adipose microvascular endothelial cell (CL2000072)
Fold Change: 0.95
Marker Score: 281
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.94
Marker Score: 390
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 369
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5190
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.9
Marker Score: 200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.82
Marker Score: 424
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 609
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.8
Marker Score: 425
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.79
Marker Score: 17713
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.78
Marker Score: 762
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1255
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 695
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.73
Marker Score: 2606
Cell Name: lactocyte (CL0002325)
Fold Change: 0.73
Marker Score: 11720
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.73
Marker Score: 949
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.73
Marker Score: 1477
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.72
Marker Score: 452
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.7
Marker Score: 728
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.68
Marker Score: 1297.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.67
Marker Score: 7562
Cell Name: reticular cell (CL0000432)
Fold Change: 0.67
Marker Score: 243
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.66
Marker Score: 3954
Cell Name: supporting cell (CL0000630)
Fold Change: 0.65
Marker Score: 1222
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.64
Marker Score: 1302
Cell Name: stromal cell (CL0000499)
Fold Change: 0.61
Marker Score: 713
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.58
Marker Score: 373
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.58
Marker Score: 150
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.56
Marker Score: 372
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 171
Cell Name: smooth muscle cell of small intestine (CL1000275)
Fold Change: 0.53
Marker Score: 139.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.53
Marker Score: 502
Cell Name: fat cell (CL0000136)
Fold Change: 0.52
Marker Score: 289
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.5
Marker Score: 303
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.49
Marker Score: 260
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.48
Marker Score: 737
Cell Name: thymocyte (CL0000893)
Fold Change: 0.48
Marker Score: 500
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.47
Marker Score: 110
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.47
Marker Score: 1148
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.46
Marker Score: 117
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.45
Marker Score: 415
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.45
Marker Score: 544
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.44
Marker Score: 186
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 439
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.42
Marker Score: 204
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.42
Marker Score: 502
Cell Name: neural cell (CL0002319)
Fold Change: 0.41
Marker Score: 198
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.4
Marker Score: 106
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 385
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.39
Marker Score: 255
Cell Name: kidney cell (CL1000497)
Fold Change: 0.39
Marker Score: 258
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.38
Marker Score: 175
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.38
Marker Score: 180
Cell Name: tendon cell (CL0000388)
Fold Change: 0.37
Marker Score: 92
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.37
Marker Score: 161

Hover over a box to see details here...

**Key characteristics:** - It is a secreted protein. - It is a glycoprotein with a molecular weight of approximately 145 kDa. - It is expressed in a variety of cell types, including fibroblasts, endothelial cells, and epithelial cells. **Pathways and functions:** - FGF7 is a key regulator of cell growth and proliferation. - It binds to its receptor, FGFR1, on the surface of target cells. - Binding of FGF7 to FGFR1 triggers the activation of the PI3K/Akt pathway. - The PI3K/Akt pathway is a central regulator of cell growth, survival, and metabolism. - Activation of the PI3K/Akt pathway by FGF7 promotes cell proliferation and inhibits apoptosis. **Clinical significance:** - Mutations in the FGF7 gene have been linked to several human cancers, including breast cancer, lung cancer, and colon cancer. - Targeting FGF7 signaling has emerged as a promising therapeutic strategy for cancer. - FGF7 is a target for several commercial antibodies used in cancer immunotherapy. **Other important points:** - FGF7 is also involved in wound healing and tissue regeneration. - It is a key regulator of angiogenesis. - It is a potential therapeutic target for a variety of diseases, including cancer, cardiovascular disease, and diabetes.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 7

Genular Protein ID: 1457303864

Symbol: FGF7_HUMAN

Name: Fibroblast growth factor 7

UniProtKB Accession Codes:

P21781 H0YNY5 Q6FGV5 Q96FG5

Database IDs:

Citations:

PubMed ID: 2475908

Title: Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.

PubMed ID: 2475908

DOI: 10.1126/science.2475908

PubMed ID: 1664700

Title: Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity.

PubMed ID: 1664700

DOI: 10.1111/j.1749-6632.1991.tb49018.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2915979

Title: Purification and characterization of a newly identified growth factor specific for epithelial cells.

PubMed ID: 2915979

DOI: 10.1073/pnas.86.3.802

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 15806171

Title: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.

PubMed ID: 15806171

DOI: 10.1038/sj.onc.1208560

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

Sequence Information:

Length: 194
Mass: 22509
Checksum: B19192474E6049E2
Sequence:

MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA 
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK 
KEQKTAHFLP MAIT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FGF7

Associated with

Cells (max top 100)

Other Information

Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. PubMed ID: 2475908

Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. PubMed ID: 1664700

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of a newly identified growth factor specific for epithelial cells. PubMed ID: 2915979

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. PubMed ID: 15806171

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046