Details for: GATA4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 23.5073
Cell Significance Index: -9.5500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 9.6701
Cell Significance Index: 309.7200 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 6.7924
Cell Significance Index: 33.0400 - Cell Name: perivascular cell (CL4033054)
Fold Change: 5.5639
Cell Significance Index: 25.6900 - Cell Name: precursor cell (CL0011115)
Fold Change: 5.4309
Cell Significance Index: 41.1800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 5.3769
Cell Significance Index: 68.8600 - Cell Name: supporting cell (CL0000630)
Fold Change: 4.6538
Cell Significance Index: 21.5000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.6759
Cell Significance Index: 282.0900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 3.6166
Cell Significance Index: 54.5000 - Cell Name: endocardial cell (CL0002350)
Fold Change: 3.4400
Cell Significance Index: 20.3100 - Cell Name: Leydig cell (CL0000178)
Fold Change: 3.4196
Cell Significance Index: 17.0600 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.6521
Cell Significance Index: 37.2000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.5742
Cell Significance Index: 55.7700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.5472
Cell Significance Index: 115.4600 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 2.4187
Cell Significance Index: 24.4000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.3587
Cell Significance Index: 448.8800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2013
Cell Significance Index: 436.8600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.1355
Cell Significance Index: 31.5200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.0917
Cell Significance Index: 144.6600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 2.0097
Cell Significance Index: 29.6700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.9852
Cell Significance Index: 52.2000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.6386
Cell Significance Index: 23.5300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3840
Cell Significance Index: 83.0900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.3172
Cell Significance Index: 153.5000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2972
Cell Significance Index: 37.3800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2100
Cell Significance Index: 119.7000 - Cell Name: acinar cell (CL0000622)
Fold Change: 1.1891
Cell Significance Index: 14.9400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0626
Cell Significance Index: 115.5800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0286
Cell Significance Index: 928.7900 - Cell Name: theca cell (CL0000503)
Fold Change: 0.9889
Cell Significance Index: 5.8100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.9801
Cell Significance Index: 16.5100 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.9155
Cell Significance Index: 10.8200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7813
Cell Significance Index: 16.6400 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.7521
Cell Significance Index: 12.6500 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.6501
Cell Significance Index: 6.1800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5983
Cell Significance Index: 102.1600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.3888
Cell Significance Index: 8.0700 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.3244
Cell Significance Index: 3.2100 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.2894
Cell Significance Index: 2.2900 - Cell Name: mural cell (CL0008034)
Fold Change: 0.2214
Cell Significance Index: 2.7000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1204
Cell Significance Index: 4.2300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1130
Cell Significance Index: 12.9000 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.1087
Cell Significance Index: 0.5200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.1029
Cell Significance Index: 1.4800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0772
Cell Significance Index: 1.1100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.0475
Cell Significance Index: 1.1500 - Cell Name: obsolete somatic cell (CL0002371)
Fold Change: 0.0323
Cell Significance Index: 0.2500 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0256
Cell Significance Index: 0.2700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0009
Cell Significance Index: -0.5800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0015
Cell Significance Index: -1.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0017
Cell Significance Index: -0.9800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0017
Cell Significance Index: -3.0700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0019
Cell Significance Index: -2.8500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0026
Cell Significance Index: -3.5000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0027
Cell Significance Index: -1.8800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0039
Cell Significance Index: -0.5400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0044
Cell Significance Index: -8.2600 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0047
Cell Significance Index: -0.0600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0068
Cell Significance Index: -0.3500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0097
Cell Significance Index: -2.0500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0116
Cell Significance Index: -8.7500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0118
Cell Significance Index: -1.3500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0132
Cell Significance Index: -8.3700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0150
Cell Significance Index: -6.8300 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0174
Cell Significance Index: -0.1800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0180
Cell Significance Index: -0.7400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0233
Cell Significance Index: -8.3600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0255
Cell Significance Index: -0.7100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0266
Cell Significance Index: -4.7900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0315
Cell Significance Index: -9.0500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0412
Cell Significance Index: -2.5300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0423
Cell Significance Index: -8.5000 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.0453
Cell Significance Index: -0.4000 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.0453
Cell Significance Index: -0.5200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0527
Cell Significance Index: -7.6700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0581
Cell Significance Index: -0.6600 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0654
Cell Significance Index: -1.6300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0688
Cell Significance Index: -8.4600 - Cell Name: lung pericyte (CL0009089)
Fold Change: -0.0762
Cell Significance Index: -0.7500 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.0818
Cell Significance Index: -0.5000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0927
Cell Significance Index: -9.6500 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0949
Cell Significance Index: -1.3600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0970
Cell Significance Index: -2.6000 - Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
Fold Change: -0.0978
Cell Significance Index: -0.8300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1077
Cell Significance Index: -2.8900 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.1125
Cell Significance Index: -0.9000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1146
Cell Significance Index: -0.7800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1150
Cell Significance Index: -5.3600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1159
Cell Significance Index: -2.9800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1356
Cell Significance Index: -8.7500 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1356
Cell Significance Index: -4.2900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.1357
Cell Significance Index: -1.1400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1358
Cell Significance Index: -2.6500 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1402
Cell Significance Index: -1.6500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1464
Cell Significance Index: -9.2300 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.1698
Cell Significance Index: -2.2900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1747
Cell Significance Index: -9.1000 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1783
Cell Significance Index: -4.3500 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1904
Cell Significance Index: -2.3600 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.1972
Cell Significance Index: -2.9500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1842357252
Symbol: GATA4_HUMAN
Name: Transcription factor GATA-4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7721094
Title: Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA.
PubMed ID: 7721094
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15734735
Title: Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.
PubMed ID: 15734735
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20081228
Title: Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.
PubMed ID: 20081228
PubMed ID: 35182466
Title: Transcription factor protein interactomes reveal genetic determinants in heart disease.
PubMed ID: 35182466
PubMed ID: 21220346
Title: Loss-of-function mutation in GATA4 causes anomalies of human testicular development.
PubMed ID: 21220346
PubMed ID: 24041700
Title: GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy.
PubMed ID: 24041700
PubMed ID: 24000169
Title: GATA4 loss-of-function mutations underlie familial tetralogy of fallot.
PubMed ID: 24000169
DOI: 10.1002/humu.22434
PubMed ID: 25017055
Title: Prevalence and spectrum of GATA4 mutations associated with sporadic dilated cardiomyopathy.
PubMed ID: 25017055
PubMed ID: 27984724
Title: Disease model of GATA4 mutation reveals transcription factor cooperativity in human cardiogenesis.
PubMed ID: 27984724
PubMed ID: 12845333
Title: GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.
PubMed ID: 12845333
DOI: 10.1038/nature01827
PubMed ID: 15810002
Title: Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect.
PubMed ID: 15810002
DOI: 10.1002/ajmg.a.30684
PubMed ID: 18055909
Title: GATA4 sequence variants in patients with congenital heart disease.
PubMed ID: 18055909
PubMed ID: 17643447
Title: Spectrum of heart disease associated with murine and human GATA4 mutation.
PubMed ID: 17643447
PubMed ID: 18672102
Title: GATA4 mutations in 486 Chinese patients with congenital heart disease.
PubMed ID: 18672102
PubMed ID: 20659440
Title: A novel mutation of GATA4 in a familial atrial septal defect.
PubMed ID: 20659440
PubMed ID: 21110066
Title: Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease.
PubMed ID: 21110066
PubMed ID: 20347099
Title: A novel mutation in GATA4 gene associated with dominant inherited familial atrial septal defect.
PubMed ID: 20347099
PubMed ID: 21637914
Title: A novel GATA4 mutation responsible for congenital ventricular septal defects.
PubMed ID: 21637914
PubMed ID: 22101736
Title: A novel GATA4 loss-of-function mutation associated with congenital ventricular septal defect.
PubMed ID: 22101736
PubMed ID: 27535533
Title: Analysis of protein-coding genetic variation in 60,706 humans.
PubMed ID: 27535533
DOI: 10.1038/nature19057
Sequence Information:
- Length: 442
- Mass: 44565
- Checksum: 141B8CD841E12C7B
- Sequence:
MYQSLAMAAN HGPPPGAYEA GGPGAFMHGA GAASSPVYVP TPRVPSSVLG LSYLQGGGAG SASGGASGGS SGGAASGAGP GTQQGSPGWS QAGADGAAYT PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYSSGGGAAG AGLAGREQYG RAGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPAA RHPNLDMFDD FSEGRECVNC GAMSTPLWRR DGTGHYLCNA CGLYHKMNGI NRPLIKPQRR LSASRRVGLS CANCQTTTTT LWRRNAEGEP VCNACGLYMK LHGVPRPLAM RKEGIQTRKR KPKNLNKSKT PAAPSGSESL PPASGASSNS SNATTSSSEE MRPIKTEPGL SSHYGHSSSV SQTFSVSAMS GHGPSIHPVL SALKLSPQGY ASPVSQSPQT SSKQDSWNSL VLADSHGDII TA
Genular Protein ID: 3304879994
Symbol: B3KUF4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
Sequence Information:
- Length: 236
- Mass: 25302
- Checksum: B62E270C775EDEC2
- Sequence:
MFDDFSEGRE CVNCGAMSTP LWRRDGTGHY LCNACGLYHK MNGINRPLIK PQRRLSASRR VGLSCANCQT TTTTLWRRNA EGEPVCNACG LYMKLHGVPR PLAMRKEGIQ TRKRKPKNLN KSKTPAAPSG SESLPPASGA SSNSSNATTS SSEEMRPIKT EPGLSSHYGH SSSVSQTFSV SAMSGHGPSI HPVLSALKLS PQGYASPVSQ SPQTSSKQDS WNSLVLADSH GDIITA
Genular Protein ID: 2957755211
Symbol: B6DU75_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 20041118
Title: Conserved usage of alternative 5' untranslated exons of the GATA4 gene.
PubMed ID: 20041118
Sequence Information:
- Length: 16
- Mass: 1642
- Checksum: EC0D1E2C52EAFF6F
- Sequence:
MYQSLAMAAN HGPPPG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.