Details for: HLA DPA1

Gene ID: 3113

Symbol: HLA DPA1

Ensembl ID: ENSG00000231389

Description: major histocompatibility complex, class II, DP alpha 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 24.03
    Marker Score: 25159
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.53
    Marker Score: 3903
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.23
    Marker Score: 10967
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.78
    Marker Score: 2901
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.24
    Marker Score: 3391
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.16
    Marker Score: 10587
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.13
    Marker Score: 4072
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.03
    Marker Score: 5838.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.95
    Marker Score: 2037.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.94
    Marker Score: 2396
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.85
    Marker Score: 4409
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.51
    Marker Score: 6841
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.37
    Marker Score: 3005
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.28
    Marker Score: 5553
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 3.23
    Marker Score: 8361
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.18
    Marker Score: 177918
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.17
    Marker Score: 1912
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.16
    Marker Score: 9383
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.14
    Marker Score: 20443
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.06
    Marker Score: 3691
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.05
    Marker Score: 1079
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 3.01
    Marker Score: 77120.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.01
    Marker Score: 34969
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.98
    Marker Score: 9412
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.98
    Marker Score: 5194
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.96
    Marker Score: 1457
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.95
    Marker Score: 2773
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.92
    Marker Score: 678
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.9
    Marker Score: 3420
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.85
    Marker Score: 6884
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.84
    Marker Score: 2151
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.83
    Marker Score: 7946
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.75
    Marker Score: 2367
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.71
    Marker Score: 1963
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.71
    Marker Score: 14217.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.7
    Marker Score: 1167
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.68
    Marker Score: 1572
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.65
    Marker Score: 4252
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.63
    Marker Score: 3878
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.57
    Marker Score: 15593
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.57
    Marker Score: 25998
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.51
    Marker Score: 1660.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.49
    Marker Score: 1434
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.4
    Marker Score: 2020
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.33
    Marker Score: 555
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.33
    Marker Score: 9690
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.31
    Marker Score: 2505
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.3
    Marker Score: 958.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.29
    Marker Score: 4569
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.28
    Marker Score: 1113
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.27
    Marker Score: 3131
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.26
    Marker Score: 787
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.25
    Marker Score: 518
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.21
    Marker Score: 1873
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.18
    Marker Score: 1503
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.17
    Marker Score: 1636
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.17
    Marker Score: 2094
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.14
    Marker Score: 8756.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.09
    Marker Score: 1283
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.05
    Marker Score: 13096
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.04
    Marker Score: 5560
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.02
    Marker Score: 2516.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.97
    Marker Score: 767
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.96
    Marker Score: 418
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.92
    Marker Score: 1924
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.89
    Marker Score: 994
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.89
    Marker Score: 613
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.87
    Marker Score: 475
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.81
    Marker Score: 902
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.8
    Marker Score: 631
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.79
    Marker Score: 1618
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.76
    Marker Score: 534
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.72
    Marker Score: 1752
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.68
    Marker Score: 579
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.66
    Marker Score: 424
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.66
    Marker Score: 532
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.64
    Marker Score: 458
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.64
    Marker Score: 1088
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.63
    Marker Score: 471
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.61
    Marker Score: 442
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.61
    Marker Score: 4009
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.6
    Marker Score: 364
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.59
    Marker Score: 381
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.58
    Marker Score: 1509
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.58
    Marker Score: 2595
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.57
    Marker Score: 1581
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.57
    Marker Score: 1071
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.56
    Marker Score: 13580
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.54
    Marker Score: 4485
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.53
    Marker Score: 4231.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.52
    Marker Score: 380
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.51
    Marker Score: 496
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.49
    Marker Score: 20080
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.49
    Marker Score: 292
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.49
    Marker Score: 514
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 1.48
    Marker Score: 443
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.48
    Marker Score: 388
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.45
    Marker Score: 1615
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.45
    Marker Score: 1062

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Other Information

**Key characteristics:** * The gene is located on chromosome 15q21.1. * It is a member of the HLA class II family of genes. * It is expressed in cells of the immune system. * It is responsible for the expression of a protein that is a major component of the human immune system. **Pathways and functions:** * The gene is involved in the adaptive immune response. * It is a key regulator of the immune system. * It is involved in the activation of CD8+ cytotoxic T cells. * It is also involved in the activation of CD4+ helper T cells. **Clinical significance:** * Mutations in the HLA class II DP alpha 1 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, lupus, and psoriasis. * These mutations can also lead to the development of cancer. * Development of these diseases can be prevented by vaccination with the HLA class II DP alpha 1 antigen. **Additional information:** * The gene is also known as DPA1. * It is a highly conserved gene, with a similar gene found in other mammals. * It is a key player in the immune system and is essential for the development of protective immune responses.

Genular Protein ID: 3402850112

Symbol: DPA1_HUMAN

Name: HLA class II histocompatibility antigen, DP alpha 1 chain

UniProtKB Accession Codes:

P20036 A9YWH7 B9UKH4 O19722 O46883 P01905 P79554 Q2Q060 Q2Q061 Q5EY03 Q5STP1 Q6DQK4 Q9BCQ1 Q9TPX3 Q9XS10

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 40 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2997750

Title: The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene.

PubMed ID: 2997750

DOI: 10.1093/nar/13.20.7515

PubMed ID: 3036829

Title: Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes.

PubMed ID: 3036829

DOI: 10.1016/s0021-9258(18)47483-2

PubMed ID: 2461352

Title: Epitope recognition by a DP alpha chain-specific monoclonal antibody (DP11.1) is influenced by the interaction between the DP alpha chain and its polymorphic DP beta chain partner.

PubMed ID: 2461352

DOI: 10.1016/0198-8859(88)90016-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 6584734

Title: Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.

PubMed ID: 6584734

DOI: 10.1038/308327a0

PubMed ID: 9234495

Title: A novel DPA1 allele (DPA1*0203) composed of known epitopes.

PubMed ID: 9234495

DOI: 10.1111/j.1399-0039.1997.tb02821.x

PubMed ID: 9694359

Title: Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302.

PubMed ID: 9694359

DOI: 10.1111/j.1399-0039.1998.tb03009.x

PubMed ID: 7725312

Title: Sequencing-based typing reveals new insight in HLA-DPA1 polymorphism.

PubMed ID: 7725312

DOI: 10.1111/j.1399-0039.1995.tb02415.x

PubMed ID: 11019928

Title: A new HLA-DPA1 allele, DPA1*02016, identified in African-American population.

PubMed ID: 11019928

DOI: 10.1034/j.1399-0039.2000.560219.x

PubMed ID: 15663751

Title: High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population.

PubMed ID: 15663751

DOI: 10.1111/j.1399-0039.2005.00339.x

PubMed ID: 18838095

Title: Identification of a novel DPA1 allele, DPA1*010602, in an East African population.

PubMed ID: 18838095

DOI: 10.1016/j.humimm.2008.09.001

PubMed ID: 18380777

Title: Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304.

PubMed ID: 18380777

DOI: 10.1111/j.1399-0039.2008.01035.x

PubMed ID: 18489436

Title: A novel HLA-DPA1*0204 allele was identified in a Chinese individual.

PubMed ID: 18489436

DOI: 10.1111/j.1399-0039.2008.01046.x

PubMed ID: 8988544

Title: DPA1*0105, a novel DPA1 variant in a negrois population.

PubMed ID: 8988544

DOI: 10.1111/j.1399-0039.1996.tb02675.x

PubMed ID: 7806277

Title: Exon 2, 3, and 4 polymorphism of HLA-DPA1.

PubMed ID: 7806277

DOI: 10.1007/bf00188437

PubMed ID: 6300884

Title: Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes.

PubMed ID: 6300884

DOI: 10.1073/pnas.80.7.1972

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 260
  • Mass: 29381
  • Checksum: 826174E963A8CB42
  • Sequence:
    • MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT GEFMFEFDED 
EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN LNTLIQRSNH TQATNDPPEV 
TVFPKEPVEL GQPNTLICHI DKFFPPVLNV TWLCNGELVT EGVAESLFLP RTDYSFHKFH 
YLTFVPSAED FYDCRVEHWG LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG 
TVLIIKSLRS GHDPRAQGTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.