Details for: HLA DPA1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 320.0998
Cell Significance Index: -49.7900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 159.7757
Cell Significance Index: -64.9100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 125.8590
Cell Significance Index: -64.7400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 120.0747
Cell Significance Index: -56.6900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 84.8705
Cell Significance Index: -56.9500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 51.6867
Cell Significance Index: -13.1100 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 44.6929
Cell Significance Index: 186.0100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.4718
Cell Significance Index: -49.9000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.9257
Cell Significance Index: -37.3100 - Cell Name: centroblast (CL0009112)
Fold Change: 13.5080
Cell Significance Index: 31.5200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.3044
Cell Significance Index: -52.5000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.6757
Cell Significance Index: -32.7900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.5228
Cell Significance Index: -23.0300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 8.0957
Cell Significance Index: 149.6300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 7.8265
Cell Significance Index: 138.3100 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 7.6342
Cell Significance Index: 34.1400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 6.7049
Cell Significance Index: 790.7200 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 6.4675
Cell Significance Index: 111.1100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 5.5530
Cell Significance Index: 63.0900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 4.1420
Cell Significance Index: 89.7400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.9661
Cell Significance Index: 255.8700 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 3.7027
Cell Significance Index: 13.8000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.5068
Cell Significance Index: 102.9900 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.5940
Cell Significance Index: 18.6300 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.1252
Cell Significance Index: 32.8800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.8299
Cell Significance Index: 48.9500 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.4199
Cell Significance Index: 9.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1791
Cell Significance Index: 1064.6800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9228
Cell Significance Index: 150.0800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5169
Cell Significance Index: 51.1300 - Cell Name: peg cell (CL4033014)
Fold Change: 0.5107
Cell Significance Index: 11.8000 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.4151
Cell Significance Index: 2.6500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3685
Cell Significance Index: 40.0800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.3639
Cell Significance Index: 275.4100 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.2191
Cell Significance Index: 22.3800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1151
Cell Significance Index: 14.1600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0867
Cell Significance Index: 16.4900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0529
Cell Significance Index: 23.3700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0356
Cell Significance Index: 4.5600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0178
Cell Significance Index: 3.2200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0005
Cell Significance Index: 0.3100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0046
Cell Significance Index: -0.2400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0138
Cell Significance Index: -2.7300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0255
Cell Significance Index: -48.0500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0306
Cell Significance Index: -56.3600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0337
Cell Significance Index: -24.9300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0358
Cell Significance Index: -55.1400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0415
Cell Significance Index: -56.4300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0455
Cell Significance Index: -25.6800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0752
Cell Significance Index: -41.0800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0774
Cell Significance Index: -2.7200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0834
Cell Significance Index: -61.1300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0889
Cell Significance Index: -4.4900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0965
Cell Significance Index: -61.2600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1258
Cell Significance Index: -57.1100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1454
Cell Significance Index: -52.1700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1467
Cell Significance Index: -8.8100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1483
Cell Significance Index: -20.3600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1550
Cell Significance Index: -3.9600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1596
Cell Significance Index: -7.2400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1604
Cell Significance Index: -33.7800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1672
Cell Significance Index: -19.1600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1829
Cell Significance Index: -31.2300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1929
Cell Significance Index: -7.9000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2472
Cell Significance Index: -49.5900 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: -0.2691
Cell Significance Index: -0.7100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2731
Cell Significance Index: -35.2800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2984
Cell Significance Index: -20.6400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3019
Cell Significance Index: -35.1800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3051
Cell Significance Index: -14.3400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3237
Cell Significance Index: -9.3300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3682
Cell Significance Index: -42.0300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3942
Cell Significance Index: -27.8800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3965
Cell Significance Index: -57.6300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4605
Cell Significance Index: -11.5100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4775
Cell Significance Index: -15.3000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4844
Cell Significance Index: -50.4400 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: -0.5332
Cell Significance Index: -3.2200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5592
Cell Significance Index: -29.0500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5869
Cell Significance Index: -43.7400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5987
Cell Significance Index: -12.7500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6093
Cell Significance Index: -46.7600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6156
Cell Significance Index: -32.3200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7828
Cell Significance Index: -49.3400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.7884
Cell Significance Index: -36.7600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8071
Cell Significance Index: -63.9200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.8886
Cell Significance Index: -38.6400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9273
Cell Significance Index: -56.8500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9334
Cell Significance Index: -52.3800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.9862
Cell Significance Index: -27.5600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.1370
Cell Significance Index: -41.7400 - Cell Name: helper T cell (CL0000912)
Fold Change: -1.1443
Cell Significance Index: -16.2600 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -1.1785
Cell Significance Index: -17.1100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.1842
Cell Significance Index: -52.3800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.2006
Cell Significance Index: -30.8600 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -1.2278
Cell Significance Index: -13.6600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -1.3531
Cell Significance Index: -20.3900 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -1.3579
Cell Significance Index: -27.6300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.3830
Cell Significance Index: -52.3700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.3916
Cell Significance Index: -27.1600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3402850112
Symbol: DPA1_HUMAN
Name: HLA class II histocompatibility antigen, DP alpha 1 chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2997750
Title: The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene.
PubMed ID: 2997750
PubMed ID: 3036829
Title: Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes.
PubMed ID: 3036829
PubMed ID: 2461352
Title: Epitope recognition by a DP alpha chain-specific monoclonal antibody (DP11.1) is influenced by the interaction between the DP alpha chain and its polymorphic DP beta chain partner.
PubMed ID: 2461352
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 6584734
Title: Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.
PubMed ID: 6584734
DOI: 10.1038/308327a0
PubMed ID: 9234495
Title: A novel DPA1 allele (DPA1*0203) composed of known epitopes.
PubMed ID: 9234495
PubMed ID: 9694359
Title: Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302.
PubMed ID: 9694359
PubMed ID: 7725312
Title: Sequencing-based typing reveals new insight in HLA-DPA1 polymorphism.
PubMed ID: 7725312
PubMed ID: 11019928
Title: A new HLA-DPA1 allele, DPA1*02016, identified in African-American population.
PubMed ID: 11019928
PubMed ID: 15663751
Title: High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population.
PubMed ID: 15663751
PubMed ID: 18838095
Title: Identification of a novel DPA1 allele, DPA1*010602, in an East African population.
PubMed ID: 18838095
PubMed ID: 18380777
Title: Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304.
PubMed ID: 18380777
PubMed ID: 18489436
Title: A novel HLA-DPA1*0204 allele was identified in a Chinese individual.
PubMed ID: 18489436
PubMed ID: 8988544
Title: DPA1*0105, a novel DPA1 variant in a negrois population.
PubMed ID: 8988544
PubMed ID: 7806277
PubMed ID: 6300884
Title: Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes.
PubMed ID: 6300884
PubMed ID: 8598037
Title: Invariant chain structure and MHC class II function.
PubMed ID: 8598037
PubMed ID: 11684289
Title: Presentation of antigens by MHC class II molecules: getting the most out of them.
PubMed ID: 11684289
PubMed ID: 18046453
Title: MHC class II molecules on the move for successful antigen presentation.
PubMed ID: 18046453
PubMed ID: 17241953
Title: Autophagy in MHC class II presentation: sampling from within.
PubMed ID: 17241953
PubMed ID: 19092054
PubMed ID: 19533806
Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.
PubMed ID: 19533806
DOI: 10.3748/wjg.15.2855
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 260
- Mass: 29381
- Checksum: 826174E963A8CB42
- Sequence:
MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT GEFMFEFDED EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN LNTLIQRSNH TQATNDPPEV TVFPKEPVEL GQPNTLICHI DKFFPPVLNV TWLCNGELVT EGVAESLFLP RTDYSFHKFH YLTFVPSAED FYDCRVEHWG LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG TVLIIKSLRS GHDPRAQGTL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.