Details for: DLK1

Gene ID: 8788

Symbol: DLK1

Ensembl ID: ENSG00000185559

Description: delta like non-canonical Notch ligand 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 13.55
    Marker Score: 240567
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 8.66
    Marker Score: 6108
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 8.09
    Marker Score: 2672
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 7.68
    Marker Score: 3520.5
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 6.57
    Marker Score: 4996
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.59
    Marker Score: 18298.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 4.82
    Marker Score: 3225.5
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.68
    Marker Score: 6581
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 4.21
    Marker Score: 2176
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 3.97
    Marker Score: 6746
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.73
    Marker Score: 5418
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.46
    Marker Score: 22530.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 2.77
    Marker Score: 2074.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.53
    Marker Score: 2698
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.22
    Marker Score: 2397.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.06
    Marker Score: 2413
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.96
    Marker Score: 3688.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.91
    Marker Score: 2033
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.81
    Marker Score: 6694.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.64
    Marker Score: 2865
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.42
    Marker Score: 1965
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.36
    Marker Score: 393
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.36
    Marker Score: 471
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 851
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.31
    Marker Score: 1077
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.2
    Marker Score: 414
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.19
    Marker Score: 12050
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7681
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.1
    Marker Score: 684
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.03
    Marker Score: 6216
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.01
    Marker Score: 3967
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1
    Marker Score: 361
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1
    Marker Score: 1438
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Marker Score: 1875
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.96
    Marker Score: 362.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.95
    Marker Score: 523
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.94
    Marker Score: 635
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.92
    Marker Score: 904
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.91
    Marker Score: 30835
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.88
    Marker Score: 881.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.88
    Marker Score: 978
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.87
    Marker Score: 875
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 654.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.85
    Marker Score: 419
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.83
    Marker Score: 216
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.83
    Marker Score: 3473
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1173
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.73
    Marker Score: 4377
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.72
    Marker Score: 492
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1460.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.66
    Marker Score: 297
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.65
    Marker Score: 431
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.64
    Marker Score: 314
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 471
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.59
    Marker Score: 6074.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.58
    Marker Score: 280
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.58
    Marker Score: 410
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.56
    Marker Score: 8817
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.54
    Marker Score: 649
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.51
    Marker Score: 256
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.5
    Marker Score: 231
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.48
    Marker Score: 2012
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.48
    Marker Score: 458
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.47
    Marker Score: 269
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.46
    Marker Score: 749
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.44
    Marker Score: 191
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.44
    Marker Score: 909
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 431
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.4
    Marker Score: 786
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.4
    Marker Score: 343
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.4
    Marker Score: 819
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.39
    Marker Score: 157
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.39
    Marker Score: 258
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.38
    Marker Score: 213
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.36
    Marker Score: 457
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.36
    Marker Score: 211
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.36
    Marker Score: 382
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 171
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.35
    Marker Score: 204
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.35
    Marker Score: 2081
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 229
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.34
    Marker Score: 367
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 202
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.33
    Marker Score: 149
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.33
    Marker Score: 250
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.33
    Marker Score: 315

Other Information

**Key Characteristics** DLK1 is a non-canonical Notch ligand, distinct from the classical Notch ligands (e.g., DLL1, DLL3, DLL4). Its unique characteristics include: 1. **Cellular localization**: DLK1 is primarily localized to the extracellular space, where it interacts with Notch receptors. 2. **Signal transduction**: Upon binding to Notch receptors, DLK1 triggers a signaling cascade that ultimately transduces signals to the nucleus, influencing gene expression and cellular behavior. 3. **Regulatory function**: DLK1 acts as a negative regulator of the Notch signaling pathway, modulating its activity and preventing excessive or inappropriate signaling. 4. **Expression pattern**: DLK1 is highly expressed in various cell types, including those involved in development, differentiation, and tissue homeostasis. **Pathways and Functions** The DLK1 gene is involved in several signaling pathways, including: 1. **Notch signaling pathway**: DLK1 binds to Notch receptors, triggering a signaling cascade that regulates gene expression, cell fate decisions, and cellular differentiation. 2. **Calcium ion binding**: DLK1 interacts with calcium ions, modulating its activity and influencing cellular responses. 3. **Cell differentiation**: DLK1 plays a role in regulating cell differentiation, particularly in the development and maintenance of various cell types. 4. **Signal transduction**: DLK1 transduces signals from the extracellular space to the nucleus, influencing gene expression and cellular behavior. **Clinical Significance** The dysregulation of DLK1 has been implicated in various diseases and disorders, including: 1. **Cancer**: Altered DLK1 expression has been observed in various cancers, including breast, lung, and colon cancer, suggesting its potential as a diagnostic or therapeutic target. 2. **Neurological disorders**: DLK1 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Developmental disorders**: DLK1 expression abnormalities have been linked to developmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Cardiovascular disease**: DLK1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac hypertrophy. In conclusion, DLK1 is a critical gene involved in various cellular processes, including cell differentiation, development, and signaling pathways. Its dysregulation has been implicated in various diseases and disorders, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 1924201263

Symbol: DLK1_HUMAN

Name: Protein delta homolog 1

UniProtKB Accession Codes:

P80370 P15803 Q96DW5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 8 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8095043

Title: dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line.

PubMed ID: 8095043

DOI: 10.1016/s0021-9258(18)53544-4

PubMed ID: 7711066

Title: dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA.

PubMed ID: 7711066

DOI: 10.1016/0167-4781(95)00007-4

PubMed ID: 2308864

Title: The sequence of an adrenal specific human cDNA, pG2.

PubMed ID: 2308864

DOI: 10.1093/nar/18.3.685

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7925474

Title: Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2.

PubMed ID: 7925474

DOI: 10.1111/j.1432-1033.1994.00083.x

PubMed ID: 8501199

Title: Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2.

PubMed ID: 8501199

DOI: 10.1093/oxfordjournals.humrep.a138110

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

Sequence Information:

  • Length: 383
  • Mass: 41300
  • Checksum: 9A2813B2801A98BD
  • Sequence:
    • MTATEALLRV LLLLLAFGHS TYGAECFPAC NPQNGFCEDD NVCRCQPGWQ GPLCDQCVTS 
PGCLHGLCGE PGQCICTDGW DGELCDRDVR ACSSAPCANN RTCVSLDDGL YECSCAPGYS 
GKDCQKKDGP CVINGSPCQH GGTCVDDEGR ASHASCLCPP GFSGNFCEIV ANSCTPNPCE 
NDGVCTDIGG DFRCRCPAGF IDKTCSRPVT NCASSPCQNG GTCLQHTQVS YECLCKPEFT 
GLTCVKKRAL SPQQVTRLPS GYGLAYRLTP GVHELPVQQP EHRILKVSMK ELNKKTPLLT 
EGQAICFTIL GVLTSLVVLG TVGIVFLNKC ETWVSNLRYN HMLRKKKNLL LQYNSGEDLA 
VNIIFPEKID MTTFSKEAGD EEI

Genular Protein ID: 4129318582

Symbol: A8K019_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K019

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 2 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 383
  • Mass: 41171
  • Checksum: A50C16F8DFBA3A40
  • Sequence:
    • MTATEALLRV LLLLLAFGHS TYGAECFPAC NPQNGFCEDD NVCRCQPGWQ GPLCDQCVTS 
PGCLHGLCGE PGQCICTDGW DGELCDRDVR ACSSAPCANN GTCVSLDDGL YECSCAPGYS 
GKDCQKKDGP CVINGSPCQH GGTCVDDEGR ASHASCLCPP GFSGNFCEIV ANSCTPNPCE 
NDGVCTDIGG DFRCRCPAGF IDKTCSRPVT NCASSPCQNG GTCLQHTQVS YECLCKPEFT 
GLTCVKKRAL SPQQVTRLPS GYGLAYRLTP GVHELPVQQP EHRILKVSMK ELNKKTPLLA 
EGQAICFTIL GVLTSLVVLG TVGIVFLNKC ETWVSNLRYN HMLRKKKNLL LQYNSGEDLA 
VNIIFPEKID MTTFSKEAGD EEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.