Details for: GATA4

Gene ID: 2626

Symbol: GATA4

Ensembl ID: ENSG00000136574

Description: GATA binding protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.25
    Marker Score: 7995
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.61
    Marker Score: 80680
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.91
    Marker Score: 29257
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.84
    Marker Score: 4383
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.68
    Marker Score: 15887
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.62
    Marker Score: 9316
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.35
    Marker Score: 1327
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1512
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.18
    Marker Score: 5922
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.1
    Marker Score: 2111
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.1
    Marker Score: 2228
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.08
    Marker Score: 13543
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.98
    Marker Score: 2138
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.72
    Marker Score: 1842
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.69
    Marker Score: 1191
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169933
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.47
    Marker Score: 1470
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.17
    Marker Score: 652
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.14
    Marker Score: 314
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.13
    Marker Score: 1976
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.08
    Marker Score: 2235
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.04
    Marker Score: 2204
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.94
    Marker Score: 507
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.93
    Marker Score: 300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1511
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.92
    Marker Score: 3030
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.9
    Marker Score: 219
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.9
    Marker Score: 340
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.83
    Marker Score: 5309
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.8
    Marker Score: 421
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.78
    Marker Score: 10398
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.78
    Marker Score: 975
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.77
    Marker Score: 3305
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.76
    Marker Score: 241
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.71
    Marker Score: 1141
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.7
    Marker Score: 477
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2872
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.68
    Marker Score: 225
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.66
    Marker Score: 470
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.65
    Marker Score: 161
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.63
    Marker Score: 3398
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.56
    Marker Score: 3557
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.53
    Marker Score: 533
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.53
    Marker Score: 115
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.52
    Marker Score: 1178
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 327
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.49
    Marker Score: 606
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.48
    Marker Score: 127.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.47
    Marker Score: 135
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 204
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.46
    Marker Score: 222
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.45
    Marker Score: 165
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.45
    Marker Score: 218
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.43
    Marker Score: 2586
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 416
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.42
    Marker Score: 144
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 401.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.41
    Marker Score: 211
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.4
    Marker Score: 305
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 222
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.38
    Marker Score: 99
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.38
    Marker Score: 169
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.37
    Marker Score: 268
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.37
    Marker Score: 115
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.37
    Marker Score: 365.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.36
    Marker Score: 78
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.35
    Marker Score: 235
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.35
    Marker Score: 823
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.34
    Marker Score: 171
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 199
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.32
    Marker Score: 1559
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 291
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3
    Marker Score: 129
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.29
    Marker Score: 693

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Other Information

**Key characteristics**: - GATA4 is a transcription factor belonging to the GATA family of transcription factors. - It is expressed in a variety of cell types, including supporting cells, cardiomyocytes, and endothelial cells. - GATA4 is a key regulator of cardiac development and function. **Pathways and functions**: - GATA4 is involved in cardiac conduction by promoting the expression of genes that are necessary for the development and maintenance of a functional cardiac conduction system. - It is also involved in the formation of the cardiovascular endothelium, which is responsible for the blood-brain barrier and the regulation of vascular tone. - GATA4 plays a role in the development of the heart and blood vessels by regulating the expression of genes involved in embryonic heart development, such as those encoding for cardiac valves, coronary arteries, and blood vessels. **Clinical significance**: - Mutations in GATA4 have been linked to a number of human diseases, including congenital heart defects, stroke, and heart failure. - GATA4 is a potential therapeutic target for these diseases, as it can be used to correct the genetic defects that cause them. **Additional information**: - GATA4 is a highly conserved transcription factor, with a similar gene product found in other vertebrates. - It is regulated by a variety of factors, including the transcription factors GATA1, GATA2, and GATA3. - GATA4 is a key regulator of cardiac development, and its dysfunction can lead to a variety of cardiovascular diseases.

Genular Protein ID: 1842357252

Symbol: GATA4_HUMAN

Name: Transcription factor GATA-4

UniProtKB Accession Codes:

P43694 B7ZKX0 B7ZKZ4 Q3MJ45 Q5IFM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 58 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 9 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 8 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7721094

Title: Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA.

PubMed ID: 7721094

DOI: 10.1016/0378-1119(94)00893-w

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15734735

Title: Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.

PubMed ID: 15734735

DOI: 10.1074/jbc.m410928200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20081228

Title: Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.

PubMed ID: 20081228

DOI: 10.1074/jbc.m109.070458

PubMed ID: 35182466

Title: Transcription factor protein interactomes reveal genetic determinants in heart disease.

PubMed ID: 35182466

DOI: 10.1016/j.cell.2022.01.021

PubMed ID: 21220346

Title: Loss-of-function mutation in GATA4 causes anomalies of human testicular development.

PubMed ID: 21220346

DOI: 10.1073/pnas.1010257108

PubMed ID: 24041700

Title: GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy.

PubMed ID: 24041700

DOI: 10.1016/j.bbrc.2013.09.023

PubMed ID: 24000169

Title: GATA4 loss-of-function mutations underlie familial tetralogy of fallot.

PubMed ID: 24000169

DOI: 10.1002/humu.22434

PubMed ID: 25017055

Title: Prevalence and spectrum of GATA4 mutations associated with sporadic dilated cardiomyopathy.

PubMed ID: 25017055

DOI: 10.1016/j.gene.2014.07.022

PubMed ID: 27984724

Title: Disease model of GATA4 mutation reveals transcription factor cooperativity in human cardiogenesis.

PubMed ID: 27984724

DOI: 10.1016/j.cell.2016.11.033

PubMed ID: 12845333

Title: GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.

PubMed ID: 12845333

DOI: 10.1038/nature01827

PubMed ID: 15810002

Title: Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect.

PubMed ID: 15810002

DOI: 10.1002/ajmg.a.30684

PubMed ID: 18055909

Title: GATA4 sequence variants in patients with congenital heart disease.

PubMed ID: 18055909

DOI: 10.1136/jmg.2007.052183

PubMed ID: 17643447

Title: Spectrum of heart disease associated with murine and human GATA4 mutation.

PubMed ID: 17643447

DOI: 10.1016/j.yjmcc.2007.06.004

PubMed ID: 18672102

Title: GATA4 mutations in 486 Chinese patients with congenital heart disease.

PubMed ID: 18672102

DOI: 10.1016/j.ejmg.2008.06.005

PubMed ID: 20659440

Title: A novel mutation of GATA4 in a familial atrial septal defect.

PubMed ID: 20659440

DOI: 10.1016/j.cca.2010.07.021

PubMed ID: 21110066

Title: Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease.

PubMed ID: 21110066

DOI: 10.1007/s10709-010-9522-4

PubMed ID: 20347099

Title: A novel mutation in GATA4 gene associated with dominant inherited familial atrial septal defect.

PubMed ID: 20347099

DOI: 10.1016/j.jtcvs.2010.01.013

PubMed ID: 21637914

Title: A novel GATA4 mutation responsible for congenital ventricular septal defects.

PubMed ID: 21637914

DOI: 10.3892/ijmm.2011.715

PubMed ID: 22101736

Title: A novel GATA4 loss-of-function mutation associated with congenital ventricular septal defect.

PubMed ID: 22101736

DOI: 10.1007/s00246-011-0146-y

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 442
  • Mass: 44565
  • Checksum: 141B8CD841E12C7B
  • Sequence:
    • MYQSLAMAAN HGPPPGAYEA GGPGAFMHGA GAASSPVYVP TPRVPSSVLG LSYLQGGGAG 
SASGGASGGS SGGAASGAGP GTQQGSPGWS QAGADGAAYT PPPVSPRFSF PGTTGSLAAA 
AAAAAAREAA AYSSGGGAAG AGLAGREQYG RAGFAGSYSS PYPAYMADVG ASWAAAAAAS 
AGPFDSPVLH SLPGRANPAA RHPNLDMFDD FSEGRECVNC GAMSTPLWRR DGTGHYLCNA 
CGLYHKMNGI NRPLIKPQRR LSASRRVGLS CANCQTTTTT LWRRNAEGEP VCNACGLYMK 
LHGVPRPLAM RKEGIQTRKR KPKNLNKSKT PAAPSGSESL PPASGASSNS SNATTSSSEE 
MRPIKTEPGL SSHYGHSSSV SQTFSVSAMS GHGPSIHPVL SALKLSPQGY ASPVSQSPQT 
SSKQDSWNSL VLADSHGDII TA

Genular Protein ID: 2957755211

Symbol: B6DU75_HUMAN

Name: N/A

UniProtKB Accession Codes:

B6DU75

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GeneTree 1 GenomeRNAi 1 HGNC 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 Proteomes 2 RefSeq 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 20041118

Title: Conserved usage of alternative 5' untranslated exons of the GATA4 gene.

PubMed ID: 20041118

DOI: 10.1371/journal.pone.0008454

Sequence Information:

  • Length: 16
  • Mass: 1642
  • Checksum: EC0D1E2C52EAFF6F
  • Sequence:
    • MYQSLAMAAN HGPPPG

Genular Protein ID: 3304879994

Symbol: B3KUF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KUF4

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GO 9 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 3 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 236
  • Mass: 25302
  • Checksum: B62E270C775EDEC2
  • Sequence:
    • MFDDFSEGRE CVNCGAMSTP LWRRDGTGHY LCNACGLYHK MNGINRPLIK PQRRLSASRR 
VGLSCANCQT TTTTLWRRNA EGEPVCNACG LYMKLHGVPR PLAMRKEGIQ TRKRKPKNLN 
KSKTPAAPSG SESLPPASGA SSNSSNATTS SSEEMRPIKT EPGLSSHYGH SSSVSQTFSV 
SAMSGHGPSI HPVLSALKLS PQGYASPVSQ SPQTSSKQDS WNSLVLADSH GDIITA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.