Details for: TAC1

Gene ID: 6863

Symbol: TAC1

Ensembl ID: ENSG00000006128

Description: tachykinin precursor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 4.6420
    Cell Significance Index: 163.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5114
    Cell Significance Index: 130.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.3889
    Cell Significance Index: 90.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2873
    Cell Significance Index: 60.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1677
    Cell Significance Index: 62.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7617
    Cell Significance Index: 108.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4701
    Cell Significance Index: 31.8500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.0896
    Cell Significance Index: 14.1300
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.0762
    Cell Significance Index: 8.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8086
    Cell Significance Index: 36.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6709
    Cell Significance Index: 14.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6389
    Cell Significance Index: 121.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3859
    Cell Significance Index: 23.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3469
    Cell Significance Index: 34.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3158
    Cell Significance Index: 285.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3063
    Cell Significance Index: 52.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2569
    Cell Significance Index: 6.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1800
    Cell Significance Index: 29.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1697
    Cell Significance Index: 18.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1106
    Cell Significance Index: 6.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0608
    Cell Significance Index: 1.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0512
    Cell Significance Index: 1.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0453
    Cell Significance Index: 3.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0193
    Cell Significance Index: 14.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0128
    Cell Significance Index: 8.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0111
    Cell Significance Index: 0.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0105
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0028
    Cell Significance Index: -1.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0113
    Cell Significance Index: -0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0144
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0164
    Cell Significance Index: -3.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0165
    Cell Significance Index: -2.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0170
    Cell Significance Index: -10.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0180
    Cell Significance Index: -0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0236
    Cell Significance Index: -8.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0236
    Cell Significance Index: -12.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0237
    Cell Significance Index: -6.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0247
    Cell Significance Index: -11.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0466
    Cell Significance Index: -5.7300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0480
    Cell Significance Index: -0.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0537
    Cell Significance Index: -10.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0660
    Cell Significance Index: -9.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0661
    Cell Significance Index: -2.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0755
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0779
    Cell Significance Index: -8.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0809
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0823
    Cell Significance Index: -9.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0824
    Cell Significance Index: -11.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0849
    Cell Significance Index: -10.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0870
    Cell Significance Index: -8.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0964
    Cell Significance Index: -2.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1027
    Cell Significance Index: -11.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1139
    Cell Significance Index: -13.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1430
    Cell Significance Index: -2.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1456
    Cell Significance Index: -9.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1484
    Cell Significance Index: -11.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1564
    Cell Significance Index: -3.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1639
    Cell Significance Index: -9.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1752
    Cell Significance Index: -8.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1758
    Cell Significance Index: -13.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1780
    Cell Significance Index: -9.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1812
    Cell Significance Index: -8.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1876
    Cell Significance Index: -9.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1920
    Cell Significance Index: -1.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2209
    Cell Significance Index: -9.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2554
    Cell Significance Index: -5.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2628
    Cell Significance Index: -4.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2641
    Cell Significance Index: -5.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2645
    Cell Significance Index: -9.1900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2708
    Cell Significance Index: -2.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2963
    Cell Significance Index: -10.3800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3052
    Cell Significance Index: -3.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3062
    Cell Significance Index: -2.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3085
    Cell Significance Index: -10.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3519
    Cell Significance Index: -4.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3586
    Cell Significance Index: -11.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3629
    Cell Significance Index: -13.3200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3814
    Cell Significance Index: -4.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3848
    Cell Significance Index: -10.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3908
    Cell Significance Index: -11.5100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.4083
    Cell Significance Index: -5.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4185
    Cell Significance Index: -5.7100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4213
    Cell Significance Index: -4.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4215
    Cell Significance Index: -7.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4441
    Cell Significance Index: -11.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4490
    Cell Significance Index: -11.9900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4526
    Cell Significance Index: -6.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4635
    Cell Significance Index: -12.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4655
    Cell Significance Index: -9.9500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4674
    Cell Significance Index: -11.6600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4732
    Cell Significance Index: -11.8200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.4766
    Cell Significance Index: -6.5900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.4801
    Cell Significance Index: -3.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4853
    Cell Significance Index: -13.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4867
    Cell Significance Index: -8.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4911
    Cell Significance Index: -9.8600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5029
    Cell Significance Index: -12.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure:** The TAC1 gene consists of three exons, which are spliced together to form a mature mRNA transcript. The gene is located on chromosome 1q21-q22 and is highly conserved across species. 2. **Protein structure:** The TAC1 precursor protein is a 104-amino acid polypeptide that is processed into three bioactive peptides: substance P, neurokinin A, and neurokinin B. These peptides are generated through proteolytic cleavage of the precursor protein. 3. **Receptor interactions:** The bioactive peptides produced from the TAC1 gene interact with specific G-protein-coupled receptors (GPCRs), including NK1, NK2, and NK3 receptors. These receptors are widely expressed in various tissues and play a crucial role in modulating neurotransmission and immune responses. 4. **Cellular expression:** The TAC1 gene is expressed in a wide range of cell types, including neurons, immune cells, epithelial cells, and fibroblasts. This broad expression pattern highlights the gene's importance in maintaining tissue homeostasis and responding to environmental stimuli. **Pathways and Functions:** The TAC1 gene plays a critical role in regulating various physiological processes, including: 1. **Pain sensation:** Substance P, produced from the TAC1 gene, interacts with NK1 receptors to modulate pain perception. This interaction is essential for regulating pain signaling in the central nervous system. 2. **Inflammation:** Neurokinin A and neurokinin B, produced from the TAC1 gene, interact with NK2 and NK3 receptors to modulate inflammatory responses. These interactions are essential for regulating the immune response to tissue injury or infection. 3. **Immune cell function:** The TAC1 gene is expressed in immune cells, including T cells and dendritic cells, where it regulates their activation, proliferation, and cytokine production. 4. **Neurotransmission:** The TAC1 gene is expressed in neurons, where it regulates neurotransmission and synaptic plasticity. **Clinical Significance:** Dysregulation of the TAC1 gene has been implicated in various diseases, including: 1. **Chronic pain:** Abnormalities in substance P signaling have been linked to chronic pain conditions, such as fibromyalgia and complex regional pain syndrome. 2. **Inflammatory disorders:** Dysregulation of neurokinin A and neurokinin B signaling has been implicated in inflammatory conditions, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** The TAC1 gene is overexpressed in certain types of cancer, including breast and lung cancer, where it promotes tumor growth and metastasis. 4. **Neurological disorders:** Abnormalities in TAC1 gene expression have been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the TAC1 gene plays a critical role in regulating neurotransmission and immune responses in the human body. Dysregulation of this gene has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 3279926530

Symbol: TKN1_HUMAN

Name: Protachykinin-1

UniProtKB Accession Codes:

P20366 O60600 O60601 Q00072 Q53GH4 Q549V0 Q549V1 Q549V2 Q6FHM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 23 EMDB 7 Ensembl 3 EvolutionaryTrace 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 3770210

Title: cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A.

PubMed ID: 3770210

DOI: 10.1016/0014-5793(86)81534-4

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1708336

Title: Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis.

PubMed ID: 1708336

DOI: 10.1210/endo-128-5-2441

PubMed ID: 3038549

Title: Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour.

PubMed ID: 3038549

DOI: 10.1111/j.1432-1033.1987.tb13567.x

PubMed ID: 9846828

Title: Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes.

PubMed ID: 9846828

DOI: 10.1016/s0165-5728(98)00170-2

PubMed ID: 2284201

Title: Characterization of the C-terminal flanking peptide of human beta-preprotachykinin.

PubMed ID: 2284201

DOI: 10.1016/0196-9781(90)90007-r

PubMed ID: 6208535

Title: Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase.

PubMed ID: 6208535

DOI: 10.1016/0196-9781(84)90020-2

PubMed ID: 21314817

Title: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha.

PubMed ID: 21314817

DOI: 10.1111/j.1742-4658.2011.08051.x

PubMed ID: 16503654

Title: Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles.

PubMed ID: 16503654

DOI: 10.1021/bi052287o

Sequence Information:

  • Length: 129
  • Mass: 15003
  • Checksum: 51412C1692368DE4
  • Sequence:
    • MKILVALAVF FLVSTQLFAE EIGANDDLNY WSDWYDSDQI KEELPEPFEH LLQRIARRPK 
PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT DSFVGLMGKR ALNSVAYERS 
AMQNYERRR

Genular Protein ID: 1033904740

Symbol: Q9Y494_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y494

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 2

Sequence Information:

  • Length: 72
  • Mass: 8274
  • Checksum: 2C02B2BA41EAAD16
  • Sequence:
    • DSDQIKEELP EPFEHLLQRI ARRPKPQQFF GLMGKRDAGH GQISHKRHKT DSFVGLMGKR 
ALNSVAYERS AM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.