Details for: HLA DPA1

Gene ID: 3113

Symbol: HLA DPA1

Ensembl ID: ENSG00000231389

Description: major histocompatibility complex, class II, DP alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 320.0998
    Cell Significance Index: -49.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 159.7757
    Cell Significance Index: -64.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 125.8590
    Cell Significance Index: -64.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 120.0747
    Cell Significance Index: -56.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 84.8705
    Cell Significance Index: -56.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.6867
    Cell Significance Index: -13.1100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 44.6929
    Cell Significance Index: 186.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.4718
    Cell Significance Index: -49.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.9257
    Cell Significance Index: -37.3100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 13.5080
    Cell Significance Index: 31.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3044
    Cell Significance Index: -52.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6757
    Cell Significance Index: -32.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5228
    Cell Significance Index: -23.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 8.0957
    Cell Significance Index: 149.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.8265
    Cell Significance Index: 138.3100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 7.6342
    Cell Significance Index: 34.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.7049
    Cell Significance Index: 790.7200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 6.4675
    Cell Significance Index: 111.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.5530
    Cell Significance Index: 63.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.1420
    Cell Significance Index: 89.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.9661
    Cell Significance Index: 255.8700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 3.7027
    Cell Significance Index: 13.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.5068
    Cell Significance Index: 102.9900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.5940
    Cell Significance Index: 18.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1252
    Cell Significance Index: 32.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.8299
    Cell Significance Index: 48.9500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.4199
    Cell Significance Index: 9.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1791
    Cell Significance Index: 1064.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9228
    Cell Significance Index: 150.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5169
    Cell Significance Index: 51.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5107
    Cell Significance Index: 11.8000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.4151
    Cell Significance Index: 2.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3685
    Cell Significance Index: 40.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3639
    Cell Significance Index: 275.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2191
    Cell Significance Index: 22.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1151
    Cell Significance Index: 14.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0867
    Cell Significance Index: 16.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0529
    Cell Significance Index: 23.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0356
    Cell Significance Index: 4.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0178
    Cell Significance Index: 3.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0005
    Cell Significance Index: 0.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0046
    Cell Significance Index: -0.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0138
    Cell Significance Index: -2.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0255
    Cell Significance Index: -48.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0306
    Cell Significance Index: -56.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0337
    Cell Significance Index: -24.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0358
    Cell Significance Index: -55.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0415
    Cell Significance Index: -56.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0455
    Cell Significance Index: -25.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0752
    Cell Significance Index: -41.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0774
    Cell Significance Index: -2.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0834
    Cell Significance Index: -61.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0889
    Cell Significance Index: -4.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0965
    Cell Significance Index: -61.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1258
    Cell Significance Index: -57.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1454
    Cell Significance Index: -52.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1467
    Cell Significance Index: -8.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1483
    Cell Significance Index: -20.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1550
    Cell Significance Index: -3.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1596
    Cell Significance Index: -7.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1604
    Cell Significance Index: -33.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1672
    Cell Significance Index: -19.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1829
    Cell Significance Index: -31.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1929
    Cell Significance Index: -7.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2472
    Cell Significance Index: -49.5900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.2691
    Cell Significance Index: -0.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2731
    Cell Significance Index: -35.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2984
    Cell Significance Index: -20.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3019
    Cell Significance Index: -35.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3051
    Cell Significance Index: -14.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3237
    Cell Significance Index: -9.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3682
    Cell Significance Index: -42.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3942
    Cell Significance Index: -27.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3965
    Cell Significance Index: -57.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4605
    Cell Significance Index: -11.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4775
    Cell Significance Index: -15.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4844
    Cell Significance Index: -50.4400
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.5332
    Cell Significance Index: -3.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5592
    Cell Significance Index: -29.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5869
    Cell Significance Index: -43.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5987
    Cell Significance Index: -12.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6093
    Cell Significance Index: -46.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6156
    Cell Significance Index: -32.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7828
    Cell Significance Index: -49.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7884
    Cell Significance Index: -36.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8071
    Cell Significance Index: -63.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8886
    Cell Significance Index: -38.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9273
    Cell Significance Index: -56.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9334
    Cell Significance Index: -52.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9862
    Cell Significance Index: -27.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1370
    Cell Significance Index: -41.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.1443
    Cell Significance Index: -16.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.1785
    Cell Significance Index: -17.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1842
    Cell Significance Index: -52.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2006
    Cell Significance Index: -30.8600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.2278
    Cell Significance Index: -13.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.3531
    Cell Significance Index: -20.3900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.3579
    Cell Significance Index: -27.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3830
    Cell Significance Index: -52.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3916
    Cell Significance Index: -27.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HLA DPA1 gene is a part of the MHC class II complex, which is a heterodimeric molecule composed of two chains: HLA-DRB1 and HLA-DPA1. The HLA-DPA1 chain is responsible for presenting peptide antigens to T-cells. The gene is highly polymorphic, with multiple alleles and variants that can influence the immune response. The HLA DPA1 protein is a transmembrane glycoprotein that is embedded in the endoplasmic reticulum membrane and is transported to the Golgi apparatus for glycosylation and assembly with the HLA-DRB1 chain. **Pathways and Functions** The HLA DPA1 gene is involved in several signaling pathways, including: 1. **Adaptive Immune Response**: The HLA DPA1 gene plays a crucial role in presenting peptide antigens to T-cells, which is essential for the adaptive immune response. 2. **Antigen Processing and Presentation**: The HLA DPA1 gene is involved in the processing and presentation of exogenous peptide antigens via MHC class II. 3. **Cytokine Signaling**: The HLA DPA1 gene is involved in cytokine signaling, including the production of type II interferon. 4. **T-Cell Activation**: The HLA DPA1 gene is involved in the activation of T-cells, including the phosphorylation of CD3 and TCR zeta chains. 5. **Immune Response**: The HLA DPA1 gene is involved in the regulation of the immune response, including the production of antibodies and the activation of immune cells. **Clinical Significance** The HLA DPA1 gene has significant clinical implications, including: 1. **Transplantation**: The HLA DPA1 gene plays a crucial role in transplantation, as mismatches between donor and recipient can lead to rejection. 2. **Autoimmune Diseases**: The HLA DPA1 gene has been associated with several autoimmune diseases, including rheumatoid arthritis and lupus. 3. **Cancer**: The HLA DPA1 gene has been implicated in the development and progression of certain cancers, including leukemia and lymphoma. 4. **Infectious Diseases**: The HLA DPA1 gene is involved in the immune response to infectious diseases, including HIV and tuberculosis. In conclusion, the HLA DPA1 gene is a critical component of the MHC class II complex, which plays a central role in the adaptive immune response. Its polymorphism and variability have significant clinical implications, including transplantation, autoimmune diseases, cancer, and infectious diseases. Further research is needed to fully understand the functions and clinical significance of the HLA DPA1 gene.

Genular Protein ID: 3402850112

Symbol: DPA1_HUMAN

Name: HLA class II histocompatibility antigen, DP alpha 1 chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2997750

Title: The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene.

PubMed ID: 2997750

DOI: 10.1093/nar/13.20.7515

PubMed ID: 3036829

Title: Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes.

PubMed ID: 3036829

DOI: 10.1016/s0021-9258(18)47483-2

PubMed ID: 2461352

Title: Epitope recognition by a DP alpha chain-specific monoclonal antibody (DP11.1) is influenced by the interaction between the DP alpha chain and its polymorphic DP beta chain partner.

PubMed ID: 2461352

DOI: 10.1016/0198-8859(88)90016-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 6584734

Title: Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.

PubMed ID: 6584734

DOI: 10.1038/308327a0

PubMed ID: 9234495

Title: A novel DPA1 allele (DPA1*0203) composed of known epitopes.

PubMed ID: 9234495

DOI: 10.1111/j.1399-0039.1997.tb02821.x

PubMed ID: 9694359

Title: Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302.

PubMed ID: 9694359

DOI: 10.1111/j.1399-0039.1998.tb03009.x

PubMed ID: 7725312

Title: Sequencing-based typing reveals new insight in HLA-DPA1 polymorphism.

PubMed ID: 7725312

DOI: 10.1111/j.1399-0039.1995.tb02415.x

PubMed ID: 11019928

Title: A new HLA-DPA1 allele, DPA1*02016, identified in African-American population.

PubMed ID: 11019928

DOI: 10.1034/j.1399-0039.2000.560219.x

PubMed ID: 15663751

Title: High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population.

PubMed ID: 15663751

DOI: 10.1111/j.1399-0039.2005.00339.x

PubMed ID: 18838095

Title: Identification of a novel DPA1 allele, DPA1*010602, in an East African population.

PubMed ID: 18838095

DOI: 10.1016/j.humimm.2008.09.001

PubMed ID: 18380777

Title: Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304.

PubMed ID: 18380777

DOI: 10.1111/j.1399-0039.2008.01035.x

PubMed ID: 18489436

Title: A novel HLA-DPA1*0204 allele was identified in a Chinese individual.

PubMed ID: 18489436

DOI: 10.1111/j.1399-0039.2008.01046.x

PubMed ID: 8988544

Title: DPA1*0105, a novel DPA1 variant in a negrois population.

PubMed ID: 8988544

DOI: 10.1111/j.1399-0039.1996.tb02675.x

PubMed ID: 7806277

Title: Exon 2, 3, and 4 polymorphism of HLA-DPA1.

PubMed ID: 7806277

DOI: 10.1007/bf00188437

PubMed ID: 6300884

Title: Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes.

PubMed ID: 6300884

DOI: 10.1073/pnas.80.7.1972

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 260
  • Mass: 29381
  • Checksum: 826174E963A8CB42
  • Sequence:
  • MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT GEFMFEFDED 
    EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN LNTLIQRSNH TQATNDPPEV 
    TVFPKEPVEL GQPNTLICHI DKFFPPVLNV TWLCNGELVT EGVAESLFLP RTDYSFHKFH 
    YLTFVPSAED FYDCRVEHWG LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG 
    TVLIIKSLRS GHDPRAQGTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.