Details for: PDE4B
Gene ID: 5142
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PDE4B
Ensembl ID: ENSG00000184588
Description: phosphodiesterase 4B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 70.48rCSI 84.19%PRS 78.83
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CSI 62.35rCSI 80.37%PRS 79.86
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CSI 60.76rCSI 83.14%PRS 83.93
-
CSI 52.13rCSI 94.71%PRS 84.99
-
CSI 49.96rCSI 93.57%PRS 83.17
-
CSI 46.98rCSI 75.55%PRS 79.63
-
CSI 45.8rCSI 30.86%PRS 97.94
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CSI 43.92rCSI 96.64%PRS 74.64
-
CSI 41.6rCSI 31.13%PRS 97.23
-
CSI 40.89rCSI 50.87%PRS 76.62
-
CSI 37.94rCSI 55.77%PRS 86.28
-
CSI 37.76rCSI 80.45%PRS 70.18
-
CSI 36.81rCSI 60.29%PRS 84.5
-
CSI 36.3rCSI 64.1%PRS 78.18
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CSI 34.1rCSI 87.65%PRS 87.52
-
CSI 33.11rCSI 74.23%PRS 79.16
-
CSI 31.26rCSI 92.4%PRS 81.76
-
CSI 30.43rCSI 67.23%PRS 81.09
-
CSI 29.86rCSI 56.37%PRS 95.1
-
CSI 28.03rCSI 67.03%PRS 81.18
-
CSI 27.41rCSI 54.42%PRS 87.77
-
CSI 27.38rCSI 21.1%PRS 93.79
-
CSI 25.78rCSI 68.66%PRS 79.56
-
CSI 24.96rCSI 78.02%PRS 80.08
-
CSI 23.66rCSI 57.49%PRS 76.63
-
CSI 22.82rCSI 15.88%PRS 97.95
-
CSI 22.64rCSI 19.42%PRS 94.07
-
CSI 21.02rCSI 16.99%PRS 95.39
-
CSI 20.41rCSI 29.57%PRS 97.37
-
CSI 20.26rCSI 14.14%PRS 93.88
-
CSI 20.1rCSI 30.33%PRS 94.66
-
CSI 19.33rCSI 33.07%PRS 96.55
-
CSI 19.26rCSI 22.25%PRS 83.94
-
CSI 19.24rCSI 69.25%PRS 76.79
-
CSI 19.11rCSI 75.7%PRS 85
-
CSI 18.92rCSI 43.69%PRS 82.33
-
CSI 18.76rCSI 29.93%PRS 83.89
-
CSI 18.22rCSI 60.38%PRS 92.91
-
CSI 18.2rCSI 25.28%PRS 89.49
-
CSI 17.82rCSI 16.44%PRS 92.06
-
CSI 17.01rCSI 11.3%PRS 92.4
-
CSI 16.34rCSI 55.95%PRS 79.05
-
CSI 15.52rCSI 16.21%PRS 96.25
-
CSI 15.48rCSI 35.34%PRS 84.89
-
CSI 15.33rCSI 13.96%PRS 97.38
-
CSI 15rCSI 78.88%PRS 81.62
-
CSI 14.95rCSI 56.51%PRS 78.94
-
CSI 14.9rCSI 32.32%PRS 80.45
-
CSI 14.55rCSI 12.24%PRS 97.38
-
CSI 14.34rCSI 19.19%PRS 91.34
-
CSI 14.2rCSI 19.35%PRS 85.13
-
CSI 14.06rCSI 12.99%PRS 97.72
-
CSI 13.89rCSI 69.04%PRS 85.94
-
CSI 13.56rCSI 13.32%PRS 97.72
-
CSI 13.3rCSI 15.58%PRS 97.42
-
CSI 13.21rCSI 34.43%PRS 92.34
-
CSI 13rCSI 11.94%PRS 94.99
-
CSI 12.97rCSI 12.8%PRS 95.59
-
CSI 12.91rCSI 10.2%PRS 84.5
-
CSI 12.84rCSI 21.95%PRS 97.43
-
CSI 12.65rCSI 74.49%PRS 79.2
-
CSI 12.36rCSI 8.87%PRS 97.92
-
CSI 12.29rCSI 16.11%PRS 95.23
-
CSI 12.21rCSI 81.05%PRS 85.44
-
CSI 12.01rCSI 39.48%PRS 80.09
-
CSI 11.52rCSI 38.59%PRS 78.27
-
CSI 11.44rCSI 9.47%PRS 92.13
-
CSI 11.39rCSI 14.62%PRS 87.53
-
CSI 11.34rCSI 25.45%PRS 97.11
-
CSI 11.33rCSI 32.84%PRS 83.15
-
CSI 11.25rCSI 42.44%PRS 76.66
-
CSI 11.11rCSI 16.97%PRS 94.58
-
CSI 11.07rCSI 11.34%PRS 92.57
-
CSI 10.99rCSI 10.8%PRS 96.82
-
CSI 10.93rCSI 20.85%PRS 95.85
-
CSI 10.92rCSI 8.2%PRS 93.99
-
CSI 10.71rCSI 8.1%PRS 97.03
-
CSI 10.58rCSI 21.74%PRS 79.94
-
CSI 10.4rCSI 12.96%PRS 95.93
-
CSI 10.4rCSI 74.36%PRS 82.08
-
CSI 10.38rCSI 7.75%PRS 96.52
-
CSI 10.31rCSI 16.08%PRS 96.96
-
CSI 10.29rCSI 9.03%PRS 93.84
-
CSI 10.14rCSI 59.9%PRS 82.64
-
CSI 10.04rCSI 20.38%PRS 74.22
-
CSI 10.03rCSI 8.03%PRS 95.31
-
CSI 9.98rCSI 7.76%PRS 97.38
-
CSI 9.92rCSI 17.39%PRS 87.67
-
CSI 9.89rCSI 7.35%PRS 96.17
-
CSI 9.87rCSI 76.43%PRS 84.06
-
CSI 9.8rCSI 14.97%PRS 96.14
-
CSI 9.67rCSI 37.38%PRS 93.83
-
CSI 9.65rCSI 70.92%PRS 83.26
-
CSI 9.62rCSI 38.73%PRS 89.46
-
CSI 9.57rCSI 17.13%PRS 89.55
-
CSI 9.44rCSI 14.39%PRS 88.08
-
CSI 9.31rCSI 18.69%PRS 85.26
-
CSI 9.26rCSI 16.65%PRS 86.41
-
CSI 9.14rCSI 16.52%PRS 92.15
-
CSI 8.96rCSI 5.29%PRS 98.68
-
CSI 0.3rCSI 6.7%PRS 97.0%
-
CSI 0.6rCSI 4.9%PRS 88.6%
-
CSI 0.7rCSI 4.3%PRS 90.1%
-
CSI 0.8rCSI 4.4%PRS 92.4%
-
CSI 0.8rCSI 4.0%PRS 97.2%
-
CSI 0.8rCSI 3.6%PRS 96.8%
-
CSI 0.8rCSI 5.4%PRS 83.4%
-
CSI 0.9rCSI 20.0%PRS 96.8%
-
CSI 1.1rCSI 2.7%PRS 96.6%
-
CSI 1.1rCSI 5.7%PRS 90.9%
-
CSI 1.2rCSI 16.6%PRS 83.9%
-
CSI 1.2rCSI 3.3%PRS 97.6%
-
CSI 1.5rCSI 4.2%PRS 91.1%
-
CSI 1.5rCSI 10.3%PRS 84.7%
-
CSI 1.5rCSI 6.4%PRS 92.1%
-
CSI 1.6rCSI 6.9%PRS 80.8%
-
CSI 1.7rCSI 5.5%PRS 97.3%
-
CSI 1.8rCSI 6.5%PRS 98.4%
-
CSI 1.8rCSI 2.5%PRS 89.7%
-
CSI 2.3rCSI 12.8%PRS 92.7%
-
CSI 2.3rCSI 3.3%PRS 87.1%
-
CSI 2.4rCSI 7.8%PRS 87.7%
-
CSI 2.6rCSI 11.4%PRS 96.2%
-
CSI 2.6rCSI 10.0%PRS 97.9%
-
CSI 2.6rCSI 4.8%PRS 95.9%
-
CSI 2.6rCSI 3.5%PRS 88.6%
-
CSI 2.6rCSI 15.8%PRS 95.7%
-
CSI 2.6rCSI 20.4%PRS 92.5%
-
CSI 2.6rCSI 10.0%PRS 84.9%
-
CSI 2.7rCSI 23.4%PRS 79.1%
-
CSI 2.7rCSI 17.3%PRS 93.5%
-
CSI 2.7rCSI 5.2%PRS 98.5%
-
CSI 2.8rCSI 7.2%PRS 85.4%
-
CSI 2.9rCSI 4.7%PRS 93.1%
-
CSI 3.0rCSI 71.7%PRS 76.6%
-
CSI 3.0rCSI 72.3%PRS 76.7%
-
CSI 3.0rCSI 4.7%PRS 89.3%
-
CSI 3.1rCSI 3.5%PRS 94.6%
-
CSI 3.1rCSI 19.6%PRS 85.2%
-
CSI 3.2rCSI 5.8%PRS 97.0%
-
CSI 3.3rCSI 20.9%PRS 85.5%
-
CSI 3.4rCSI 3.0%PRS 89.7%
-
CSI 3.4rCSI 19.0%PRS 97.1%
-
CSI 3.4rCSI 2.7%PRS 92.1%
-
CSI 3.4rCSI 9.8%PRS 93.1%
-
CSI 3.4rCSI 5.2%PRS 90.1%
-
CSI 3.5rCSI 13.7%PRS 75.1%
-
CSI 3.5rCSI 3.0%PRS 91.2%
-
CSI 3.6rCSI 72.4%PRS 83.5%
-
CSI 3.6rCSI 6.1%PRS 92.9%
-
CSI 3.6rCSI 73.4%PRS 82.8%
-
CSI 3.6rCSI 7.5%PRS 85.5%
-
CSI 3.7rCSI 15.4%PRS 89.0%
-
CSI 3.7rCSI 5.5%PRS 94.1%
-
CSI 3.8rCSI 13.3%PRS 94.7%
-
CSI 3.8rCSI 59.9%PRS 91.5%
-
CSI 3.8rCSI 6.1%PRS 86.6%
-
CSI 3.9rCSI 17.3%PRS 77.4%
-
CSI 3.9rCSI 7.1%PRS 95.3%
-
CSI 4.0rCSI 6.5%PRS 92.7%
-
CSI 4.0rCSI 19.7%PRS 94.3%
-
CSI 4.0rCSI 5.7%PRS 83.5%
-
CSI 4.0rCSI 21.8%PRS 94.5%
-
CSI 4.2rCSI 8.1%PRS 98.1%
-
CSI 4.4rCSI 4.2%PRS 96.6%
-
CSI 4.5rCSI 11.6%PRS 97.8%
-
CSI 4.6rCSI 21.8%PRS 87.5%
-
CSI 4.6rCSI 10.2%PRS 95.0%
-
CSI 4.6rCSI 7.2%PRS 91.9%
-
CSI 4.8rCSI 3.4%PRS 97.5%
-
CSI 4.8rCSI 27.3%PRS 80.9%
-
CSI 5.2rCSI 20.8%PRS 91.5%
-
CSI 5.2rCSI 29.3%PRS 88.5%
-
CSI 5.4rCSI 10.8%PRS 92.3%
-
CSI 5.5rCSI 10.9%PRS 96.8%
-
CSI 5.5rCSI 25.6%PRS 96.6%
-
CSI 5.5rCSI 8.4%PRS 95.8%
-
CSI 5.8rCSI 16.7%PRS 98.6%
-
CSI 6.0rCSI 24.2%PRS 84.2%
-
CSI 6.0rCSI 7.5%PRS 95.3%
-
CSI 6.2rCSI 7.5%PRS 72.5%
-
CSI 6.4rCSI 23.1%PRS 96.7%
-
CSI 6.4rCSI 10.7%PRS 78.8%
-
CSI 6.6rCSI 5.3%PRS 98.2%
-
CSI 6.8rCSI 25.6%PRS 86.8%
-
CSI 6.9rCSI 29.4%PRS 84.6%
-
CSI 7.0rCSI 12.5%PRS 63.0%
-
CSI 7.2rCSI 15.8%PRS 93.2%
-
CSI 7.2rCSI 8.9%PRS 90.6%
-
CSI 7.3rCSI 83.3%PRS 79.1%
-
CSI 7.3rCSI 6.4%PRS 96.1%
-
CSI 7.4rCSI 18.7%PRS 93.3%
-
CSI 7.4rCSI 11.8%PRS 95.0%
-
CSI 7.4rCSI 6.4%PRS 93.0%
-
CSI 7.5rCSI 8.4%PRS 97.1%
-
CSI 7.5rCSI 9.0%PRS 94.4%
-
CSI 7.6rCSI 9.7%PRS 83.3%
-
CSI 7.6rCSI 23.8%PRS 81.7%
-
CSI 7.7rCSI 66.1%PRS 83.6%
-
CSI 7.8rCSI 17.8%PRS 91.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 562338834
Symbol: PDE4B_HUMAN
Name: DPDE4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8392015
Title: The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family.
PubMed ID: 8392015
PubMed ID: 8413254
Title: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
PubMed ID: 8413254
PubMed ID: 9371714
Title: Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
PubMed ID: 9371714
DOI: 10.1042/bj3280549
PubMed ID: 8384210
Title: A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.
PubMed ID: 8384210
PubMed ID: 17519386
Title: PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).
PubMed ID: 17519386
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10846163
Title: Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity.
PubMed ID: 10846163
PubMed ID: 15003452
Title: Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
PubMed ID: 15003452
PubMed ID: 15260978
Title: A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.
PubMed ID: 15260978
PubMed ID: 15576036
Title: Structural basis for the activity of drugs that inhibit phosphodiesterases.
PubMed ID: 15576036
PubMed ID: 15685167
Title: A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.
PubMed ID: 15685167
DOI: 10.1038/nbt1059
PubMed ID: 17727341
Title: Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
PubMed ID: 17727341
DOI: 10.1042/bj20070970
PubMed ID: 18539455
Title: Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.
PubMed ID: 18539455
Sequence Information:
- Length: 736
- Mass: 83343
- Checksum: 208FCE9CD40EF5EB
- Sequence:
MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL QLPPLSQRQS ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG PSPGRSPLDP QASSSAGLVL HATFPGHSQR RESFLYRSDS DYDLSPKAMS RNSSLPSEQH GDDLIVTPFA QVLASLRSVR NNFTILTNLH GTSNKRSPAA SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR SVSEMASNKF KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL NIFNVAGYSH NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH SDVAYHNSLH AADVAQSTHV LLSTPALDAV FTDLEILAAI FAAAIHDVDH PGVSNQFLIN TNSELALMYN DESVLENHHL AVGFKLLQEE HCDIFMNLTK KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS SGVLLLDNYT DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN WYQSMIPQSP SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS YFSSTKTLCV IDPENRDSLG ETDIDIATED KSPVDT
Genular Protein ID: 1567967116
Symbol: Q59GM8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 726
- Mass: 82677
- Checksum: D44DDCDEEC5051FB
- Sequence:
HSLQDMTAKD SSKELTASEP EVCIKTFKEQ MHLELELPRL PGNRPTSPKI SPRSSPRNSP CFFRKLLVNK SIRQRRRFTV AHTCFDVENG PSPGRSPLDP QASSSAGLVL HATFPGHSQR RESFLYRSDS DYDLSPKAMS RNSSLPSEQH GDDLIVTPFA QVLASLRSVR NNFTILTNLH GTSNKRSPAA SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR SVSEMASNKF KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL NIFNVAGYSH NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH SDVAYHNSLH AADVAQSTHV LLSTPALDAV FTDLEILAAI FAAAIHDVDH PGVSNQFLIN TNSELALMYN DESVLENHHL AVGFKLLQEE HCDIFMNLTK KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS SGVLLLDNYT DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN WYQSMIPQSP SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS YFSSTKTLCV IDPENRDSLG ETDIDIATED KSPVDT
Genular Protein ID: 1081393144
Symbol: Q68CX5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 14
- Mass: 1599
- Checksum: C23271517D299F82
- Sequence:
MKKSRSVMTV MADD
Genular Protein ID: 2001170048
Symbol: X5DR82_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 24722188
Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
PubMed ID: 24722188
Sequence Information:
- Length: 661
- Mass: 75200
- Checksum: 5E44C3634FFAC96C
- Sequence:
MKKSRSVMTV MADDVMLKNF DVENGPSPGR SPLDPQASSS AGLVLHATFP GHSQRRESFL YRSDSDYDLS PKAMSRNSSL PSEQHGDDLI VTPFAQVLAS LRSVRNNFTI LTNLHGTSNK RSPAASQPPV SRVNPQEESY QKLAMETLEE LDWCLDQLET IQTYRSVSEM ASNKFKRMLN RELTHLSEMS RSGNQVSEYI SNTFLDKQND VEIPSPTQKD REKKKKQQLM TQISGVKKLM HSSSLNNTSI SRFGVNTENE DHLAKELEDL NKWGLNIFNV AGYSHNRPLT CIMYAIFQER DLLKTFRISS DTFITYMMTL EDHYHSDVAY HNSLHAADVA QSTHVLLSTP TLDAVFTDLE ILAAIFAAAI HDVDHPGVSN QFLINTNSEL ALMYNDESVL ENHHLAVGFK LLQEEHCDIF MNLTKKQRQT LRKMVIDMVL ATDMSKHMSL LADLKTMVET KKVTSSGVLL LDNYTDRIQV LRNMVHCADL SNPTKSLELY RQWTDRIMEE FFQQGDKERE RGMEISPMCD KHTASVEKSQ VGFIDYIVHP LWETWADLVQ PDAQDILDTL EDNRNWYQSM IPQSPSPPLD EQNRDCQGLM EKFQFELTLD EEDSEGPEKE GEGHSYFSST KTLCVIDPEN RDSLGETDID IATEDKSPVD T