Details for: WNT2

Gene ID: 7472

Symbol: WNT2

Ensembl ID: ENSG00000105989

Description: Wnt family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 31.6613
    Cell Significance Index: 195.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7160
    Cell Significance Index: 41.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2003
    Cell Significance Index: 34.4100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1636
    Cell Significance Index: 19.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9794
    Cell Significance Index: 20.5000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.6271
    Cell Significance Index: 3.0000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2339
    Cell Significance Index: 3.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1107
    Cell Significance Index: 2.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0705
    Cell Significance Index: 14.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0604
    Cell Significance Index: 3.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0087
    Cell Significance Index: 0.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0062
    Cell Significance Index: 4.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0034
    Cell Significance Index: -0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0052
    Cell Significance Index: -7.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0086
    Cell Significance Index: -5.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0087
    Cell Significance Index: -3.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0102
    Cell Significance Index: -5.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0103
    Cell Significance Index: -2.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0217
    Cell Significance Index: -4.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0236
    Cell Significance Index: -2.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0239
    Cell Significance Index: -4.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0244
    Cell Significance Index: -3.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0281
    Cell Significance Index: -1.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0315
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0330
    Cell Significance Index: -5.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0343
    Cell Significance Index: -4.4300
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0350
    Cell Significance Index: -0.2200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0356
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0380
    Cell Significance Index: -4.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0449
    Cell Significance Index: -1.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0527
    Cell Significance Index: -0.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0540
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0569
    Cell Significance Index: -6.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0574
    Cell Significance Index: -2.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0618
    Cell Significance Index: -4.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0623
    Cell Significance Index: -2.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0665
    Cell Significance Index: -4.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0780
    Cell Significance Index: -2.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0782
    Cell Significance Index: -6.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0822
    Cell Significance Index: -0.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0823
    Cell Significance Index: -5.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0848
    Cell Significance Index: -2.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0848
    Cell Significance Index: -2.1800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1000
    Cell Significance Index: -1.3500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1001
    Cell Significance Index: -1.6500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1099
    Cell Significance Index: -1.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1101
    Cell Significance Index: -6.1800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1148
    Cell Significance Index: -0.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1213
    Cell Significance Index: -6.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1229
    Cell Significance Index: -5.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1240
    Cell Significance Index: -4.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1272
    Cell Significance Index: -3.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1333
    Cell Significance Index: -4.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1338
    Cell Significance Index: -2.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1361
    Cell Significance Index: -7.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1394
    Cell Significance Index: -4.8400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1455
    Cell Significance Index: -2.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1467
    Cell Significance Index: -4.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1470
    Cell Significance Index: -5.5700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1504
    Cell Significance Index: -1.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1536
    Cell Significance Index: -2.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1642
    Cell Significance Index: -4.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1728
    Cell Significance Index: -4.3100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1767
    Cell Significance Index: -1.6800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1774
    Cell Significance Index: -1.9400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1823
    Cell Significance Index: -2.5200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1887
    Cell Significance Index: -3.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1926
    Cell Significance Index: -7.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1946
    Cell Significance Index: -4.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1965
    Cell Significance Index: -4.5400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1969
    Cell Significance Index: -1.9100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2013
    Cell Significance Index: -3.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2018
    Cell Significance Index: -3.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2030
    Cell Significance Index: -5.0700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2059
    Cell Significance Index: -2.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2076
    Cell Significance Index: -5.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2113
    Cell Significance Index: -9.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2116
    Cell Significance Index: -2.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2117
    Cell Significance Index: -6.1000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2213
    Cell Significance Index: -2.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2252
    Cell Significance Index: -5.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2255
    Cell Significance Index: -4.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2266
    Cell Significance Index: -3.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2271
    Cell Significance Index: -4.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2276
    Cell Significance Index: -4.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2291
    Cell Significance Index: -4.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2312
    Cell Significance Index: -5.8900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2317
    Cell Significance Index: -4.6200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2390
    Cell Significance Index: -2.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2393
    Cell Significance Index: -7.5700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2476
    Cell Significance Index: -3.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** WNT2 exhibits several key characteristics that distinguish it from other Wnt family members: 1. **Cellular localization**: WNT2 is primarily expressed in epithelial cells, fibroblasts, and certain types of neurons, suggesting its role in tissue development and maintenance. 2. **Signaling pathways**: WNT2 activates the canonical Wnt signaling pathway, which is characterized by the stabilization of β-catenin and its translocation to the nucleus, where it regulates gene transcription. 3. **Receptor binding**: WNT2 binds to Frizzled receptors and co-receptors, such as LRP5 and LRP6, which are essential for the activation of the canonical Wnt signaling pathway. 4. **Expression patterns**: WNT2 is expressed in various tissues, including the heart, lung, liver, and brain, and is also found in certain types of cancer cells. **Pathways and Functions** WNT2's role in various signaling pathways and cellular processes can be summarized as follows: 1. **Cardiac development**: WNT2 is involved in the regulation of cardiac muscle cell proliferation and differentiation, which is crucial for heart development and function. 2. **Cell proliferation**: WNT2 promotes cell proliferation in various tissues, including the lung, liver, and brain, by activating the canonical Wnt signaling pathway. 3. **Cell differentiation**: WNT2 regulates cell differentiation in certain tissues, such as the development of cardiac muscle cells and neurons. 4. **Tissue morphogenesis**: WNT2 is involved in the regulation of tissue morphogenesis, including the development of the lung, liver, and brain. 5. **Cancer**: WNT2 has been implicated in the development and progression of various cancers, including colorectal, breast, and lung cancer. **Clinical Significance** WNT2's dysregulation has been associated with several diseases, including: 1. **Cardiovascular disorders**: Aberrant expression of WNT2 has been linked to cardiovascular diseases, such as aortic aneurysms and cardiac arrhythmias. 2. **Cancer**: WNT2 overexpression has been observed in various types of cancer, including colorectal, breast, and lung cancer. 3. **Neurological disorders**: WNT2 has been implicated in the development and progression of neurological conditions, such as Alzheimer's disease and Parkinson's disease. 4. **Birth defects**: WNT2 has been linked to various birth defects, including heart defects and lung abnormalities. In conclusion, WNT2 is a multifunctional gene that plays a critical role in various developmental and cellular processes. Its dysregulation has been associated with several diseases, highlighting the importance of understanding WNT2's role in normal development and disease.

Genular Protein ID: 1037608693

Symbol: WNT2_HUMAN

Name: Protein Wnt-2

UniProtKB Accession Codes:

P09544 A4D0V1 Q75N05 Q9UDP9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2971536

Title: Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.

PubMed ID: 2971536

DOI: 10.1002/j.1460-2075.1988.tb03003.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20018874

Title: Wnt2 regulates progenitor proliferation in the developing ventral midbrain.

PubMed ID: 20018874

DOI: 10.1074/jbc.m109.079822

PubMed ID: 11449391

Title: Evidence supporting WNT2 as an autism susceptibility gene.

PubMed ID: 11449391

DOI: 10.1002/ajmg.1401

PubMed ID: 11840514

Title: No association between the WNT2 gene and autistic disorder.

PubMed ID: 11840514

DOI: 10.1002/ajmg.10182

Sequence Information:

  • Length: 360
  • Mass: 40418
  • Checksum: AA96325BF68C4788
  • Sequence:
    • MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS QRQLCHRHPD 
VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV LLRSSRESAF VYAISSAGVV 
FAITRACSQG EVKSCSCDPK KMGSAKDSKG IFDWGGCSDN IDYGIKFARA FVDAKERKGK 
DARALMNLHN NRAGRKAVKR FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG 
AIQVVMNQDG TGFTVANERF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG 
MDSCEVMCCG RGYDTSHVTR MTKCGCKFHW CCAVRCQDCL EALDVHTCKA PKNADWTTAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.