Details for: PYCR1

Gene ID: 5831

Symbol: PYCR1

Ensembl ID: ENSG00000183010

Description: pyrroline-5-carboxylate reductase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.8622
    Cell Significance Index: -11.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.1061
    Cell Significance Index: -13.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.5102
    Cell Significance Index: -14.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.2928
    Cell Significance Index: -15.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.7370
    Cell Significance Index: -14.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.3524
    Cell Significance Index: -15.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3348
    Cell Significance Index: -16.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0686
    Cell Significance Index: -16.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.7793
    Cell Significance Index: 440.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3141
    Cell Significance Index: 69.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.0144
    Cell Significance Index: 32.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0208
    Cell Significance Index: 25.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6240
    Cell Significance Index: 75.7200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.5017
    Cell Significance Index: 8.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4008
    Cell Significance Index: 1264.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2874
    Cell Significance Index: 77.2900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.1668
    Cell Significance Index: 7.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0938
    Cell Significance Index: 177.9000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.8452
    Cell Significance Index: 11.7300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.7436
    Cell Significance Index: 6.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6569
    Cell Significance Index: 45.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6176
    Cell Significance Index: 21.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5481
    Cell Significance Index: 25.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4491
    Cell Significance Index: 58.0200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.4133
    Cell Significance Index: 8.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4004
    Cell Significance Index: 79.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3897
    Cell Significance Index: 5.8400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3727
    Cell Significance Index: 5.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3660
    Cell Significance Index: 16.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2903
    Cell Significance Index: 8.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2532
    Cell Significance Index: 8.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2418
    Cell Significance Index: 18.0200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2222
    Cell Significance Index: 1.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1999
    Cell Significance Index: 109.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1475
    Cell Significance Index: 25.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1430
    Cell Significance Index: 3.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1334
    Cell Significance Index: 25.3900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 0.1310
    Cell Significance Index: 0.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1257
    Cell Significance Index: 12.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1052
    Cell Significance Index: 2.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0850
    Cell Significance Index: 37.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0662
    Cell Significance Index: 0.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0604
    Cell Significance Index: 45.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0544
    Cell Significance Index: 0.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0521
    Cell Significance Index: 7.1500
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.0196
    Cell Significance Index: 0.1200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0112
    Cell Significance Index: 0.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0055
    Cell Significance Index: 0.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0021
    Cell Significance Index: -1.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0074
    Cell Significance Index: -13.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0146
    Cell Significance Index: -26.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0153
    Cell Significance Index: -1.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0171
    Cell Significance Index: -6.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0178
    Cell Significance Index: -27.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0191
    Cell Significance Index: -13.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0209
    Cell Significance Index: -28.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0220
    Cell Significance Index: -14.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0255
    Cell Significance Index: -14.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0255
    Cell Significance Index: -18.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0300
    Cell Significance Index: -6.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0310
    Cell Significance Index: -19.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0352
    Cell Significance Index: -4.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0378
    Cell Significance Index: -6.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0424
    Cell Significance Index: -19.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0437
    Cell Significance Index: -1.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0482
    Cell Significance Index: -13.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0541
    Cell Significance Index: -1.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0624
    Cell Significance Index: -1.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0685
    Cell Significance Index: -4.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0760
    Cell Significance Index: -7.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0793
    Cell Significance Index: -9.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1004
    Cell Significance Index: -14.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1052
    Cell Significance Index: -22.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1198
    Cell Significance Index: -8.4700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1202
    Cell Significance Index: -0.7400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1290
    Cell Significance Index: -1.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1435
    Cell Significance Index: -8.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1535
    Cell Significance Index: -15.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1565
    Cell Significance Index: -17.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1741
    Cell Significance Index: -4.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1891
    Cell Significance Index: -14.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1925
    Cell Significance Index: -10.8000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2114
    Cell Significance Index: -3.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2225
    Cell Significance Index: -11.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2253
    Cell Significance Index: -13.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2279
    Cell Significance Index: -17.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2284
    Cell Significance Index: -15.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2424
    Cell Significance Index: -15.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2430
    Cell Significance Index: -12.6600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2536
    Cell Significance Index: -3.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2663
    Cell Significance Index: -6.8500
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.2711
    Cell Significance Index: -1.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2758
    Cell Significance Index: -8.1000
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.2771
    Cell Significance Index: -2.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2849
    Cell Significance Index: -7.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3072
    Cell Significance Index: -13.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3213
    Cell Significance Index: -8.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3215
    Cell Significance Index: -9.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3317
    Cell Significance Index: -17.2300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3454
    Cell Significance Index: -2.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PYCR1 is a mitochondrial enzyme with a distinct expression profile, predominantly found in cells involved in energy metabolism, such as tracheobronchial smooth muscle cells, pancreatic acinar cells, and preosteoblasts. Its expression is also evident in germ cells, suggesting a role in early development. The gene's protein product, P5CR1_HUMAN, exhibits high sequence identity among different species, indicating a conserved function across organisms. **Pathways and Functions:** PYCR1 is involved in several cellular processes, including: 1. **L-Proline Biosynthetic Process:** PYCR1 catalyzes the conversion of pyrroline-5-carboxylate to proline, a critical step in the biosynthesis of proline, which plays a role in collagen synthesis, protein structure, and oxidative stress mitigation. 2. **Glutamate and Glutamine Metabolism:** PYCR1 is linked to the metabolism of glutamate and glutamine, two amino acids involved in neurotransmission and energy production. 3. **Cellular Response to Oxidative Stress:** PYCR1 has been implicated in the regulation of oxidative stress-induced apoptosis, suggesting a role in maintaining cellular homeostasis under conditions of oxidative stress. 4. **Mitochondrial Function:** PYCR1 is involved in the regulation of mitochondrial membrane potential, which is essential for maintaining energy production and cellular survival. **Clinical Significance:** Dysregulation of PYCR1 has been implicated in various diseases, including: 1. **Metabolic Disorders:** Alterations in PYCR1 expression have been linked to metabolic disorders, such as obesity and diabetes, characterized by impaired glucose and lipid metabolism. 2. **Oxidative Stress-Induced Diseases:** PYCR1's role in regulating oxidative stress-induced apoptosis suggests its involvement in diseases related to oxidative stress, such as neurodegenerative disorders and cancer. 3. **Cardiovascular Diseases:** PYCR1's involvement in mitochondrial function and energy production makes it a potential target for cardiovascular disease prevention and treatment. In conclusion, PYCR1 plays a critical role in maintaining cellular homeostasis, regulating energy metabolism, and mitigating oxidative stress. Further research is necessary to fully elucidate the molecular mechanisms underlying PYCR1's functions and to explore its therapeutic potential in various diseases.

Genular Protein ID: 491157737

Symbol: P5CR1_HUMAN

Name: Pyrroline-5-carboxylate reductase 1, mitochondrial

UniProtKB Accession Codes:

P32322 A6NFM2 B4DMU0 Q6FHI4 Q96DI6 Q9HBQ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 2 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1730675

Title: Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae.

PubMed ID: 1730675

DOI: 10.1016/s0021-9258(18)48364-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19648921

Title: Mutations in PYCR1 cause cutis laxa with progeroid features.

PubMed ID: 19648921

DOI: 10.1038/ng.413

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24930674

Title: Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.

PubMed ID: 24930674

DOI: 10.18632/oncotarget.1561

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16730026

Title: Crystal structure of human pyrroline-5-carboxylate reductase.

PubMed ID: 16730026

DOI: 10.1016/j.jmb.2006.04.053

PubMed ID: 19576563

Title: Mutation in pyrroline-5-carboxylate reductase 1 gene in families with cutis laxa type 2.

PubMed ID: 19576563

DOI: 10.1016/j.ajhg.2009.06.008

PubMed ID: 22052856

Title: Compound heterozygous mutations in PYCR1 further expand the phenotypic spectrum of De Barsy syndrome.

PubMed ID: 22052856

DOI: 10.1002/ajmg.a.34326

Sequence Information:

  • Length: 319
  • Mass: 33361
  • Checksum: 9E8C4DED0638EFC5
  • Sequence:
    • MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDLA TVSALRKMGV KLTPHNKETV 
QHSDVLFLAV KPHIIPFILD EIGADIEDRH IVVSCAAGVT ISSIEKKLSA FRPAPRVIRC 
MTNTPVVVRE GATVYATGTH AQVEDGRLME QLLSSVGFCT EVEEDLIDAV TGLSGSGPAY 
AFTALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLHS EQHPGQLKDN VSSPGGATIH 
ALHVLESGGF RSLLINAVEA SCIRTRELQS MADQEQVSPA AIKKTILDKV KLDSPAGTAL 
SPSGHTKLLP RSLAPAGKD

Genular Protein ID: 127070546

Symbol: J3QL32_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QL32

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 1 Gene3D 2 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 2 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 217
  • Mass: 22601
  • Checksum: FCEDDF323301279D
  • Sequence:
    • MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDLA TVSALRKMGV KLTPHNKETV 
QHSDVLFLAV KPHIIPFILD EIGADIEDRH IVVSCAAGVT ISSIEKKLSA FRPAPRVIRC 
MTNTPVVVRE GATVYATGTH AQVEDGRLME QLLSSVGFCT EVEEDLIDAV TGLSGSGPAY 
AFTALDALAD GGVKMGLPRR LAVRLGAQAL LGAAVHG

Genular Protein ID: 4225243487

Symbol: Q8TBX0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TBX0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 171
  • Mass: 17718
  • Checksum: E2DD8F2FE0E38CC2
  • Sequence:
    • MEQLLSSVGF CTEVEEDLID AVTGLSGSGP AYAFTALDAL ADGGVKMGLP RRLAVRLGAQ 
ALLGAAKMLL HSEQHPGQLK DNVSSPGGAT IHALHVLESG GFRSLLINAV EASCIRTREL 
QSMADQEQVS PAAIKKTILD KVKLDSPAGT ALSPSGHTKL LPRSLAPAGK D

Genular Protein ID: 402261397

Symbol: E2QRB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

E2QRB3

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 15 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HAMAP 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 2 SAM 1 SUPFAM 2 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 288
  • Mass: 30213
  • Checksum: 7D8AE105D35C9512
  • Sequence:
    • MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDLA TVSALRKMGV KLTPHNKETV 
QHSDVLFLAV KPHIIPFILD EIGADIEDRH IVVSCAAGVT ISSIEKKLSA FRPAPRVIRC 
MTNTPVVVRE GATVYATGTH AQVEDGRLME QLLSSVGFCT EVEEDLIDAV TGLSGSGPAY 
GAAKMLLHSE QHPGQLKDNV SSPGGATIHA LHVLESGGFR SLLINAVEAS CIRTRELQSM 
ADQEQVSPAA IKKTILDKVK LDSPAGTALS PSGHTKLLPR SLAPAGKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.