Details for: WNT2

Gene ID: 7472

Symbol: WNT2

Ensembl ID: ENSG00000105989

Description: Wnt family member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 9.71
    Marker Score: 7769
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.57
    Marker Score: 6789
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.28
    Marker Score: 14388
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.25
    Marker Score: 1065
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7281
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.04
    Marker Score: 433
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.96
    Marker Score: 1318
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.91
    Marker Score: 478
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.88
    Marker Score: 1082
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.86
    Marker Score: 29262
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.83
    Marker Score: 206
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.82
    Marker Score: 206
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1589
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1434
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.74
    Marker Score: 1931
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.72
    Marker Score: 300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.66
    Marker Score: 10257
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 391.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.54
    Marker Score: 1116
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.54
    Marker Score: 519
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.53
    Marker Score: 303
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.46
    Marker Score: 206
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.45
    Marker Score: 101
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.42
    Marker Score: 133
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.38
    Marker Score: 178
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.35
    Marker Score: 183.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3
    Marker Score: 164
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.28
    Marker Score: 146
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 157
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.24
    Marker Score: 78
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 140
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.23
    Marker Score: 132
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.22
    Marker Score: 219
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.22
    Marker Score: 61
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.22
    Marker Score: 120
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 127
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.21
    Marker Score: 92
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 137
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.21
    Marker Score: 51
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 210
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.18
    Marker Score: 159
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 64
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.17
    Marker Score: 131
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 147
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.16
    Marker Score: 197
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 91
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.15
    Marker Score: 234
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.15
    Marker Score: 190
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 332
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.13
    Marker Score: 246
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 23
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.12
    Marker Score: 474
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1
    Marker Score: 402
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 306.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.09
    Marker Score: 1525
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.09
    Marker Score: 373
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.08
    Marker Score: 155
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 106
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.07
    Marker Score: 60

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Other Information

**Key Characteristics** WNT2 exhibits several key characteristics that distinguish it from other Wnt family members: 1. **Cellular localization**: WNT2 is primarily expressed in epithelial cells, fibroblasts, and certain types of neurons, suggesting its role in tissue development and maintenance. 2. **Signaling pathways**: WNT2 activates the canonical Wnt signaling pathway, which is characterized by the stabilization of β-catenin and its translocation to the nucleus, where it regulates gene transcription. 3. **Receptor binding**: WNT2 binds to Frizzled receptors and co-receptors, such as LRP5 and LRP6, which are essential for the activation of the canonical Wnt signaling pathway. 4. **Expression patterns**: WNT2 is expressed in various tissues, including the heart, lung, liver, and brain, and is also found in certain types of cancer cells. **Pathways and Functions** WNT2's role in various signaling pathways and cellular processes can be summarized as follows: 1. **Cardiac development**: WNT2 is involved in the regulation of cardiac muscle cell proliferation and differentiation, which is crucial for heart development and function. 2. **Cell proliferation**: WNT2 promotes cell proliferation in various tissues, including the lung, liver, and brain, by activating the canonical Wnt signaling pathway. 3. **Cell differentiation**: WNT2 regulates cell differentiation in certain tissues, such as the development of cardiac muscle cells and neurons. 4. **Tissue morphogenesis**: WNT2 is involved in the regulation of tissue morphogenesis, including the development of the lung, liver, and brain. 5. **Cancer**: WNT2 has been implicated in the development and progression of various cancers, including colorectal, breast, and lung cancer. **Clinical Significance** WNT2's dysregulation has been associated with several diseases, including: 1. **Cardiovascular disorders**: Aberrant expression of WNT2 has been linked to cardiovascular diseases, such as aortic aneurysms and cardiac arrhythmias. 2. **Cancer**: WNT2 overexpression has been observed in various types of cancer, including colorectal, breast, and lung cancer. 3. **Neurological disorders**: WNT2 has been implicated in the development and progression of neurological conditions, such as Alzheimer's disease and Parkinson's disease. 4. **Birth defects**: WNT2 has been linked to various birth defects, including heart defects and lung abnormalities. In conclusion, WNT2 is a multifunctional gene that plays a critical role in various developmental and cellular processes. Its dysregulation has been associated with several diseases, highlighting the importance of understanding WNT2's role in normal development and disease.

Genular Protein ID: 1037608693

Symbol: WNT2_HUMAN

Name: Protein Wnt-2

UniProtKB Accession Codes:

P09544 A4D0V1 Q75N05 Q9UDP9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2971536

Title: Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.

PubMed ID: 2971536

DOI: 10.1002/j.1460-2075.1988.tb03003.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20018874

Title: Wnt2 regulates progenitor proliferation in the developing ventral midbrain.

PubMed ID: 20018874

DOI: 10.1074/jbc.m109.079822

PubMed ID: 11449391

Title: Evidence supporting WNT2 as an autism susceptibility gene.

PubMed ID: 11449391

DOI: 10.1002/ajmg.1401

PubMed ID: 11840514

Title: No association between the WNT2 gene and autistic disorder.

PubMed ID: 11840514

DOI: 10.1002/ajmg.10182

Sequence Information:

  • Length: 360
  • Mass: 40418
  • Checksum: AA96325BF68C4788
  • Sequence:
    • MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS QRQLCHRHPD 
VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV LLRSSRESAF VYAISSAGVV 
FAITRACSQG EVKSCSCDPK KMGSAKDSKG IFDWGGCSDN IDYGIKFARA FVDAKERKGK 
DARALMNLHN NRAGRKAVKR FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG 
AIQVVMNQDG TGFTVANERF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG 
MDSCEVMCCG RGYDTSHVTR MTKCGCKFHW CCAVRCQDCL EALDVHTCKA PKNADWTTAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.