Details for: CIITA

Gene ID: 4261

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CIITA

Ensembl ID: ENSG00000179583

Description: class II major histocompatibility complex transactivator

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmablast CL0000980
    CSI 25.67
    rCSI 20.19%
    PRS 84.64
  • myeloid dendritic cell CL0000782
    CSI 8.98
    rCSI 13%
    PRS 91.59
  • mononuclear phagocyte CL0000113
    CSI 8.79
    rCSI 19.34%
    PRS 83.48
  • elicited macrophage CL0000861
    CSI 5.72
    rCSI 5.25%
    PRS 87.14
  • common dendritic progenitor CL0001029
    CSI 4.75
    rCSI 5.97%
    PRS 88.08
  • plasmacytoid dendritic cell, human CL0001058
    CSI 4.54
    rCSI 3.17%
    PRS 82.93
  • mature B cell CL0000785
    CSI 4.14
    rCSI 3.6%
    PRS 88.76
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 4.11
    rCSI 9.37%
    PRS 73.6
  • naive B cell CL0000788
    CSI 4.1
    rCSI 3.52%
    PRS 86.26
  • small pre-B-II cell CL0000954
    CSI 4.05
    rCSI 3.9%
    PRS 92.46
  • Kupffer cell CL0000091
    CSI 3.92
    rCSI 8.97%
    PRS 80.53
  • Langerhans cell CL0000453
    CSI 3.59
    rCSI 5.49%
    PRS 90.21
  • unswitched memory B cell CL0000970
    CSI 3.27
    rCSI 2.75%
    PRS 91.57
  • secretory cell CL0000151
    CSI 3.21
    rCSI 3.35%
    PRS 79.08
  • conventional dendritic cell CL0000990
    CSI 3.12
    rCSI 2.6%
    PRS 80.23
  • inflammatory macrophage CL0000863
    CSI 3.07
    rCSI 5.24%
    PRS 93.75
  • multi-ciliated epithelial cell CL0005012
    CSI 3.05
    rCSI 3.05%
    PRS 73.61
  • basal cell of epidermis CL0002187
    CSI 3.04
    rCSI 5.38%
    PRS 49.26
  • lung interstitial macrophage CL4033043
    CSI 2.99
    rCSI 6.72%
    PRS 91.19
  • CD14-positive monocyte CL0001054
    CSI 2.95
    rCSI 3.67%
    PRS 88.5
  • precursor B cell CL0000817
    CSI 2.94
    rCSI 2.58%
    PRS 86.84
  • memory B cell CL0000787
    CSI 2.92
    rCSI 2.88%
    PRS 92.06
  • pro-B cell CL0000826
    CSI 2.74
    rCSI 2.27%
    PRS 82.07
  • class switched memory B cell CL0000972
    CSI 2.71
    rCSI 2.02%
    PRS 91.31
  • B cell CL0000236
    CSI 2.7
    rCSI 3.61%
    PRS 87.05
  • dendritic cell CL0000451
    CSI 2.56
    rCSI 3.16%
    PRS 83.94
  • immature B cell CL0000816
    CSI 2.55
    rCSI 1.9%
    PRS 89.87
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.52
    rCSI 6.57%
    PRS 80.91
  • blood vessel endothelial cell CL0000071
    CSI 2.36
    rCSI 4.89%
    PRS 76.58
  • monocyte CL0000576
    CSI 2.24
    rCSI 4.05%
    PRS 84.97
  • hematopoietic stem cell CL0000037
    CSI 2.15
    rCSI 1.43%
    PRS 82.47
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.09
    rCSI 2.01%
    PRS 79.08
  • central nervous system macrophage CL0000878
    CSI 2.05
    rCSI 6.8%
    PRS 84.46
  • alternatively activated macrophage CL0000890
    CSI 2.05
    rCSI 2.58%
    PRS 88.57
  • microglial cell CL0000129
    CSI 2.03
    rCSI 8.17%
    PRS 81.46
  • granulocyte monocyte progenitor cell CL0000557
    CSI 1.91
    rCSI 1.66%
    PRS 83.57
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.84
    rCSI 2.4%
    PRS 89.88
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.68
    rCSI 1.3%
    PRS 82.49
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 1.68
    rCSI 4.03%
    PRS 91.83
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.67
    rCSI 2.02%
    PRS 87.13
  • transitional stage B cell CL0000818
    CSI 1.6
    rCSI 5.22%
    PRS 94.09
  • alveolar macrophage CL0000583
    CSI 1.48
    rCSI 2.43%
    PRS 83.57
  • dendritic cell, human CL0001056
    CSI 1.45
    rCSI 2.22%
    PRS 87.94
  • cardiac endothelial cell CL0010008
    CSI 1.4
    rCSI 5.63%
    PRS 79.42
  • germinal center B cell CL0000844
    CSI 1.37
    rCSI 4.09%
    PRS 89.29
  • intermediate monocyte CL0002393
    CSI 1.24
    rCSI 1.88%
    PRS 84.88
  • lung macrophage CL1001603
    CSI 1.17
    rCSI 2.6%
    PRS 86.57
  • large pre-B-II cell CL0000957
    CSI 1.13
    rCSI 3.23%
    PRS 85.07
  • myeloid dendritic cell, human CL0001057
    CSI 1.03
    rCSI 5.78%
    PRS 92.65
  • innate lymphoid cell CL0001065
    CSI 0.74
    rCSI 1.52%
    PRS 76.96
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 0.48
    rCSI 5.23%
    PRS 89.92
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.47
    rCSI 2.82%
    PRS 90.51
  • B-1 B cell CL0000819
    CSI 0.15
    rCSI 3.84%
    PRS 94.33

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CIITA](/details-gene/4261), the class II major histocompatibility complex transactivator, is a master regulator of gene expression essential for the adaptive immune system. It functions as a non-DNA-binding transcriptional coactivator that governs the expression of MHC class II genes. Its critical role is underscored by the fact that mutations in [CIITA](/details-gene/4261) are the cause of hereditary MHC class II deficiency, also known as bare lymphocyte syndrome ([Link](https://doi.org/10.1016/s0092-8674(05)80090-x)), a severe immunodeficiency disorder ([153245](https://omim.org/entry/600005)). Expression analysis reveals that [CIITA](/details-gene/4261) is most significantly active in professional antigen-presenting cells (APCs), with exceptionally high significance observed in [plasmablast](/details-cell/CL0000980)s, various dendritic cell subsets, and macrophages, highlighting its central function in initiating T-cell mediated immune responses. ## Cellular Roles and Expression Landscape The expression profile of [CIITA](/details-gene/4261) firmly establishes its identity as a key determinant of the antigen-presenting cell phenotype. **Overall**, the gene shows its highest significance in hematopoietic cells of both the myeloid and lymphoid lineages responsible for orchestrating adaptive immunity. Its most prominent role is observed in the B-cell lineage, culminating in an exceptionally high cell significance index (CSI) in [plasmablast](/details-cell/CL0000980)s. A detailed analysis reveals high significance across a spectrum of professional APCs, including [myeloid dendritic cell](/details-cell/CL0000782), [mononuclear phagocyte](/details-cell/CL0000113), and various tissue-resident phagocytes such as [Kupffer cell](/details-cell/CL0000091)s in the liver and [Langerhans cell](/details-cell/CL0000453)s in the skin. This broad expression pattern is consistent with its canonical function in enabling these cells to present exogenous antigens to CD4+ T-helper cells. The gene is also a defining marker for multiple stages of B-cell development and activation, including [naive B cell](/details-cell/CL0000788), [mature B cell](/details-cell/CL0000785), and [unswitched memory B cell](/details-cell/CL0000970). Interestingly, [CIITA](/details-gene/4261) also demonstrates significant expression in certain non-hematopoietic cell types, such as the [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145). This suggests a role for inducible MHC class II expression in epithelial barrier tissues, which can allow them to function as non-professional APCs during inflammation or infection, a finding supported by research demonstrating a role for [CIITA](/details-gene/4261) in antiviral resistance ([Link](https://doi.org/10.1126/science.abb3753)). ## Pathways and Molecular Function Functionally, [CIITA](/details-gene/4261) is the principal driver of the `Positive regulation of mhc class ii biosynthetic process` ([GO:0045348](https://www.ebi.ac.uk/QuickGO/term/GO:0045348)), and it also contributes to the `Positive regulation of mhc class i biosynthetic process` ([GO:0045345](https://www.ebi.ac.uk/QuickGO/term/GO:0045345)). It executes this function by acting as a `Transcription coactivator activity` ([GO:0003713](https://www.ebi.ac.uk/QuickGO/term/GO:0003713)) that remodels local chromatin structure ([GO:0006338](https://www.ebi.ac.uk/QuickGO/term/GO:0006338)) at MHC gene promoters. Localized to the `Nucleoplasm` ([GO:0005654](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)), its transport into the nucleus is dependent on `Gtp binding` ([GO:0005525](https://www.ebi.ac.uk/QuickGO/term/GO:0005525)) ([Link](https://doi.org/10.1126/science.285.5432.1402)). The activity of [CIITA](/details-gene/4261) is tightly integrated with cytokine signaling pathways, particularly `Interferon gamma signaling` ([R-HSA-877300](https://reactome.org/content/detail/R-HSA-877300)), as it is the primary downstream effector that mediates IFN-gamma-induced MHC class II expression. Beyond its coactivator role, emerging evidence suggests [CIITA](/details-gene/4261) possesses intrinsic enzymatic functions, including `Acyltransferase activity` ([GO:0016746](https://www.ebi.ac.uk/QuickGO/term/GO:0016746)) ([Link](https://doi.org/10.1016/s1097-2765(01)00159-9)) and `Protein serine kinase activity` ([GO:0106310](https://www.ebi.ac.uk/QuickGO/term/GO:0106310)) ([Link](https://doi.org/10.1016/j.bbagrm.2013.09.001)), suggesting a more complex regulatory capacity than previously understood. Its stability and function are further regulated through interactions with other proteins, including its stabilization within the `Pml body` ([GO:0016605](https://www.ebi.ac.uk/QuickGO/term/GO:0016605)) ([Link](https://doi.org/10.1083/jcb.201112015)). ## Research Directions The unique expression pattern and multifaceted functions of [CIITA](/details-gene/4261) suggest several avenues for future investigation. **Proposed Hypotheses:** 1. The induction of [CIITA](/details-gene/4261) in respiratory epithelial cells, such as the [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145), represents a direct, intrinsic antiviral host defense mechanism that restricts viral replication or entry, partially independent of its canonical function in T-cell antigen presentation. 2. The exceptionally high expression of [CIITA](/details-gene/4261) in [plasmablast](/details-cell/CL0000980)s may serve a non-canonical role beyond maintaining MHC class II expression, potentially by regulating transcriptional programs or chromatin states required for the high-rate immunoglobulin secretion and survival characteristic of this cell type. **Experimental Approach:** To test the first hypothesis regarding the direct antiviral role of [CIITA](/details-gene/4261) in epithelial cells, one could utilize a human bronchial epithelial cell line. A [CIITA](/details-gene/4261) knockout could be generated using CRISPR-Cas9. Both wild-type and knockout cells would then be treated with IFN-gamma to induce an antiviral state, followed by infection with a respiratory virus (e.g., a SARS-CoV-2 pseudovirus). By quantifying viral load via qPCR and concurrently measuring MHC class II surface expression by flow cytometry, it would be possible to determine if the antiviral effects of [CIITA](/details-gene/4261) induction are separable from its function in antigen presentation. **Therapeutic Potential:** As loss of [CIITA](/details-gene/4261) function leads to severe immunodeficiency, therapeutic strategies would focus on its activation or targeted delivery, rather than inhibition. Its role as the master switch for antigen presentation makes it a compelling target for cancer immunotherapy. Pharmacological induction or gene-delivery of [CIITA](/details-gene/4261) to tumor cells that lack MHC class II expression could convert immunologically "cold" tumors into "hot" tumors, thereby sensitizing them to checkpoint blockade inhibitors and T-cell-mediated cytotoxicity. Such an approach could represent a novel strategy to overcome immune evasion in a subset of cancers.

Genular Protein ID: 1682763990

Symbol: C2TA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P33076 A0N0N9 D3DUG0 E9PFE0 Q29675 Q8SNB8 Q96KL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 ELM 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8402893

Title: Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome).

PubMed ID: 8402893

DOI: 10.1016/s0092-8674(05)80090-x

PubMed ID: 7749984

Title: Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA).

PubMed ID: 7749984

DOI: 10.1016/1074-7613(95)90033-0

PubMed ID: 12919287

Title: Structural and functional characteristics of a dominant-negative isoform of porcine MHC class II transactivator.

PubMed ID: 12919287

DOI: 10.1046/j.1365-2370.2003.00397.x

PubMed ID: 12859996

Title: K-562 cells lack MHC class II expression due to an alternatively spliced CIITA transcript with a truncated coding region.

PubMed ID: 12859996

DOI: 10.1016/s0145-2126(03)00072-9

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10464099

Title: GTP binding by class II transactivator: role in nuclear import.

PubMed ID: 10464099

DOI: 10.1126/science.285.5432.1402

PubMed ID: 11172716

Title: Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250.

PubMed ID: 11172716

DOI: 10.1016/s1097-2765(01)00159-9

PubMed ID: 17493635

Title: The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.

PubMed ID: 17493635

DOI: 10.1016/j.jmb.2007.04.033

PubMed ID: 16600381

Title: ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription.

PubMed ID: 16600381

DOI: 10.1016/j.molimm.2006.02.029

PubMed ID: 20937824

Title: Novel functions for TAF7, a regulator of TAF1-independent transcription.

PubMed ID: 20937824

DOI: 10.1074/jbc.m110.173864

PubMed ID: 23007646

Title: PML promotes MHC class II gene expression by stabilizing the class II transactivator.

PubMed ID: 23007646

DOI: 10.1083/jcb.201112015

PubMed ID: 24036077

Title: Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity.

PubMed ID: 24036077

DOI: 10.1016/j.bbagrm.2013.09.001

PubMed ID: 32855215

Title: MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

PubMed ID: 32855215

DOI: 10.1126/science.abb3753

PubMed ID: 10501838

Title: Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA.

PubMed ID: 10501838

DOI: 10.1007/s002510050579

PubMed ID: 11466404

Title: Mutation in the class II trans-activator leading to a mild immunodeficiency.

PubMed ID: 11466404

DOI: 10.4049/jimmunol.167.3.1787

PubMed ID: 11862382

Title: Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency.

PubMed ID: 11862382

DOI: 10.1007/s00251-001-0395-7

Sequence Information:

  • Length: 1130
  • Mass: 123514
  • Checksum: 7A61CAA4F3FFECE0
  • Sequence:
    • MRCLAPRPAG SYLSEPQGSS QCATMELGPL EGGYLELLNS DADPLCLYHF YDQMDLAGEE 
EIELYSEPDT DTINCDQFSR LLCDMEGDEE TREAYANIAE LDQYVFQDSQ LEGLSKDIFK 
HIGPDEVIGE SMEMPAEVGQ KSQKRPFPEE LPADLKHWKP AEPPTVVTGS LLVRPVSDCS 
TLPCLPLPAL FNQEPASGQM RLEKTDQIPM PFSSSSLSCL NLPEGPIQFV PTISTLPHGL 
WQISEAGTGV SSIFIYHGEV PQASQVPPPS GFTVHGLPTS PDRPGSTSPF APSATDLPSM 
PEPALTSRAN MTEHKTSPTQ CPAAGEVSNK LPKWPEPVEQ FYRSLQDTYG AEPAGPDGIL 
VEVDLVQARL ERSSSKSLER ELATPDWAER QLAQGGLAEV LLAAKEHRRP RETRVIAVLG 
KAGQGKSYWA GAVSRAWACG RLPQYDFVFS VPCHCLNRPG DAYGLQDLLF SLGPQPLVAA 
DEVFSHILKR PDRVLLILDG FEELEAQDGF LHSTCGPAPA EPCSLRGLLA GLFQKKLLRG 
CTLLLTARPR GRLVQSLSKA DALFELSGFS MEQAQAYVMR YFESSGMTEH QDRALTLLRD 
RPLLLSHSHS PTLCRAVCQL SEALLELGED AKLPSTLTGL YVGLLGRAAL DSPPGALAEL 
AKLAWELGRR HQSTLQEDQF PSADVRTWAM AKGLVQHPPR AAESELAFPS FLLQCFLGAL 
WLALSGEIKD KELPQYLALT PRKKRPYDNW LEGVPRFLAG LIFQPPARCL GALLGPSAAA 
SVDRKQKVLA RYLKRLQPGT LRARQLLELL HCAHEAEEAG IWQHVVQELP GRLSFLGTRL 
TPPDAHVLGK ALEAAGQDFS LDLRSTGICP SGLGSLVGLS CVTRFRAALS DTVALWESLQ 
QHGETKLLQA AEEKFTIEPF KAKSLKDVED LGKLVQTQRT RSSSEDTAGE LPAVRDLKKL 
EFALGPVSGP QAFPKLVRIL TAFSSLQHLD LDALSENKIG DEGVSQLSAT FPQLKSLETL 
NLSQNNITDL GAYKLAEALP SLAASLLRLS LYNNCICDVG AESLARVLPD MVSLRVMDVQ 
YNKFTAAGAQ QLAASLRRCP HVETLAMWTP TIPFSVQEHL QQQDSRISLR

Genular Protein ID: 370954130

Symbol: Q66X48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q66X48

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 1107
  • Mass: 120936
  • Checksum: 16A1103F13FC3663
  • Sequence:
    • MELGPLEGGY LEPLNSDADP LCLYHFYDQM DLAGEEEIEL YSEPDTDTIN CDQFSRLLCD 
MEGDEETREA YANIAELDQY VFQDSQLEGL SKDIFIEHIG PDEVIGESME MPAEVGQKSQ 
KRPFPEELPA DLKHWKPAEP PTVVAGSLLV GPVSDCSTLS CLPLPALFNQ EPASGQMRLE 
KTDQIPMPFS SSSLSCLNLP EGPIQFVPTI STLPHGLWQI SEAGTGVSSI FIYHGEVPQA 
SQVPPPSGFT VHGLPTSPDR PGSTSPFAPS ATDLPSMPEP ALTSRANMTE HKTSPTQCPA 
AGEVSNKLPK WPEPVEQFYR SLQDTYGAEP AGPDGILVEV DLVQARLERS SSKGLERELA 
TPDWAERQLA QGGLAEVLLA AKEHRRPRET RVIAVLGKAG QGKSYWAGAV SRAWACGRLP 
QYDFVFSVPC HCLNRPGDAY GLQDLLFSLG PQPLVAADEV FSHILKRPDR VLLILDGFEE 
LEAQDGFLHS TCGPAPAEPC SLRGLLAGLF QKKLLRGCTL LLTARPRGRL VQSLSKADAL 
FELSGFSMEQ AQAYVMRYFE SSGMTEHQDR ALTLLRDRPL LLSHSHSPTL CRAVCQLSEA 
LLELGEDAKL PSTLTGLYVG LLGRAALGSP PGALAELAKL AWELGRRHQS TLQEDQFPSA 
DVRTWAMAKG LVQHPPRAAE SELAFPSFLL QCFLGALWLA LSGEIKDKEL PQYLALTPRK 
KRPYDNWLEG VPRFLAGLIF QPPARCLGAL LGPSAAASVD RKQKVLARYL KRLQPGTLRA 
RQLLELLHCA HEAEEAGIWQ HVVQELPGRL SFLGTRLTPL DAHVLGKALE AAGQDFSLDL 
RSTGICPSGL GSLVGLSCVT RFRAALSDTV ALWESLRQHG ETKLLQAAEE KFTIEPFKAK 
SLKDVEDLGK LVQTQRTRSS SEDTAGELPA VRDLKKLEFA LGPVSGPQAF PKLVRILTAF 
SSLQHLDLDA LSENKIGDEG VSQLSATFPQ LKSLETLNLS QNNITDLGAY KLAEALPSLA 
ASLLRLSLYN NCICDVGAES LARVLPDMVS LRVMDVQYNK FTAAGAQQLA ASLRRCPHVE 
TLAMWTPTIP FSVQEHLQQQ DSRISLR

Genular Protein ID: 1026598499

Symbol: A0A0B4J1S1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J1S1

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 2 PhylomeDB 1 Proteomes 2 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 1130
  • Mass: 123415
  • Checksum: D698094576546509
  • Sequence:
    • MRCLAPRPAG SYLSEPQGSS QCATMELGPL EGGYLELLNS DADPLCLYHF YDQMDLAGEE 
EIELYSEPDT DTINCDQFSR LLCDMEGDEE TREAYANIAE LDQYVFQDSQ LEGLSKDIFK 
HIGPDEVIGE SMEMPAEVGQ KSQKRPFPEE LPADLKHWKP AEPPTVVTGS LLVGPVSDCS 
TLPCLPLPAL FNQEPASGQM RLEKTDQIPM PFSSSSLSCL NLPEGPIQFV PTISTLPHGL 
WQISEAGTGV SSIFIYHGEV PQASQVPPPS GFTVHGLPTS PDRPGSTSPF APSATDLPSM 
PEPALTSRAN MTEHKTSPTQ CPAAGEVSNK LPKWPEPVEQ FYRSLQDTYG AEPAGPDGIL 
VEVDLVQARL ERSSSKSLER ELATPDWAER QLAQGGLAEV LLAAKEHRRP RETRVIAVLG 
KAGQGKSYWA GAVSRAWACG RLPQYDFVFS VPCHCLNRPG DAYGLQDLLF SLGPQPLVAA 
DEVFSHILKR PDRVLLILDG FEELEAQDGF LHSTCGPAPA EPCSLRGLLA GLFQKKLLRG 
CTLLLTARPR GRLVQSLSKA DALFELSGFS MEQAQAYVMR YFESSGMTEH QDRALTLLRD 
RPLLLSHSHS PTLCRAVCQL SEALLELGED AKLPSTLTGL YVGLLGRAAL DSPPGALAEL 
AKLAWELGRR HQSTLQEDQF PSADVRTWAM AKGLVQHPPR AAESELAFPS FLLQCFLGAL 
WLALSGEIKD KELPQYLALT PRKKRPYDNW LEGVPRFLAG LIFQPPARCL GALLGPSAAA 
SVDRKQKVLA RYLKRLQPGT LRARQLLELL HCAHEAEEAG IWQHVVQELP GRLSFLGTRL 
TPPDAHVLGK ALEAAGQDFS LDLRSTGICP SGLGSLVGLS CVTRFRAALS DTVALWESLQ 
QHGETKLLQA AEEKFTIEPF KAKSLKDVED LGKLVQTQRT RSSSEDTAGE LPAVRDLKKL 
EFALGPVSGP QAFPKLVRIL TAFSSLQHLD LDALSENKIG DEGVSQLSAT FPQLKSLETL 
NLSQNNITDL GAYKLAEALP SLAASLLRLS LYNNCICDVG AESLARVLPD MVSLRVMDVQ 
YNKFTAAGAQ QLAASLRRCP HVETLAMWTP TIPFSVQEHL QQQDSRISLR

Genular Protein ID: 310262737

Symbol: A0A087X2I7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X2I7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 1131
  • Mass: 123529
  • Checksum: 75EF94F4CEC4AB3A
  • Sequence:
    • MRCLAPRPAG SYLSEPQGSS QCATMELGPL EGGYLELLNS DADPLCLYHF YDQMDLAGEE 
EIELYSEPDT DTINCDQFSR LLCDMEGDEE TREAYANIAE LDQYVFQDSQ LEGLSKDIFI 
EHIGPDEVIG ESMEMPAEVG QKSQKRPFPE ELPADLKHWK PAEPPTVVTG SLLVGPVSDC 
STLPCLPLPA LFNQEPASGQ MRLEKTDQIP MPFSSSSLSC LNLPEGPIQF VPTISTLPHG 
LWQISEAGTG VSSIFIYHGE VPQASQVPPP SGFTVHGLPT SPDRPGSTSP FAPSATDLPS 
MPEPALTSRA NMTEHKTSPT QCPAAGEVSN KLPKWPEPVE QFYRSLQDTY GAEPAGPDGI 
LVEVDLVQAR LERSSSKSLE RELATPDWAE RQLAQGGLAE VLLAAKEHRR PRETRVIAVL 
GKAGQGKSYW AGAVSRAWAC GRLPQYDFVF SVPCHCLNRP GDAYGLQDLL FSLGPQPLVA 
ADEVFSHILK RPDRVLLILD GFEELEAQDG FLHSTCGPAP AEPCSLRGLL AGLFQKKLLR 
GCTLLLTARP RGRLVQSLSK ADALFELSGF SMEQAQAYVM RYFESSGMTE HQDRALTLLR 
DRPLLLSHSH SPTLCRAVCQ LSEALLELGE DAKLPSTLTG LYVGLLGRAA LDSPPGALAE 
LAKLAWELGR RHQSTLQEDQ FPSADVRTWA MAKGLVQHPP RAAESELAFP SFLLQCFLGA 
LWLALSGEIK DKELPQYLAL TPRKKRPYDN WLEGVPRFLA GLIFQPPARC LGALLGPSAA 
ASVDRKQKVL ARYLKRLQPG TLRARQLLEL LHCAHEAEEA GIWQHVVQEL PGRLSFLGTR 
LTPPDAHVLG KALEAAGQDF SLDLRSTGIC PSGLGSLVGL SCVTRFRAAL SDTVALWESL 
QQHGETKLLQ AAEEKFTIEP FKAKSLKDVE DLGKLVQTQR TRSSSEDTAG ELPAVRDLKK 
LEFALGPVSG PQAFPKLVRI LTAFSSLQHL DLDALSENKI GDEGVSQLSA TFPQLKSLET 
LNLSQNNITD LGAYKLAEAL PSLAASLLRL SLYNNCICDV GAESLARVLP DMVSLRVMDV 
QYNKFTAAGA QQLAASLRRC PHVETLAMWT PTIPFSVQEH LQQQDSRISL R