Details for: SLN

Gene ID: 6588

Symbol: SLN

Ensembl ID: ENSG00000170290

Description: sarcolipin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 6.2715
    Cell Significance Index: 153.0200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 5.8468
    Cell Significance Index: 94.3400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.5665
    Cell Significance Index: 12.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5172
    Cell Significance Index: 13.6000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3918
    Cell Significance Index: 3.0200
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 0.3746
    Cell Significance Index: 2.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2728
    Cell Significance Index: 4.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2350
    Cell Significance Index: 12.3400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.2306
    Cell Significance Index: 3.4500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.2191
    Cell Significance Index: 2.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1661
    Cell Significance Index: 2.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1194
    Cell Significance Index: 3.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1177
    Cell Significance Index: 7.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0394
    Cell Significance Index: 0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0268
    Cell Significance Index: 41.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0232
    Cell Significance Index: 2.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0217
    Cell Significance Index: 39.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0037
    Cell Significance Index: 1.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0020
    Cell Significance Index: -0.4100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0064
    Cell Significance Index: -2.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0071
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0099
    Cell Significance Index: -5.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0106
    Cell Significance Index: -5.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0111
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0199
    Cell Significance Index: -2.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0213
    Cell Significance Index: -0.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0220
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0229
    Cell Significance Index: -4.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0275
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0306
    Cell Significance Index: -5.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0347
    Cell Significance Index: -3.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0404
    Cell Significance Index: -5.5500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0430
    Cell Significance Index: -0.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0522
    Cell Significance Index: -5.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0646
    Cell Significance Index: -8.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0660
    Cell Significance Index: -4.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0666
    Cell Significance Index: -3.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0697
    Cell Significance Index: -5.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0726
    Cell Significance Index: -3.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0746
    Cell Significance Index: -2.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0800
    Cell Significance Index: -4.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0863
    Cell Significance Index: -5.5700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0902
    Cell Significance Index: -1.2400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0989
    Cell Significance Index: -1.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1032
    Cell Significance Index: -2.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1119
    Cell Significance Index: -8.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1148
    Cell Significance Index: -1.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1161
    Cell Significance Index: -1.9900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1186
    Cell Significance Index: -1.3100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1192
    Cell Significance Index: -1.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1272
    Cell Significance Index: -4.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1280
    Cell Significance Index: -3.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1306
    Cell Significance Index: -5.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1318
    Cell Significance Index: -4.1700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1351
    Cell Significance Index: -1.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1386
    Cell Significance Index: -3.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1422
    Cell Significance Index: -4.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1443
    Cell Significance Index: -3.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1444
    Cell Significance Index: -4.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1461
    Cell Significance Index: -6.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1472
    Cell Significance Index: -4.8200
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1499
    Cell Significance Index: -1.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1511
    Cell Significance Index: -4.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1532
    Cell Significance Index: -5.8000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1542
    Cell Significance Index: -1.9800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1563
    Cell Significance Index: -2.4800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1658
    Cell Significance Index: -1.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.1723
    Cell Significance Index: -1.8000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1726
    Cell Significance Index: -1.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1753
    Cell Significance Index: -8.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1766
    Cell Significance Index: -5.0400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1788
    Cell Significance Index: -1.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1827
    Cell Significance Index: -6.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1886
    Cell Significance Index: -2.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1895
    Cell Significance Index: -5.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1937
    Cell Significance Index: -2.0100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2020
    Cell Significance Index: -1.2500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2039
    Cell Significance Index: -2.4800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2120
    Cell Significance Index: -1.1100
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.2123
    Cell Significance Index: -2.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2125
    Cell Significance Index: -5.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2135
    Cell Significance Index: -5.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2138
    Cell Significance Index: -5.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2154
    Cell Significance Index: -3.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2166
    Cell Significance Index: -2.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2214
    Cell Significance Index: -6.3800
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.2247
    Cell Significance Index: -2.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2249
    Cell Significance Index: -3.3200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2266
    Cell Significance Index: -2.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2306
    Cell Significance Index: -5.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2321
    Cell Significance Index: -8.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2373
    Cell Significance Index: -6.4600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2388
    Cell Significance Index: -4.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2421
    Cell Significance Index: -5.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2440
    Cell Significance Index: -4.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Sarcolipin is a protein that belongs to the ATPase family, which is involved in the transport of calcium ions across cell membranes. It is specifically expressed in muscle cells, where it regulates the influx and efflux of calcium ions, essential for muscle contraction and relaxation. Sarcolipin also exhibits inhibitory activity against certain calcium transporters, further modulating calcium homeostasis in muscle cells. **Pathways and Functions:** Sarcolipin is involved in several key pathways, including: 1. **Ion Channel Transport:** Sarcolipin regulates the transport of small molecules, including calcium ions, across cell membranes, influencing muscle contraction and relaxation. 2. **Calcium Ion Transport:** Sarcolipin modulates the influx and efflux of calcium ions, maintaining calcium homeostasis in muscle cells. 3. **Muscle Contraction:** Sarcolipin plays a crucial role in regulating muscle contraction by controlling the release of calcium ions from the sarcoplasmic reticulum. 4. **Negative Regulation of ATPase-Coupled Calcium Transporters:** Sarcolipin inhibits the activity of certain calcium transporters, preventing excessive calcium influx and maintaining calcium homeostasis. **Clinical Significance:** Dysregulation of sarcolipin expression or function has been implicated in various muscle-related disorders, including: 1. **Muscular Dystrophy:** Mutations in the gene encoding sarcolipin have been associated with certain types of muscular dystrophy, highlighting the protein's importance in muscle function. 2. **Cardiac Arrhythmias:** Alterations in sarcolipin expression or function may contribute to cardiac arrhythmias, emphasizing the protein's role in maintaining calcium homeostasis in cardiac myocytes. 3. **Muscle Weakness:** Sarcolipin dysfunction may lead to muscle weakness, particularly in skeletal muscle, underscoring the protein's importance in regulating muscle contraction and relaxation. In conclusion, sarcolipin is a critical protein that regulates calcium ion transport and muscle contraction, highlighting its importance in muscle physiology and immunology. Further research is needed to fully elucidate the role of sarcolipin in various disease states, but its dysregulation has already been implicated in several muscle-related disorders.

Genular Protein ID: 1079057604

Symbol: SARCO_HUMAN

Name: N/A

UniProtKB Accession Codes:

O00631 Q6ICV3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9367679

Title: Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease.

PubMed ID: 9367679

DOI: 10.1006/geno.1997.4967

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9575189

Title: Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase.

PubMed ID: 9575189

DOI: 10.1074/jbc.273.20.12360

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 11781085

Title: Structure and orientation of sarcolipin in lipid environments.

PubMed ID: 11781085

DOI: 10.1021/bi011243m

Sequence Information:

  • Length: 31
  • Mass: 3762
  • Checksum: 9B245D9ACD26C58F
  • Sequence:
    • MGINTRELFL NFTIVLITVI LMWLLVRSYQ Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.