Details for: PDGFRL

Gene ID: 5157

Symbol: PDGFRL

Ensembl ID: ENSG00000104213

Description: platelet derived growth factor receptor like

Associated with

  • Biological_process
    (GO:0008150)
  • Cellular_component
    (GO:0005575)
  • Extracellular region
    (GO:0005576)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Platelet-derived growth factor beta-receptor activity
    (GO:0005019)
  • Platelet-derived growth factor receptor-beta signaling pathway
    (GO:0035791)
  • Platelet activating factor receptor activity
    (GO:0004992)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 33.4023
    Cell Significance Index: -13.7600
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 7.2979
    Cell Significance Index: 46.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.4439
    Cell Significance Index: 30.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.4051
    Cell Significance Index: 97.6100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.9276
    Cell Significance Index: 17.2000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.0463
    Cell Significance Index: 32.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.9137
    Cell Significance Index: 117.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.6719
    Cell Significance Index: 26.5300
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 1.5607
    Cell Significance Index: 15.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4182
    Cell Significance Index: 27.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8605
    Cell Significance Index: 163.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7836
    Cell Significance Index: 16.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.7640
    Cell Significance Index: 38.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6421
    Cell Significance Index: 13.4400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5709
    Cell Significance Index: 6.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3910
    Cell Significance Index: 6.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3717
    Cell Significance Index: 4.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3594
    Cell Significance Index: 49.3500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.3322
    Cell Significance Index: 1.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3129
    Cell Significance Index: 30.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2788
    Cell Significance Index: 251.7600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2716
    Cell Significance Index: 3.9000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2687
    Cell Significance Index: 2.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2379
    Cell Significance Index: 129.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2310
    Cell Significance Index: 82.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1940
    Cell Significance Index: 28.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1880
    Cell Significance Index: 30.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1519
    Cell Significance Index: 16.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1294
    Cell Significance Index: 2.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1207
    Cell Significance Index: 4.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0780
    Cell Significance Index: 4.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0499
    Cell Significance Index: 3.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0444
    Cell Significance Index: 1.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0440
    Cell Significance Index: 30.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0293
    Cell Significance Index: 5.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0282
    Cell Significance Index: 3.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0209
    Cell Significance Index: 2.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0191
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0187
    Cell Significance Index: 3.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0157
    Cell Significance Index: 0.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0134
    Cell Significance Index: 0.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0052
    Cell Significance Index: 1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0048
    Cell Significance Index: 9.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -12.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0077
    Cell Significance Index: -11.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0110
    Cell Significance Index: -1.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0115
    Cell Significance Index: -5.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0177
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0212
    Cell Significance Index: -13.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0224
    Cell Significance Index: -16.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0239
    Cell Significance Index: -13.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0243
    Cell Significance Index: -15.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0279
    Cell Significance Index: -1.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0282
    Cell Significance Index: -12.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0286
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0395
    Cell Significance Index: -11.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0422
    Cell Significance Index: -3.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0487
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0767
    Cell Significance Index: -16.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0781
    Cell Significance Index: -9.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0796
    Cell Significance Index: -5.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0996
    Cell Significance Index: -12.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1019
    Cell Significance Index: -2.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1123
    Cell Significance Index: -11.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1236
    Cell Significance Index: -1.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1280
    Cell Significance Index: -13.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1283
    Cell Significance Index: -14.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1289
    Cell Significance Index: -9.6100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1437
    Cell Significance Index: -0.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1471
    Cell Significance Index: -4.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1642
    Cell Significance Index: -4.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1737
    Cell Significance Index: -8.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2010
    Cell Significance Index: -7.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2031
    Cell Significance Index: -6.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2037
    Cell Significance Index: -10.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2075
    Cell Significance Index: -16.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2220
    Cell Significance Index: -14.9300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2416
    Cell Significance Index: -4.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2455
    Cell Significance Index: -15.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2540
    Cell Significance Index: -13.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2552
    Cell Significance Index: -14.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2591
    Cell Significance Index: -16.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2710
    Cell Significance Index: -14.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2780
    Cell Significance Index: -7.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2833
    Cell Significance Index: -18.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2846
    Cell Significance Index: -6.0400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2846
    Cell Significance Index: -5.9400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.2877
    Cell Significance Index: -2.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3026
    Cell Significance Index: -3.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3033
    Cell Significance Index: -9.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3088
    Cell Significance Index: -13.4300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3148
    Cell Significance Index: -7.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3226
    Cell Significance Index: -6.9700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3226
    Cell Significance Index: -2.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PDGFRL gene is a member of the PDGF receptor family, which consists of four subtypes: PDGFR-α, PDGFR-β, PDGFR-γ, and PDGFR-βIII. The PDGFRL gene is unique in that it shares structural homology with PDGFR-β, but lacks the kinase domain, rendering it non-tyrosine kinase. Instead, it activates downstream signaling pathways through the G-protein coupled receptor (GPCR) mechanism. **Pathways and Functions:** The PDGFRL gene is involved in several key signaling pathways, including: 1. **G-protein coupled receptor signaling pathway:** PDGFRL activates G-protein coupled receptors, which in turn trigger a cascade of downstream signaling events, including the activation of mitogen-activated protein kinases (MAPKs) and phosphatidylinositol 3-kinase (PI3K). 2. **Platelet-derived growth factor beta-receptor activity:** PDGFRL interacts with PDGF-β, a potent mitogen, and activates its signaling pathway, leading to increased cell proliferation, migration, and survival. 3. **Platelet-derived growth factor receptor-beta signaling pathway:** PDGFRL is a key component of this pathway, which is involved in regulating cellular differentiation, migration, and survival in various cell types. **Clinical Significance:** Dysregulation of the PDGFRL gene has been implicated in various diseases, including: 1. **Cancer:** Overexpression of PDGFRL has been observed in various types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth, invasion, and metastasis. 2. **Cardiovascular disorders:** PDGFRL is involved in the regulation of vascular smooth muscle cell proliferation and migration, which is critical in the development of atherosclerosis and restenosis after angioplasty. 3. **Fibrosis:** PDGFRL is a key player in the regulation of fibroblast function, which is critical in the development of fibrotic diseases, including liver, kidney, and pulmonary fibrosis. In conclusion, the PDGFRL gene is a complex and multifunctional gene that plays a critical role in regulating cellular proliferation, differentiation, and survival. Its dysregulation has significant implications for various diseases, including cancer, cardiovascular disorders, and fibrosis. Further research is needed to fully elucidate the mechanisms by which PDGFRL regulates cellular function and to explore its potential as a therapeutic target for these diseases.

Genular Protein ID: 4119528063

Symbol: PGFRL_HUMAN

Name: Platelet-derived growth factor receptor-like protein

UniProtKB Accession Codes:

Q15198 A8K085 Q6FH04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7898930

Title: Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene.

PubMed ID: 7898930

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19815557

Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

PubMed ID: 19815557

DOI: 10.1074/jbc.m109.072660

PubMed ID: 22926996

Title: Genetic variant on PDGFRL associated with Behcet disease in Chinese Han populations.

PubMed ID: 22926996

DOI: 10.1002/humu.22208

Sequence Information:

  • Length: 375
  • Mass: 41861
  • Checksum: DF7FE6EB3FB2A802
  • Sequence:
    • MKVWLLLGLL LVHEALEDVT GQHLPKNKRP KEPGENRIKP TNKKVKPKIP KMKDRDSANS 
APKTQSIMMQ VLDKGRFQKP AATLSLLAGQ TVELRCKGSR IGWSYPAYLD TFKDSRLSVK 
QNERYGQLTL VNSTSADTGE FSCWVQLCSG YICRKDEAKT GSTYIFFTEK GELFVPSPSY 
FDVVYLNPDR QAVVPCRVTV LSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSEH 
QGVVYCRAEA GGRSQISVKY QLLYVAVPSG PPSTTILASS NKVKSGDDIS VLCTVLGEPD 
VEVEFTWIFP GQKDERPVTI QDTWRLIHRG LGHTTRISQS VITVEDFETI DAGYYICTAQ 
NLQGQTTVAT TVEFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.