Details for: DLK1

Gene ID: 8788

Symbol: DLK1

Ensembl ID: ENSG00000185559

Description: delta like non-canonical Notch ligand 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.6465
    Cell Significance Index: -8.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.0241
    Cell Significance Index: -8.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.2888
    Cell Significance Index: -10.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 21.8043
    Cell Significance Index: 279.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 19.0166
    Cell Significance Index: 509.5600
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 12.5400
    Cell Significance Index: 62.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.8859
    Cell Significance Index: -8.4900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.8890
    Cell Significance Index: 40.6000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 3.8807
    Cell Significance Index: 22.7800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.7415
    Cell Significance Index: 62.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1206
    Cell Significance Index: 619.2900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.5476
    Cell Significance Index: 21.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8809
    Cell Significance Index: 39.3700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1.7225
    Cell Significance Index: 8.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6040
    Cell Significance Index: 45.9800
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: 0.8549
    Cell Significance Index: 6.4800
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.6938
    Cell Significance Index: 4.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6779
    Cell Significance Index: 7.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6501
    Cell Significance Index: 75.7600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6450
    Cell Significance Index: 4.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.6046
    Cell Significance Index: 4.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5520
    Cell Significance Index: 14.7400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.5306
    Cell Significance Index: 3.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4389
    Cell Significance Index: 15.2500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3071
    Cell Significance Index: 4.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1986
    Cell Significance Index: 1.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1754
    Cell Significance Index: 5.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0798
    Cell Significance Index: 1.3400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0617
    Cell Significance Index: 0.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0027
    Cell Significance Index: -0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0144
    Cell Significance Index: -7.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0162
    Cell Significance Index: -10.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0185
    Cell Significance Index: -11.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0227
    Cell Significance Index: -6.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0264
    Cell Significance Index: -12.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0269
    Cell Significance Index: -3.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0294
    Cell Significance Index: -5.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0396
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0440
    Cell Significance Index: -9.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0453
    Cell Significance Index: -2.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0479
    Cell Significance Index: -9.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0558
    Cell Significance Index: -2.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0672
    Cell Significance Index: -5.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0744
    Cell Significance Index: -10.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0763
    Cell Significance Index: -7.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0794
    Cell Significance Index: -10.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1050
    Cell Significance Index: -1.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1113
    Cell Significance Index: -5.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1136
    Cell Significance Index: -1.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1144
    Cell Significance Index: -11.6900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1210
    Cell Significance Index: -1.7400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1245
    Cell Significance Index: -1.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1278
    Cell Significance Index: -3.3600
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.1292
    Cell Significance Index: -0.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1481
    Cell Significance Index: -8.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1489
    Cell Significance Index: -11.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1590
    Cell Significance Index: -10.6900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1725
    Cell Significance Index: -1.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1787
    Cell Significance Index: -10.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1815
    Cell Significance Index: -9.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1859
    Cell Significance Index: -5.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1905
    Cell Significance Index: -12.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1916
    Cell Significance Index: -11.7800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1935
    Cell Significance Index: -2.4300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2001
    Cell Significance Index: -1.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2020
    Cell Significance Index: -10.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2024
    Cell Significance Index: -2.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2028
    Cell Significance Index: -8.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2083
    Cell Significance Index: -9.7100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2159
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.2245
    Cell Significance Index: -2.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2287
    Cell Significance Index: -8.6600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2456
    Cell Significance Index: -2.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2593
    Cell Significance Index: -8.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2855
    Cell Significance Index: -10.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3024
    Cell Significance Index: -8.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3037
    Cell Significance Index: -11.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3092
    Cell Significance Index: -7.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3171
    Cell Significance Index: -6.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3284
    Cell Significance Index: -10.4600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3367
    Cell Significance Index: -10.6500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3496
    Cell Significance Index: -5.1000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3532
    Cell Significance Index: -5.8200
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.3553
    Cell Significance Index: -3.7500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3581
    Cell Significance Index: -2.2300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3666
    Cell Significance Index: -4.5400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3681
    Cell Significance Index: -3.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3682
    Cell Significance Index: -9.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3750
    Cell Significance Index: -10.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3820
    Cell Significance Index: -9.8200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3898
    Cell Significance Index: -5.6600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3954
    Cell Significance Index: -3.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3956
    Cell Significance Index: -9.8800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4011
    Cell Significance Index: -3.8100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4042
    Cell Significance Index: -5.2300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4073
    Cell Significance Index: -4.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DLK1 is a non-canonical Notch ligand, distinct from the classical Notch ligands (e.g., DLL1, DLL3, DLL4). Its unique characteristics include: 1. **Cellular localization**: DLK1 is primarily localized to the extracellular space, where it interacts with Notch receptors. 2. **Signal transduction**: Upon binding to Notch receptors, DLK1 triggers a signaling cascade that ultimately transduces signals to the nucleus, influencing gene expression and cellular behavior. 3. **Regulatory function**: DLK1 acts as a negative regulator of the Notch signaling pathway, modulating its activity and preventing excessive or inappropriate signaling. 4. **Expression pattern**: DLK1 is highly expressed in various cell types, including those involved in development, differentiation, and tissue homeostasis. **Pathways and Functions** The DLK1 gene is involved in several signaling pathways, including: 1. **Notch signaling pathway**: DLK1 binds to Notch receptors, triggering a signaling cascade that regulates gene expression, cell fate decisions, and cellular differentiation. 2. **Calcium ion binding**: DLK1 interacts with calcium ions, modulating its activity and influencing cellular responses. 3. **Cell differentiation**: DLK1 plays a role in regulating cell differentiation, particularly in the development and maintenance of various cell types. 4. **Signal transduction**: DLK1 transduces signals from the extracellular space to the nucleus, influencing gene expression and cellular behavior. **Clinical Significance** The dysregulation of DLK1 has been implicated in various diseases and disorders, including: 1. **Cancer**: Altered DLK1 expression has been observed in various cancers, including breast, lung, and colon cancer, suggesting its potential as a diagnostic or therapeutic target. 2. **Neurological disorders**: DLK1 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Developmental disorders**: DLK1 expression abnormalities have been linked to developmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Cardiovascular disease**: DLK1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac hypertrophy. In conclusion, DLK1 is a critical gene involved in various cellular processes, including cell differentiation, development, and signaling pathways. Its dysregulation has been implicated in various diseases and disorders, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 1924201263

Symbol: DLK1_HUMAN

Name: Protein delta homolog 1

UniProtKB Accession Codes:

P80370 P15803 Q96DW5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 8 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8095043

Title: dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line.

PubMed ID: 8095043

DOI: 10.1016/s0021-9258(18)53544-4

PubMed ID: 7711066

Title: dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA.

PubMed ID: 7711066

DOI: 10.1016/0167-4781(95)00007-4

PubMed ID: 2308864

Title: The sequence of an adrenal specific human cDNA, pG2.

PubMed ID: 2308864

DOI: 10.1093/nar/18.3.685

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7925474

Title: Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2.

PubMed ID: 7925474

DOI: 10.1111/j.1432-1033.1994.00083.x

PubMed ID: 8501199

Title: Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2.

PubMed ID: 8501199

DOI: 10.1093/oxfordjournals.humrep.a138110

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

Sequence Information:

  • Length: 383
  • Mass: 41300
  • Checksum: 9A2813B2801A98BD
  • Sequence:
    • MTATEALLRV LLLLLAFGHS TYGAECFPAC NPQNGFCEDD NVCRCQPGWQ GPLCDQCVTS 
PGCLHGLCGE PGQCICTDGW DGELCDRDVR ACSSAPCANN RTCVSLDDGL YECSCAPGYS 
GKDCQKKDGP CVINGSPCQH GGTCVDDEGR ASHASCLCPP GFSGNFCEIV ANSCTPNPCE 
NDGVCTDIGG DFRCRCPAGF IDKTCSRPVT NCASSPCQNG GTCLQHTQVS YECLCKPEFT 
GLTCVKKRAL SPQQVTRLPS GYGLAYRLTP GVHELPVQQP EHRILKVSMK ELNKKTPLLT 
EGQAICFTIL GVLTSLVVLG TVGIVFLNKC ETWVSNLRYN HMLRKKKNLL LQYNSGEDLA 
VNIIFPEKID MTTFSKEAGD EEI

Genular Protein ID: 4129318582

Symbol: A8K019_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K019

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 2 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 383
  • Mass: 41171
  • Checksum: A50C16F8DFBA3A40
  • Sequence:
    • MTATEALLRV LLLLLAFGHS TYGAECFPAC NPQNGFCEDD NVCRCQPGWQ GPLCDQCVTS 
PGCLHGLCGE PGQCICTDGW DGELCDRDVR ACSSAPCANN GTCVSLDDGL YECSCAPGYS 
GKDCQKKDGP CVINGSPCQH GGTCVDDEGR ASHASCLCPP GFSGNFCEIV ANSCTPNPCE 
NDGVCTDIGG DFRCRCPAGF IDKTCSRPVT NCASSPCQNG GTCLQHTQVS YECLCKPEFT 
GLTCVKKRAL SPQQVTRLPS GYGLAYRLTP GVHELPVQQP EHRILKVSMK ELNKKTPLLA 
EGQAICFTIL GVLTSLVVLG TVGIVFLNKC ETWVSNLRYN HMLRKKKNLL LQYNSGEDLA 
VNIIFPEKID MTTFSKEAGD EEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.