FGF7 | ENSG00000140285 | NCBI 2252

Details for: FGF7

Gene ID: 2252

Symbol: FGF7

Ensembl ID: ENSG00000140285

Description: fibroblast growth factor 7

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2b ligand binding and activation
(R-HSA-190377)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Actin cytoskeleton organization
(GO:0030036)
Branching involved in salivary gland morphogenesis
(GO:0060445)
Chemoattractant activity
(GO:0042056)
Cytoplasm
(GO:0005737)
Endothelial cell proliferation
(GO:0001935)
Epidermis development
(GO:0008544)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Gaba-ergic synapse
(GO:0098982)
Golgi apparatus
(GO:0005794)
Growth factor activity
(GO:0008083)
Hair follicle morphogenesis
(GO:0031069)
Heparin binding
(GO:0008201)
Lung development
(GO:0030324)
Mesenchymal cell proliferation
(GO:0010463)
Myoblast proliferation
(GO:0051450)
Neurogenesis
(GO:0022008)
Positive chemotaxis
(GO:0050918)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of epithelial cell proliferation involved in lung morphogenesis
(GO:0060501)
Positive regulation of keratinocyte migration
(GO:0051549)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of myoblast proliferation
(GO:2000288)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Postsynapse
(GO:0098794)
Protein binding
(GO:0005515)
Protein localization to cell surface
(GO:0034394)
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
(GO:0060665)
Regulation of cell migration
(GO:0030334)
Regulation of synapse maturation
(GO:0090128)
Response to wounding
(GO:0009611)
Secretion by lung epithelial cell involved in lung growth
(GO:0061033)
Signal transduction
(GO:0007165)
Type 2 fibroblast growth factor receptor binding
(GO:0005111)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 110.8359
Cell Significance Index: -17.2400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 67.0824
Cell Significance Index: -17.0200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 45.5883
Cell Significance Index: -18.7800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 34.8850
Cell Significance Index: -16.4700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.9745
Cell Significance Index: -17.2300
Cell Name: theca cell (CL0000503)
Fold Change: 6.2008
Cell Significance Index: 36.4300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.2372
Cell Significance Index: -16.7200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.6347
Cell Significance Index: 104.1900
Cell Name: preadipocyte (CL0002334)
Fold Change: 3.5523
Cell Significance Index: 69.3300
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 3.1233
Cell Significance Index: 16.4400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 2.0560
Cell Significance Index: 103.9000
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.8064
Cell Significance Index: 11.3600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2976
Cell Significance Index: 246.9400
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.1896
Cell Significance Index: 4.5600
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.1565
Cell Significance Index: 7.1600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1340
Cell Significance Index: 51.4000
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.7691
Cell Significance Index: 11.7000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7254
Cell Significance Index: 99.6200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6887
Cell Significance Index: 68.1300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.6774
Cell Significance Index: 5.6900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6085
Cell Significance Index: 46.7000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.5938
Cell Significance Index: 12.4300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5331
Cell Significance Index: 481.3100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.5133
Cell Significance Index: 5.5800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4315
Cell Significance Index: 9.1900
Cell Name: keratocyte (CL0002363)
Fold Change: 0.3965
Cell Significance Index: 6.2900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3698
Cell Significance Index: 60.1400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.3460
Cell Significance Index: 5.7900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3071
Cell Significance Index: 33.4000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2267
Cell Significance Index: 11.9000
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.2026
Cell Significance Index: 2.9100
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.2012
Cell Significance Index: 2.9700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1625
Cell Significance Index: 9.7600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1441
Cell Significance Index: 18.4700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1244
Cell Significance Index: 8.6100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0921
Cell Significance Index: 40.7400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0524
Cell Significance Index: 32.7000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0430
Cell Significance Index: 32.5700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0336
Cell Significance Index: 12.0400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0272
Cell Significance Index: 18.8200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0259
Cell Significance Index: 0.4000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0194
Cell Significance Index: 0.6800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0176
Cell Significance Index: 27.1500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0166
Cell Significance Index: 1.9400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0147
Cell Significance Index: 27.0300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0112
Cell Significance Index: 2.2500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0032
Cell Significance Index: 2.3900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0031
Cell Significance Index: 5.8300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0007
Cell Significance Index: 0.4300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0009
Cell Significance Index: -1.2600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0080
Cell Significance Index: -0.2300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0124
Cell Significance Index: -1.8000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0124
Cell Significance Index: -7.0000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0136
Cell Significance Index: -9.9700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0163
Cell Significance Index: -1.0000
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0210
Cell Significance Index: -11.4500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0246
Cell Significance Index: -11.1500
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0271
Cell Significance Index: -5.3700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0277
Cell Significance Index: -0.6000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0342
Cell Significance Index: -7.2000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0358
Cell Significance Index: -6.4500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0383
Cell Significance Index: -2.7100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0411
Cell Significance Index: -7.0200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0519
Cell Significance Index: -14.9200
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0590
Cell Significance Index: -0.4000
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.0718
Cell Significance Index: -0.4400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0734
Cell Significance Index: -7.5000
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0851
Cell Significance Index: -0.8200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0966
Cell Significance Index: -11.8800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0989
Cell Significance Index: -12.7800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1072
Cell Significance Index: -7.9900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1256
Cell Significance Index: -14.3400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1343
Cell Significance Index: -15.3900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1433
Cell Significance Index: -2.1600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1536
Cell Significance Index: -7.2200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1551
Cell Significance Index: -16.1500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1587
Cell Significance Index: -18.7100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1620
Cell Significance Index: -5.1900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1703
Cell Significance Index: -13.4900
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.1741
Cell Significance Index: -1.9000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1875
Cell Significance Index: -4.8200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1930
Cell Significance Index: -12.9800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2090
Cell Significance Index: -13.1700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2247
Cell Significance Index: -6.2800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2475
Cell Significance Index: -13.8900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2483
Cell Significance Index: -16.0200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2538
Cell Significance Index: -11.0400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2540
Cell Significance Index: -15.6100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2594
Cell Significance Index: -13.5100
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.3003
Cell Significance Index: -1.8800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3080
Cell Significance Index: -14.3600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3389
Cell Significance Index: -14.9900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3515
Cell Significance Index: -18.2600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3666
Cell Significance Index: -12.7400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3966
Cell Significance Index: -15.0200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3969
Cell Significance Index: -14.5700
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.4020
Cell Significance Index: -4.4400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4045
Cell Significance Index: -10.8000
Cell Name: skin fibroblast (CL0002620)
Fold Change: -0.4049
Cell Significance Index: -0.9400
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4246
Cell Significance Index: -9.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FGF7 is a 19-kDa protein with a single polypeptide chain, consisting of 154 amino acids. It is a ligand for the fibroblast growth factor receptor 2 (FGFR2) and other receptor tyrosine kinases, such as FGFR1, FGFR3, and IGF1R. FGF7 is secreted by various cell types, including epithelial and mesenchymal cells, and its expression is regulated by multiple signaling pathways, including the PI3K/Akt pathway and the MAPK/ERK pathway. FGF7 has been shown to bind to heparin and other glycosaminoglycans, which is essential for its biological activity. **Pathways and Functions** FGF7 signaling pathway is involved in various biological processes, including: 1. **Cell proliferation and differentiation**: FGF7 stimulates the proliferation and differentiation of epithelial and mesenchymal cells, including keratinocytes, fibroblasts, and smooth muscle cells. 2. **Morphogenesis**: FGF7 plays a critical role in the development and morphogenesis of various tissues, including the skin, lung, and salivary glands. 3. **Angiogenesis**: FGF7 promotes angiogenesis by stimulating the proliferation and migration of endothelial cells. 4. **Tissue repair**: FGF7 is involved in the regulation of tissue repair and wound healing by stimulating the proliferation and differentiation of fibroblasts and other cell types. 5. **Cancer**: Abnormal expression of FGF7 has been implicated in several types of cancer, including lung, breast, and prostate cancer. **Clinical Significance** FGF7 has been implicated in various diseases, including: 1. **Cancer**: FGF7 overexpression has been associated with tumorigenesis and metastasis in several types of cancer. 2. **Cardiovascular disease**: FGF7 has been implicated in the development of atherosclerosis and cardiovascular disease. 3. **Neurological disorders**: FGF7 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Wound healing**: FGF7 has been used as a therapeutic agent to promote wound healing and tissue repair. 5. **Developmental disorders**: FGF7 has been implicated in the development of developmental disorders, including congenital heart defects and craniofacial abnormalities. In conclusion, FGF7 is a multifunctional protein that plays a critical role in various biological processes, including cell proliferation, differentiation, and migration. Its dysregulation has been implicated in several diseases, including cancer, cardiovascular disease, and developmental disorders. Further research is needed to fully understand the mechanisms of FGF7 signaling and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 7

Genular Protein ID: 1457303864

Symbol: FGF7_HUMAN

Name: Fibroblast growth factor 7

UniProtKB Accession Codes:

P21781 H0YNY5 Q6FGV5 Q96FG5

Database IDs:

Citations:

PubMed ID: 2475908

Title: Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.

PubMed ID: 2475908

DOI: 10.1126/science.2475908

PubMed ID: 1664700

Title: Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity.

PubMed ID: 1664700

DOI: 10.1111/j.1749-6632.1991.tb49018.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2915979

Title: Purification and characterization of a newly identified growth factor specific for epithelial cells.

PubMed ID: 2915979

DOI: 10.1073/pnas.86.3.802

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 15806171

Title: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.

PubMed ID: 15806171

DOI: 10.1038/sj.onc.1208560

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

Sequence Information:

Length: 194
Mass: 22509
Checksum: B19192474E6049E2
Sequence:

MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA 
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK 
KEQKTAHFLP MAIT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF7

Associated with

Cells (max top 100)

Other Information

Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. PubMed ID: 2475908

Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. PubMed ID: 1664700

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of a newly identified growth factor specific for epithelial cells. PubMed ID: 2915979

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. PubMed ID: 15806171

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046