Details for: MMP2

Gene ID: 4313

Symbol: MMP2

Ensembl ID: ENSG00000087245

Description: matrix metallopeptidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 161.6250
    Cell Significance Index: -25.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.0925
    Cell Significance Index: -23.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.6435
    Cell Significance Index: -24.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.3622
    Cell Significance Index: -20.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.1610
    Cell Significance Index: -23.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.4796
    Cell Significance Index: -20.5100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 11.3905
    Cell Significance Index: 70.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 10.4680
    Cell Significance Index: 61.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.1100
    Cell Significance Index: 289.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 9.8004
    Cell Significance Index: 125.5100
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 8.2406
    Cell Significance Index: 47.2500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.2918
    Cell Significance Index: 42.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2518
    Cell Significance Index: -24.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4112
    Cell Significance Index: 468.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3359
    Cell Significance Index: 69.8300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.0353
    Cell Significance Index: 18.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1341
    Cell Significance Index: 46.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.0114
    Cell Significance Index: 31.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8079
    Cell Significance Index: 57.9100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.6439
    Cell Significance Index: 9.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6330
    Cell Significance Index: 85.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5986
    Cell Significance Index: 31.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4094
    Cell Significance Index: 180.6800
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 1.2763
    Cell Significance Index: 12.8800
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.0524
    Cell Significance Index: 2.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8141
    Cell Significance Index: 11.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8113
    Cell Significance Index: 8.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7306
    Cell Significance Index: 139.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6522
    Cell Significance Index: 32.9600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6426
    Cell Significance Index: 7.3000
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5653
    Cell Significance Index: 2.8200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.5629
    Cell Significance Index: 3.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4864
    Cell Significance Index: 48.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4574
    Cell Significance Index: 413.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3619
    Cell Significance Index: 27.7700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.3108
    Cell Significance Index: 1.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2625
    Cell Significance Index: 42.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1871
    Cell Significance Index: 33.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1724
    Cell Significance Index: 18.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0950
    Cell Significance Index: 18.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0768
    Cell Significance Index: 1.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0568
    Cell Significance Index: 6.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0394
    Cell Significance Index: 2.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0167
    Cell Significance Index: 9.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0085
    Cell Significance Index: 3.0600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0021
    Cell Significance Index: 0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0048
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0077
    Cell Significance Index: -14.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0115
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0137
    Cell Significance Index: -8.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0143
    Cell Significance Index: -26.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0170
    Cell Significance Index: -26.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0202
    Cell Significance Index: -27.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0290
    Cell Significance Index: -1.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0296
    Cell Significance Index: -18.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0300
    Cell Significance Index: -22.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0321
    Cell Significance Index: -23.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0424
    Cell Significance Index: -19.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0469
    Cell Significance Index: -2.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0477
    Cell Significance Index: -21.1100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0532
    Cell Significance Index: -0.2800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0581
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0622
    Cell Significance Index: -13.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0628
    Cell Significance Index: -10.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0633
    Cell Significance Index: -18.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0809
    Cell Significance Index: -8.2600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1090
    Cell Significance Index: -1.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1137
    Cell Significance Index: -16.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1248
    Cell Significance Index: -25.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1254
    Cell Significance Index: -2.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1292
    Cell Significance Index: -3.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1482
    Cell Significance Index: -19.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1536
    Cell Significance Index: -4.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1657
    Cell Significance Index: -19.3100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1732
    Cell Significance Index: -0.8400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1874
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1877
    Cell Significance Index: -21.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2034
    Cell Significance Index: -9.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2276
    Cell Significance Index: -26.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2378
    Cell Significance Index: -24.7700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.2424
    Cell Significance Index: -2.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2740
    Cell Significance Index: -6.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2754
    Cell Significance Index: -16.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2863
    Cell Significance Index: -21.3400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3413
    Cell Significance Index: -3.7700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3608
    Cell Significance Index: -2.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3631
    Cell Significance Index: -5.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3825
    Cell Significance Index: -25.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3949
    Cell Significance Index: -24.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3959
    Cell Significance Index: -18.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4040
    Cell Significance Index: -14.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4181
    Cell Significance Index: -6.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4566
    Cell Significance Index: -25.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4727
    Cell Significance Index: -11.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4939
    Cell Significance Index: -12.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5042
    Cell Significance Index: -14.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5094
    Cell Significance Index: -26.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MMP2 is a 92-kDa protein that belongs to the MMP family, which is characterized by the presence of a zinc-binding site and a catalytic domain. The enzyme is secreted by cells and has a wide range of substrates, including collagens, elastins, and other ECM components. MMP2 is highly specific for the degradation of type IV collagen, which is a major component of the basement membrane. The enzyme is also capable of degrading other ECM components, such as laminin and fibronectin. **Pathways and Functions** MMP2 is involved in various signaling pathways that regulate cellular processes, including: 1. **ECM remodeling**: MMP2 plays a crucial role in the degradation of the ECM, which is essential for tissue repair, angiogenesis, and cancer metastasis. 2. **Cell migration**: MMP2 regulates the migration of cells, including fibroblasts, epithelial cells, and immune cells, by degrading the ECM and creating a permissive environment for cell movement. 3. **Angiogenesis**: MMP2 is involved in the formation of new blood vessels by degrading the ECM and promoting the migration of endothelial cells. 4. **Inflammation**: MMP2 is released by immune cells, such as macrophages and neutrophils, and plays a role in the regulation of inflammatory responses by degrading the ECM and promoting the migration of immune cells. 5. **Tissue repair**: MMP2 is involved in the repair of damaged tissues by degrading the ECM and promoting the migration of cells to the site of injury. **Clinical Significance** MMP2 has been implicated in various diseases, including: 1. **Cancer**: MMP2 is overexpressed in many types of cancer, including breast, lung, and prostate cancer, and is involved in the degradation of the ECM and the promotion of tumor metastasis. 2. **Arthritis**: MMP2 is involved in the degradation of the ECM and the promotion of joint inflammation in rheumatoid arthritis. 3. **Cardiovascular disease**: MMP2 is involved in the degradation of the ECM and the promotion of vascular remodeling in atherosclerosis. 4. **Neurodegenerative diseases**: MMP2 has been implicated in the degradation of the ECM and the promotion of neuronal damage in Alzheimer's disease and other neurodegenerative disorders. In conclusion, MMP2 is a critical enzyme that plays a key role in the degradation of the ECM and the regulation of cellular processes. Its dysregulation has been implicated in various diseases, and its potential as a therapeutic target is an area of active research.

Genular Protein ID: 3163446676

Symbol: MMP2_HUMAN

Name: Gelatinase A

UniProtKB Accession Codes:

P08253 B2R6U1 B4DWH3 E9PE45 Q9UCJ8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 1 EMBL 22 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 58 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 7 RefSeq 5 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2162831

Title: Structure of the human type IV collagenase gene.

PubMed ID: 2162831

DOI: 10.1016/s0021-9258(19)38559-x

PubMed ID: 1851724

Title: On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes.

PubMed ID: 1851724

DOI: 10.1016/0888-7543(91)90408-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2158484

Title: Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16.

PubMed ID: 2158484

DOI: 10.1016/0888-7543(90)90486-e

PubMed ID: 2834383

Title: H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

PubMed ID: 2834383

DOI: 10.1016/s0021-9258(18)68680-6

PubMed ID: 1480041

Title: TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family.

PubMed ID: 1480041

PubMed ID: 1655733

Title: Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site.

PubMed ID: 1655733

DOI: 10.1016/s0021-9258(18)55224-8

PubMed ID: 8646777

Title: Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

PubMed ID: 8646777

DOI: 10.1016/s0092-8674(00)81235-0

PubMed ID: 9119036

Title: Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases.

PubMed ID: 9119036

DOI: 10.1111/j.1432-1033.1997.t01-1-00653.x

PubMed ID: 9476898

Title: Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity.

PubMed ID: 9476898

DOI: 10.1016/s0092-8674(00)80931-9

PubMed ID: 10559137

Title: Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor.

PubMed ID: 10559137

DOI: 10.1161/01.res.85.10.906

PubMed ID: 11029402

Title: Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction.

PubMed ID: 11029402

DOI: 10.1161/01.res.87.8.670

PubMed ID: 11751392

Title: Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2.

PubMed ID: 11751392

PubMed ID: 11179305

Title: Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.

PubMed ID: 11179305

DOI: 10.1128/iai.69.3.1402-1408.2001

PubMed ID: 11710594

Title: Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity.

PubMed ID: 11710594

DOI: 10.1007/s004320100271

PubMed ID: 12714657

Title: Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy.

PubMed ID: 12714657

DOI: 10.1167/iovs.02-0662

PubMed ID: 12879005

Title: Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.

PubMed ID: 12879005

DOI: 10.1038/sj.onc.1206542

PubMed ID: 14766804

Title: Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro.

PubMed ID: 14766804

DOI: 10.1096/fj.02-1202fje

PubMed ID: 17435175

Title: Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation.

PubMed ID: 17435175

DOI: 10.1096/fj.06-7938com

PubMed ID: 19493954

Title: Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts.

PubMed ID: 19493954

DOI: 10.1093/cvr/cvp175

PubMed ID: 18971601

Title: Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes.

PubMed ID: 18971601

DOI: 10.1159/000166183

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22509276

Title: A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.

PubMed ID: 22509276

DOI: 10.1371/journal.pone.0034177

PubMed ID: 7583664

Title: Crystal structure of the haemopexin-like C-terminal domain of gelatinase A.

PubMed ID: 7583664

DOI: 10.1038/nsb1195-938

PubMed ID: 8549817

Title: The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function.

PubMed ID: 8549817

DOI: 10.1016/0014-5793(95)01435-7

PubMed ID: 10356396

Title: Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed.

PubMed ID: 10356396

DOI: 10.1126/science.284.5420.1667

PubMed ID: 10545322

Title: The second type II module from human matrix metalloproteinase 2: structure, function and dynamics.

PubMed ID: 10545322

DOI: 10.1016/s0969-2126(00)80057-x

PubMed ID: 11320090

Title: Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct.

PubMed ID: 11320090

DOI: 10.1074/jbc.m101105200

PubMed ID: 12147339

Title: Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor.

PubMed ID: 12147339

DOI: 10.1016/s0167-4838(02)00307-2

PubMed ID: 11928808

Title: The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains.

PubMed ID: 11928808

DOI: 10.1515/bc.2002.014

PubMed ID: 12032297

Title: Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2.

PubMed ID: 12032297

DOI: 10.1073/pnas.102185399

PubMed ID: 21813640

Title: Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of beta-amyloid precursor protein-derived inhibitor.

PubMed ID: 21813640

DOI: 10.1074/jbc.m111.264176

PubMed ID: 11431697

Title: Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome.

PubMed ID: 11431697

DOI: 10.1038/90100

PubMed ID: 15691365

Title: Winchester syndrome caused by a homozygous mutation affecting the active site of matrix metalloproteinase 2.

PubMed ID: 15691365

DOI: 10.1111/j.1399-0004.2004.00402.x

PubMed ID: 16542393

Title: A novel homozygous MMP2 mutation in a family with Winchester syndrome.

PubMed ID: 16542393

DOI: 10.1111/j.1399-0004.2006.00584.x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 660
  • Mass: 73882
  • Checksum: BC7147DC8B49F289
  • Sequence:
    • MEALMARGAL TGPLRALCLL GCLLSHAAAA PSPIIKFPGD VAPKTDKELA VQYLNTFYGC 
PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP RCGNPDVANY NFFPRKPKWD 
KNQITYRIIG YTPDLDPETV DDAFARAFQV WSDVTPLRFS RIHDGEADIM INFGRWEHGD 
GYPFDGKDGL LAHAFAPGTG VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN 
GKEYNSCTDT GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNAEGQP CKFPFRFQGT 
SYDSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV FPFTFLGNKY 
ESCTSAGRSD GKMWCATTAN YDDDRKWGFC PDQGYSLFLV AAHEFGHAMG LEHSQDPGAL 
MAPIYTYTKN FRLSQDDIKG IQELYGASPD IDLGTGPTPT LGPVTPEICK QDIVFDGIAQ 
IRGEIFFFKD RFIWRTVTPR DKPMGPLLVA TFWPELPEKI DAVYEAPQEE KAVFFAGNEY 
WIYSASTLER GYPKPLTSLG LPPDVQRVDA AFNWSKNKKT YIFAGDKFWR YNEVKKKMDP 
GFPKLIADAW NAIPDNLDAV VDLQGGGHSY FFKGAYYLKL ENQSLKSVKF GSIKSDWLGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.