Details for: STC2

Gene ID: 8614

Symbol: STC2

Ensembl ID: ENSG00000113739

Description: stanniocalcin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 21.0036
    Cell Significance Index: 129.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.2581
    Cell Significance Index: -8.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.6201
    Cell Significance Index: -8.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.2148
    Cell Significance Index: 154.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.5204
    Cell Significance Index: 411.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.1524
    Cell Significance Index: 193.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.8613
    Cell Significance Index: 23.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5479
    Cell Significance Index: 80.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.3848
    Cell Significance Index: 22.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5364
    Cell Significance Index: 53.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4906
    Cell Significance Index: 442.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4667
    Cell Significance Index: 860.6900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 0.4586
    Cell Significance Index: 0.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4310
    Cell Significance Index: 20.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4134
    Cell Significance Index: 8.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3750
    Cell Significance Index: 577.2800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3646
    Cell Significance Index: 2.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3299
    Cell Significance Index: 35.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2978
    Cell Significance Index: 48.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2800
    Cell Significance Index: 16.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2577
    Cell Significance Index: 6.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2438
    Cell Significance Index: 2.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2239
    Cell Significance Index: 122.2900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.2026
    Cell Significance Index: 2.4000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1969
    Cell Significance Index: 3.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1667
    Cell Significance Index: 226.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1453
    Cell Significance Index: 10.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1023
    Cell Significance Index: 19.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0974
    Cell Significance Index: 12.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0748
    Cell Significance Index: 14.8400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0612
    Cell Significance Index: 0.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0546
    Cell Significance Index: 0.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0482
    Cell Significance Index: 5.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0410
    Cell Significance Index: 1.1800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0389
    Cell Significance Index: 0.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0389
    Cell Significance Index: 2.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0331
    Cell Significance Index: 0.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0239
    Cell Significance Index: 2.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0205
    Cell Significance Index: 3.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0163
    Cell Significance Index: 0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0162
    Cell Significance Index: 0.5700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0127
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0034
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0019
    Cell Significance Index: 1.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0033
    Cell Significance Index: -2.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0048
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0087
    Cell Significance Index: -4.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -7.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0134
    Cell Significance Index: -0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0146
    Cell Significance Index: -9.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0161
    Cell Significance Index: -4.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0174
    Cell Significance Index: -6.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0192
    Cell Significance Index: -4.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0205
    Cell Significance Index: -2.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0254
    Cell Significance Index: -3.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0348
    Cell Significance Index: -6.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0352
    Cell Significance Index: -1.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0376
    Cell Significance Index: -6.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0534
    Cell Significance Index: -7.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0613
    Cell Significance Index: -0.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0625
    Cell Significance Index: -9.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0648
    Cell Significance Index: -7.9700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0665
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0712
    Cell Significance Index: -4.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0749
    Cell Significance Index: -2.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0766
    Cell Significance Index: -7.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0785
    Cell Significance Index: -4.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0950
    Cell Significance Index: -1.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1004
    Cell Significance Index: -1.6800
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.1023
    Cell Significance Index: -0.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1112
    Cell Significance Index: -2.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1199
    Cell Significance Index: -3.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1221
    Cell Significance Index: -9.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1259
    Cell Significance Index: -2.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1274
    Cell Significance Index: -7.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1320
    Cell Significance Index: -3.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1348
    Cell Significance Index: -3.2700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1420
    Cell Significance Index: -1.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1497
    Cell Significance Index: -6.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1513
    Cell Significance Index: -9.3000
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1521
    Cell Significance Index: -1.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1552
    Cell Significance Index: -3.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1593
    Cell Significance Index: -10.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1689
    Cell Significance Index: -4.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1736
    Cell Significance Index: -4.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1741
    Cell Significance Index: -6.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1758
    Cell Significance Index: -9.1300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1837
    Cell Significance Index: -5.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1885
    Cell Significance Index: -5.3800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1967
    Cell Significance Index: -1.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2059
    Cell Significance Index: -2.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2065
    Cell Significance Index: -7.5800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2144
    Cell Significance Index: -0.9900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2158
    Cell Significance Index: -2.0500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2290
    Cell Significance Index: -5.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2317
    Cell Significance Index: -10.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STC2 is a secreted protein that belongs to the stanniocalcin family, characterized by its unique structure and function. It is primarily expressed in epithelial cells, including those of the mammary gland, lens, kidney, and colon. STC2 has been shown to be involved in various cellular processes, including cell proliferation, differentiation, and survival. Its expression is tightly regulated by hormonal and oxidative stress signals, highlighting its role as a key modulator of cellular homeostasis. **Pathways and Functions:** STC2 has been implicated in multiple signaling pathways, including: 1. **Cellular response to hypoxia:** STC2 regulates the expression of genes involved in hypoxia-inducible factor (HIF) signaling, thereby modulating the cellular response to low oxygen levels. 2. **Decidualization and embryo implantation:** STC2 plays a crucial role in the regulation of implantation and decidualization, processes critical for successful pregnancy. 3. **Endoplasmic reticulum unfolded protein response (ER-UPR):** STC2 modulates the ER-UPR, a stress response pathway that regulates protein folding and degradation. 4. **Hormone activity:** STC2 interacts with various hormones, including insulin-like growth factor (IGF) and peptide hormones, influencing their signaling pathways. 5. **Intracellular calcium ion homeostasis:** STC2 regulates the trafficking of calcium ions into and out of cells, maintaining calcium homeostasis. **Clinical Significance:** STC2 has been implicated in various diseases and disorders, including: 1. **Pregnancy complications:** Abnormal expression of STC2 has been linked to pregnancy-related complications, such as recurrent miscarriage and preeclampsia. 2. **Cancer:** STC2 has been shown to promote tumor growth and metastasis in certain types of cancer, including breast and ovarian cancer. 3. **Neurological disorders:** STC2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Metabolic disorders:** STC2 plays a role in regulating glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as diabetes and obesity. In conclusion, STC2 is a multifaceted protein that plays a critical role in maintaining immune homeostasis and regulating various cellular processes. Its dysregulation has been implicated in various diseases and disorders, highlighting the need for further research into the mechanisms underlying its function and potential therapeutic applications.

Genular Protein ID: 4053170222

Symbol: STC2_HUMAN

Name: Stanniocalcin-2

UniProtKB Accession Codes:

O76061

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 6 Ensembl 1 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9723890

Title: Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2.

PubMed ID: 9723890

DOI: 10.1016/s0303-7207(98)00097-5

PubMed ID: 9753616

Title: Molecular cloning of a second human stanniocalcin homologue (STC2).

PubMed ID: 9753616

DOI: 10.1006/bbrc.1998.9300

PubMed ID: 10022771

Title: Molecular cloning and characterization of stanniocalcin-related protein.

PubMed ID: 10022771

DOI: 10.1016/s0303-7207(98)00163-4

PubMed ID: 10450831

Title: Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells.

PubMed ID: 10450831

DOI: 10.1055/s-2007-978764

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 302
  • Mass: 33249
  • Checksum: 9B90D8911524FA22
  • Sequence:
    • MCAERLGQFM TLALVLATFD PARGTDATNP PEGPQDRSSQ QKGRLSLQNT AEIQHCLVNA 
GDVGCGVFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK SFIKDALKCK AHALRHRFGC 
ISRKCPAIRE MVSQLQRECY LKHDLCAAAQ ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT 
CGEEVKEAIT HSVQVQCEQN WGSLCSILSF CTSAIQKPPT APPERQPQVD RTKLSRAHHG 
EAGHHLPEPS SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI 
RR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.