Details for: PRRX2

Gene ID: 51450

Symbol: PRRX2

Ensembl ID: ENSG00000167157

Description: paired related homeobox 2

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.9119
    Cell Significance Index: 22.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2689
    Cell Significance Index: 65.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6078
    Cell Significance Index: 30.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5810
    Cell Significance Index: 4.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4577
    Cell Significance Index: 9.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3727
    Cell Significance Index: 5.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3428
    Cell Significance Index: 6.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2695
    Cell Significance Index: 3.8600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2294
    Cell Significance Index: 1.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1677
    Cell Significance Index: 74.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1648
    Cell Significance Index: 21.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1338
    Cell Significance Index: 6.2900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1256
    Cell Significance Index: 0.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0580
    Cell Significance Index: 31.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0541
    Cell Significance Index: 10.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0535
    Cell Significance Index: 6.9200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0170
    Cell Significance Index: 0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0122
    Cell Significance Index: 2.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0032
    Cell Significance Index: 0.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0055
    Cell Significance Index: -0.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0064
    Cell Significance Index: -9.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0090
    Cell Significance Index: -3.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0093
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0094
    Cell Significance Index: -7.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0108
    Cell Significance Index: -6.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0126
    Cell Significance Index: -1.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0146
    Cell Significance Index: -6.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0190
    Cell Significance Index: -5.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0295
    Cell Significance Index: -2.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0309
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0317
    Cell Significance Index: -6.6900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0318
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0328
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0399
    Cell Significance Index: -6.8100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0415
    Cell Significance Index: -0.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0633
    Cell Significance Index: -7.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0668
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0754
    Cell Significance Index: -8.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0764
    Cell Significance Index: -1.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0819
    Cell Significance Index: -6.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0902
    Cell Significance Index: -1.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0930
    Cell Significance Index: -6.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0950
    Cell Significance Index: -5.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1058
    Cell Significance Index: -6.5000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1158
    Cell Significance Index: -0.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1180
    Cell Significance Index: -9.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1206
    Cell Significance Index: -4.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1245
    Cell Significance Index: -3.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1299
    Cell Significance Index: -3.4800
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1421
    Cell Significance Index: -1.2900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1471
    Cell Significance Index: -2.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1545
    Cell Significance Index: -2.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1657
    Cell Significance Index: -4.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1682
    Cell Significance Index: -7.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1724
    Cell Significance Index: -4.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1730
    Cell Significance Index: -6.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1773
    Cell Significance Index: -9.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1872
    Cell Significance Index: -6.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1921
    Cell Significance Index: -9.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1936
    Cell Significance Index: -7.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1956
    Cell Significance Index: -5.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2028
    Cell Significance Index: -6.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2141
    Cell Significance Index: -11.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2157
    Cell Significance Index: -5.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2168
    Cell Significance Index: -10.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2173
    Cell Significance Index: -6.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2346
    Cell Significance Index: -5.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2364
    Cell Significance Index: -10.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2440
    Cell Significance Index: -4.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2478
    Cell Significance Index: -5.4300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2498
    Cell Significance Index: -4.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2510
    Cell Significance Index: -6.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2526
    Cell Significance Index: -6.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2536
    Cell Significance Index: -9.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2551
    Cell Significance Index: -6.8300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.2575
    Cell Significance Index: -2.3900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2603
    Cell Significance Index: -2.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2633
    Cell Significance Index: -10.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2649
    Cell Significance Index: -6.7500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2873
    Cell Significance Index: -3.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2934
    Cell Significance Index: -10.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2980
    Cell Significance Index: -4.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3048
    Cell Significance Index: -6.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3050
    Cell Significance Index: -6.5900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3119
    Cell Significance Index: -4.4400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.3183
    Cell Significance Index: -0.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3195
    Cell Significance Index: -6.8300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3208
    Cell Significance Index: -6.7000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3261
    Cell Significance Index: -1.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3287
    Cell Significance Index: -6.6000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3312
    Cell Significance Index: -6.7400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3366
    Cell Significance Index: -4.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRRX2 is a member of the paired homeobox gene family, which is characterized by the presence of a paired box (PBX) domain and a homeodomain. This gene is highly conserved across species, indicating its essential role in fundamental biological processes. PRRX2 exhibits a unique expression pattern, with significant expression in inflammatory cells, fibroblasts, and epithelial cells. This suggests that PRRX2 may play a critical role in regulating immune responses and tissue development. **Pathways and Functions:** PRRX2 is involved in several key pathways, including: 1. **Chromatin and DNA-binding transcription factor activity:** PRRX2 regulates gene expression by binding to specific DNA sequences and modulating chromatin structure. 2. **RNA polymerase II-specific transcription regulation:** PRRX2 influences the expression of genes involved in immune responses and cellular differentiation. 3. **Regulation of DNA-templated transcription:** PRRX2 regulates the expression of genes involved in tissue development and immune responses. 4. **Sequence-specific double-stranded DNA binding:** PRRX2 binds to specific DNA sequences, influencing gene expression and cellular differentiation. **Clinical Significance:** PRRX2 has been implicated in various diseases, including: 1. **Autoimmune disorders:** PRRX2 has been shown to regulate immune cell function and may contribute to the development of autoimmune diseases. 2. **Cancer:** PRRX2 has been implicated in the regulation of cellular differentiation and may play a role in cancer development and progression. 3. **Neurological disorders:** PRRX2 has been shown to regulate neural development and may contribute to the development of neurological disorders. In conclusion, PRRX2 is a complex gene that plays a critical role in regulating immune responses, cellular differentiation, and tissue development. Further studies are needed to fully understand the mechanisms by which PRRX2 influences these biological processes and to elucidate its clinical significance in various diseases. **Future Directions:** To further elucidate the role of PRRX2 in immune regulation and cellular differentiation, future studies should focus on: 1. **Characterizing PRRX2 expression patterns:** Further studies are needed to determine the expression patterns of PRRX2 in different tissues and cell types. 2. **Investigating PRRX2 function:** Studies should be conducted to determine the specific mechanisms by which PRRX2 regulates immune cell function and cellular differentiation. 3. **Elucidating the clinical significance of PRRX2:** Further studies are needed to determine the clinical significance of PRRX2 in various diseases, including autoimmune disorders, cancer, and neurological disorders.

Genular Protein ID: 2912375564

Symbol: PRRX2_HUMAN

Name: Paired mesoderm homeobox protein 2

UniProtKB Accession Codes:

Q99811 Q5SZB5 Q9UIB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11063257

Title: Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome.

PubMed ID: 11063257

DOI: 10.1007/s003350010193

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9665387

Title: Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds.

PubMed ID: 9665387

DOI: 10.1046/j.1523-1747.1998.00238.x

Sequence Information:

  • Length: 253
  • Mass: 27079
  • Checksum: C7A861D46DC46DD3
  • Sequence:
    • MDSAAAAFAL DKPALGPGPP PPPPALGPGD CAQARKNFSV SHLLDLEEVA AAGRLAARPG 
ARAEAREGAA REPSGGSSGS EAAPQDGECP SPGRGSAAKR KKKQRRNRTT FNSSQLQALE 
RVFERTHYPD AFVREELARR VNLSEARVQV WFQNRRAKFR RNERAMLASR SASLLKSYSQ 
EAAIEQPVAP RPTALSPDYL SWTASSPYST VPPYSPGSSG PATPGVNMAN SIASLRLKAK 
EFSLHHSQVP TVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.