Details for: CL0000819

Cell ID: CL0000819

Cell Name: B-1 B cell

Marker Score Threshold: 1743
(Derived using integrated single-cell and genomic data)

Description: A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive.

Synonyms: B-1 B lymphocyte, B-1 B-cell, B-1 B-lymphocyte, B-1 cell, B1 B cell, B1 B lymphocyte, B1 B-cell, B1 B-lymphocyte, B1 cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.03
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.97
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.97
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.97
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.97
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.96
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.96
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.93
    Ensembl ID: ENSG00000169100
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.87
    Ensembl ID: ENSG00000005022
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.86
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.8
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.74
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.71
    Ensembl ID: ENSG00000154518
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.65
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.63
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.61
    Ensembl ID: ENSG00000143933
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.54
    Ensembl ID: ENSG00000134825
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.52
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.47
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.47
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.45
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.43
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.43
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 2.42
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.36
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.32
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 2.31
    Ensembl ID: ENSG00000023445
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 2.3
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.18
    Ensembl ID: ENSG00000168421
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 2.16
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.11
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.11
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.07
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.04
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.01
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 2
    Ensembl ID: ENSG00000010671
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.93
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.91
    Ensembl ID: ENSG00000004059
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.91
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.87
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.86
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.85
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.82
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.82
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.78
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 1.77
    Ensembl ID: ENSG00000160683
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.76
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.74
    Ensembl ID: ENSG00000140379
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.71
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.71
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.69
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.68
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.65
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.65
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.65
    Ensembl ID: ENSG00000102575
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.61
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.61
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.58
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 1.57
    Ensembl ID: ENSG00000136573
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.54
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.53
    Ensembl ID: ENSG00000177556
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.53
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.5
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104765
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.47
    Ensembl ID: ENSG00000171791
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.46
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.45
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.45
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.44
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.43
    Ensembl ID: ENSG00000149311
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.43
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.4
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.36
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.35
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.32
    Ensembl ID: ENSG00000140299
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.32
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.31
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.31
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.29
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.27
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.26
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.26
    Ensembl ID: ENSG00000074370
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.22
    Ensembl ID: ENSG00000060971
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.18
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.15
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.13
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.11
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.11
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.11
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.1
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.08
    Ensembl ID: ENSG00000012779
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.08
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.04
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.03
    Ensembl ID: ENSG00000204574
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.02
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.01
    Ensembl ID: ENSG00000196975
Hovered Details

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Hovered Details

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**Key Characteristics** * **Surface Marker Expression**: B-1 B cells are characterized by their expression of the CD43 surface marker. * **IgM Production**: B-1 B cells are the primary source of natural IgM immunoglobulin, producing large quantities in response to various microorganisms without prior antigenic stimulation. * **T-Independent IgA Production**: B-1 B cells are involved in the production of T-independent IgA immunoglobulin in mucosal areas. * **Innate Immune Response**: B-1 B cells play a crucial role in the innate immune response, providing immediate defense against pathogens. * **Cytoskeleton Organization**: The B-1 B cell gene ARHGDIB is involved in the regulation of the cytoskeleton, including the Cdc42 and Rac1 GTPase cycles. **Clinical Significance** * **Autoimmune Diseases**: Abnormalities in B-1 B cell function and IgM production have been implicated in autoimmune diseases such as rheumatoid arthritis and lupus. * **Infectious Diseases**: The B-1 B cell response plays a crucial role in the defense against bacterial and viral infections, making them an important target for the development of vaccines and therapeutic strategies. * **Cancer**: B-1 B cells have been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma. * **Immunodeficiency Disorders**: Dysregulation of B-1 B cell function has been associated with immunodeficiency disorders such as X-linked agammaglobulinemia and Bruton's agammaglobulinemia. In conclusion, the B-1 B cell is a unique lineage of B lymphocytes that plays a crucial role in the innate immune response and the production of natural IgM immunoglobulin. Understanding the characteristics and clinical significance of B-1 B cells is essential for the development of therapeutic strategies for autoimmune diseases, infectious diseases, and cancer.