Details for: RNASET2

Gene ID: 8635

Symbol: RNASET2

Ensembl ID: ENSG00000026297

Description: ribonuclease T2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 305.7632
    Cell Significance Index: -47.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 139.7632
    Cell Significance Index: -35.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 131.0846
    Cell Significance Index: -54.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 124.6255
    Cell Significance Index: -50.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.9971
    Cell Significance Index: -51.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.5653
    Cell Significance Index: -55.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.7784
    Cell Significance Index: -51.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 53.8784
    Cell Significance Index: -51.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.6389
    Cell Significance Index: -47.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.5822
    Cell Significance Index: -47.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.5442
    Cell Significance Index: -49.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.7010
    Cell Significance Index: 247.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.5642
    Cell Significance Index: -28.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.5279
    Cell Significance Index: 102.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.4129
    Cell Significance Index: 1863.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2603
    Cell Significance Index: 145.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8684
    Cell Significance Index: 97.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.7779
    Cell Significance Index: 52.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7620
    Cell Significance Index: 47.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.6643
    Cell Significance Index: 44.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6387
    Cell Significance Index: 76.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3312
    Cell Significance Index: 99.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3243
    Cell Significance Index: 12.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2473
    Cell Significance Index: 86.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1117
    Cell Significance Index: 50.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0598
    Cell Significance Index: 15.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9653
    Cell Significance Index: 871.5700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8752
    Cell Significance Index: 13.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8405
    Cell Significance Index: 151.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8010
    Cell Significance Index: 110.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7436
    Cell Significance Index: 96.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7403
    Cell Significance Index: 91.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7315
    Cell Significance Index: 38.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7150
    Cell Significance Index: 84.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6421
    Cell Significance Index: 122.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5770
    Cell Significance Index: 40.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5493
    Cell Significance Index: 110.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5123
    Cell Significance Index: 183.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4790
    Cell Significance Index: 211.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4622
    Cell Significance Index: 78.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4398
    Cell Significance Index: 27.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3689
    Cell Significance Index: 10.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3533
    Cell Significance Index: 34.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2844
    Cell Significance Index: 81.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2202
    Cell Significance Index: 28.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2200
    Cell Significance Index: 9.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1167
    Cell Significance Index: 4.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0845
    Cell Significance Index: 2.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0660
    Cell Significance Index: 1.4300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0513
    Cell Significance Index: 1.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0396
    Cell Significance Index: 4.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0109
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0142
    Cell Significance Index: -10.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0207
    Cell Significance Index: -15.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0213
    Cell Significance Index: -40.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0283
    Cell Significance Index: -52.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0335
    Cell Significance Index: -18.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0340
    Cell Significance Index: -52.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0404
    Cell Significance Index: -54.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0424
    Cell Significance Index: -32.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0736
    Cell Significance Index: -3.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0794
    Cell Significance Index: -50.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0950
    Cell Significance Index: -10.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0976
    Cell Significance Index: -20.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1154
    Cell Significance Index: -52.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1912
    Cell Significance Index: -21.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2334
    Cell Significance Index: -27.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2389
    Cell Significance Index: -47.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2482
    Cell Significance Index: -6.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2596
    Cell Significance Index: -6.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2766
    Cell Significance Index: -8.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2958
    Cell Significance Index: -15.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3233
    Cell Significance Index: -5.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3354
    Cell Significance Index: -48.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3663
    Cell Significance Index: -41.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4513
    Cell Significance Index: -18.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4703
    Cell Significance Index: -48.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4840
    Cell Significance Index: -37.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5073
    Cell Significance Index: -13.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5109
    Cell Significance Index: -10.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5183
    Cell Significance Index: -13.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5268
    Cell Significance Index: -12.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5952
    Cell Significance Index: -36.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6056
    Cell Significance Index: -10.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6459
    Cell Significance Index: -51.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7319
    Cell Significance Index: -41.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7387
    Cell Significance Index: -46.5600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.7577
    Cell Significance Index: -8.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7883
    Cell Significance Index: -22.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7946
    Cell Significance Index: -53.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8481
    Cell Significance Index: -18.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9552
    Cell Significance Index: -33.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0256
    Cell Significance Index: -13.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0848
    Cell Significance Index: -21.4500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -1.0907
    Cell Significance Index: -8.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0940
    Cell Significance Index: -22.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1435
    Cell Significance Index: -32.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1588
    Cell Significance Index: -42.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.1627
    Cell Significance Index: -6.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNASET2 is a small, single-stranded RNA-binding protein that exhibits endonuclease and exonuclease activities. It is a member of the RNase T family, which is characterized by its ability to hydrolyze RNA into smaller fragments. RNASET2 is highly conserved across species, with high sequence identity to RNASET1, another member of this family. The enzyme is primarily expressed in cells of the immune system, with highest levels detected in neutrophils and monocytes. **Pathways and Functions** RNASET2 is involved in several key pathways and processes, including: 1. **Innate Immune Response**: RNASET2 plays a crucial role in the innate immune response by regulating the degradation of RNA in neutrophils and monocytes. This enzyme is involved in the production of antimicrobial peptides and the regulation of inflammatory responses. 2. **Immune System Development**: RNASET2 is also involved in the development and maturation of immune cells, including neutrophils, monocytes, and B cells. The enzyme is required for the proper functioning of these cells and the regulation of their differentiation and survival. 3. **Gene Expression Regulation**: RNASET2 is involved in the regulation of gene expression by degrading specific RNA molecules, including microRNAs and long non-coding RNAs. This enzyme plays a crucial role in the regulation of cellular processes, including proliferation, differentiation, and survival. 4. **Extracellular RNA Degradation**: RNASET2 is also involved in the degradation of extracellular RNA, including RNA released from apoptotic cells. This enzyme plays a crucial role in the clearance of extracellular RNA and the regulation of the extracellular environment. **Clinical Significance** Dysregulation of RNASET2 has been implicated in various diseases, including: 1. **Autoimmune Disorders**: RNASET2 has been shown to play a role in the development of autoimmune disorders, including rheumatoid arthritis and lupus. The enzyme is involved in the regulation of immune responses and the clearance of extracellular RNA. 2. **Cancer**: RNASET2 has been implicated in the development and progression of cancer, including leukemia and lymphoma. The enzyme is involved in the regulation of gene expression and the degradation of extracellular RNA. 3. **Neurological Disorders**: RNASET2 has been shown to play a role in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. The enzyme is involved in the regulation of gene expression and the degradation of extracellular RNA. In conclusion, RNASET2 is a critical enzyme involved in the regulation of RNA metabolism and immune system function. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining immune system homeostasis and overall health.

Genular Protein ID: 4170503025

Symbol: RNT2_HUMAN

Name: Ribonuclease T2

UniProtKB Accession Codes:

O00584 B2RDA7 E1P5C3 Q5T8Q0 Q8TCU2 Q9BZ46 Q9BZ47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192857

Title: Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies.

PubMed ID: 9192857

DOI: 10.1006/geno.1997.4679

PubMed ID: 11821951

Title: Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer.

PubMed ID: 11821951

DOI: 10.1038/sj.onc.1205067

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15809705

Title: Tumor and metastasis suppression by the human RNASET2 gene.

PubMed ID: 15809705

PubMed ID: 16620762

Title: Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins.

PubMed ID: 16620762

DOI: 10.1016/j.abb.2006.02.022

PubMed ID: 19525954

Title: RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.

PubMed ID: 19525954

DOI: 10.1038/ng.398

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21199949

Title: rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA.

PubMed ID: 21199949

DOI: 10.1073/pnas.1009811107

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28730546

Title: Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2.

PubMed ID: 28730546

DOI: 10.1007/s13238-017-0448-9

PubMed ID: 30385512

Title: Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2).

PubMed ID: 30385512

DOI: 10.1074/jbc.ra118.005433

PubMed ID: 30184494

Title: Mitochondrial Trafficking and Processing of Telomerase RNA TERC.

PubMed ID: 30184494

DOI: 10.1016/j.celrep.2018.08.003

PubMed ID: 31778653

Title: TLR8 Is a Sensor of RNase T2 Degradation Products.

PubMed ID: 31778653

DOI: 10.1016/j.cell.2019.11.001

PubMed ID: 22735700

Title: Structure and activity of the only human RNase T2.

PubMed ID: 22735700

DOI: 10.1093/nar/gks614

Sequence Information:

  • Length: 256
  • Mass: 29481
  • Checksum: 7C8BB08B8ED853EB
  • Sequence:
    • MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK IQNDCRDPPD 
YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV IHSFPNRSRF WKHEWEKHGT 
CAAQVDALNS QKKYFGRSLE LYRELDLNSV LLKLGIKPSI NYYQVADFKD ALARVYGVIP 
KIQCLPPSQD EEVQTIGQIE LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV 
CEDGPVFYPP PKKTKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.