Details for: CIITA

Gene ID: 4261

Symbol: CIITA

Ensembl ID: ENSG00000179583

Description: class II major histocompatibility complex transactivator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.0474
    Cell Significance Index: -10.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.6012
    Cell Significance Index: -9.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 23.7760
    Cell Significance Index: -12.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.7351
    Cell Significance Index: -10.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.5986
    Cell Significance Index: 139.9500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 3.4468
    Cell Significance Index: 42.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6871
    Cell Significance Index: 108.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4301
    Cell Significance Index: -3.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2182
    Cell Significance Index: 143.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1714
    Cell Significance Index: 21.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7727
    Cell Significance Index: 20.6700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.7649
    Cell Significance Index: 13.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7565
    Cell Significance Index: 74.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6603
    Cell Significance Index: 596.1900
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.6462
    Cell Significance Index: 2.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5327
    Cell Significance Index: 31.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4824
    Cell Significance Index: 52.4800
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.4557
    Cell Significance Index: 1.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3964
    Cell Significance Index: 64.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3471
    Cell Significance Index: 5.3700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3418
    Cell Significance Index: 3.5400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3417
    Cell Significance Index: 4.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2677
    Cell Significance Index: 18.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1491
    Cell Significance Index: 5.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1082
    Cell Significance Index: 1.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1069
    Cell Significance Index: 20.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0929
    Cell Significance Index: 18.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0889
    Cell Significance Index: 2.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0673
    Cell Significance Index: 13.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0605
    Cell Significance Index: 1.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0488
    Cell Significance Index: 1.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0205
    Cell Significance Index: 3.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0134
    Cell Significance Index: 7.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0134
    Cell Significance Index: 25.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0074
    Cell Significance Index: 10.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0026
    Cell Significance Index: 4.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0012
    Cell Significance Index: 1.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0019
    Cell Significance Index: -0.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0023
    Cell Significance Index: -1.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0044
    Cell Significance Index: -1.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0055
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0096
    Cell Significance Index: -6.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0145
    Cell Significance Index: -10.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0153
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0171
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0196
    Cell Significance Index: -8.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0218
    Cell Significance Index: -12.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0254
    Cell Significance Index: -3.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0291
    Cell Significance Index: -8.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0291
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0349
    Cell Significance Index: -4.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0368
    Cell Significance Index: -1.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0487
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0570
    Cell Significance Index: -12.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0634
    Cell Significance Index: -10.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0659
    Cell Significance Index: -8.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0750
    Cell Significance Index: -10.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0808
    Cell Significance Index: -10.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0814
    Cell Significance Index: -9.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0855
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0919
    Cell Significance Index: -10.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0971
    Cell Significance Index: -10.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1089
    Cell Significance Index: -5.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1224
    Cell Significance Index: -8.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1325
    Cell Significance Index: -5.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1435
    Cell Significance Index: -6.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1459
    Cell Significance Index: -8.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1471
    Cell Significance Index: -4.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1487
    Cell Significance Index: -10.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1492
    Cell Significance Index: -11.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1494
    Cell Significance Index: -2.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1546
    Cell Significance Index: -11.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1549
    Cell Significance Index: -9.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1623
    Cell Significance Index: -4.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1658
    Cell Significance Index: -6.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1877
    Cell Significance Index: -10.5300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1919
    Cell Significance Index: -2.3100
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.2029
    Cell Significance Index: -1.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2116
    Cell Significance Index: -11.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2201
    Cell Significance Index: -7.7100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2209
    Cell Significance Index: -9.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2225
    Cell Significance Index: -5.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2513
    Cell Significance Index: -6.4200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2539
    Cell Significance Index: -8.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2564
    Cell Significance Index: -7.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2754
    Cell Significance Index: -13.9200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2784
    Cell Significance Index: -3.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2785
    Cell Significance Index: -8.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2816
    Cell Significance Index: -9.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2992
    Cell Significance Index: -7.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3078
    Cell Significance Index: -6.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3115
    Cell Significance Index: -11.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3204
    Cell Significance Index: -6.8000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3371
    Cell Significance Index: -4.9300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3390
    Cell Significance Index: -2.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3434
    Cell Significance Index: -9.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulation**: CIITA is a transcriptional activator that regulates the expression of MHC class II genes. It binds to specific DNA sequences, known as enhancers, and recruits coactivators to initiate transcription. 2. **Complex Structure**: CIITA is a multifunctional protein with multiple domains, including a DNA-binding domain, a histone acetyltransferase (HAT) domain, and a transactivation domain. 3. **Interactions with Other Proteins**: CIITA interacts with various proteins, including coactivators, corepressors, and histone modifiers, to fine-tune MHC class II expression. 4. **Expression in Immune Cells**: CIITA is primarily expressed in immune cells, including dendritic cells, B cells, and T cells, where it plays a crucial role in antigen presentation and immune response. **Pathways and Functions** 1. **Cytokine Signaling**: CIITA is involved in the regulation of cytokine signaling pathways, including those mediated by interferon-gamma (IFN-γ) and type II interferons. 2. **Immune Response**: CIITA plays a critical role in the regulation of the immune response, particularly in the context of MHC class II-mediated antigen presentation. 3. **Transcriptional Regulation**: CIITA regulates the expression of MHC class II genes through the recruitment of coactivators and the modulation of chromatin structure. 4. **Cellular Proliferation**: CIITA is also involved in the regulation of cellular proliferation, particularly in the context of immune cell activation. **Clinical Significance** 1. **Autoimmune Diseases**: Dysregulation of CIITA expression has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Infectious Diseases**: CIITA plays a critical role in the regulation of the immune response to infections, particularly those caused by viruses and bacteria. 3. **Cancer Immunotherapy**: CIITA is a target for cancer immunotherapy, as its dysregulation can lead to impaired antigen presentation and immune evasion. 4. **Vaccine Development**: CIITA is a potential target for vaccine development, as its regulation of MHC class II expression can influence the efficacy of vaccine-induced immunity. In conclusion, CIITA is a crucial transcriptional regulator that plays a pivotal role in the expression of MHC class II molecules. Its dysregulation has been implicated in various autoimmune and infectious diseases, making it a promising target for therapeutic intervention. Further research is needed to fully elucidate the complexities of CIITA function and its role in the immune system.

Genular Protein ID: 1682763990

Symbol: C2TA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P33076 A0N0N9 D3DUG0 E9PFE0 Q29675 Q8SNB8 Q96KL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 ELM 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8402893

Title: Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome).

PubMed ID: 8402893

DOI: 10.1016/s0092-8674(05)80090-x

PubMed ID: 7749984

Title: Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA).

PubMed ID: 7749984

DOI: 10.1016/1074-7613(95)90033-0

PubMed ID: 12919287

Title: Structural and functional characteristics of a dominant-negative isoform of porcine MHC class II transactivator.

PubMed ID: 12919287

DOI: 10.1046/j.1365-2370.2003.00397.x

PubMed ID: 12859996

Title: K-562 cells lack MHC class II expression due to an alternatively spliced CIITA transcript with a truncated coding region.

PubMed ID: 12859996

DOI: 10.1016/s0145-2126(03)00072-9

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10464099

Title: GTP binding by class II transactivator: role in nuclear import.

PubMed ID: 10464099

DOI: 10.1126/science.285.5432.1402

PubMed ID: 11172716

Title: Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250.

PubMed ID: 11172716

DOI: 10.1016/s1097-2765(01)00159-9

PubMed ID: 17493635

Title: The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.

PubMed ID: 17493635

DOI: 10.1016/j.jmb.2007.04.033

PubMed ID: 16600381

Title: ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription.

PubMed ID: 16600381

DOI: 10.1016/j.molimm.2006.02.029

PubMed ID: 20937824

Title: Novel functions for TAF7, a regulator of TAF1-independent transcription.

PubMed ID: 20937824

DOI: 10.1074/jbc.m110.173864

PubMed ID: 23007646

Title: PML promotes MHC class II gene expression by stabilizing the class II transactivator.

PubMed ID: 23007646

DOI: 10.1083/jcb.201112015

PubMed ID: 24036077

Title: Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity.

PubMed ID: 24036077

DOI: 10.1016/j.bbagrm.2013.09.001

PubMed ID: 32855215

Title: MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

PubMed ID: 32855215

DOI: 10.1126/science.abb3753

PubMed ID: 10501838

Title: Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA.

PubMed ID: 10501838

DOI: 10.1007/s002510050579

PubMed ID: 11466404

Title: Mutation in the class II trans-activator leading to a mild immunodeficiency.

PubMed ID: 11466404

DOI: 10.4049/jimmunol.167.3.1787

PubMed ID: 11862382

Title: Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency.

PubMed ID: 11862382

DOI: 10.1007/s00251-001-0395-7

Sequence Information:

  • Length: 1130
  • Mass: 123514
  • Checksum: 7A61CAA4F3FFECE0
  • Sequence:
    • MRCLAPRPAG SYLSEPQGSS QCATMELGPL EGGYLELLNS DADPLCLYHF YDQMDLAGEE 
EIELYSEPDT DTINCDQFSR LLCDMEGDEE TREAYANIAE LDQYVFQDSQ LEGLSKDIFK 
HIGPDEVIGE SMEMPAEVGQ KSQKRPFPEE LPADLKHWKP AEPPTVVTGS LLVRPVSDCS 
TLPCLPLPAL FNQEPASGQM RLEKTDQIPM PFSSSSLSCL NLPEGPIQFV PTISTLPHGL 
WQISEAGTGV SSIFIYHGEV PQASQVPPPS GFTVHGLPTS PDRPGSTSPF APSATDLPSM 
PEPALTSRAN MTEHKTSPTQ CPAAGEVSNK LPKWPEPVEQ FYRSLQDTYG AEPAGPDGIL 
VEVDLVQARL ERSSSKSLER ELATPDWAER QLAQGGLAEV LLAAKEHRRP RETRVIAVLG 
KAGQGKSYWA GAVSRAWACG RLPQYDFVFS VPCHCLNRPG DAYGLQDLLF SLGPQPLVAA 
DEVFSHILKR PDRVLLILDG FEELEAQDGF LHSTCGPAPA EPCSLRGLLA GLFQKKLLRG 
CTLLLTARPR GRLVQSLSKA DALFELSGFS MEQAQAYVMR YFESSGMTEH QDRALTLLRD 
RPLLLSHSHS PTLCRAVCQL SEALLELGED AKLPSTLTGL YVGLLGRAAL DSPPGALAEL 
AKLAWELGRR HQSTLQEDQF PSADVRTWAM AKGLVQHPPR AAESELAFPS FLLQCFLGAL 
WLALSGEIKD KELPQYLALT PRKKRPYDNW LEGVPRFLAG LIFQPPARCL GALLGPSAAA 
SVDRKQKVLA RYLKRLQPGT LRARQLLELL HCAHEAEEAG IWQHVVQELP GRLSFLGTRL 
TPPDAHVLGK ALEAAGQDFS LDLRSTGICP SGLGSLVGLS CVTRFRAALS DTVALWESLQ 
QHGETKLLQA AEEKFTIEPF KAKSLKDVED LGKLVQTQRT RSSSEDTAGE LPAVRDLKKL 
EFALGPVSGP QAFPKLVRIL TAFSSLQHLD LDALSENKIG DEGVSQLSAT FPQLKSLETL 
NLSQNNITDL GAYKLAEALP SLAASLLRLS LYNNCICDVG AESLARVLPD MVSLRVMDVQ 
YNKFTAAGAQ QLAASLRRCP HVETLAMWTP TIPFSVQEHL QQQDSRISLR

Genular Protein ID: 370954130

Symbol: Q66X48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q66X48

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 1107
  • Mass: 120936
  • Checksum: 16A1103F13FC3663
  • Sequence:
    • MELGPLEGGY LEPLNSDADP LCLYHFYDQM DLAGEEEIEL YSEPDTDTIN CDQFSRLLCD 
MEGDEETREA YANIAELDQY VFQDSQLEGL SKDIFIEHIG PDEVIGESME MPAEVGQKSQ 
KRPFPEELPA DLKHWKPAEP PTVVAGSLLV GPVSDCSTLS CLPLPALFNQ EPASGQMRLE 
KTDQIPMPFS SSSLSCLNLP EGPIQFVPTI STLPHGLWQI SEAGTGVSSI FIYHGEVPQA 
SQVPPPSGFT VHGLPTSPDR PGSTSPFAPS ATDLPSMPEP ALTSRANMTE HKTSPTQCPA 
AGEVSNKLPK WPEPVEQFYR SLQDTYGAEP AGPDGILVEV DLVQARLERS SSKGLERELA 
TPDWAERQLA QGGLAEVLLA AKEHRRPRET RVIAVLGKAG QGKSYWAGAV SRAWACGRLP 
QYDFVFSVPC HCLNRPGDAY GLQDLLFSLG PQPLVAADEV FSHILKRPDR VLLILDGFEE 
LEAQDGFLHS TCGPAPAEPC SLRGLLAGLF QKKLLRGCTL LLTARPRGRL VQSLSKADAL 
FELSGFSMEQ AQAYVMRYFE SSGMTEHQDR ALTLLRDRPL LLSHSHSPTL CRAVCQLSEA 
LLELGEDAKL PSTLTGLYVG LLGRAALGSP PGALAELAKL AWELGRRHQS TLQEDQFPSA 
DVRTWAMAKG LVQHPPRAAE SELAFPSFLL QCFLGALWLA LSGEIKDKEL PQYLALTPRK 
KRPYDNWLEG VPRFLAGLIF QPPARCLGAL LGPSAAASVD RKQKVLARYL KRLQPGTLRA 
RQLLELLHCA HEAEEAGIWQ HVVQELPGRL SFLGTRLTPL DAHVLGKALE AAGQDFSLDL 
RSTGICPSGL GSLVGLSCVT RFRAALSDTV ALWESLRQHG ETKLLQAAEE KFTIEPFKAK 
SLKDVEDLGK LVQTQRTRSS SEDTAGELPA VRDLKKLEFA LGPVSGPQAF PKLVRILTAF 
SSLQHLDLDA LSENKIGDEG VSQLSATFPQ LKSLETLNLS QNNITDLGAY KLAEALPSLA 
ASLLRLSLYN NCICDVGAES LARVLPDMVS LRVMDVQYNK FTAAGAQQLA ASLRRCPHVE 
TLAMWTPTIP FSVQEHLQQQ DSRISLR

Genular Protein ID: 1026598499

Symbol: A0A0B4J1S1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J1S1

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 2 PhylomeDB 1 Proteomes 2 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 1130
  • Mass: 123415
  • Checksum: D698094576546509
  • Sequence:
    • MRCLAPRPAG SYLSEPQGSS QCATMELGPL EGGYLELLNS DADPLCLYHF YDQMDLAGEE 
EIELYSEPDT DTINCDQFSR LLCDMEGDEE TREAYANIAE LDQYVFQDSQ LEGLSKDIFK 
HIGPDEVIGE SMEMPAEVGQ KSQKRPFPEE LPADLKHWKP AEPPTVVTGS LLVGPVSDCS 
TLPCLPLPAL FNQEPASGQM RLEKTDQIPM PFSSSSLSCL NLPEGPIQFV PTISTLPHGL 
WQISEAGTGV SSIFIYHGEV PQASQVPPPS GFTVHGLPTS PDRPGSTSPF APSATDLPSM 
PEPALTSRAN MTEHKTSPTQ CPAAGEVSNK LPKWPEPVEQ FYRSLQDTYG AEPAGPDGIL 
VEVDLVQARL ERSSSKSLER ELATPDWAER QLAQGGLAEV LLAAKEHRRP RETRVIAVLG 
KAGQGKSYWA GAVSRAWACG RLPQYDFVFS VPCHCLNRPG DAYGLQDLLF SLGPQPLVAA 
DEVFSHILKR PDRVLLILDG FEELEAQDGF LHSTCGPAPA EPCSLRGLLA GLFQKKLLRG 
CTLLLTARPR GRLVQSLSKA DALFELSGFS MEQAQAYVMR YFESSGMTEH QDRALTLLRD 
RPLLLSHSHS PTLCRAVCQL SEALLELGED AKLPSTLTGL YVGLLGRAAL DSPPGALAEL 
AKLAWELGRR HQSTLQEDQF PSADVRTWAM AKGLVQHPPR AAESELAFPS FLLQCFLGAL 
WLALSGEIKD KELPQYLALT PRKKRPYDNW LEGVPRFLAG LIFQPPARCL GALLGPSAAA 
SVDRKQKVLA RYLKRLQPGT LRARQLLELL HCAHEAEEAG IWQHVVQELP GRLSFLGTRL 
TPPDAHVLGK ALEAAGQDFS LDLRSTGICP SGLGSLVGLS CVTRFRAALS DTVALWESLQ 
QHGETKLLQA AEEKFTIEPF KAKSLKDVED LGKLVQTQRT RSSSEDTAGE LPAVRDLKKL 
EFALGPVSGP QAFPKLVRIL TAFSSLQHLD LDALSENKIG DEGVSQLSAT FPQLKSLETL 
NLSQNNITDL GAYKLAEALP SLAASLLRLS LYNNCICDVG AESLARVLPD MVSLRVMDVQ 
YNKFTAAGAQ QLAASLRRCP HVETLAMWTP TIPFSVQEHL QQQDSRISLR

Genular Protein ID: 310262737

Symbol: A0A087X2I7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X2I7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 1131
  • Mass: 123529
  • Checksum: 75EF94F4CEC4AB3A
  • Sequence:
    • MRCLAPRPAG SYLSEPQGSS QCATMELGPL EGGYLELLNS DADPLCLYHF YDQMDLAGEE 
EIELYSEPDT DTINCDQFSR LLCDMEGDEE TREAYANIAE LDQYVFQDSQ LEGLSKDIFI 
EHIGPDEVIG ESMEMPAEVG QKSQKRPFPE ELPADLKHWK PAEPPTVVTG SLLVGPVSDC 
STLPCLPLPA LFNQEPASGQ MRLEKTDQIP MPFSSSSLSC LNLPEGPIQF VPTISTLPHG 
LWQISEAGTG VSSIFIYHGE VPQASQVPPP SGFTVHGLPT SPDRPGSTSP FAPSATDLPS 
MPEPALTSRA NMTEHKTSPT QCPAAGEVSN KLPKWPEPVE QFYRSLQDTY GAEPAGPDGI 
LVEVDLVQAR LERSSSKSLE RELATPDWAE RQLAQGGLAE VLLAAKEHRR PRETRVIAVL 
GKAGQGKSYW AGAVSRAWAC GRLPQYDFVF SVPCHCLNRP GDAYGLQDLL FSLGPQPLVA 
ADEVFSHILK RPDRVLLILD GFEELEAQDG FLHSTCGPAP AEPCSLRGLL AGLFQKKLLR 
GCTLLLTARP RGRLVQSLSK ADALFELSGF SMEQAQAYVM RYFESSGMTE HQDRALTLLR 
DRPLLLSHSH SPTLCRAVCQ LSEALLELGE DAKLPSTLTG LYVGLLGRAA LDSPPGALAE 
LAKLAWELGR RHQSTLQEDQ FPSADVRTWA MAKGLVQHPP RAAESELAFP SFLLQCFLGA 
LWLALSGEIK DKELPQYLAL TPRKKRPYDN WLEGVPRFLA GLIFQPPARC LGALLGPSAA 
ASVDRKQKVL ARYLKRLQPG TLRARQLLEL LHCAHEAEEA GIWQHVVQEL PGRLSFLGTR 
LTPPDAHVLG KALEAAGQDF SLDLRSTGIC PSGLGSLVGL SCVTRFRAAL SDTVALWESL 
QQHGETKLLQ AAEEKFTIEP FKAKSLKDVE DLGKLVQTQR TRSSSEDTAG ELPAVRDLKK 
LEFALGPVSG PQAFPKLVRI LTAFSSLQHL DLDALSENKI GDEGVSQLSA TFPQLKSLET 
LNLSQNNITD LGAYKLAEAL PSLAASLLRL SLYNNCICDV GAESLARVLP DMVSLRVMDV 
QYNKFTAAGA QQLAASLRRC PHVETLAMWT PTIPFSVQEH LQQQDSRISL R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.